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  1. Article ; Online: Multi-push (MP) acoustic radiation force (ARF) ultrasound for assessing tissue viscoelasticity, in vivo.

    Scola, Mallory R / Baggesen, Leslie M / Gallippi, Caterina M

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

    2012  Volume 2012, Page(s) 2323–2326

    Abstract: Acoustic radiation force (ARF) ultrasound is a method of elastographic imaging in which micron-scale tissue displacements, induced and tracked by ultrasound, reflect clinically relevant tissue mechanical properties. Our laboratory has recently shown that ...

    Abstract Acoustic radiation force (ARF) ultrasound is a method of elastographic imaging in which micron-scale tissue displacements, induced and tracked by ultrasound, reflect clinically relevant tissue mechanical properties. Our laboratory has recently shown that tissue viscoelasticity is assessed using the novel Multi-Push (MP) ARF method. MP ARF applies the Voigt model for viscoelastic materials and compares the displacements achieved by successive ARF excitations to qualitatively or quantitatively represent the relaxation time for constant stress, which is a direct descriptor of the viscoelastic response of the tissue. We have demonstrated MP ARF in custom viscoelastic tissue mimicking materials and implemented the method in vivo in canine muscle and human renal allografts, with strong spatial correlation between MP ARF findings and histochemical features and previously reported mechanical changes with renal disease. These data support that noninvasive MP ARF is capable of clinically relevant assessment of tissue viscoelastic properties.
    MeSH term(s) Animals ; Dogs ; Elastic Modulus/physiology ; Elasticity Imaging Techniques/methods ; Humans ; Image Interpretation, Computer-Assisted/methods ; Kidney/diagnostic imaging ; Kidney/physiology ; Muscle, Skeletal/diagnostic imaging ; Muscle, Skeletal/physiology ; Viscosity
    Language English
    Publishing date 2012-08-06
    Publishing country United States
    Document type Journal Article
    ISSN 2694-0604
    ISSN (online) 2694-0604
    DOI 10.1109/EMBC.2012.6346428
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A review of current methods for assessing hemostasis in vivo and introduction to a potential alternative approach.

    Scola, Mallory R / Baggesen, Leslie M / Nichols, Tim C / Key, Nigel S / Gallippi, Caterina M

    Thrombosis research

    2012  Volume 129 Suppl 2, Page(s) S57–61

    Abstract: A validated method for assessing hemostasis in vivo is critical for testing the hemostatic efficacy of therapeutic agents in preclinical animal models and in patients with inherited bleeding disorders, such as von Willebrand disease (VWD) and hemophilia ... ...

    Abstract A validated method for assessing hemostasis in vivo is critical for testing the hemostatic efficacy of therapeutic agents in preclinical animal models and in patients with inherited bleeding disorders, such as von Willebrand disease (VWD) and hemophilia A, or with acquired bleeding disorders such as those resulting from medications or disease processes. In this review, we discuss current methods for assessing hemostasis in vivo and the associated challenges. We also present ARFI-Monitored Hemostatic Challenge; a new, potentially alternate method for in vivo hemostasis monitoring that is in development by our group.
    MeSH term(s) Animals ; Blood Coagulation Disorders/blood ; Blood Coagulation Disorders/diagnostic imaging ; Blood Coagulation Disorders/therapy ; Disease Models, Animal ; Dogs ; Hemophilia A/blood ; Hemophilia A/diagnostic imaging ; Hemophilia A/therapy ; Hemostasis/drug effects ; Hemostasis/physiology ; Humans ; Ultrasonography ; von Willebrand Diseases/blood ; von Willebrand Diseases/diagnostic imaging ; von Willebrand Diseases/therapy
    Language English
    Publishing date 2012-03-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2012.02.035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 863: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: ARFI ultrasound for in vivo hemostasis assessment postcardiac catheterization, part I: preclinical studies.

    Behler, Russell H / Scola, Mallory R / Nichols, Timothy C / Bellinger, Dwight A / Gallippi, Caterina M

    Ultrasonic imaging

    2009  Volume 31, Issue 3, Page(s) 153–158

    Abstract: The world wide prevalence of cardiovascular disease leads to over seven million annual percutaneous coronary catheterization procedures, the majority of which exploit femoral artery access. Femoral puncture sites ('arteriotomies') can be associated with ... ...

    Abstract The world wide prevalence of cardiovascular disease leads to over seven million annual percutaneous coronary catheterization procedures, the majority of which exploit femoral artery access. Femoral puncture sites ('arteriotomies') can be associated with severe vessel complications after sheath removal if hemostasis is not properly achieved. Hemostasis onset is routinely determined by examination for bleeding at the skin puncture; however, clotting along the puncture path can obscure subcutaneous bleeding, and therefore hemostasis is blindly assessed. We hypothesize that hemostasis assessment can be un-blinded by Acoustic Radiation Force Impulse (ARFI) ultrasound. In this first of a two-part series, we present in vivo ARFI hemostasis imaging data obtained in relevant canine models of femoral artery puncture. Above arteriotomies, ARFI-induced displacements were large (3.5 to >5.0 microm) relative to surrounding soft tissue soon after needle removal, which was consistent with our expectation for pooled extravasated blood. ARFI-induced displacements above arteriotomies decreased in magnitude (to approximately 2 microm) some time after needle removal and suggested the onset of hemostasis. This preclinical investigation served as proof of concept and justification for a pilot human study, which is presented in part two of this series.
    MeSH term(s) Animals ; Cardiac Catheterization/adverse effects ; Cardiac Catheterization/methods ; Disease Models, Animal ; Dogs ; Elasticity Imaging Techniques/methods ; Femoral Artery/diagnostic imaging ; Femoral Artery/injuries ; Hemorrhage/diagnostic imaging ; Hemorrhage/etiology ; Hemostasis/physiology ; Punctures/adverse effects
    Language English
    Publishing date 2009-09-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603271-0
    ISSN 1096-0910 ; 0161-7346
    ISSN (online) 1096-0910
    ISSN 0161-7346
    DOI 10.1177/016173460903100301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1530: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article: ARFI Ultrasound Monitoring of Hemorrhage and Hemostasis In Vivo in Canine Von Willebrand Disease and Hemophilia

    Scola, Mallory R / Nichols, Timothy C / Zhu, Hongtu / Caughey, Melissa C / Merricks, Elizabeth P / Raymer, Robin A / Margaritis, Paris / High, Katherine A / Gallippi, Caterina M

    Ultrasound in medicine & biology. 2011 Dec., v. 37, no. 12

    2011  

    Abstract: A validated method for assessing hemostasis in vivo is critical for testing the hemostatic efficacy of therapeutic agents designed for patients with bleeding disorders such as von Willebrand disease (VWD) and hemophilia A. We hypothesize that rate of ... ...

    Abstract A validated method for assessing hemostasis in vivo is critical for testing the hemostatic efficacy of therapeutic agents designed for patients with bleeding disorders such as von Willebrand disease (VWD) and hemophilia A. We hypothesize that rate of bleeding and time to hemostasis can be monitored in vivo by acoustic radiation force impulse (ARFI) ultrasound. We performed ARFI imaging following 12-gauge needle puncture of hind limb muscle encompassing an ∼2 mm vein in six normal, eight naïve hemophilia A before and after infusing canine factor VIII, three hemophilia A expressing canine factor VIIa following gene transfer, and two naïve VWD dogs. Serial data sets were processed with custom software to (1) estimate the rate of hemorrhage and (2) estimate the time of hemostasis onset. The rate of hemorrhage during the first 30 min following puncture was markedly increased in the VWD dogs relative to normal but was not significantly different between normal, naïve hemophilia A or hemophilia A expressing cFVIIa. ARFI-derived times to hemostasis were significantly longer in naïve hemophilia A dogs than in normal dogs and were shortened by canine coagulation factors VIII and VIIa. These data support our hypothesis that rate of hemorrhage and time to hemostasis in vivo in response to a standardized hemostatic challenge can be detected by ARFI ultrasound in canine models of VWD and hemophilia. These data also suggest that the ARFI-monitored hemostatic challenge is relevant for in vivo testing of the hemostatic efficacy of therapeutic clotting factor replacement products used to treat inherited bleeding disorders.
    Keywords acoustics ; coagulation ; computer software ; data collection ; dogs ; factor VIII ; gene transfer ; hemophilia ; hemorrhage ; hemostasis ; image analysis ; models ; monitoring ; muscles ; patients ; ultrasonics
    Language English
    Dates of publication 2011-12
    Size p. 2126-2132.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 186150-5
    ISSN 1879-291X ; 0301-5629
    ISSN (online) 1879-291X
    ISSN 0301-5629
    DOI 10.1016/j.ultrasmedbio.2011.09.006
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 963: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article: ARFI ultrasound for in vivo hemostasis assessment postcardiac catheterization, part II: pilot clinical results.

    Behler, Russell H / Scola, Mallory R / Nichols, Timothy C / Caughey, Melissa C / Fisher, Melrose W / Zhu, Hongtu / Gallippi, Caterina M

    Ultrasonic imaging

    2009  Volume 31, Issue 3, Page(s) 159–171

    Abstract: In this second of a two part series, we present pilot clinical data demonstrating Acoustic Radiation Force Impulse (ARFI) ultrasound for monitoring the onset of subcutaneous hemostasis at femoral artery puncture sites (arteriotomies), in vivo. We ... ...

    Abstract In this second of a two part series, we present pilot clinical data demonstrating Acoustic Radiation Force Impulse (ARFI) ultrasound for monitoring the onset of subcutaneous hemostasis at femoral artery puncture sites (arteriotomies), in vivo. We conducted a randomized, reader-blinded investigation of 20 patient volunteers who underwent diagnostic percutaneous coronary catheterization. After sheath removal (6 French), patients were randomized to treatment with either standard of care manual compression alone or, to expedite hemostasis, manual compression augmented with a p-GlcNAc fiber-based hemostatic dressing (Marine Polymer Technologies, Danvers MA). Concurrent with manual compression, serial ARFI imaging began at the time of sheath removal and continued every minute for 15 min. Serial data sets were processed with custom software to (1) estimate the time of hemostasis onset, and (2) render hybrid ARFI/B-Mode images to highlight displacements considered to correspond to extravasted blood. Images were read by an observer blinded to the treatment groups. Average estimated times to hemostasis in patient volunteers treated with manual compression alone (n = 10) and manual compression augmented by hemostatic dressing (n = 9) were, respectively, 13.00 +/- 1.56 and 9.44 +/- 3.09 min, which are statistically significantly different (p = 0.0065, Wilcoxon two-sample test). Example images are shown for three selected patient volunteers. These pilot data suggest that ARFI ultrasound is relevant to monitoring subcutaneous bleeding from femoral arteriotomies clinically and that time to hemostasis was significantly reduced by use of the hemostatic dressing.
    MeSH term(s) Acetylglucosamine/administration & dosage ; Aged ; Cardiac Catheterization/methods ; Elasticity Imaging Techniques/methods ; Female ; Femoral Artery/diagnostic imaging ; Femoral Artery/injuries ; Hemostasis/physiology ; Hemostatic Techniques/instrumentation ; Humans ; Male ; Middle Aged ; Occlusive Dressings ; Pilot Projects ; Postoperative Hemorrhage/diagnostic imaging ; Postoperative Hemorrhage/prevention & control ; Pressure ; Punctures ; Time Factors
    Chemical Substances poly-N-acetyl glucosamine ; Acetylglucosamine (V956696549)
    Language English
    Publishing date 2009-09-23
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 603271-0
    ISSN 1096-0910 ; 0161-7346
    ISSN (online) 1096-0910
    ISSN 0161-7346
    DOI 10.1177/016173460903100302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1530: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: ARFI ultrasound monitoring of hemorrhage and hemostasis in vivo in canine von Willebrand disease and hemophilia.

    Scola, Mallory R / Nichols, Timothy C / Zhu, Hongtu / Caughey, Melissa C / Merricks, Elizabeth P / Raymer, Robin A / Margaritis, Paris / High, Katherine A / Gallippi, Caterina M

    Ultrasound in medicine & biology

    2011  Volume 37, Issue 12, Page(s) 2126–2132

    Abstract: A validated method for assessing hemostasis in vivo is critical for testing the hemostatic efficacy of therapeutic agents designed for patients with bleeding disorders such as von Willebrand disease (VWD) and hemophilia A. We hypothesize that rate of ... ...

    Abstract A validated method for assessing hemostasis in vivo is critical for testing the hemostatic efficacy of therapeutic agents designed for patients with bleeding disorders such as von Willebrand disease (VWD) and hemophilia A. We hypothesize that rate of bleeding and time to hemostasis can be monitored in vivo by acoustic radiation force impulse (ARFI) ultrasound. We performed ARFI imaging following 12-gauge needle puncture of hind limb muscle encompassing an ∼2 mm vein in six normal, eight naïve hemophilia A before and after infusing canine factor VIII, three hemophilia A expressing canine factor VIIa following gene transfer, and two naïve VWD dogs. Serial data sets were processed with custom software to (1) estimate the rate of hemorrhage and (2) estimate the time of hemostasis onset. The rate of hemorrhage during the first 30 min following puncture was markedly increased in the VWD dogs relative to normal but was not significantly different between normal, naïve hemophilia A or hemophilia A expressing cFVIIa. ARFI-derived times to hemostasis were significantly longer in naïve hemophilia A dogs than in normal dogs and were shortened by canine coagulation factors VIII and VIIa. These data support our hypothesis that rate of hemorrhage and time to hemostasis in vivo in response to a standardized hemostatic challenge can be detected by ARFI ultrasound in canine models of VWD and hemophilia. These data also suggest that the ARFI-monitored hemostatic challenge is relevant for in vivo testing of the hemostatic efficacy of therapeutic clotting factor replacement products used to treat inherited bleeding disorders.
    MeSH term(s) Animals ; Dogs ; Elasticity Imaging Techniques/methods ; Hemophilia A/complications ; Hemophilia A/diagnostic imaging ; Hemophilia A/physiopathology ; Hemorrhage/diagnostic imaging ; Hemorrhage/etiology ; Hemorrhage/physiopathology ; Hemostasis ; Reproducibility of Results ; Sensitivity and Specificity ; von Willebrand Diseases/complications ; von Willebrand Diseases/diagnostic imaging ; von Willebrand Diseases/physiopathology
    Language English
    Publishing date 2011-10-26
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 186150-5
    ISSN 1879-291X ; 0301-5629
    ISSN (online) 1879-291X
    ISSN 0301-5629
    DOI 10.1016/j.ultrasmedbio.2011.09.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 963: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article ; Online: Treatment and long-term outcome in primary nephrogenic diabetes insipidus.

    Lopez-Garcia, Sergio C / Downie, Mallory L / Kim, Ji Soo / Boyer, Olivia / Walsh, Stephen B / Nijenhuis, Tom / Papizh, Svetlana / Yadav, Pallavi / Reynolds, Ben C / Decramer, Stéphane / Besouw, Martine / Perelló Carrascosa, Manel / La Scola, Claudio / Trepiccione, Francesco / Ariceta, Gema / Hummel, Aurélie / Dossier, Claire / Sayer, John A / Konrad, Martin /
    Keijzer-Veen, Mandy G / Awan, Atif / Basu, Biswanath / Chauveau, Dominique / Madariaga, Leire / Koster-Kamphuis, Linda / Furlano, Mónica / Zacchia, Miriam / Marzuillo, Pierluigi / Tse, Yincent / Dursun, Ismail / Pinarbasi, Ayse Seda / Tramma, Despoina / Hoorn, Ewout J / Gokce, Ibrahim / Nicholls, Kathleen / Eid, Loai A / Sartz, Lisa / Riordan, Michael / Hooman, Nakysa / Printza, Nikoleta / Bonny, Olivier / Arango Sancho, Pedro / Schild, Raphael / Sinha, Rajiv / Guarino, Stefano / Martinez Jimenez, Victor / Rodríguez Peña, Lidia / Belge, Hendrica / Devuyst, Olivier / Wlodkowski, Tanja / Emma, Francesco / Levtchenko, Elena / Knoers, Nine V A M / Bichet, Daniel G / Schaefer, Franz / Kleta, Robert / Bockenhauer, Detlef

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2020  

    Abstract: Background: Primary nephrogenic diabetes insipidus (NDI) is a rare disorder and little is known about treatment practices and long-term outcome.: Methods: Paediatric and adult nephrologists contacted through European professional organizations ... ...

    Abstract Background: Primary nephrogenic diabetes insipidus (NDI) is a rare disorder and little is known about treatment practices and long-term outcome.
    Methods: Paediatric and adult nephrologists contacted through European professional organizations entered data in an online form.
    Results: Data were collected on 315 patients (22 countries, male 84%, adults 35%). Mutation testing had been performed in 270 (86%); pathogenic variants were identified in 258 (96%). The median (range) age at diagnosis was 0.6 (0.0-60) years and at last follow-up 14.0 (0.1-70) years. In adults, height was normal with a mean (standard deviation) score of -0.39 (±1.0), yet there was increased prevalence of obesity (body mass index >30 kg/m2; 41% versus 16% European average; P < 0.001). There was also increased prevalence of chronic kidney disease (CKD) Stage ≥2 in children (32%) and adults (48%). Evidence of flow uropathy was present in 38%. A higher proportion of children than adults (85% versus 54%; P < 0.001) received medications to reduce urine output. Patients ≥25 years were less likely to have a university degree than the European average (21% versus 35%; P = 0.003) but full-time employment was similar. Mental health problems, predominantly attention-deficit hyperactivity disorder (16%), were reported in 36% of patients.
    Conclusion: This large NDI cohort shows an overall favourable outcome with normal adult height and only mild to moderate CKD in most. Yet, while full-time employment was similar to the European average, educational achievement was lower, and more than half had urological and/or mental health problems.
    Language English
    Publishing date 2020-12-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfaa243
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 329: Show issues

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