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  1. Article ; Online: Miz-1 regulates translation of Trp53 via ribosomal protein L22 in cells undergoing V(D)J recombination.

    Rashkovan, Marissa / Vadnais, Charles / Ross, Julie / Gigoux, Mathieu / Suh, Woong-Kyung / Gu, Wei / Kosan, Christian / Möröy, Tarik

    Proceedings of the National Academy of Sciences of the United States of America

    2014  Volume 111, Issue 50, Page(s) E5411–9

    Abstract: ... which are generated through V(D)J recombination in lymphoid precursors. These precursors must be protected ... from DNA damage-induced cell death, however, because V(D)J recombination generates double-strand breaks and ... its apoptosis-inducing functions in lymphocytes, precisely at differentiation stages in which V(D)J ...

    Abstract To be effective, the adaptive immune response requires a large repertoire of antigen receptors, which are generated through V(D)J recombination in lymphoid precursors. These precursors must be protected from DNA damage-induced cell death, however, because V(D)J recombination generates double-strand breaks and may activate p53. Here we show that the BTB/POZ domain protein Miz-1 restricts p53-dependent induction of apoptosis in both pro-B and DN3a pre-T cells that actively rearrange antigen receptor genes. Miz-1 exerts this function by directly activating the gene for ribosomal protein L22 (Rpl22), which binds to p53 mRNA and negatively regulates its translation. This mechanism limits p53 expression levels and thus contains its apoptosis-inducing functions in lymphocytes, precisely at differentiation stages in which V(D)J recombination occurs.
    MeSH term(s) Analysis of Variance ; Animals ; Cell Death/physiology ; Chromatin Immunoprecipitation ; Flow Cytometry ; Gene Expression Regulation/genetics ; Gene Expression Regulation/physiology ; Genetic Vectors/genetics ; Immunoblotting ; Immunoprecipitation ; Lymphoid Progenitor Cells/physiology ; Mice ; Mice, Inbred C57BL ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Protein Biosynthesis/genetics ; Protein Biosynthesis/physiology ; Protein Inhibitors of Activated STAT/genetics ; Protein Inhibitors of Activated STAT/metabolism ; RNA-Binding Proteins/metabolism ; Real-Time Polymerase Chain Reaction ; Ribosomal Proteins/metabolism ; Tumor Suppressor Protein p53/metabolism ; V(D)J Recombination/genetics ; V(D)J Recombination/physiology
    Chemical Substances Miz1 protein, mouse ; Nuclear Proteins ; Protein Inhibitors of Activated STAT ; RNA-Binding Proteins ; RPL22 protein, mouse ; Ribosomal Proteins ; Tumor Suppressor Protein p53
    Language English
    Publishing date 2014-12-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1412107111
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1148: Show issues Location:
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  2. Article: Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle.

    Jiang, Hao / Chang, Fu-Chung / Ross, Ashley E / Lee, Jihyun / Nakayama, Keiichi / Nakayama, Keiko / Desiderio, Stephen

    Molecular cell

    2005  Volume 18, Issue 6, Page(s) 699–709

    Abstract: The periodic destruction of RAG-2 at the G1-to-S transition couples V(D)J recombination to the G0 ... regulation of the V(D)J recombinase in a cell-free system. The ubiquitin-proteasomal pathway carries out ...

    Abstract The periodic destruction of RAG-2 at the G1-to-S transition couples V(D)J recombination to the G0 and G1 cell cycle phases and coordinates RAG-mediated DNA cleavage with DNA repair by nonhomologous end joining. To define the mechanism by which this occurs, we reproduced cell cycle-dependent regulation of the V(D)J recombinase in a cell-free system. The ubiquitin-proteasomal pathway carries out destruction of RAG-2 in lysates of S phase cells and during S phase in vivo. Remarkably, the Skp2-SCF ubiquitin ligase, which plays a central role in cell cycle regulation through the destruction of p27, mediates ubiquitylation of RAG-2 in vitro and degradation of RAG-2 in vivo. The regulation of antigen receptor gene assembly by Skp2-SCF provides an unexpected and direct mechanistic link between DNA recombination and the cell cycle.
    MeSH term(s) Cell Cycle/physiology ; DNA-Binding Proteins/metabolism ; G1 Phase ; HeLa Cells ; Humans ; Nuclear Proteins ; Recombination, Genetic ; S Phase ; S-Phase Kinase-Associated Proteins/metabolism ; Ubiquitin/metabolism ; VDJ Recombinases/metabolism
    Chemical Substances DNA-Binding Proteins ; Nuclear Proteins ; RAG2 protein, human ; S-Phase Kinase-Associated Proteins ; Ubiquitin ; V(D)J recombination activating protein 2 ; VDJ Recombinases (EC 2.7.7.-)
    Language English
    Publishing date 2005-06-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2005.05.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Drury J. McMillen, D.D.S.

    Ross, G

    Midwestern dentist

    1969  Volume 45, Issue 4, Page(s) 16

    MeSH term(s) Dentists
    Language English
    Publishing date 1969-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603717-3
    ISSN 0026-3478
    ISSN 0026-3478
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online: (Table S1) Chronostratigraphic constrains for sediment core AND1-1B, supplementary data to: Naish, Tim R; Powell, Ross; Levy, R; Wilson, Gary S; Scherer, Reed P; Talarico, Franco; Krissek, Lawrence A; Niessen, Frank; Pompilio, Massimo; Wilson, Terry; Carter, Lionel; DeConto, Robert M; Huybers, P; McKay, R; Pollard, David; Ross, J; Winter, Diane M; Barrett, Peter J; Browne, G; Cody, R; Cowan, Ellen A; Crampton, J; Dunbar, Gavin B; Dunbar, N; Florindo, Fabio; Gebhardt, Andrea Catalina; Graham, IJ; Hannah, Mike J; Hansaraj, D; Harwood, David M; Helling, D; Henrys, Stuart; Hinnov, L; Kuhn, Gerhard; Kyle, Philip R; Läufer, Andreas L; Maffioli, P; Magens, Diana; Mandernack, Kevin W; McIntosh, WC; Millan, C; Morin, Roger H; Ohneiser, Christian; Paulsen, Timothy S; Persico, Davide; Raine, J Ian; Reed, J; Riesselman, C; Sagnotti, Leo; Schmitt, D R; Sjunneskog, C; Strong, P; Taviani, Marco; Vogel, Stefan; Wilch, T; Williams, Trevor (2009): Obliquity-paced Pliocene West Antarctic ice sheet oscillations. Nature, 458(7236), 322-329

    Naish, Tim R / Krissek, Lawrence A / Levy, R / Niessen, Frank / Pompilio, Massimo / Powell, Ross / Scherer, Reed P / Talarico, Franco / Wilson, Gary S / al., et

    2009  

    Abstract: ... from the upper 600 m of the AND-1B sediment core recovered from beneath the northwest part of the Ross ice shelf ... collapsed, resulting in a switch from grounded ice, or ice shelves, to open waters in the Ross embayment ...

    Abstract Thirty years after oxygen isotope records from microfossils deposited in ocean sediments confirmed the hypothesis that variations in the Earth's orbital geometry control the ice ages (Hays et al., 1976, doi:10.1126/science.194.4270.1121), fundamental questions remain over the response of the Antarctic ice sheets to orbital cycles (Raymo and Huybers, 2008, doi:10.1038/nature06589). Furthermore, an understanding of the behaviour of the marine-based West Antarctic ice sheet (WAIS) during the 'warmer-than-present' early-Pliocene epoch (~5-3 Myr ago) is needed to better constrain the possible range of ice-sheet behaviour in the context of future global warming (Solomon et al., 2007). Here we present a marine glacial record from the upper 600 m of the AND-1B sediment core recovered from beneath the northwest part of the Ross ice shelf by the ANDRILL programme and demonstrate well-dated, ~40-kyr cyclic variations in ice-sheet extent linked to cycles in insolation influenced by changes in the Earth's axial tilt (obliquity) during the Pliocene. Our data provide direct evidence for orbitally induced oscillations in the WAIS, which periodically collapsed, resulting in a switch from grounded ice, or ice shelves, to open waters in the Ross embayment when planetary temperatures were up to ~3° C warmer than today ( Kim and Crowley, 2000, doi:10.1029/1999PA000459) and atmospheric CO2 concentration was as high as ~400 p.p.m.v. (van der Burgh et al., 1993, doi:10.1126/science.260.5115.1788, Raymo et al., 1996, doi:10.1016/0377-8398(95)00048-8). The evidence is consistent with a new ice-sheet/ice-shelf model (Pollard and DeConto, 2009, doi:10.1038/nature07809) that simulates fluctuations in Antarctic ice volume of up to +7 m in equivalent sea level associated with the loss of the WAIS and up to +3 m in equivalent sea level from the East Antarctic ice sheet, in response to ocean-induced melting paced by obliquity. During interglacial times, diatomaceous sediments indicate high surface-water productivity, minimal summer sea ice and air temperatures above freezing, suggesting an additional influence of surface melt (Huybers, 2006, doi:10.1126/science.1125249) under conditions of elevated CO2.
    Language English
    Dates of publication 2009-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Online
    Note This dataset is supplement to doi:10.1038/nature07867
    DOI 10.1594/PANGAEA.769658
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  5. Book: Faust's Anesthesiology Review

    Gali, Bhargavi / Gaitan, Brantley D. / Renew, J. Ross / Mueller, Jeffrey T. / Johnson, Rebecca L. / Trentman, Terence L. / Weingarten, Toby N.

    2023  

    Size 832 p.
    Publisher Elsevier - Health Sciences Division
    Document type Book
    Note PDA Manuell_25
    Format 216 x 281 x 31
    ISBN 9780323879163 ; 0323879160
    Database PDA

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  6. Article: Dr. D. A. W. Rittey, S.B., St.J., MB., Ch.B (Edin.).

    Ross, F / Blair, D

    The Central African journal of medicine

    1977  Volume 23, Issue 4, Page(s) 90–92

    MeSH term(s) History, 20th Century ; Zimbabwe
    Language English
    Publishing date 1977-04
    Publishing country Zimbabwe
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 123798-6
    ISSN 0008-9176
    ISSN 0008-9176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 310: Show issues Location:
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  7. Book ; Online ; E-Book: Principles and practice of hospital medicine

    McKean, Sylvia C. / Ross, John J. / Dressler, Daniel D. / Scheurer, Danielle

    2017  

    Author's details editors, Sylvia C. McKean, John J. Ross, Daniel D. Dressler, Danielle B. Scheurer
    MeSH term(s) Clinical Medicine. ; Hospitals. ; Hospital Medicine ; Hospitalization ; Hospitalists ; Inpatients.
    Subject code 362.11
    Language English
    Edition 2nd edition
    Publisher McGraw-Hill Education Medical
    Publishing place New York
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 978-0-07-184313-3 ; 0-07-184313-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Article ; Online: Addressing Cannabis Use During Adolescence.

    Riggs, Paula / Hinckley, Jesse D / Ross, J Megan

    The Psychiatric clinics of North America

    2023  Volume 46, Issue 4, Page(s) xiii–xv

    MeSH term(s) Humans ; Adolescent ; Cannabis/adverse effects ; Marijuana Smoking ; Risk Factors ; Longitudinal Studies
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Editorial
    ZDB-ID 431518-2
    ISSN 1558-3147 ; 0193-953X
    ISSN (online) 1558-3147
    ISSN 0193-953X
    DOI 10.1016/j.psc.2023.06.018
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  9. Article ; Online: Tissue oxygen partial pressure as a viability metric for ex vivo brain tissue slices.

    Voss, Logan J / Steyn-Ross, D Alistair

    Journal of neuroscience methods

    2023  Volume 396, Page(s) 109932

    Abstract: Background: Despite the prevalent use of the ex vivo brain slice preparation in neurophysiology research, a reliable method for judging tissue viability - and thus suitability of a slice for inclusion in an experiment - is lacking. The utility of ... ...

    Abstract Background: Despite the prevalent use of the ex vivo brain slice preparation in neurophysiology research, a reliable method for judging tissue viability - and thus suitability of a slice for inclusion in an experiment - is lacking. The utility of indirect electrophysiological measures of tissue health is model-specific and needs to be used cautiously. In this study, we verify a more direct test of slice viability, based on tissue oxygen consumption rate.
    New method: We hypothesised that the minimum intra-slice partial pressure of oxygen (pO
    Results: Tissue pO
    Comparison with existing methods: While measurement of tissue oxygen levels and oxygen consumption is not new, intra-tissue pO
    Conclusion: The results confirm that tissue oxygen minimum pO
    Language English
    Publishing date 2023-07-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282721-9
    ISSN 1872-678X ; 0165-0270
    ISSN (online) 1872-678X
    ISSN 0165-0270
    DOI 10.1016/j.jneumeth.2023.109932
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Determination of Krogh Coefficient for Oxygen Consumption Measurement from Thin Slices of Rodent Cortical Tissue Using a Fick's Law Model of Diffusion.

    Steyn-Ross, D Alistair / Steyn-Ross, Moira L / Sleigh, Jamie W / Voss, Logan J

    International journal of molecular sciences

    2023  Volume 24, Issue 7

    Abstract: To investigate the impact of experimental interventions on living biological tissue, ex vivo rodent brain slices are often used as a more controllable alternative to a live animal model. However, for meaningful results, the biological sample must be ... ...

    Abstract To investigate the impact of experimental interventions on living biological tissue, ex vivo rodent brain slices are often used as a more controllable alternative to a live animal model. However, for meaningful results, the biological sample must be known to be healthy and viable. One of the gold-standard approaches to identifying tissue viability status is to measure the rate of tissue oxygen consumption under specific controlled conditions. Here, we work with thin (400 μm) slices of mouse cortical brain tissue which are sustained by a steady flow of oxygenated artificial cerebralspinal fluid (aCSF) at room temperature. To quantify tissue oxygen consumption (
    MeSH term(s) Animals ; Mice ; Rodentia ; Diffusion ; Oxygen ; Respiratory Function Tests ; Oxygen Consumption
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-03-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24076450
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