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  1. Article ; Online: Cost-effective 3D documentation device in forensic medicine.

    Sieberth, Till / Meindl, Michael / Sagmeister, Bernhard / Franckenberg, Sabine / Ptacek, Wolfgang

    Forensic science international

    2024  Volume 357, Page(s) 112005

    Abstract: 3D documentation in forensics and forensic medicine is being introduced more frequently in various institutes around the world. However, several institutes lack capacity in finances as well as staff to perform 3D documentations regularly. This technical ... ...

    Abstract 3D documentation in forensics and forensic medicine is being introduced more frequently in various institutes around the world. However, several institutes lack capacity in finances as well as staff to perform 3D documentations regularly. This technical paper aims to present a 3D documentation device that is low cost and easy to use and is a viable entry level solution for forensic medical departments. For this the small single-board computer Raspberry Pi 4 was used in conjunction with its high quality (HQ) camera module to create the 3DLamp - a flexible, low cost and easy to use documentation device. Besides a detailed description of the device this paper also presents four case examples where a 3D documentation was performed and analyses the acquired data and the created 3D models. It was found that the device returns feasible 3D models that appear usable for forensic 3D reconstructions.
    MeSH term(s) Humans ; Photogrammetry ; Cost-Benefit Analysis ; Imaging, Three-Dimensional ; Forensic Medicine ; Documentation
    Language English
    Publishing date 2024-03-21
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 424042-x
    ISSN 1872-6283 ; 0379-0738
    ISSN (online) 1872-6283
    ISSN 0379-0738
    DOI 10.1016/j.forsciint.2024.112005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 1104: Show issues Location:
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  2. Article ; Online: Biomechanical Comparison of 5 Different Fixation Constructs in a Trapeziometacarpal Joint Arthrodesis Model.

    Sehjal, Ranjit / Rusli, Wan / Kedgley, Angela E / Sagmeister, Markus Ludwig / Williamson, Mark / Smith, Andrew

    The Journal of hand surgery

    2023  

    Abstract: Purpose: Trapeziometacarpal joint (TMC) arthrodesis has a high rate of nonunion. This biomechanical analysis sought to determine the stiffness of 5 fixation methods in a TMC joint arthrodesis model.: Methods: Five fixation constructs were tested in a ...

    Abstract Purpose: Trapeziometacarpal joint (TMC) arthrodesis has a high rate of nonunion. This biomechanical analysis sought to determine the stiffness of 5 fixation methods in a TMC joint arthrodesis model.
    Methods: Five fixation constructs were tested in a validated porcine model: crossed 1.1-mm K-wires, crossed 1.6-mm K-wires, crossed headless compression screws (HCSs), compression plating (CP), and locked compression plating (LCP). The cantilever bending stiffness was measured in abduction, adduction, flexion, and extension. Samples were loaded to failure in extension, and the mode of failure was examined.
    Results: The crossed HCSs performed consistently well in all tests. Loading to failure resulted in screw pullout. In abduction and adduction, HCS and 1.6-mm K-wires were significantly stiffer than the other constructs. The mean load to failure in extension was similar in the HCS, CP, and LCP groups (304 N/mm, 311 N/mm, and 293 N/mm, respectively). There were no differences between CP and LCP in any biomechanical tests, and the mode of failure was through plate bending. The crossed 1.1-mm K-wires performed poorly in all tests.
    Conclusions: Crossed HCS displayed the greatest overall stability. Standard plating in compression mode and LCP had a similar biomechanical performance.
    Clinical relevance: The ideal construct stiffness required for the successful union after TMC joint arthrodesis is unknown, but HCS has the best overall biomechanical performance and, therefore, might be considered the best choice for this clinical setting.
    Language English
    Publishing date 2023-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605716-0
    ISSN 1531-6564 ; 0363-5023
    ISSN (online) 1531-6564
    ISSN 0363-5023
    DOI 10.1016/j.jhsa.2022.12.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1431: Show issues Location:
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  3. Article: Oligonucleotide Therapeutics for Age-Related Musculoskeletal Disorders: Successes and Challenges.

    Nicholson, Thomas A / Sagmeister, Michael / Wijesinghe, Susanne N / Farah, Hussein / Hardy, Rowan S / Jones, Simon W

    Pharmaceutics

    2023  Volume 15, Issue 1

    Abstract: Age-related disorders of the musculoskeletal system including sarcopenia, osteoporosis and arthritis represent some of the most common chronic conditions worldwide, for which there remains a great clinical need to develop safer and more efficacious ... ...

    Abstract Age-related disorders of the musculoskeletal system including sarcopenia, osteoporosis and arthritis represent some of the most common chronic conditions worldwide, for which there remains a great clinical need to develop safer and more efficacious pharmacological treatments. Collectively, these conditions involve multiple tissues, including skeletal muscle, bone, articular cartilage and the synovium within the joint lining. In this review, we discuss the potential for oligonucleotide therapies to combat the unmet clinical need in musculoskeletal disorders by evaluating the successes of oligonucleotides to modify candidate pathological gene targets and cellular processes in relevant tissues and cells of the musculoskeletal system. Further, we discuss the challenges that remain for the clinical development of oligonucleotides therapies for musculoskeletal disorders and evaluate some of the current approaches to overcome these.
    Language English
    Publishing date 2023-01-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15010237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The intra-muscular course and distribution of the anterior interosseous nerve within pronator quadratus: An anatomical study.

    Trowbridge, S / Sagmeister, M L / Lewis, T L / Vidakovic, H / Hammer, N / Kieser, D C

    Journal of clinical orthopaedics and trauma

    2022  Volume 28, Page(s) 101868

    Abstract: Background: The anterior interosseous nerve (AIN) is a terminal motor branch of the median nerve innervating the following three muscles from proximal to distal: Flexor pollicis longus (FPL), the radial half of flexor digitorum profundus (FDP), and the ... ...

    Abstract Background: The anterior interosseous nerve (AIN) is a terminal motor branch of the median nerve innervating the following three muscles from proximal to distal: Flexor pollicis longus (FPL), the radial half of flexor digitorum profundus (FDP), and the pronator quadratus (PQ). The aim of this study was to define the course of the AIN within the PQ to aid surgeons performing distal radial procedures.
    Methods: Ten embalmed cadaveric forearms were dissected to identify the path of the AIN within PQ. An en-bloc excision of the PQ with its supplying AIN and vasculature was performed to identify a safe zone where PQ can be elevated without damaging AIN. A scoping literature search was performed to identify other studies reporting the path of AIN through PQ.
    Results: The mean distance from the radial border of the radius perpendicular to the point at which the AIN enters the PQ was 22.3 mm (range 21-24 mm). The mean distance from the distal wrist crease to the AIN entering PQ was 74.3 mm (range 59-84 mm). The mean number of nerve branches to PQ was 5.2 (range 3-8). In all specimens, the AIN was found to lie on the radial side of the anterior interosseous artery (AIA).
    Conclusions: The AIN courses on the deep surface of the PQ in a longitudinal proximal to distal direction. A 'safe zone' was identified within 20 mm of the radial border of the distal radius, which may be utilised by surgeons in a muscle-splitting approach to the distal radius.
    Language English
    Publishing date 2022-04-12
    Publishing country India
    Document type Journal Article
    ZDB-ID 2596956-0
    ISSN 2213-3445 ; 0976-5662
    ISSN (online) 2213-3445
    ISSN 0976-5662
    DOI 10.1016/j.jcot.2022.101868
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Conference proceedings: Modellierung der potenziellen Auswirkungen der prophylaktischen Salpingektomie bei nicht-gynäkologischen Eingriffen

    Sagmeister, H / Schierlinger-Brandmayr, F / Mauberger, M / Url, P / Kramer, D / Sieghartsleitner, E / Lax, S / Vössner, S / Tamussino, K

    Geburtshilfe und Frauenheilkunde

    2024  Volume 84, Issue 04

    Language German
    Publishing date 2024-03-19
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 80111-2
    ISSN 1438-8804 ; 0016-5751 ; 1615-3359
    ISSN (online) 1438-8804
    ISSN 0016-5751 ; 1615-3359
    DOI 10.1055/s-0044-1783937
    Database Thieme publisher's database

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    Um I Zs.190: Show issues Location:
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    Zs.MO 655: Show issues

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  6. Book ; Thesis: Netzwerke in der freien Wohlfahrtspflege

    Sagmeister, Monika

    Umgang mit Veränderungen durch Vernetzung der Führungskräfte

    (Schriftenreihe Führung und Führungskräfte ; 4)

    2014  

    Author's details Monika Sagmeister
    Series title Schriftenreihe Führung und Führungskräfte ; 4
    Keywords Soziale Unterstützung ; Führungskraft ; Freie Wohlfahrtspflege ; Einrichtung ; Soziales Netzwerk ; Change Management ; Gemeinnützige Organisation ; Organisatorischer Wandel ; Führungskräfte ; Sozialkapital ; Deutschland
    Language German
    Size 245 S., [16] Bl., graph. Darst., 21 cm
    Publisher Kovač
    Publishing place Hamburg
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Regensburg, 2014
    ISBN 3830078609 ; 9783830078609
    Database ECONomics Information System

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  7. Book ; Thesis: Netzwerke in der freien Wohlfahrtspflege

    Sagmeister, Monika

    Umgang mit Veränderungen durch Vernetzung der Führungskräfte

    (Schriftenreihe Führung und Führungskräfte ; 4)

    2014  

    Author's details Monika Sagmeister
    Series title Schriftenreihe Führung und Führungskräfte ; 4
    Keywords Soziale Unterstützung ; Führungskraft ; Freie Wohlfahrtspflege ; Einrichtung ; Soziales Netzwerk ; Change Management ; Gemeinnützige Organisation ; Organisatorischer Wandel ; Führungskräfte ; Sozialkapital ; Deutschland
    Language German
    Size 245 S., [16] Bl., graph. Darst., 21 cm
    Publisher Kovač
    Publishing place Hamburg
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Regensburg, 2014
    ISBN 3830078609 ; 9783830078609
    Database Former special subject collection: coastal and deep sea fishing

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  8. Article ; Online: Implications of tricuspid regurgitation and right ventricular volume overload in patients with heart failure with preserved ejection fraction.

    Kresoja, Karl-Patrik / Rosch, Sebastian / Schöber, Anne Rebecca / Fengler, Karl / Schlotter, Florian / Bombace, Sara / Sagmeister, Paula / von Roeder, Maximilian / Kister, Tobias / Gutberlet, Matthias / Thiele, Holger / Rommel, Karl-Philipp / Lurz, Philipp

    European journal of heart failure

    2024  

    Abstract: Aims: The aim of this study was to assess the pathophysiological implications of severe tricuspid regurgitation (TR) in patients with heart failure with preserved ejection fraction (HFpEF) by using tricuspid transcatheter edge-to-edge repair (T-TEER) as ...

    Abstract Aims: The aim of this study was to assess the pathophysiological implications of severe tricuspid regurgitation (TR) in patients with heart failure with preserved ejection fraction (HFpEF) by using tricuspid transcatheter edge-to-edge repair (T-TEER) as a model of right ventricular (RV) volume overload relief.
    Methods and results: This prospective interventional single arm trial (NCT04782908) included patients with invasively diagnosed HFpEF. The following parameters were prospectively assessed before and after T-TEER: left ventricular (LV) diastolic properties by invasive pressure-volume loop recordings; biventricular time-volume curves and function as well as septal curvature by cardiac magnetic resonance imaging; strain analyses for timing of septal motion. Overall, 20 patients (median age 78, interquartile range [IQR] 72-83 years, 65% female) were included. T-TEER reduced TR by a median of 2 (of 5) grades (IQR 2-1). T-TEER increased LV stroke volume and LV end-diastolic volume (LVEDV) (p < 0.001), without increasing LV end-diastolic pressure (LVEDP) (p = 0.094), consequently diastolic function improved with a reduction in LVEDP/LVEDV (p = 0.001) and a rightward shift of the end-diastolic pressure-volume relationship. The increase in LVEDV correlated with a decrease in RV end-diastolic volume (p < 0.001) and LV transmural pressure increased (p = 0.028). Secondary to a decrease in early RV filling, improvements in early LV filling were observed, correlating with an alleviation of leftwards bowing of the septum (p < 0.01, respectively).
    Conclusion: Diastolic LV properties in patients with HFpEF and severe TR are importantly determined by ventricular interaction in the setting of RV volume overload. T-TEER reduces RV volume overload and improves biventricular interaction and physiology.
    Language English
    Publishing date 2024-03-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.3195
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5299: Show issues Location:
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  9. Article ; Online: Kidney transplantation in ANCA-associated vasculitis.

    Sagmeister, Michael S / Grigorescu, Melissa / Schönermarck, Ulf

    Journal of nephrology

    2019  Volume 32, Issue 6, Page(s) 919–926

    Abstract: The kidney is commonly affected in patients with ANCA-associated vasculitis (AAV), causing end-stage renal disease (ESRD) in 20-40% of cases. Kidney transplantation is the treatment of choice for eligible patients with ESRD due to AAV. This review ... ...

    Abstract The kidney is commonly affected in patients with ANCA-associated vasculitis (AAV), causing end-stage renal disease (ESRD) in 20-40% of cases. Kidney transplantation is the treatment of choice for eligible patients with ESRD due to AAV. This review provides a summary of patient and graft outcome after kidney transplantation in AAV patients, the risk of relapse and the optimal time of transplantation. We also address the rare event of de novo ANCA-associated vasculitis after kidney transplantation and the treatment options.
    MeSH term(s) Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/complications ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/surgery ; Humans ; Kidney Failure, Chronic/etiology ; Kidney Failure, Chronic/surgery ; Kidney Transplantation ; Recurrence
    Language English
    Publishing date 2019-08-30
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-019-00642-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3369: Show issues Location:
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  10. Article: High glucose treatment promotes extracellular matrix proteome remodeling in Mller glial cells.

    Sagmeister, Sandra / Merl-Pham, Juliane / Petrera, Agnese / Deeg, Cornelia A / Hauck, Stefanie M

    PeerJ

    2021  Volume 9, Page(s) e11316

    Abstract: Background: The underlying pathomechanisms in diabetic retinopathy (DR) remain incompletely understood. The aim of this study was to add to the current knowledge about the particular role of retinal Mller glial cells (RMG) in the initial processes of DR. ...

    Abstract Background: The underlying pathomechanisms in diabetic retinopathy (DR) remain incompletely understood. The aim of this study was to add to the current knowledge about the particular role of retinal Mller glial cells (RMG) in the initial processes of DR.
    Methods: Applying a quantitative proteomic workflow, we investigated changes of primary porcine RMG under short term high glucose treatment as well as glycolysis inhibition treatment.
    Results: We revealed significant changes in RMG proteome primarily in proteins building the extracellular matrix (ECM) indicating fundamental remodeling processes of ECM as novel rapid response to high glucose treatment. Among others, Osteopontin (SPP1) as well as its interacting integrins were significantly downregulated and organotypic retinal explant culture confirmed the selective loss of SPP1 in RMG upon treatment. Since SPP1 in the retina has been described neuroprotective for photoreceptors and functions against experimentally induced cell swelling, its rapid loss under diabetic conditions may point to a direct involvement of RMG to the early neurodegenerative processes driving DR. Data are available via ProteomeXchange with identifier PXD015879.
    Language English
    Publishing date 2021-05-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.11316
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