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Article ; Online: The Role of Neuropeptide Y in the Nucleus Accumbens.

Tanaka, Masaki / Yamada, Shunji / Watanabe, Yoshihisa

International journal of molecular sciences

2021 Volume 22, Issue 14

Abstract: Neuropeptide Y (NPY), an abundant peptide in the central nervous system, is expressed in neurons ...

Abstract	Neuropeptide Y (NPY), an abundant peptide in the central nervous system, is expressed in neurons of various regions throughout the brain. The physiological and behavioral effects of NPY are mainly mediated through Y1, Y2, and Y5 receptor subtypes, which are expressed in regions regulating food intake, fear and anxiety, learning and memory, depression, and posttraumatic stress. In particular, the nucleus accumbens (NAc) has one of the highest NPY concentrations in the brain. In this review, we summarize the role of NPY in the NAc. NPY is expressed principally in medium-sized aspiny neurons, and numerous NPY immunoreactive fibers are observed in the NAc. Alterations in NPY expression under certain conditions through intra-NAc injections of NPY or receptor agonists/antagonists revealed NPY to be involved in the characteristic functions of the NAc, such as alcohol intake and drug addiction. In addition, control of mesolimbic dopaminergic release via NPY receptors may take part in these functions. NPY in the NAc also participates in fat intake and emotional behavior. Accumbal NPY neurons and fibers may exert physiological and pathophysiological actions partly through neuroendocrine mechanisms and the autonomic nervous system.
MeSH term(s)	Animals ; Autonomic Nervous System/metabolism ; Humans ; Neurons/metabolism ; Neuropeptide Y/metabolism ; Nucleus Accumbens/metabolism ; Receptors, Neuropeptide Y/metabolism
Chemical Substances	Neuropeptide Y ; Receptors, Neuropeptide Y
Language	English
Publishing date	2021-07-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22147287
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Article: The Accuracy of Ankle Eccentric Torque Control Explains Dynamic Postural Control During the Y-Balance Test.

Nozu, Shojiro / Johnson, Kristin A / Tanaka, Tsukasa / Inoue, Mika / Nishio, Hirofumi / Takazawa, Yuji

International journal of sports physical therapy

2023 Volume 18, Issue 5, Page(s) 1113–1122

Abstract: Background: The Y-Balance Test (YBT), especially the posteromedial (PM) reach direction (PM-YBT ...

Abstract	Background: The Y-Balance Test (YBT), especially the posteromedial (PM) reach direction (PM-YBT), is able to identify dynamic postural control deficits in those who have ankle instability. However, there still exists a need to understand how sensorimotor function at the ankle explains the performance during the PM-YBT. Hypothesis/purpose: The purpose of this study was to determine whether the ability to accurately control eccentric ankle torque explained PM-YBT performance. It was hypothesized that eccentric dorsiflexion/plantarflexion torque control would be positively related to the maximum reach distance (MRD) of PM-YBT. Study design: Cross-sectional study. Methods: Twelve healthy subjects performed the PM-YBT, maximum voluntary isometric contractions (MVIC) for both dorsiflexion and plantarflexion muscle strength, and then the torque control testing of the ankle. The torque control testing provided a target torque level on a screen in front of the subject and passive rotations of the ankle joint in the sagittal plane at 10 deg/sec between plantarflexion to dorsiflexion. Subjects were then instructed to eccentrically contract the dorsiflexors and plantar flexors to generate torque while the ankle joint rotated. The accuracy of torque control during eccentric dorsiflexion and plantarflexion by calculating absolute errors, the area between the target torque and the produced torque were evaluated. Tibialis anterior and soleus muscle activities were simultaneously recorded during testing. A step-wise linear regression model was used to determine the best model predicted the MRD of the PM-YBT (PM-MRD). Results: A step-wise linear regression developed a model explaining only eccentric dorsiflexion torque control predicted higher PM-MRD score (R Conclusion: The accuracy of torque control during eccentric dorsiflexion predicts better performance in the PM-YBT. Level of evidence: 3b.
Language	English
Publishing date	2023-10-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2628664-6
ISSN	2159-2896
ISSN	2159-2896
DOI	10.26603/001c.87760
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Article: Genetic Variation in Y-Chromosome Genes of Sika Deer (

Tanaka, Kazuaki / Hoshi, Asuka / Nojima, Rai / Suzuki, Kaho / Takiguchi, Harutaka / Takatsuki, Seiki / Takizawa, Tatsuya / Hosoi, Eiji / Tamate, Hidetoshi B / Hayashida, Maki / Anezaki, Tomoko / Fukue, Yuko / Minami, Masato

Zoological science

2020 Volume 37, Issue 5, Page(s) 411–416

Abstract: Sika deer ( ...

Abstract	Sika deer (
MeSH term(s)	Animals ; Deer/genetics ; Genotype ; Japan ; Male ; Phylogeography ; Polymorphism, Single Nucleotide ; Y Chromosome/genetics
Language	English
Publishing date	2020-09-24
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2038883-4
ISSN	2212-3830 ; 0289-0003
ISSN (online)	2212-3830
ISSN	0289-0003
DOI	10.2108/zs200043
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Article ; Online: Deletion of Y chromosome before allogeneic hematopoietic stem cell transplantation in male recipients with female donors.

Tamaki, Masaharu / Kameda, Kazuaki / Kimura, Shun-Ichi / Harada, Naonori / Uchida, Naoyuki / Doki, Noriko / Tanaka, Masatsugu / Ikegame, Kazuhiro / Sawa, Masashi / Katayama, Yuta / Miyakoshi, Shigesaburo / Ara, Takahide / Kanda, Junya / Onizuka, Makoto / Fukuda, Takahiro / Atsuta, Yoshiko / Kanda, Yoshinobu / Yakushijin, Kimikazu / Nakasone, Hideki

Blood advances

2022 Volume 6, Issue 6, Page(s) 1895–1903

Abstract: ... hematopoietic stem cell transplantation (allo-HCT). H-Y antigens, which are encoded by Y chromosome, are important targets of the GVL ... effect. Thus, deletion of the Y chromosome (del[Y]) might cause the GVL effect to deteriorate ... in a transplantation involving a female donor and male recipient, although the clinical significance of the del(Y ...

Abstract	The graft-versus-leukemia (GVL) effect is one of the curative mechanisms of allogeneic hematopoietic stem cell transplantation (allo-HCT). H-Y antigens, which are encoded by Y chromosome, are important targets of the GVL effect. Thus, deletion of the Y chromosome (del[Y]) might cause the GVL effect to deteriorate in a transplantation involving a female donor and male recipient, although the clinical significance of the del(Y) group remains to be elucidated. In this study, we evaluated adult male patients who underwent allo-HCT between 2010 and 2019 in Japan. There were 155 cases in the del(Y) group and 4149 cases without del(Y) who underwent female-to-male allo-HCT. Del(Y) was significantly associated with inferior overall survival (hazard ratio [HR], 1.24; 95% confidence interval [CI], 1.00-1.53; P = .049) and an increased risk of relapse (HR, 1.40; 95% CI, 1.08-1.80; P = .0098) in multivariate analyses. There was no significant difference in nonrelapse mortality between recipients with and without del(Y) (HR, 1.08; 95% CI, 0.769-1.51; P = .67). In contrast, del(Y) was not significantly associated with any clinical outcomes in the cohort of male-to-male allo-HCT. A higher incidence of relapse might have been caused by attenuation of the GVL effect resulting from a lack of H-Y antigens. Because a GVL effect resulting from sex mismatch may not be expected in men with del(Y) who undergo allo-HCT with a female donor, additional post-allo-HCT strategies might be required to prevent disease relapse.
MeSH term(s)	Adult ; Female ; Graft vs Leukemia Effect ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Male ; Recurrence ; Tissue Donors ; Y Chromosome
Language	English
Publishing date	2022-01-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2021006456
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Article ; Online: Comparison of the gastric microbiome in Billroth I and Roux-en-Y reconstructions after distal gastrectomy.

Imai, Yoshiro / Lee, Sang-Woong / Sakaguchi, Shoichi / Kato-Kogoe, Nahoko / Taniguchi, Kohei / Omori, Michi / Tanaka, Ryo / Honda, Kotaro / Osumi, Wataru / Nakano, Takashi / Ueno, Takaaki / Uchiyama, Kazuhisa

Scientific reports

2022 Volume 12, Issue 1, Page(s) 10594

Abstract: ... This study aimed to compare the gastric microbiota following Billroth I and Roux-en-Y reconstructions after ... Billroth I and Roux-en-Y reconstructions, respectively. During upper gastrointestinal endoscopy, gastric ... I and Roux-en-Y reconstructions (observed operational taxonomic units, p = 0.58; Shannon index, p = 0.95 ...

Abstract	The changes in gastric microbiota following reconstruction after gastrectomy have not been reported. This study aimed to compare the gastric microbiota following Billroth I and Roux-en-Y reconstructions after distal gastrectomy. We enrolled 71 gastrectomized patients with gastric cancer; 31 and 40 underwent Billroth I and Roux-en-Y reconstructions, respectively. During upper gastrointestinal endoscopy, gastric fluid was collected immediately before and 6 months after distal gastrectomy. Deoxyribonucleic acid isolated from each sample was evaluated using 16S ribosomal ribonucleic acid metagenomic analysis. Analysis revealed that the gastric microbiota's species richness (expressed as the alpha diversity) was significantly lower after than before distal gastrectomy (operational taxonomic units, p = 0.001; Shannon index, p = 0.03). The interindividual diversity (beta diversity) was significantly different before and after distal gastrectomy (unweighted UniFrac distances, p = 0.04; weighted UniFrac distances, p = 0.001; Bray-Curtis, p = 0.001). Alpha and beta diversity were not significantly different between Billroth I and Roux-en-Y reconstructions (observed operational taxonomic units, p = 0.58; Shannon index, p = 0.95; unweighted UniFrac distances, p = 0.65; weighted UniFrac distances, p = 0.67; Bray-Curtis, p = 0.63). Our study demonstrated significant differences in gastric microbiota diversity, composition, and community before and after distal gastrectomy but no difference between Billroth I and Roux-en-Y reconstruction after distal gastrectomy.
MeSH term(s)	Anastomosis, Roux-en-Y ; Gastrectomy ; Gastroenterostomy ; Gastrointestinal Microbiome ; Humans ; Postoperative Complications/surgery ; Stomach Neoplasms/surgery ; Treatment Outcome
Language	English
Publishing date	2022-06-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-14886-4
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Article ; Online: Neuropeptide Y neurons in the nucleus accumbens modulate anxiety-like behavior.

Yamada, Shunji / Islam, Mohammad Shyful / van Kooten, Nienke / Bovee, Sonny / Oh, Yoon-Mi / Tsujimura, Atsushi / Watanabe, Yoshihisa / Tanaka, Masaki

Experimental neurology

2020 Volume 327, Page(s) 113216

Abstract: Neuropeptide Y (NPY) is a 36-amino acid neuropeptide that is widely expressed ...

Abstract	Neuropeptide Y (NPY) is a 36-amino acid neuropeptide that is widely expressed in the central nervous system, including the cerebral cortex, nucleus accumbens (NAc) and hypothalamus. We previously analyzed the behavior of transgenic mice exclusively expressing an unedited RNA isoform of the 5-HT
MeSH term(s)	Animals ; Anxiety/genetics ; Anxiety/metabolism ; Behavior, Animal/physiology ; Mice ; Mice, Transgenic ; Motor Activity/physiology ; Neurons/metabolism ; Neuropeptide Y/genetics ; Neuropeptide Y/metabolism ; Nucleus Accumbens/metabolism ; Receptors, Neuropeptide Y/metabolism
Chemical Substances	Neuropeptide Y ; Receptors, Neuropeptide Y
Language	English
Publishing date	2020-01-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	207148-4
ISSN	1090-2430 ; 0014-4886
ISSN (online)	1090-2430
ISSN	0014-4886
DOI	10.1016/j.expneurol.2020.113216
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Article ; Online: Neuropeptide Y modulates membrane excitability in neonatal rat mesencephalic V neurons.

Seki, Soju / Tanaka, Susumu / Yamada, Saori / Tsuji, Tadataka / Enomoto, Akifumi / Ono, Yudai / Chandler, Scott H / Kogo, Mikihiko

Journal of neuroscience research

2020 Volume 98, Issue 5, Page(s) 921–935

Abstract: Neuropeptide Y (NPY) is one of a number of neuropeptides with powerful orexigenic effects ...

Abstract	Neuropeptide Y (NPY) is one of a number of neuropeptides with powerful orexigenic effects. Intracerebroventricular administration of NPY induces increases in food intake and alters feeding rate. Besides it role in feeding behavior, NPY also has significant effects on neuronal systems related to other spontaneous behaviors such as rearing and grooming. In the present study, we examined the direct effects of NPY on mesencephalic V neurons (Mes V), which are important sensory neurons involved in oral motor reflexes and rhythmical jaw movements, as well as masticatory proprioception. Coronal brain slices were prepared from neonatal Sprague-Dawley rats (P3-17) and whole-cell patch clamp recordings were obtained from Mes V neurons. Bath application of NPY depolarized the membrane potential and induced inward current in most neurons. Application of NPY shortened the duration of the afterhyperpolarization following an action potential, and increased the mean spike frequency during repetitive discharge. In those neurons which exhibited rhythmical burst discharge in response to maintained current injection, the bursting frequency was also increased. These effects were mediated predominately by both Y1 and Y5 receptors.
MeSH term(s)	Action Potentials/drug effects ; Animals ; Animals, Newborn ; Membrane Potentials/drug effects ; Neurons/drug effects ; Neuropeptide Y/pharmacology ; Patch-Clamp Techniques ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Neuropeptide Y
Language	English
Publishing date	2020-01-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	195324-2
ISSN	1097-4547 ; 0360-4012
ISSN (online)	1097-4547
ISSN	0360-4012
DOI	10.1002/jnr.24583
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Article ; Online: Role of systemic inflammation in functional recovery, dysphagia, and 1-y mortality in heart failure: A prospective cohort study.

Matsuo, Haruyo / Yoshimura, Yoshihiro / Fujita, Shoji / Maeno, Yuichi / Tanaka, Sayoko

Nutrition (Burbank, Los Angeles County, Calif.)

2021 Volume 91-92, Page(s) 111465

Abstract: ... Index gain. Secondary outcome measures were dysphagia at discharge and all-cause 1-y mortality after ... systemic inflammation and study outcomes.: Results: A total of 184 participants (mean age, 79.1 y; 48.4 ... associated with 1-y mortality after discharge (P = 0.003).: Conclusions: Baseline systemic inflammation ...

Abstract	Objectives: This study evaluated the relationship between systemic inflammation and clinical outcomes in people hospitalized with acute heart failure (AHF). Methods: We prospectively enrolled people newly hospitalized with AHF after excluding those with concomitant infectious or inflammatory diseases. Systemic inflammation was evaluated using the modified Glasgow Prognostic Score (mGPS) at hospitalization, and participants were classified into low-grade and high-grade inflammation groups (mGPS 0-1 and 2, respectively). The primary outcome measure was functional recovery, evaluated using the Barthel Index gain. Secondary outcome measures were dysphagia at discharge and all-cause 1-y mortality after discharge. Multivariable analyses and Kaplan-Meier estimates were used to determine the association between systemic inflammation and study outcomes. Results: A total of 184 participants (mean age, 79.1 y; 48.4% female, 51.6% male) were included; 148 (80.4%) and 36 (19.6%), respectively, had low-grade and high-grade inflammation. Participants with high-grade inflammation were significantly older, had lower body mass index and muscle strength, and had lower nutrient intake, swallowing status, and Barthel Index than those with low-grade inflammation. In multivariable analyses, mGPS was significantly associated with Barthel Index gain (β = -0.229, P = 0.004) and Food Intake Level Scale (odds ratio = 5.067, P = 0.034) at discharge; mGPS was associated with 1-y mortality after discharge (P = 0.003). Conclusions: Baseline systemic inflammation was negatively associated with improvements in physical function and dysphagia and with 1-y survival in people with AHF. These findings highlight the importance of focusing on the assessment of systemic inflammation to accurately predict the functional prognosis of people with AHF.
MeSH term(s)	Aged ; Deglutition Disorders/etiology ; Female ; Heart Failure ; Humans ; Inflammation ; Male ; Prognosis ; Prospective Studies ; Recovery of Function
Language	English
Publishing date	2021-08-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	639259-3
ISSN	1873-1244 ; 0899-9007
ISSN (online)	1873-1244
ISSN	0899-9007
DOI	10.1016/j.nut.2021.111465
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Article ; Online: Anesthetic management of scapular Y-osteotomy using a combination of suprascapular nerve block and erector spinae plane block for Sprengel deformity associated with Klippel-Feil syndrome: a case report.

Okada, Mizuho / Tanaka, Nobuhiro / Suzuka, Takanori / Kadoya, Yuma / Saisu, Takashi / Kawaguchi, Masahiko

JA clinical reports

2023 Volume 9, Issue 1, Page(s) 55

Abstract: Background: Klippel-Feil syndrome (KFS) occurs in 1/40,000 individuals and is characterized by cervical fusion. Thirty percent of patients with KFS present with Sprengel deformity, leading to orthopedic problems and limited shoulder abduction. No ... ...

Abstract	Background: Klippel-Feil syndrome (KFS) occurs in 1/40,000 individuals and is characterized by cervical fusion. Thirty percent of patients with KFS present with Sprengel deformity, leading to orthopedic problems and limited shoulder abduction. No reports exist regarding anesthetic procedures for pediatric scapular osteotomies. Case presentation: We report a case of a 4-year-and-7-month-old boy (95.6 cm, 14.7 kg) who underwent left scapular osteotomy. At the age of 8 months, he also underwent a right lower lobectomy due to a congenital pulmonary airway malformation. We decided to use a combination of suprascapular nerve block (SSNB), erector spinae plane block (ESPB), and general anesthesia. He received regular acetaminophen administration and fentanyl 5-10 μg/hour intravenously until 20 h postoperatively and remained on ≤ 2/10 in the Wong-Baker Face Scale (0: no hurt; 10: hurts worst). Conclusion: The combination of SSNB and ESPB could be an option for perioperative analgesia for scapular osteotomies.
Language	English
Publishing date	2023-08-29
Publishing country	Germany
Document type	Journal Article
ISSN	2363-9024
ISSN (online)	2363-9024
DOI	10.1186/s40981-023-00647-3
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Article ; Online: Spin-Glass Magnetic Properties of A-Site Columnar-Ordered Quadruple Perovskites Y

Liu, Ran / Khalyavin, Dmitry D / Tsunoda, Naoki / Kumagai, Yu / Oba, Fumiyasu / Katsuya, Yoshio / Tanaka, Masahiko / Yamaura, Kazunari / Belik, Alexei A

Inorganic chemistry

2019 Volume 58, Issue 21, Page(s) 14830–14841

Abstract: Y ...

Abstract	Y
Language	English
Publishing date	2019-10-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.9b02542
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