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  1. Article: How Does Hospital Microbiota Contribute to Healthcare-Associated Infections?

    Cruz-López, Flora / Martínez-Meléndez, Adrián / Garza-González, Elvira

    Microorganisms

    2023  Volume 11, Issue 1

    Abstract: Healthcare-associated infections (HAIs) are still a global public health concern, associated with high mortality and increased by the phenomenon of antimicrobial resistance. Causative agents of HAIs are commonly found in the hospital environment and are ... ...

    Abstract Healthcare-associated infections (HAIs) are still a global public health concern, associated with high mortality and increased by the phenomenon of antimicrobial resistance. Causative agents of HAIs are commonly found in the hospital environment and are monitored in epidemiological surveillance programs; however, the hospital environment is a potential reservoir for pathogenic microbial strains where microorganisms may persist on medical equipment surfaces, on the environment surrounding patients, and on corporal surfaces of patients and healthcare workers (HCWs). The characterization of hospital microbiota may provide knowledge regarding the relatedness between commensal and pathogenic microorganisms, their role in HAIs development, and the environmental conditions that favor its proliferation. This information may contribute to the effective control of the dissemination of pathogens and to improve infection control programs. In this review, we describe evidence of the contribution of hospital microbiota to HAI development and the role of environmental factors, antimicrobial resistance, and virulence factors of the microbial community in persistence on hospital surfaces.
    Language English
    Publishing date 2023-01-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11010192
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Editorial: Multidrug gram-negative bacilli : current situation and future perspective.

    López-Jácome, Luis Esaú / Franco-Cendejas, Rafael / García-Contreras, Rodolfo / Garza-González, Elvira

    Frontiers in cellular and infection microbiology

    2023  Volume 13, Page(s) 1327413

    MeSH term(s) Gram-Negative Bacteria ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-11-09
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2023.1327413
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Review of the Impact of Biofilm Formation on Recurrent

    Rubio-Mendoza, Daira / Martínez-Meléndez, Adrián / Maldonado-Garza, Héctor Jesús / Córdova-Fletes, Carlos / Garza-González, Elvira

    Microorganisms

    2023  Volume 11, Issue 10

    Abstract: Clostridioides ... ...

    Abstract Clostridioides difficile
    Language English
    Publishing date 2023-10-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11102525
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Neglected bacterial infections in COVID-19 patients.

    Martínez-Meléndez, Adrián / Garza-González, Elvira / Morfín-Otero, Rayo / Cruz-López, Flora

    Gaceta medica de Mexico

    2022  Volume 158, Issue 1, Page(s) 63

    Title translation Infecciones bacterianas desatendidas en pacientes con COVID-19.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Bacterial Infections/drug therapy ; COVID-19 ; Humans
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-04-11
    Publishing country Mexico
    Document type Letter
    ZDB-ID 425456-9
    ISSN 0016-3813
    ISSN 0016-3813
    DOI 10.24875/GMM.M22000642
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Transcriptomic analysis of biofilm formation in strains of Clostridioides difficile associated with recurrent and non-recurrent infection reveals potential candidate markers for recurrence.

    Rubio-Mendoza, Daira / Córdova-Fletes, Carlos / Martínez-Meléndez, Adrián / Morfín-Otero, Rayo / Maldonado-Garza, Héctor Jesús / Garza-González, Elvira

    PloS one

    2023  Volume 18, Issue 8, Page(s) e0289593

    Abstract: The transcriptomic profile in a biofilm model of ribotypes (RT) 001 and 027 associated with recurrent Clostridioides difficile infection (R-CDI) and not associated with recurrent (NR)-CDI was analyzed to identify genes that may favor the recurrence. ... ...

    Abstract The transcriptomic profile in a biofilm model of ribotypes (RT) 001 and 027 associated with recurrent Clostridioides difficile infection (R-CDI) and not associated with recurrent (NR)-CDI was analyzed to identify genes that may favor the recurrence. Twenty strains were selected, 10 RT001 and 10 RT027. From each ribotype, 5 were R-CDI and 5 NR-CDI. Biofilm and nonadherent cells were prepared from each clinical isolate, and the RNA was extracted. RNA samples were pooled in 8 combinations implying ribotype, recurrence, and biofilm formation. Each pool was separately labeled with Cy3 dye and hybridized on a microarray designed for this study. Slides were scanned, analyzed, and gene expression was compared between unique and grouped pools using the Student's t-test with Benjamini-Hochberg correction when appropriate. Validation was carried out by qRT-PCR for selected genes. Results: After comparisons of differentially expressed genes from both ribotypes of R-CDI strains (nonadherent cells vs. biofilm) and both ribotypes in biofilm (R-CDI vs. NR-CDI), we found 3 genes over-expressed and 1 under-expressed in common (adj. p ≤ 0.05). Overexpressed genes were CAJ70148 (a putative dehydrogenase), CAJ68100 (a secretion type II system protein from the GspH (pseudopilins) family), and CAJ69725 (a putative membrane protein); under-expressed was CAJ68151 (a segregation and condensation protein A). Because CAJ70148, CAJ68100, CAJ69725 and CAJ68151 were differentially expressed in biofilm in strains associated with R-CDI, they may support the biofilm favoring the recurrence of CDI. However, further studies will be needed for poorly studied genes.
    MeSH term(s) Humans ; Clostridioides difficile/genetics ; Clostridioides/genetics ; Transcriptome ; Recurrence ; Clostridium Infections/genetics ; Clostridium Infections/drug therapy ; Biofilms ; Ribotyping ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-08-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0289593
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Diagnostic syndromic multiplex approaches for gastrointestinal infections.

    Maldonado-Garza, Héctor Jesús / Garza-González, Elvira / Bocanegra-Ibarias, Paola / Flores-Treviño, Samantha

    Expert review of gastroenterology & hepatology

    2021  Volume 15, Issue 7, Page(s) 743–757

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Bacteriological Techniques ; COVID-19/diagnosis ; COVID-19/virology ; COVID-19 Testing ; Clinical Decision-Making ; Communicable Diseases/diagnosis ; Communicable Diseases/etiology ; Communicable Diseases/therapy ; Gastrointestinal Diseases/diagnosis ; Gastrointestinal Diseases/etiology ; Gastrointestinal Diseases/therapy ; Humans ; Molecular Diagnostic Techniques ; Parasitology ; Predictive Value of Tests ; Prognosis
    Language English
    Publishing date 2021-03-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2481021-6
    ISSN 1747-4132 ; 1747-4124
    ISSN (online) 1747-4132
    ISSN 1747-4124
    DOI 10.1080/17474124.2021.1899807
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Changes in the Progression of Chronic Kidney Disease in Patients Undergoing Fecal Microbiota Transplantation.

    Arteaga-Muller, Giovanna Yazmín / Flores-Treviño, Samantha / Bocanegra-Ibarias, Paola / Robles-Espino, Diana / Garza-González, Elvira / Fabela-Valdez, Graciela Catalina / Camacho-Ortiz, Adrián

    Nutrients

    2024  Volume 16, Issue 8

    Abstract: Chronic kidney disease (CKD) is a progressive loss of renal function in which gut dysbiosis is involved. Fecal microbiota transplantation (FMT) may be a promising alternative for restoring gut microbiota and treating CKD. This study evaluated the changes ...

    Abstract Chronic kidney disease (CKD) is a progressive loss of renal function in which gut dysbiosis is involved. Fecal microbiota transplantation (FMT) may be a promising alternative for restoring gut microbiota and treating CKD. This study evaluated the changes in CKD progression in patients treated with FMT. Patients with diabetes and/or hypertension with CKD clinical stages 2, 3, and 4 in this single-center, double-blind, randomized, placebo-controlled clinical trial (NCT04361097) were randomly assigned to receive either FMT or placebo capsules for 6 months. Laboratory and stool metagenomic analyses were performed. A total of 28 patients were included (15 FMT and 13 placebo). Regardless of CKD stages, patients responded similarly to FMT treatment. More patients (53.8%) from the placebo group progressed to CKD than the FMT group (13.3%). The FMT group maintained stable renal function parameters (serum creatinine and urea nitrogen) compared to the placebo group. Adverse events after FMT treatment were mild or moderate gastrointestinal symptoms. The abundance of Firmicutes and Actinobacteria decreased whereas Bacteroidetes, Proteobacteria and
    MeSH term(s) Humans ; Renal Insufficiency, Chronic/therapy ; Renal Insufficiency, Chronic/microbiology ; Fecal Microbiota Transplantation ; Male ; Female ; Disease Progression ; Middle Aged ; Double-Blind Method ; Gastrointestinal Microbiome ; Aged ; Feces/microbiology ; Dysbiosis/therapy ; Treatment Outcome ; Adult ; Creatinine/blood
    Chemical Substances Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2024-04-10
    Publishing country Switzerland
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu16081109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: An Update on

    Martínez-Meléndez, Adrián / Cruz-López, Flora / Morfin-Otero, Rayo / Maldonado-Garza, Héctor J / Garza-González, Elvira

    Toxins

    2022  Volume 14, Issue 5

    Abstract: Infection ... ...

    Abstract Infection with
    MeSH term(s) Antibodies, Bacterial ; Bacterial Toxins/genetics ; Bacterial Toxins/toxicity ; Clostridioides difficile/genetics ; Cross Infection ; Enterocolitis, Pseudomembranous ; Humans
    Chemical Substances Antibodies, Bacterial ; Bacterial Toxins
    Language English
    Publishing date 2022-04-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518395-3
    ISSN 2072-6651 ; 2072-6651
    ISSN (online) 2072-6651
    ISSN 2072-6651
    DOI 10.3390/toxins14050305
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Efficacy and

    Cruz-López, Flora / Martínez-Meléndez, Adrian / Morfin-Otero, Rayo / Rodriguez-Noriega, Eduardo / Maldonado-Garza, Héctor J / Garza-González, Elvira

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 884365

    Abstract: Infections by Gram-negative multi-drug resistant (MDR) bacterial species are difficult to treat using available antibiotics. Overuse of carbapenems has contributed to widespread resistance to these antibiotics; as a result, carbapenem-resistant ... ...

    Abstract Infections by Gram-negative multi-drug resistant (MDR) bacterial species are difficult to treat using available antibiotics. Overuse of carbapenems has contributed to widespread resistance to these antibiotics; as a result, carbapenem-resistant Enterobacterales (CRE),
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Carbapenems/pharmacology ; Carbapenems/therapeutic use ; Cephalosporins/pharmacology ; Cephalosporins/therapeutic use ; Drug Resistance, Multiple, Bacterial ; Gram-Negative Bacteria ; Gram-Negative Bacterial Infections/drug therapy ; Gram-Negative Bacterial Infections/microbiology ; Humans ; Microbial Sensitivity Tests ; Tazobactam/pharmacology ; Tazobactam/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Carbapenems ; Cephalosporins ; Tazobactam (SE10G96M8W)
    Language English
    Publishing date 2022-05-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.884365
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: [No title information]

    Adrián Martínez-Meléndez / Elvira Garza-González / Rayo Morfín-Otero / Flora Cruz-López

    Gaceta Médica de México, Vol 158, Iss

    2022  Volume 1

    Keywords Public aspects of medicine ; RA1-1270 ; Internal medicine ; RC31-1245
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Permanyer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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