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  1. Article ; Online: Stephen T. Lutz: palliative radiotherapy, a growing subspecialty. Interview by Nancy Q. Zhong.

    Lutz, Stephen T

    Annals of palliative medicine

    2015  Volume 4, Issue 1, Page(s) 43–45

    MeSH term(s) Humans ; Palliative Care ; Societies, Medical ; United States
    Language English
    Publishing date 2015-01
    Publishing country China
    Document type Interview ; Portraits
    ISSN 2224-5839
    ISSN (online) 2224-5839
    DOI 10.3978/j.issn.2224-5820.2015.01.07
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  2. Article ; Online: Palliative radiotherapy: history, recent advances, and future directions.

    Lutz, Stephen T

    Annals of palliative medicine

    2019  Volume 8, Issue 3, Page(s) 240–245

    Abstract: Radiotherapy has been used to palliate cancer symptoms since shortly after the time that X rays were discovered late in the 1800's. The 20th century witnessed improvements in treatment planning and delivery that permitted radiotherapy to serve as a ... ...

    Abstract Radiotherapy has been used to palliate cancer symptoms since shortly after the time that X rays were discovered late in the 1800's. The 20th century witnessed improvements in treatment planning and delivery that permitted radiotherapy to serve as a successful, timely, and cost-efficient palliative intervention. Palliative radiation oncology has risen to the level of its own subspecialty, as evidenced by the formation of palliative radiation oncology clinical services and dedicated palliative radiotherapy guidelines, while additional changes have begun to alter the very definition and goals of palliative radiotherapy. Local treatment may now be offered with dual goals of symptom relief and the potential for increased disease-free or overall survival. While these new directions show great promise, novel strategies must be formulated to manage the increased complexity, workload, and cost of these approaches.
    MeSH term(s) Age Factors ; Cancer Pain/radiotherapy ; History, 20th Century ; Humans ; Insurance, Health, Reimbursement ; Life Expectancy ; Neoplasms/mortality ; Neoplasms/radiotherapy ; Palliative Care/history ; Palliative Care/methods ; Patient Care Planning/history ; Patient Care Planning/organization & administration ; Tomography, X-Ray Computed/history ; Tomography, X-Ray Computed/instrumentation
    Language English
    Publishing date 2019-03-15
    Publishing country China
    Document type Historical Article ; Journal Article ; Review
    ZDB-ID 2828544-X
    ISSN 2224-5839 ; 2224-5820
    ISSN (online) 2224-5839
    ISSN 2224-5820
    DOI 10.21037/apm.2019.03.02
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Nickel-catalyzed enantioselective arylation of pyridine.

    Lutz, J Patrick / Chau, Stephen T / Doyle, Abigail G

    Chemical science

    2016  Volume 7, Issue 7, Page(s) 4105–4109

    Abstract: We report an enantioselective Ni-catalyzed cross coupling of arylzinc reagents with pyridiniumions ... ...

    Abstract We report an enantioselective Ni-catalyzed cross coupling of arylzinc reagents with pyridiniumions formed
    Language English
    Publishing date 2016-03-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/c6sc00702c
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  4. Article ; Online: External beam radiotherapy and bone metastases.

    Johnstone, Candice / Lutz, Stephen T

    Annals of palliative medicine

    2014  Volume 3, Issue 2, Page(s) 114–122

    Abstract: Management of bone metastasis is a multi-disciplinary effort that involves coordination between several medical specialties. External beam radiation therapy (EBRT) remains a powerful and efficient method of palliating pain and preventing skeletal ... ...

    Abstract Management of bone metastasis is a multi-disciplinary effort that involves coordination between several medical specialties. External beam radiation therapy (EBRT) remains a powerful and efficient method of palliating pain and preventing skeletal complications from osseous metastasis. Various fractionation schemes, ranging from 8 Gy in a single dose to 30 Gy in 10 fractions, provide equivalent pain relief as demonstrated by dozens of randomized clinical trials. Toxicity profiles are well established and the treatment is generally well tolerated. Radiopharmaceuticals and high-dose, stereotactic radiation therapy are adjuncts to EBRT whose role is being elucidated through clinical trials. Multiple organizations have compiled guidelines and quality metrics to help refine the role of each modality in the management of painful osseous metastases.
    Language English
    Publishing date 2014-04
    Publishing country China
    Document type Journal Article
    ZDB-ID 2828544-X
    ISSN 2224-5839 ; 2224-5820
    ISSN (online) 2224-5839
    ISSN 2224-5820
    DOI 10.3978/j.issn.2224-5820.2014.04.06
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  5. Article: A call to action: hospice and palliative medicine board certification.

    Lutz, Stephen T

    International journal of radiation oncology, biology, physics

    2008  Volume 72, Issue 1, Page(s) 9–10

    MeSH term(s) Certification ; Hospice Care/standards ; Humans ; Interdisciplinary Communication ; Interprofessional Relations ; Palliative Care/standards ; Patient Care Team/organization & administration ; Radiation Oncology/education ; Radiation Oncology/standards
    Language English
    Publishing date 2008-09-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2008.04.061
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1218: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: The role of hypofractionated radiation in the management of non-osseous metastatic or uncontrolled local cancer.

    Johnstone, Candice / Lutz, Stephen T

    Annals of palliative medicine

    2014  Volume 3, Issue 4, Page(s) 291–303

    Abstract: Radiation therapy is often used to palliate symptoms caused by cancer. Short course, or "hypofractionated" palliative radiation therapy provides equivalent palliation in the setting of non-osseous metastasis or uncontrolled localized cancer while being ... ...

    Abstract Radiation therapy is often used to palliate symptoms caused by cancer. Short course, or "hypofractionated" palliative radiation therapy provides equivalent palliation in the setting of non-osseous metastasis or uncontrolled localized cancer while being more convenient and cost-effective than longer courses of radiation. Hypofractionated palliative radiation plays a role in the management of obstruction due to tumor, neurologic symptoms, pain caused by localized bulky disease, and bleeding in patients with primary tumors of the lung, head and neck, bladder, rectum, gynecologic malignancies, and metastasis to the liver, lung and brain. Hypofractionated palliative radiation is well tolerated with minimal and self-limited side effects. The side effects that do occur are generally limited to the body region treated and last from a few days to a few weeks.
    Language English
    Publishing date 2014-10
    Publishing country China
    Document type Journal Article
    ZDB-ID 2828544-X
    ISSN 2224-5839 ; 2224-5820
    ISSN (online) 2224-5839
    ISSN 2224-5820
    DOI 10.3978/j.issn.2224-5820.2014.10.01
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  7. Article ; Online: Hypoaminoacidemia underpins glucagon-mediated energy expenditure and weight loss.

    Hope, David C D / Hinds, Charlotte E / Lopes, Tatiana / Vincent, Matthew L / Shrewsbury, Jed V / Yu, Arthur T C / Davies, Iona / Scott, Rebecca / Jones, Ben / Murphy, Kevin G / Minnion, James S / Sardini, Alessandro / Carling, David / Lutz, Thomas A / Bloom, Stephen R / Tan, Tricia M M / Owen, Bryn M

    Cell reports. Medicine

    2022  Volume 3, Issue 11, Page(s) 100810

    Abstract: Glucagon analogs show promise as components of next-generation, multi-target, anti-obesity therapeutics. The biology of chronic glucagon treatment, in particular, its ability to induce energy expenditure and weight loss, remains poorly understood. Using ... ...

    Abstract Glucagon analogs show promise as components of next-generation, multi-target, anti-obesity therapeutics. The biology of chronic glucagon treatment, in particular, its ability to induce energy expenditure and weight loss, remains poorly understood. Using a long-acting glucagon analog, G108, we demonstrate that glucagon-mediated body weight loss is intrinsically linked to the hypoaminoacidemia associated with its known amino acid catabolic action. Mechanistic studies reveal an energy-consuming response to low plasma amino acids in G108-treated mice, prevented by dietary amino acid supplementation and mimicked by a rationally designed low amino acid diet. Therefore, low plasma amino acids are a pre-requisite for G108-mediated energy expenditure and weight loss. However, preventing hypoaminoacidemia with additional dietary protein does not affect the ability of G108 to improve glycemia or hepatic steatosis in obese mice. These studies provide a mechanism for glucagon-mediated weight loss and confirm the hepatic glucagon receptor as an attractive molecular target for metabolic disease therapeutics.
    MeSH term(s) Mice ; Animals ; Glucagon/metabolism ; Weight Loss ; Energy Metabolism/physiology ; Receptors, Glucagon/metabolism ; Mice, Obese ; Amino Acids/pharmacology
    Chemical Substances Glucagon (9007-92-5) ; Receptors, Glucagon ; Amino Acids
    Language English
    Publishing date 2022-11-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2666-3791
    ISSN (online) 2666-3791
    DOI 10.1016/j.xcrm.2022.100810
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  8. Article ; Online: Latitudinal patterns in stabilizing density dependence of forest communities.

    Hülsmann, Lisa / Chisholm, Ryan A / Comita, Liza / Visser, Marco D / de Souza Leite, Melina / Aguilar, Salomon / Anderson-Teixeira, Kristina J / Bourg, Norman A / Brockelman, Warren Y / Bunyavejchewin, Sarayudh / Castaño, Nicolas / Chang-Yang, Chia-Hao / Chuyong, George B / Clay, Keith / Davies, Stuart J / Duque, Alvaro / Ediriweera, Sisira / Ewango, Corneille / Gilbert, Gregory S /
    Holík, Jan / Howe, Robert W / Hubbell, Stephen P / Itoh, Akira / Johnson, Daniel J / Kenfack, David / Král, Kamil / Larson, Andrew J / Lutz, James A / Makana, Jean-Remy / Malhi, Yadvinder / McMahon, Sean M / McShea, William J / Mohamad, Mohizah / Nasardin, Musalmah / Nathalang, Anuttara / Norden, Natalia / Oliveira, Alexandre A / Parmigiani, Renan / Perez, Rolando / Phillips, Richard P / Pongpattananurak, Nantachai / Sun, I-Fang / Swanson, Mark E / Tan, Sylvester / Thomas, Duncan / Thompson, Jill / Uriarte, Maria / Wolf, Amy T / Yao, Tze Leong / Zimmerman, Jess K / Zuleta, Daniel / Hartig, Florian

    Nature

    2024  Volume 627, Issue 8004, Page(s) 564–571

    Abstract: Numerous studies have shown reduced performance in plants that are surrounded by neighbours of the same ... ...

    Abstract Numerous studies have shown reduced performance in plants that are surrounded by neighbours of the same species
    MeSH term(s) Biodiversity ; Forests ; Geographic Mapping ; Models, Biological ; Species Specificity ; Trees/classification ; Trees/physiology ; Tropical Climate
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-024-07118-4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
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  9. Article ; Online: Symptom persistence and recovery among COVID-19 survivors during a limited outbreak in Canterbury, New Zealand: a prospective cohort study.

    Cheung, Jeanette / Nordmeier, Kim / Kelland, Sarah / Harrington, Michael / Williman, Jonathan / Storer, Malina / Beaglehole, Ben / Beckert, Lutz / Chambers, Stephen T / Epton, Michael J / Freeman, Josh / Murdoch, David R / Werno, Anja M / Maze, Michael J

    Internal medicine journal

    2022  Volume 53, Issue 1, Page(s) 37–45

    Abstract: Background: In Canterbury, near complete identification of coronavirus disease 2019 (COVID-19) cases during a limited outbreak provides unique insights into sequelae.: Aims: The current study aimed to measure symptom persistence, time to return to ... ...

    Abstract Background: In Canterbury, near complete identification of coronavirus disease 2019 (COVID-19) cases during a limited outbreak provides unique insights into sequelae.
    Aims: The current study aimed to measure symptom persistence, time to return to normal activity, generalised anxiety and health-related quality of life (HrQoL) among COVID-19 survivors compared with uninfected participants.
    Methods: The authors conducted a prospective cohort study of people tested for COVID-19 by reverse transcriptase polymerase chain reaction of nasopharyngeal swabs from 1 March to 30 June 2020. They enrolled participants who tested positive and negative at a 1:2 ratio, and administered community-acquired pneumonia, 7-item generalised anxiety disorder (GAD-7) and HrQoL (RAND-36) questionnaires.
    Results: The authors recruited 145 participants, 48 with COVID-19 and 97 without COVID-19. The mean time from COVID-19 testing to completing the health questionnaire was 306 days. The mean age of patients was 46.7 years, and 70% were women. Four (8%) COVID-19-positive and eight (8%) COVID-19-negative participants required hospitalisation. Fatigue (30/48 [63%] vs 13/97 [13%]; P < 0.001), dyspnoea (13/48 [27%] vs 6/97 [6%]; P < 0.001) and chest pain (10/48 [21%] vs 1/97 [1%]; P < 0.001) were persistent in those with COVID-19. Fewer COVID-19-positive participants returned to normal activity levels (35/48 [73%] vs 94/97 97%; P < 0.001), with longer times taken (median 21 vs 14 days; P = 0.007). The GAD-7 and RAND-36 scores of both groups were similar across all anxiety and HrQoL subscales.
    Conclusions: Persistent symptoms and longer recovery times were found in COVID-19 survivors, but not impaired generalised anxiety levels or HrQoL compared with COVID-19-uninfected participants.
    MeSH term(s) Humans ; Female ; Middle Aged ; Male ; COVID-19/epidemiology ; SARS-CoV-2 ; COVID-19 Testing ; New Zealand/epidemiology ; Prospective Studies ; Quality of Life ; Disease Outbreaks
    Language English
    Publishing date 2022-09-30
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2045436-3
    ISSN 1445-5994 ; 1444-0903
    ISSN (online) 1445-5994
    ISSN 1444-0903
    DOI 10.1111/imj.15930
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    Zs.A 792: Show issues Location:
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    Zs.MO 424: Show issues

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  10. Article ; Online: A Dimeric Hydride-Bridged Complex with Geometrically Distinct Iron Centers Giving Rise to an

    Hickey, Anne K / Greer, Samuel M / Valdez-Moreira, Juan A / Lutz, Sean A / Pink, Maren / DeGayner, Jordan A / Harris, T David / Hill, Stephen / Telser, Joshua / Smith, Jeremy M

    Journal of the American Chemical Society

    2019  Volume 141, Issue 30, Page(s) 11970–11975

    Abstract: Structural and spectroscopic characterization of the dimeric iron hydride complex [ ... ...

    Abstract Structural and spectroscopic characterization of the dimeric iron hydride complex [Ph
    Language English
    Publishing date 2019-07-19
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.9b04389
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    Z 4' 55/32: Show issues
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