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  1. Article: A review of emotion deficits in schizophrenia.

    Trémeau, Fabien

    Dialogues in clinical neuroscience

    2006  Volume 8, Issue 1, Page(s) 59–70

    Abstract: Emotion deficits in schizophrenia have been described since the time of Kraepelin. However, no comprehensive review of clinical emotion studies has ever been conducted. In this work, studies that used diagnostic criteria and were published in English ... ...

    Abstract Emotion deficits in schizophrenia have been described since the time of Kraepelin. However, no comprehensive review of clinical emotion studies has ever been conducted. In this work, studies that used diagnostic criteria and were published in English were selected from an extensive PubMed search. Fifty-five studies on emotion expression repeatedly showed that individuals with schizophrenia (IWSs) display fewer overt expressions than nonpatient comparison subjects (NCSs) in verbal, facial, and acoustic channels. No clear differences were found between IWSs and depressed subjects. Sixty-nine studies examined emotion experience in schizophrenia. IWSs report higher anhedonia, and they tend to show more negative emotions in real-life event studies. In evocative studies, they report a similar degree of pleasantness and a similar or higher degree of unpleasantness. From 110 studies, it can be concluded that emotion recognition is impaired in schizophrenia in all channels. These deficits in social perception are correlated with neurocognitive deficits and some social skills. IWSs show dysfunction in the three domains of emotion expression, emotion experience, and emotion recognition, and these dysfunctions appear to be independent of each other across domains. These deficits in basic emotion processing may be linked to psychopathology and functional outcomes.
    MeSH term(s) Affective Symptoms/etiology ; Emotions/physiology ; Facial Expression ; Humans ; Perception/physiology ; Psychiatric Status Rating Scales ; PubMed/statistics & numerical data ; Recognition, Psychology/physiology ; Schizophrenia/complications ; Schizophrenia/physiopathology ; Schizophrenic Psychology
    Language English
    Publishing date 2006-04-26
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 2188781-0
    ISSN 1294-8322
    ISSN 1294-8322
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Optimizing dosing in atypical neuroleptic monotherapy.

    Trémeau, Fabien / Citrome, Leslie

    Dialogues in clinical neuroscience

    2011  Volume 4, Issue 4, Page(s) 438–443

    Abstract: ATYPICAL NEUROLEPTICS HAVE BECOME THE FIRST LINE OF TREATMENT FOR PSYCHOTIC DISORDERS, BUT SOME QUESTIONS REMAIN: what are their optimal dosages and is more medication more efficacious? For clozapine, it is recommended to aim for a plasma level above 350 ...

    Abstract ATYPICAL NEUROLEPTICS HAVE BECOME THE FIRST LINE OF TREATMENT FOR PSYCHOTIC DISORDERS, BUT SOME QUESTIONS REMAIN: what are their optimal dosages and is more medication more efficacious? For clozapine, it is recommended to aim for a plasma level above 350 ng/mL for nonresponders and partial responders. It should be specified that this plasma level should be obtained exactly 12 h after the last dose. For risperidone, optimal daily doses range between 4 and 8 mg, and there is no indication that a higher dose would bring additional improvement. For olanzapine, a quite different situation is encountered. There is a good indication that daily doses of 30 and 40 mg can increase clinical response. It appears that plasma levels above 23 ng/mL may predict response. For quetiapine, reports on the utility of dosages greater than 800 mg/day are anecdotal at this point, and more studies should be conducted. For ziprasidone, dosages above 40 mg/day should be used, but daily doses above 200 mg have not yet been systematically investigated.
    Language English
    Publishing date 2011-10-28
    Publishing country France
    Document type Journal Article
    ZDB-ID 2188781-0
    ISSN 1294-8322
    ISSN 1294-8322
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  3. Article ; Online: Review: emotion identification deficits are associated with functional impairments in people with schizophrenia.

    Tremeau, Fabien / Antonius, Daniel

    Evidence-based mental health

    2012  Volume 15, Issue 4, Page(s) 106

    Language English
    Publishing date 2012-11
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 2009065-1
    ISSN 1468-960X ; 1362-0347
    ISSN (online) 1468-960X
    ISSN 1362-0347
    DOI 10.1136/ebmental-2012-100880
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  4. Article ; Online: Loneliness in schizophrenia and its possible correlates. An exploratory study.

    Trémeau, Fabien / Antonius, Daniel / Malaspina, Dolores / Goff, Donald C / Javitt, Daniel C

    Psychiatry research

    2016  Volume 246, Page(s) 211–217

    Abstract: Social attachment is a biological and affective need. When this need is not met, people experience loneliness. Loneliness is associated with impaired social cognition, and is a risk factor for broad based morbidity across the adult lifespan even after ... ...

    Abstract Social attachment is a biological and affective need. When this need is not met, people experience loneliness. Loneliness is associated with impaired social cognition, and is a risk factor for broad based morbidity across the adult lifespan even after controlling for multiple factors. However, little is known about loneliness in schizophrenia. Eighty-seven non-depressed individuals with schizophrenia or schizoaffective disorder (including 51 inpatients) and 58 control subjects completed the revised UCLA Loneliness scale. Social cognition was assessed with a self-report questionnaire and a performance-based task. Social trait perception was assessed with a facial task. Comorbid medical diagnoses were available for all inpatients. Patients reported greater loneliness levels than controls, while in- and out-patients did not significantly differ. In patients, loneliness was associated with self-report measures of social cognition. Patients' loneliness scores predicted a diagnosis of drug abuse/dependence, number of drugs used, hypertension and abnormal hemoglobin A1c levels. Patients experienced higher levels of loneliness than controls, independently of their objective social isolation. Loneliness did not rely on the same psychological processes in patients than in controls. Loneliness in schizophrenia is a symptom that deserves more scrutiny, particularly as it relates to the high prevalence of metabolic syndrome in this population.
    MeSH term(s) Adult ; Comorbidity ; Female ; Humans ; Loneliness/psychology ; Male ; Middle Aged ; Psychotic Disorders/epidemiology ; Psychotic Disorders/psychology ; Schizophrenia/epidemiology ; Schizophrenic Psychology
    Language English
    Publishing date 2016-09-26
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 445361-x
    ISSN 1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7123 ; 1872-7506
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.psychres.2016.09.043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Inpatients with schizophrenia report impaired situational motivation but intact global and social motivation.

    Trémeau, Fabien / Goldman, Jennifer / Antonius, Daniel / Javitt, Daniel C

    Psychiatry research

    2013  Volume 210, Issue 1, Page(s) 43–49

    Abstract: It is well established that individuals with schizophrenia are less active and engaged than healthy control subjects, and motivation deficits are considered a core symptom of the disease. However, it remains unclear if schizophrenia individuals perceive ... ...

    Abstract It is well established that individuals with schizophrenia are less active and engaged than healthy control subjects, and motivation deficits are considered a core symptom of the disease. However, it remains unclear if schizophrenia individuals perceive themselves as less motivated than others, and there is a scarcity in research examining the relationship between perceived motivation, psychopathology and personality traits. Eighty-six inpatients with schizophrenia and 45 non-patient control participants completed the Motivation and Energy Inventory, which consists of Global Motivation, Social Motivation and Situational Motivation (the motivation individuals experience when they are engaging in an activity). Participants also completed personality questionnaires and an affective evocative task. Compared to controls, schizophrenia participants reported lower situational motivation, and comparable global and social motivation. Situational motivation was negatively predicted by negative temperament, affective ambivalence and depression level. Our results are consistent with the idea that schizophrenia individuals are not impaired in their motivational disposition but lack energy during the implementation of their goals. This may reflect impairment in the prediction, maintenance and/or modulation of required effort and energy during goal-directed actions, and is predicted by some affective processes. Improving situational motivation may be an effective therapeutic approach in people with schizophrenia.
    MeSH term(s) Adolescent ; Adult ; Aged ; Female ; Humans ; Inpatients ; Male ; Middle Aged ; Mood Disorders/diagnosis ; Mood Disorders/etiology ; Motivation/physiology ; Personality Disorders/diagnosis ; Personality Disorders/etiology ; Psychiatric Status Rating Scales ; Schizophrenia/complications ; Schizophrenic Psychology ; Self Report ; Social Behavior ; Young Adult
    Language English
    Publishing date 2013-11-30
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 445361-x
    ISSN 1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7123 ; 1872-7506
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.psychres.2013.05.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Behavioral validation of avolition in schizophrenia.

    Trémeau, Fabien / Nolan, Karen A / Malaspina, Dolores / Javitt, Daniel C

    Schizophrenia research

    2012  Volume 138, Issue 2-3, Page(s) 255–261

    Abstract: Background: Since Kraepelin, avolition, a core symptom of schizophrenia, has been defined as a decrease in spontaneous, self-initiated and purposeful behaviors observed in daily life activities. However, the concurrent validity of commonly-used ... ...

    Abstract Background: Since Kraepelin, avolition, a core symptom of schizophrenia, has been defined as a decrease in spontaneous, self-initiated and purposeful behaviors observed in daily life activities. However, the concurrent validity of commonly-used avolition measures has not been studied, and direct observation may offer a more objective way to measure avolition.
    Method: A direct observation measure of spontaneous and self-initiated behaviors that can be observed in an inpatient setting was defined with the use of time sampling method. This direct observation measure was used with fifty inpatients with schizophrenia. Additionally, patients were asked to rate their current interest in and their level of engagement in 10 active behaviors during the preceding 7 days. Clinicians rated the patients' engagement in the same activities for the preceding 7 days as well.
    Results: The direct observation measure showed very good psychometric properties. Three clinical negative symptom scales showed moderate to high correlation with the direct measure. Concerning the retrospective ratings, patients' self-assessments were poorly correlated with clinicians' ratings, but showed high correlation with their subjective interests.
    Conclusions: Clinical rating scales of negative symptoms show moderate to good concurrent validity as measures of avolition in schizophrenia. However, patients' self-reports do not appear to provide valid indices of avolition. Our results favor clinical negative symptoms scales that use observers' reports only, over patients' self-reports. The direct observation of patients' behavior offers a precise and objective measure of avolition that may be useful in drug challenges and clinical trials.
    MeSH term(s) Adult ; Female ; Humans ; Interpersonal Relations ; Male ; Middle Aged ; Motivation ; Observation/methods ; Psychometrics/instrumentation ; Reproducibility of Results ; Schizophrenia/physiopathology ; Schizophrenic Psychology ; Self-Assessment
    Language English
    Publishing date 2012-07
    Publishing country Netherlands
    Document type Journal Article ; Validation Studies
    ZDB-ID 639422-x
    ISSN 1573-2509 ; 0920-9964
    ISSN (online) 1573-2509
    ISSN 0920-9964
    DOI 10.1016/j.schres.2012.02.018
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  7. Article ; Online: Immediate affective motivation is not impaired in schizophrenia.

    Trémeau, Fabien / Antonius, Daniel / Nolan, Karen / Butler, Pamela / Javitt, Daniel C

    Schizophrenia research

    2014  Volume 159, Issue 1, Page(s) 157–163

    Abstract: Background: Among the various cognitive and affective evaluations that contribute to decisions about whether to engage in a future activity, three affective evaluations are particularly relevant: 1) interest in the activity itself, 2) the pleasure ... ...

    Abstract Background: Among the various cognitive and affective evaluations that contribute to decisions about whether to engage in a future activity, three affective evaluations are particularly relevant: 1) interest in the activity itself, 2) the pleasure anticipated from the activity and 3) the excitement experienced while looking forward to the activity. In addition to these pre-activity evaluations, affective evaluations that are done after the activity is completed impact people's motivation to repeat the same activity. Although extant research suggests that these affective processes may be impaired in schizophrenia, it is not clear whether these impairments are mostly secondary to cognitive deficits.
    Method: In three independent studies utilizing simple laboratory tasks with minimal cognitive demands, patients with schizophrenia or schizoaffective disorder and healthy control subjects evaluated their pleasure, interest, and excitement immediately before and after completing the tasks.
    Results: Patients' anticipated pleasure and posttest evaluations of pleasure and interest were significantly greater than controls'. No group differences were found for excitement. In patients, there were significant negative correlations between anticipated pleasure, pretest excitement and depression scores, and between pretest interest and negative symptoms.
    Conclusions: In these experiments, immediate affective evaluations reported by participants with schizophrenia or schizoaffective disorder were greater or similar to controls'. This finding is consistent with recent affective research showing that experiences of pleasure are intact in schizophrenia. These results emphasize the need to disentangle affective from cognitive processes in order to better understand the complex impairments present in schizophrenia spectrum disorders.
    MeSH term(s) Adult ; Cognition Disorders/diagnosis ; Cognition Disorders/etiology ; Female ; Humans ; Male ; Middle Aged ; Motivation ; Neuropsychological Tests ; Psychiatric Status Rating Scales ; Schizophrenia/complications ; Schizophrenic Psychology
    Language English
    Publishing date 2014-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 639422-x
    ISSN 1573-2509 ; 0920-9964
    ISSN (online) 1573-2509
    ISSN 0920-9964
    DOI 10.1016/j.schres.2014.08.001
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  8. Article ; Online: Familiarity preference in schizophrenia is associated with ambivalent attitudes towards others.

    Antonius, Daniel / Bruce, Kira L / Moisa, Bethanie / Sinclair, Samuel Justin / Malaspina, Dolores / Trémeau, Fabien

    Schizophrenia research

    2013  Volume 150, Issue 1, Page(s) 229–234

    Abstract: Objective: Preferences or attitudes towards others are often shaped through implicit memory processes, and they serve a critical function in our social lives. Preferences driven by implicit familiarity (mere exposure effect) are particularly important ... ...

    Abstract Objective: Preferences or attitudes towards others are often shaped through implicit memory processes, and they serve a critical function in our social lives. Preferences driven by implicit familiarity (mere exposure effect) are particularly important when making judgments about others and forming attitudes of liking and social interaction. In schizophrenia, little is known about the effect of familiarity preference on judgments and attitudes toward others.
    Methods: Subjects included 79 patients with a diagnosis of schizophrenia or schizoaffective disorder and 61 non-patient control subjects. Familiarity preference and trait judgments about others were assessed using a computer task in which neutral faces were rated on positive and negative character traits. "Attractiveness" was rated twice at the beginning and at the end, to measure familiarity preference. Clinical ratings were also obtained.
    Results: Patients and controls both demonstrated a positive familiarity preference effect. However, the groups differed on the predictive value of familiarity preference for trait judgments. In both groups, the presence of a familiarity preference effect predicted greater positive trait judgments. In patients only, the presence of a familiarity preference effect also predicted, although the correlation was less significant, greater negative trait judgments.
    Conclusion: The findings are consistent with a preserved familiarity preference effect in individuals with schizophrenia and that the effect is primarily associated with changes in positive attitudes. However, in individuals with schizophrenia this effect is also linked with inferences about negative traits, resulting in ambivalence towards others. This finding may contribute to the impaired social functioning of people with schizophrenia.
    MeSH term(s) Adolescent ; Adult ; Aged ; Analysis of Variance ; Attitude ; Female ; Humans ; Linear Models ; Male ; Memory Disorders/etiology ; Middle Aged ; Predictive Value of Tests ; Psychiatric Status Rating Scales ; Psychotic Disorders/complications ; Psychotic Disorders/psychology ; Recognition, Psychology/physiology ; Schizophrenia/complications ; Schizophrenic Psychology ; Young Adult
    Language English
    Publishing date 2013-08-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 639422-x
    ISSN 1573-2509 ; 0920-9964
    ISSN (online) 1573-2509
    ISSN 0920-9964
    DOI 10.1016/j.schres.2013.07.056
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  9. Article ; Online: High dose quetiapine in the treatment of psychosis due to traumatic brain injury: a case report.

    Trémeau, Fabien / Mauro, Cristina J / Shope, Constance / Riber, Leah M / Dhami, Surjit / Citrome, Leslie

    Progress in neuro-psychopharmacology & biological psychiatry

    2011  Volume 35, Issue 1, Page(s) 280–281

    MeSH term(s) Adult ; Antipsychotic Agents/therapeutic use ; Brain Injuries/complications ; Dibenzothiazepines/therapeutic use ; Dose-Response Relationship, Drug ; Humans ; Male ; Psychotic Disorders/drug therapy ; Psychotic Disorders/etiology ; Quetiapine Fumarate
    Chemical Substances Antipsychotic Agents ; Dibenzothiazepines ; Quetiapine Fumarate (2S3PL1B6UJ)
    Language English
    Publishing date 2011-01-15
    Publishing country England
    Document type Letter
    ZDB-ID 781181-0
    ISSN 1878-4216 ; 0278-5846
    ISSN (online) 1878-4216
    ISSN 0278-5846
    DOI 10.1016/j.pnpbp.2010.09.011
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  10. Article ; Online: Deficits in implicit facial recognition of fear in aggressive patients with schizophrenia.

    Antonius, Daniel / Kline, Brian / Sinclair, Samuel Justin / White-Ajmani, Mandi / Gianfagna, Sara / Malaspina, Dolores / Trémeau, Fabien

    Schizophrenia research

    2012  Volume 143, Issue 2-3, Page(s) 401–402

    MeSH term(s) Adult ; Aggression/psychology ; Facial Expression ; Fear/psychology ; Female ; Humans ; Male ; Middle Aged ; Recognition, Psychology/physiology ; Schizophrenia/physiopathology ; Schizophrenic Psychology ; Social Perception
    Language English
    Publishing date 2012-12-29
    Publishing country Netherlands
    Document type Letter ; Research Support, N.I.H., Extramural
    ZDB-ID 639422-x
    ISSN 1573-2509 ; 0920-9964
    ISSN (online) 1573-2509
    ISSN 0920-9964
    DOI 10.1016/j.schres.2012.11.038
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