LIVIVO - Search results -

Search results

Result 1 - 10 of total 38

Search options

Article ; Online: Tissue-localized immune responses in people with cystic fibrosis and respiratory nontuberculous mycobacteria infection

Don Hayes Jr. / Rajni Kant Shukla / Yizi Cheng / Emrah Gecili / Marlena R. Merling / Rhonda D. Szczesniak / Assem G. Ziady / Jason C. Woods / Luanne Hall-Stoodley / Namal P.M. Liyanage / Richard T. Robinson

JCI Insight, Vol 7, Iss

2022 Volume 12

Abstract: Nontuberculous mycobacteria (NTM) are an increasingly common cause of respiratory infection in people with cystic fibrosis (PwCF). Relative to those with no history of NTM infection (CF-NTMNEG), PwCF and a history of NTM infection (CF-NTMPOS) are more ... ...

Abstract	Nontuberculous mycobacteria (NTM) are an increasingly common cause of respiratory infection in people with cystic fibrosis (PwCF). Relative to those with no history of NTM infection (CF-NTMNEG), PwCF and a history of NTM infection (CF-NTMPOS) are more likely to develop severe lung disease and experience complications over the course of treatment. In other mycobacterial infections (e.g., tuberculosis), an overexuberant immune response causes pathology and compromises organ function; however, since the immune profiles of CF-NTMPOS and CF-NTMNEG airways are largely unexplored, it is unknown which, if any, immune responses distinguish these cohorts or concentrate in damaged tissues. Here, we evaluated lung lobe–specific immune profiles of 3 cohorts (CF-NTMPOS, CF-NTMNEG, and non-CF adults) and found that CF-NTMPOS airways are distinguished by a hyperinflammatory cytokine profile. Importantly, the CF-NTMPOS airway immune profile was dominated by B cells, classical macrophages, and the cytokines that support their accumulation. These and other immunological differences between cohorts, including the near absence of NK cells and complement pathway members, were enriched in the most damaged lung lobes. The implications of these findings for our understanding of lung disease in PwCF are discussed, as are how they may inform the development of host-directed therapies to improve NTM disease treatment.
Keywords	Infectious disease ; Pulmonology ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	American Society for Clinical investigation
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Recipient Age Impacts Long-Term Survival in Adult Subjects with Cystic Fibrosis after Lung Transplantation.

Sethi, Jaskaran / Bugajski, Andrew / Patel, Kapil N / Davis, Nicole M / Wille, Keith M / Qureshi, Muhammad Raheel / Banday, Mudassir M / Lin, Muling / Emani, Vamsi / Weill, David / Tumin, Dmitry / Hayes, Don / Jr / Sharma, Nirmal S

Annals of the American Thoracic Society

2020 Volume 18, Issue 1, Page(s) 44–50

Abstract: Rationale: ...

Abstract	Rationale:
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Cystic Fibrosis/mortality ; Cystic Fibrosis/surgery ; Humans ; Lung Transplantation ; Proportional Hazards Models ; Retrospective Studies ; Survival Rate ; Young Adult
Language	English
Publishing date	2020-08-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2717461-X
ISSN	2325-6621 ; 1943-5665 ; 2325-6621
ISSN (online)	2325-6621 ; 1943-5665
ISSN	2325-6621
DOI	10.1513/AnnalsATS.201908-637OC
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5828: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Registration of seven recombinant inbred lines of upland cotton with improved fiber length or strength

Jenkins, Johnie N. / McCarty, Jack C., Jr / Hayes, Russell W. / Wubben, Martin J. / Fang, David D. / Thyssen, Gregory N. / Zeng, Linghe / Campbell, B. Todd / Jones, Don C.

Journal of plant registrations. 2022 Jan., v. 16, no. 1

2022

Abstract: The genetic base for upland cotton (Gossypium hirsutum L.) is narrow for the economically important fiber traits of strength and length. We developed random mated population RMUP‐C5 from 11 parental lines and released seed in 2008. We have now developed ... ...

Abstract	The genetic base for upland cotton (Gossypium hirsutum L.) is narrow for the economically important fiber traits of strength and length. We developed random mated population RMUP‐C5 from 11 parental lines and released seed in 2008. We have now developed 550 recombinant inbred lines (RILs) from this population and evaluated them for fiber properties in eight environments. We report the development and release of seven RILs with improved fiber strength and/or upper half mean length: MS‐RIL‐009 (Reg. no. GP‐1100, PI 698460), MS‐RIL‐037 (Reg. no. GP‐1101, PI 698461), MS‐RIL‐204 (Reg. no. GP‐1102, PI 698462), MS‐RIL‐219 (Reg no. GP‐1103, PI 698463), MS‐RIL‐282 (Reg. no. GP‐1104, PI 698464), MS‐RIL‐303 (Reg. no. GP‐1105, PI 698465), and MS‐RIL‐490 (Reg. no. GP‐1106, PI 698466). Fiber strength and length for the seven lines are as follows: MS‐RIL 009 (384, 30.0), MS‐RIL 037 (369, 31.3), MS‐RIL‐204 (333, 32.5), MS‐RIL‐219 (345, 31.8), MS‐RIL‐282 (295, 31.4), MS‐RIL‐303 (379, 31.4) and MS‐RIL‐490 (318, 33.0), kN m kg–¹ and mm, respectively. Fibers of MS‐RILS 037, 219, and 303 are significantly stronger and longer, fibers of 009 are significantly stronger, and fibers of 204, 282, and 490 are significantly longer than fibers of ‘Acala Ultima’ or ‘Fibermax 966’, the parental lines with the strongest (326–334 kN m kg–¹) and longest (29.3–30.0 mm) fibers. MS‐RIL‐009, MS‐RIL‐037, MS‐RIL‐219, and MS‐RIL‐303 are homozygous for favorable alleles at the A07 strength quantitative trait locus (QTL). All lines except MS‐RIL‐009 are homozygous for favorable alleles at the D11 length QTL.
Keywords	Gossypium hirsutum ; genetic background ; homozygosity ; quantitative trait loci
Language	English
Dates of publication	2022-01
Size	p. 94-99.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2381569-3
ISSN	1940-3496 ; 1936-5209
ISSN (online)	1940-3496
ISSN	1936-5209
DOI	10.1002/plr2.20193
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 7757: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Repeated injury promotes tracheobronchial tissue stem cell attrition

Moumita Ghosh / Cynthia L. Hill / Alfahdah Alsudayri / Scott W. Lallier / Don Hayes Jr. / Saranga Wijeratne / Zhang Hong Tan / Tendy Chiang / John E. Mahoney / Gianni Carraro / Barry R. Stripp / Susan D. Reynolds

Stem Cells Translational Medicine, Vol 10, Iss 12, Pp 1696-

2021 Volume 1713

Abstract: Abstract Chronic lung disease has been attributed to stem cell aging and/or exhaustion. We investigated these mechanisms using mouse and human tracheobronchial tissue‐specific stem cells (TSC). In mouse, chromatin labeling and flow cytometry demonstrated ...

Abstract	Abstract Chronic lung disease has been attributed to stem cell aging and/or exhaustion. We investigated these mechanisms using mouse and human tracheobronchial tissue‐specific stem cells (TSC). In mouse, chromatin labeling and flow cytometry demonstrated that naphthalene (NA) injury activated a subset of TSC. These activated TSC continued to proliferate after the epithelium was repaired and a clone study demonstrated that ~96% of activated TSC underwent terminal differentiation. Despite TSC attrition, epithelial repair after a second NA injury was normal. The second injury accelerated proliferation of previously activated TSC and a nucleotide‐label retention study indicated that the second injury recruited TSC that were quiescent during the first injury. These mouse studies indicate that (a) injury causes selective activation of the TSC pool; (b) activated TSC are predisposed to further proliferation; and (c) the activated state leads to terminal differentiation. In human TSC, repeated proliferation also led to terminal differentiation and depleted the TSC pool. A clone study identified long‐ and short‐lived TSC and showed that short‐lived TSC clones had significantly shorter telomeres than their long‐lived counterparts. The TSC pool was significantly depleted in dyskeratosis congenita donors, who harbor mutations in telomere biology genes. The remaining TSC had short telomeres and short lifespans. Collectively, the mouse and human studies support a model in which epithelial injury increases the biological age of the responding TSC. When applied to chronic lung disease, this model suggests that repeated injury accelerates the biological aging process resulting in abnormal repair and disease initiation.
Keywords	airway epithelial stem cell ; basal cell ; biological aging ; chronic lung disease ; Medicine (General) ; R5-920 ; Cytology ; QH573-671
Subject code	610
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Oxford University Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Advanced Microparticulate/Nanoparticulate Respirable Dry Powders of a Selective RhoA/Rho Kinase (Rock) Inhibitor for Targeted Pulmonary Inhalation Aerosol Delivery.

Muralidharan, Priya / Hayes, Don / Fineman, Jeffrey R / Black, Stephen M / Mansour, Heidi M

Pharmaceutics

2021 Volume 13, Issue 12

Abstract: Pulmonary hypertension (PH) is a progressive disease that eventually leads to heart failure and potentially death for some patients. There are many unique advantages to treating pulmonary diseases directly and non-invasively by inhalation aerosols and ... ...

Abstract	Pulmonary hypertension (PH) is a progressive disease that eventually leads to heart failure and potentially death for some patients. There are many unique advantages to treating pulmonary diseases directly and non-invasively by inhalation aerosols and dry powder inhalers (DPIs) possess additional unique advantages. There continues to be significant unmet medical needs in the effective treatment of PH that target the underlying mechanisms. To date, there is no FDA-approved DPI indicated for the treatment of PH. Fasudil is a novel RhoA/Rho kinase (ROCK) inhibitor that has shown great potential in effectively treating pulmonary hypertension. This systematic study is the first to report on the design and development of DPI formulations comprised of respirable nanoparticles/microparticles using particle engineering design by advanced spray drying. In addition, comprehensive physicochemical characterization, in vitro aerosol aerosol dispersion performance with different types of human DPI devices, in vitro cell-drug dose response cell viability of different human respiratory cells from distinct lung regions, and in vitro transepithelial electrical resistance (TEER) as air-interface culture (AIC) demonstrated that these innovative DPI fasudil formulations are safe on human lung cells and have high aerosol dispersion performance properties.
Language	English
Publishing date	2021-12-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics13122188
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Improvement in Bronchiectasis on CT Imaging in a Pediatric Patient with Cystic Fibrosis on Ivacaftor Therapy

Hayes Jr., Don / Long, Frederick R. / McCoy, Karen S. / Sheikh, Shahid I.

Respiration

2014 Volume 88, Issue 4, Page(s) 345–345

Institution	Departments of Pediatrics Internal Medicine and Radiology, The Ohio State University College of Medicine, and Sections of Pulmonary Medicine, and Department of Radiology, Nationwide Children's Hospital, Columbus, Ohio, USA
Keywords	Bronchiectasis ; Pediatrics ; Cystic fibrosis ; Chest ; Children ; Computed tomography ; Ivacaftor
Language	English
Publishing date	2014-08-21
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
Note	The Eye Catcher
ZDB-ID	206674-9
ISSN	1423-0356 ; 0025-7931
ISSN (online)	1423-0356
ISSN	0025-7931
DOI	10.1159/000365999
Database	Karger publisher's database

In stock of ZB MED Cologne/Königswinter

Uh II Zs.138: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Method of direct segmental intra-hepatic delivery using a rat liver hilar clamp model

Beal, Eliza W / Dumond, Curtis / Kim, Jung-Lye / Mumtaz, Khalid / Hayes Jr., Don / Washburn, Ken / Whitson, Bryan A / Black, Sylvester M

Journal of visualized experiments. 2017 Apr. 02, , no. 122

2017

Abstract: Major hepatic surgery with inflow occlusion, and liver transplantation, necessitate a period of warm ischemia, and a period of reperfusion leading to ischemia/reperfusion (I/R) injury with myriad negative consequences. Potential I/R injury in marginal ... ...

Abstract	Major hepatic surgery with inflow occlusion, and liver transplantation, necessitate a period of warm ischemia, and a period of reperfusion leading to ischemia/reperfusion (I/R) injury with myriad negative consequences. Potential I/R injury in marginal organs destined for liver transplantation contributes to the current donor shortage secondary to a decreased organ utilization rate. A significant need exists to explore hepatic I/R injury in order to mediate its impact on graft function in transplantation. Rat liver hilar clamp models are used to investigate the impact of different molecules on hepatic I/R injury. Depending on the model, these molecules have been delivered using inhalation, epidural infusion, intraperitoneal injection, intravenous administration or injection into the peripheral superior mesenteric vein. A rat liver hilar clamp model has been developed for use in studying the impact of pharmacologic molecules in ameliorating I/R injury. The described model for rat liver hilar clamp includes direct cannulation of the portal supply to the ischemic hepatic segment via a side branch of the portal vein, allowing for direct segmental hepatic delivery. Our approach is to induce ischemia in the left lateral and median lobes for 60 min, during which time the substance under study is infused. In this case, pegylated-superoxide dismutase (PEG-SOD), a free radical scavenger, is infused directly into the ischemic segment. This series of experiments demonstrates that infusion of PEG-SOD is protective against hepatic I/R injury. Advantages of this approach include direct injection of the molecule into the ischemic segment with consequent decrease in volume of distribution and reduction in systemic side effects.
Keywords	adverse effects ; breathing ; enzymes ; free radical scavengers ; intraperitoneal injection ; intravenous injection ; ischemia ; liver ; liver transplant ; models ; portal vein ; rats
Language	English
Dates of publication	2017-0402
Size	p. e54729.
Publishing place	Journal of Visualized Experiments
Document type	Article
ZDB-ID	2259946-0
ISSN	1940-087X
ISSN	1940-087X
DOI	10.3791/54729
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: Advanced therapeutic inhalation aerosols of a Nrf2 activator and RhoA/Rho kinase (ROCK) inhibitor for targeted pulmonary drug delivery in pulmonary hypertension: design, characterization, aerosolization,

Acosta, Maria F / Muralidharan, Priya / Grijalva, Carissa L / Abrahamson, Michael D / Hayes, Don / Fineman, Jeffrey R / Black, Stephen M / Mansour, Heidi M

Therapeutic advances in respiratory disease

2021 Volume 15, Page(s) 1753466621998245

Abstract: Inhalable nanostructured microparticles of simvastatin, a Nrf2 activator and RhoA/Rho kinase (ROCK) inhibitor, were rationally designed for targeted pulmonary delivery as dry powder inhalers (DPIs) for the treatment of pulmonary hypertension (PH). ... ...

Abstract	Inhalable nanostructured microparticles of simvastatin, a Nrf2 activator and RhoA/Rho kinase (ROCK) inhibitor, were rationally designed for targeted pulmonary delivery as dry powder inhalers (DPIs) for the treatment of pulmonary hypertension (PH). Advanced particle engineering design technology was employed to develop inhalable dry powders using different dilute feed concentrations and spray drying pump rates. Several analytical techniques were used comprehensively to characterize the physicochemical properties of the resulting powders. Scanning electron microscopy (SEM) was used to visualize particle morphology (shape), surface structure, size, and size distribution. Karl Fischer titration (KFT) was employed to quantify the residual water content in the powders. X-ray powder diffraction (XRPD) was used to determine crystallinity. Hot-stage microscopy (HSM) under cross-polarizing lens was used to observe the presence or absence of birefringence characteristic of crystallinity. Differential scanning calorimetry (DSC) was employed to quantify thermotropic phase behavior. Attenuated total reflectance (ATR)-Fourier-transform infrared (FTIR) spectroscopy and Raman spectroscopy were used to determine the molecular fingerprint of simvastatin powders before and after particle engineering design.
MeSH term(s)	Administration, Inhalation ; Aerosols ; Animals ; Cell Culture Techniques ; Crystallization ; Disease Models, Animal ; Drug Delivery Systems ; Dry Powder Inhalers ; Humans ; Hypertension, Pulmonary/drug therapy ; Hypertension, Pulmonary/physiopathology ; Lung/metabolism ; Lung/physiopathology ; Male ; NF-E2-Related Factor 2/drug effects ; NF-E2-Related Factor 2/metabolism ; Nanostructures ; Particle Size ; Powders ; Rats ; Rats, Sprague-Dawley ; Sheep ; Simvastatin/administration & dosage ; Simvastatin/chemistry ; Simvastatin/pharmacology ; Vascular Resistance/drug effects ; rho-Associated Kinases/antagonists & inhibitors
Chemical Substances	Aerosols ; NF-E2-Related Factor 2 ; Powders ; Simvastatin (AGG2FN16EV) ; rho-Associated Kinases (EC 2.7.11.1)
Language	English
Publishing date	2021-03-15
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2476459-0
ISSN	1753-4666 ; 1753-4658
ISSN (online)	1753-4666
ISSN	1753-4658
DOI	10.1177/1753466621998245
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6753: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Correction to: Influence of Cystic Fibrosis‑Related Diabetes on Mental Health in Adults: A Single‑Center Study.

Hjelm, Michelle / Tumin, Dmitry / Nemastil, Christopher J / Salvator, Ann E / Hayes, Don

Lung

2020 Volume 198, Issue 6, Page(s) 965

Abstract: ... Prof. Don Hayes Jr. During production process, "Jr." was missed to add after the author name ...

Abstract	The original version of this article unfortunately contained a mistake in one of the co-author name Prof. Don Hayes Jr. During production process, "Jr." was missed to add after the author name. The author name is corrected with this correction. The original article has been corrected.
Language	English
Publishing date	2020-11-24
Publishing country	United States
Document type	Published Erratum
ZDB-ID	6165-7
ISSN	1432-1750 ; 0341-2040
ISSN (online)	1432-1750
ISSN	0341-2040
DOI	10.1007/s00408-020-00410-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uh II Zs.20: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Method of isolated Ex Vivo lung perfusion in a rat model: lessons learned from developing a rat evlp program

Nelson, Kevin / Bobba, Christopher / Eren, Emre / Spata, Tyler / Tadres, Malak / Hayes, Jr., Don / Black, Sylvester M / Ghadiali, Samir / Whitson, Bryan A

Journal of visualized experiments. 2015 Feb. 25, , no. 96

2015

Abstract: The number of acceptable donor lungs available for lung transplantation is severely limited due to poor quality. Ex-Vivo Lung Perfusion (EVLP) has allowed lung transplantation in humans to become more readily available by enabling the ability to assess ... ...

Abstract	The number of acceptable donor lungs available for lung transplantation is severely limited due to poor quality. Ex-Vivo Lung Perfusion (EVLP) has allowed lung transplantation in humans to become more readily available by enabling the ability to assess organs and expand the donor pool. As this technology expands and improves, the ability to potentially evaluate and improve the quality of substandard lungs prior to transplant is a critical need. In order to more rigorously evaluate these approaches, a reproducible animal model needs to be established that would allow for testing of improved techniques and management of the donated lungs as well as to the lung-transplant recipient. In addition, an EVLP animal model of associated pathologies, e.g., ventilation induced lung injury (VILI), would provide a novel method to evaluate treatments for these pathologies. Here, we describe the development of a rat EVLP lung program and refinements to this method that allow for a reproducible model for future expansion. We also describe the application of this EVLP system to model VILI in rat lungs. The goal is to provide the research community with key information and “pearls of wisdom”/techniques that arose from trial and error and are critical to establishing an EVLP system that is robust and reproducible.
Keywords	animal models ; humans ; lungs ; pearls ; rats
Language	English
Dates of publication	2015-0225
Size	p. e52309.
Publishing place	Journal of Visualized Experiments
Document type	Article
ZDB-ID	2259946-0
ISSN	1940-087X
ISSN	1940-087X
DOI	10.3791/52309
Database	NAL-Catalogue (AGRICOLA)

Order via subito

To top

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito