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Article ; Online: Introduced the ITGB1-DT as a novel biomarker associated with five potential drugs using bioinformatics analysis of breast cancer proteomics data and RT-PCR.

Yousefian Naeini, Zahra / Esfandiari, Negin / Hashemi, Mehrdad / Hushmandi, Kiavash / Arbabian, Sedighe / Entezari, Maliheh

Molecular and cellular probes

2023 Volume 71, Page(s) 101930

Abstract: Background: Breast cancer (BC) has been identified as a significant contributor to the rising number of female cancer deaths. As, it has become clear that breast cancer development depends on the interplay of several biological factors against a single ... ...

Abstract	Background: Breast cancer (BC) has been identified as a significant contributor to the rising number of female cancer deaths. As, it has become clear that breast cancer development depends on the interplay of several biological factors against a single molecule. This research aimed to use proteomics to gain a regulatory and metabolic understanding of BC pathophysiology. Method: For the study, a breast cancer proteomics dataset was downloaded from ProteomeXchange and then analyzed by employing MaxQuant and Perseus. Functional enrichment analysis through Metascape and Cytoscape software showed DEPs related biomedical phenomena with potential abruption. The expression of selected lncRNA in terms of the highest connectivity parameters was then quantitatively assessed through RT-PCR in 30 tumor tissues of breast cancer patients, as compared to the adjacent healthy ones. Result: The results indicated that among the 3048 identified proteins, 1149 were differentially expressed, which could be mainly enriched in several key terms. Furthermore, the obtained findings revealed that ITGB1-DT was significantly overexpressed in tumor tissues. Moreover, we found five potential compounds that could be attributed to ITGB1-DT targets (ATN-161, Firategrast, SB-683698, dabigatran-etexilate, and tranexamic-acid). Conclusion: These analyses proposed that ITGB1-DT could be employed as a differentiated factor to identify breast tumor tissues in healthy samples. Besides this, Firategrast could be introduced as a potential remedial agent for breast cancer patients. Overall, from the analysis of a proteomics dataset, an integrative map was generated, and a novel biomarker that may have been implicated in the early detection of BC was introduced.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Proteomics ; Biomarkers ; Computational Biology
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-09-11
Publishing country	England
Document type	Journal Article
ZDB-ID	639082-1
ISSN	1096-1194 ; 0890-8508
ISSN (online)	1096-1194
ISSN	0890-8508
DOI	10.1016/j.mcp.2023.101930
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Article ; Online: Colon cancer transcriptome.

Mokhtari, Khatere / Peymani, Maryam / Rashidi, Mohsen / Hushmandi, Kiavash / Ghaedi, Kamran / Taheriazam, Afshin / Hashemi, Mehrdad

Progress in biophysics and molecular biology

2023 Volume 180-181, Page(s) 49–82

Abstract: Over the last four decades, methodological innovations have continuously changed transcriptome profiling. It is now feasible to sequence and quantify the transcriptional outputs of individual cells or thousands of samples using RNA sequencing (RNA-seq). ... ...

Abstract	Over the last four decades, methodological innovations have continuously changed transcriptome profiling. It is now feasible to sequence and quantify the transcriptional outputs of individual cells or thousands of samples using RNA sequencing (RNA-seq). These transcriptomes serve as a connection between cellular behaviors and their underlying molecular mechanisms, such as mutations. This relationship, in the context of cancer, provides a chance to unravel tumor complexity and heterogeneity and uncover novel biomarkers or treatment options. Since colon cancer is one of the most frequent malignancies, its prognosis and diagnosis seem to be critical. The transcriptome technology is developing for an earlier and more accurate diagnosis of cancer which can provide better protectivity and prognostic utility to medical teams and patients. A transcriptome is a whole set of expressed coding and non-coding RNAs in an individual or cell population. The cancer transcriptome includes RNA-based changes. The combined genome and transcriptome of a patient may provide a comprehensive picture of their cancer, and this information is beginning to affect treatment decision-making in real-time. A full assessment of the transcriptome of colon (colorectal) cancer has been assessed in this review paper based on risk factors such as age, obesity, gender, alcohol use, race, and also different stages of cancer, as well as non-coding RNAs like circRNAs, miRNAs, lncRNAs, and siRNAs. Similarly, they have been examined independently in the transcriptome study of colon cancer.
MeSH term(s)	Humans ; Transcriptome/genetics ; MicroRNAs/genetics ; Gene Expression Profiling ; Colonic Neoplasms/genetics ; Biomarkers ; Gene Regulatory Networks
Chemical Substances	MicroRNAs ; Biomarkers
Language	English
Publishing date	2023-04-13
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	209302-9
ISSN	1873-1732 ; 0079-6107
ISSN (online)	1873-1732
ISSN	0079-6107
DOI	10.1016/j.pbiomolbio.2023.04.002
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Article ; Online: Multi-lead ECG heartbeat classification of heart disease based on HOG local feature descriptor

Mohammad Ali Sheikh Beig Goharrizi / Amir Teimourpour / Manijeh Falah / Kiavash Hushmandi / Mohsen Saberi Isfeedvajani

Computer Methods and Programs in Biomedicine Update, Vol 3, Iss , Pp 100093- (2023)

2023

Abstract: Introduction: ECG data play an important role in the diagnostics of various cardiovascular diseases. Classification of multi-lead ECG signals could be challenging even for well-trained physicians. In this study we propose a new approach for multi-lead ... ...

Abstract	Introduction: ECG data play an important role in the diagnostics of various cardiovascular diseases. Classification of multi-lead ECG signals could be challenging even for well-trained physicians. In this study we propose a new approach for multi-lead ECG classification. Method: Five-types of 15-lead ECG data namely healthy control, bundle branch block, cardiomyopathy, Dysrhythmia, and myocardial infarction patients from two types of datasets, 5319 and 6647 heartbeats from Baqiyatallah and PTB Diagnostic ECG database, were used, respectively. One-dimensional total variation regularization was used to denoising ECG data. Heartbeats were extracted by one cardiologist and saved as images with jpg format. Histogram of oriented gradients method was used to extract feature of images. for classification task support vector machine and fully connected neural network were used. Five-fold cross validation was used for validating the models. Result: For 15-lead ECG PTB Diagnostic database, the best classification models are SVM model with cubic (accuracy: 99.9%, Range: 99.77% - 100%) and quadratic (accuracy: 99.88%, Range: 99.77%-100%) kernel function, for this dataset fully connected accuracy is 99.4% with range of 99.02%- 99.70%. Regarding to the Baqyatallah dataset SVM with cubic (accuracy: 99.83%, Range:99.72%-100%) and quadratic (accuracy: 99.77%, Range: 99.62%-99.9%) were the best classification model and the accuracy for fully connected neural network was 99.1% with the range of 98.59%-99.62% based on HOG descriptors. Expected sigmodal kernel all classification method have accuracy more than 99%. Discussion: simultaneous use of HOG feature extraction method and appropriate classification algorithm such as SVM or fully connected neural network can classify 15-lead ECG heart-beat for different heart disease with high accuracy and adding other relevant patients’ information can be easily done in order to increase the method performance.
Keywords	Multi-lead ECG ; HOG ; SVM ; Fully connected neural network ; Heart disease classification ; Computer applications to medicine. Medical informatics ; R858-859.7
Subject code	006
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: HMGA2 regulation by miRNAs in cancer: Affecting cancer hallmarks and therapy response.

Hashemi, Mehrdad / Rashidi, Mohsen / Hushmandi, Kiavash / Ten Hagen, Timo L M / Salimimoghadam, Shokooh / Taheriazam, Afshin / Entezari, Maliheh / Falahati, Mojtaba

Pharmacological research

2023 Volume 190, Page(s) 106732

Abstract: High mobility group A 2 (HMGA2) is a protein that modulates the structure of chromatin in the nucleus. Importantly, aberrant expression of HMGA2 occurs during carcinogenesis, and this protein is an upstream mediator of cancer hallmarks including evasion ... ...

Abstract	High mobility group A 2 (HMGA2) is a protein that modulates the structure of chromatin in the nucleus. Importantly, aberrant expression of HMGA2 occurs during carcinogenesis, and this protein is an upstream mediator of cancer hallmarks including evasion of apoptosis, proliferation, invasion, metastasis, and therapy resistance. HMGA2 targets critical signaling pathways such as Wnt/β-catenin and mTOR in cancer cells. Therefore, suppression of HMGA2 function notably decreases cancer progression and improves outcome in patients. As HMGA2 is mainly oncogenic, targeting expression by non-coding RNAs (ncRNAs) is crucial to take into consideration since it affects HMGA2 function. MicroRNAs (miRNAs) belong to ncRNAs and are master regulators of vital cell processes, which affect all aspects of cancer hallmarks. Long ncRNAs (lncRNAs) and circular RNAs (circRNAs), other members of ncRNAs, are upstream mediators of miRNAs. The current review intends to discuss the importance of the miRNA/HMGA2 axis in modulation of various types of cancer, and mentions lncRNAs and circRNAs, which regulate this axis as upstream mediators. Finally, we discuss the effect of miRNAs and HMGA2 interactions on the response of cancer cells to therapy. Regarding the critical role of HMGA2 in regulation of critical signaling pathways in cancer cells, and considering the confirmed interaction between HMGA2 and one of the master regulators of cancer, miRNAs, targeting miRNA/HMGA2 axis in cancer therapy is promising and this could be the subject of future clinical trial experiments.
MeSH term(s)	Humans ; Cell Line, Tumor ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neoplasms/drug therapy ; Neoplasms/genetics ; RNA, Circular/genetics ; RNA, Long Noncoding/metabolism ; RNA, Untranslated/genetics ; HMGA2 Protein/metabolism
Chemical Substances	MicroRNAs ; RNA, Circular ; RNA, Long Noncoding ; RNA, Untranslated ; HMGA2 Protein
Language	English
Publishing date	2023-03-15
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1003347-6
ISSN	1096-1186 ; 0031-6989 ; 1043-6618
ISSN (online)	1096-1186
ISSN	0031-6989 ; 1043-6618
DOI	10.1016/j.phrs.2023.106732
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Article ; Online: Noncoding RNAs as regulators of STAT3 pathway in gastrointestinal cancers: Roles in cancer progression and therapeutic response.

Ashrafizadeh, Milad / Mohan, Chakrabhavi D / Rangappa, Shobith / Zarrabi, Ali / Hushmandi, Kiavash / Kumar, Alan Prem / Sethi, Gautam / Rangappa, Kanchugarakoppal S

Medicinal research reviews

2023 Volume 43, Issue 5, Page(s) 1263–1321

Abstract: Gastrointestinal (GI) tumors (cancers of the esophagus, gastric, liver, pancreas, colon, and rectum) contribute to a large number of deaths worldwide. STAT3 is an oncogenic transcription factor that promotes the transcription of genes associated with ... ...

Abstract	Gastrointestinal (GI) tumors (cancers of the esophagus, gastric, liver, pancreas, colon, and rectum) contribute to a large number of deaths worldwide. STAT3 is an oncogenic transcription factor that promotes the transcription of genes associated with proliferation, antiapoptosis, survival, and metastasis. STAT3 is overactivated in many human malignancies including GI tumors which accelerates tumor progression, metastasis, and drug resistance. Research in recent years demonstrated that noncoding RNAs (ncRNAs) play a major role in the regulation of many signaling pathways including the STAT3 pathway. The major types of endogenous ncRNAs that are being extensively studied in oncology are microRNAs, long noncoding RNAs, and circular RNAs. These ncRNAs can either be tumor-promoters or tumor-suppressors and each one of them imparts their activity via different mechanisms. The STAT3 pathway is also tightly modulated by ncRNAs. In this article, we have elaborated on the tumor-promoting role of STAT3 signaling in GI tumors. Subsequently, we have comprehensively discussed the oncogenic as well as tumor suppressor functions and mechanism of action of ncRNAs that are known to modulate STAT3 signaling in GI cancers.
MeSH term(s)	Humans ; MicroRNAs/genetics ; RNA, Long Noncoding/genetics ; Gastrointestinal Neoplasms/genetics ; Signal Transduction ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism
Chemical Substances	MicroRNAs ; RNA, Long Noncoding ; STAT3 protein, human ; STAT3 Transcription Factor
Language	English
Publishing date	2023-03-23
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	603210-2
ISSN	1098-1128 ; 0198-6325
ISSN (online)	1098-1128
ISSN	0198-6325
DOI	10.1002/med.21950
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Article: Apoptotic Genes of Bax, Bad, Bcl2, and P53 in A549 Lung Cancer Cells Comparison of the Effect of Echinophora platyloba DC. Extract and Cordia myxa L Extract on the Expression of Apoptotic Genes of Bax, Bad, Bcl2, and P53 in A549 Lung Cancer Cells.

Kalantari, Mahshad / Entezari, Maliheh / Movafagh, Abolfazl / Hushmandi, Kiavash / Dehghani, Hossein

The Gulf journal of oncology

2021 Volume 1, Issue 35, Page(s) 7–13

Abstract: Introduction: Lung cancer is the most deadly and sumptuous cancer across the globe. Cancer occurrence is increasing progressively and there is no ideal cure yet. Therefore, new therapeutic areas are needed. The use of herbal extracts due to its ... ...

Abstract	Introduction: Lung cancer is the most deadly and sumptuous cancer across the globe. Cancer occurrence is increasing progressively and there is no ideal cure yet. Therefore, new therapeutic areas are needed. The use of herbal extracts due to its properties such as antioxidant activity, anti-proliferative effect, and few side effects can be promising in the treatment of cancer. This study aimed to compare the effect of Echinophora platyloba DC. and Cordia myxa L extracts on apoptosis induction in A549 cancer cells. Materials and methods: In this experiment, the A549 cell line was first cultured in DMEM medium containing 10% FBS and then treated with different concentrations of both compounds. MTT assay was performed to determine IC50 and to compare the viability of cells treated with different concentrations of Echinophora platyloba DC. and Cordia myxa L seed on days 1, 3 and 5. QRT-PCR test was used to investigate the effects of Echinophora platyloba DC. and Cordia myxa L with IC50 on apoptosis induction. Results: MTT results showed that both plant extracts resulted in cell death and decreased viability of lung cancer cells. But the percentage of viability decreased by Echinophora platyloba DC. was more. Also, Echinophora platyloba DC. significantly increased the expression of Bax, P53 and Bad apoptotic genes and decreased the expression of Bcl2 gene, which induces apoptotic death and the cytotoxic effect of Echinophora platyloba DC. over Cordia myxa L. Conclusion: In comparing the effects of these two extracts Echinophora platyloba DC. was more effective than Cordia myxa L and had greater cytotoxicity on A549 cancerous cells in a lesser concentration and could be an appropriate drug candidate for the treatment of lung cancer.
MeSH term(s)	A549 Cells ; Apoptosis ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Plant Extracts/chemistry
Chemical Substances	Plant Extracts
Language	English
Publishing date	2021-03-11
Publishing country	Kuwait
Document type	Journal Article
ISSN	2078-2101
ISSN	2078-2101
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Article ; Online: The protective impact of curcumin, vitamin D and E along with manganese oxide and Iron (III) oxide nanoparticles in rats with scrotal hyperthermia: Role of apoptotic genes, miRNA and circRNA.

Paskeh, Mahshid Deldar Abad / Babaei, Nahid / Hashemi, Mehrdad / Doosti, Abbas / Hushmandi, Kiavash / Entezari, Maliheh / Samarghandian, Saeed

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

2023 Volume 81, Page(s) 127320

Abstract: Background: Infertility is one of the major factors affecting most people around the world. Short-term exposure to high temperatures can cause hyperthermia, which is one of the causes of male infertility. The aim of this study was to investigate the ... ...

Abstract	Background: Infertility is one of the major factors affecting most people around the world. Short-term exposure to high temperatures can cause hyperthermia, which is one of the causes of male infertility. The aim of this study was to investigate the protective effect of curcumin, vitamins D and E along with Iron (III) oxide nanoparticles (Fe2O3-NPs) and manganese oxide nanoparticles (MnO2-NPs) on semen parameters and its effect on miRNA21 and circRNA0001518 expression. Material and methods: In this study, the lower part of the rat was exposed to 43 °C for 5 weeks every other day for 5 weeks. Then the animals were killed. Tissue samples were collected for sperm parameters analysis, and tissue samples were taken for evaluation of apoptosis levels in germ cells, and RNA extraction in order to examine the expression of Bax, Bcl-2, miRNA, and CircRNA genes. Results: The results of this study showed that administration of curcumin, vitamin D, and vitamin E with Fe2O3-NPs and MnO2-NPs can improve the parameters of semen, Bax gene expression, Bcl-2 as well as miRNA and CircRNA in rats with testicular hyperthermia. In addition, curcumin by reducing the toxicity of Fe2O3 nanoparticles was able to reduce its negative effects and also reduce apoptosis in germ cells. This decrease in apoptosis was attributed to decreased Bcl-2 gene expression and increased expression of Bax, miRNA-21, and circRNA0001518. Conclusion: All the results of this study confirmed that Fe2O3-NPs and Mno2-NPs containing antioxidants or vitamins are useful in improving fertility in rats due to scrotal hyperthermia. Although Fe2O3-NPs and Mno2-NPs containing both antioxidants and vitamins had a greater effect on improving fertility and reducing the toxic effects of nanoparticles.
MeSH term(s)	Humans ; Rats ; Male ; Animals ; Vitamin D ; Manganese Compounds ; Oxides/toxicity ; Curcumin/pharmacology ; RNA, Circular ; Iron ; MicroRNAs/genetics ; bcl-2-Associated X Protein ; Metal Nanoparticles/toxicity ; Semen ; Nanoparticles ; Antioxidants ; Vitamins ; Hyperthermia, Induced
Chemical Substances	Vitamin D (1406-16-2) ; manganese oxide (64J2OA7MH3) ; Manganese Compounds ; Oxides ; Curcumin (IT942ZTH98) ; RNA, Circular ; Iron (E1UOL152H7) ; MicroRNAs ; bcl-2-Associated X Protein ; Antioxidants ; Vitamins
Language	English
Publishing date	2023-10-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1236267-0
ISSN	1878-3252 ; 1611-602X ; 0946-672X
ISSN (online)	1878-3252 ; 1611-602X
ISSN	0946-672X
DOI	10.1016/j.jtemb.2023.127320
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Article ; Online: Mortality trend before and after the onset of the Corona crisis

vahid rahmani / Razieh Zehedi / Kiavash Hushmandi / Karamatollah rahmanian / Leila Fakhravar

فصلنامه دانشگاه علوم پزشکی جهرم, Vol 19, Iss 1, Pp 21-

—has the mortality changed its course?

2021 Volume 33

Abstract: Background & Objectives: The critical conditions of the epidemic covid-19 may have different effects on the rate of mortality of other people in the community. The aim of this study was to determine the evaluation of mortality trend before and after the ... ...

Abstract	Background & Objectives: The critical conditions of the epidemic covid-19 may have different effects on the rate of mortality of other people in the community. The aim of this study was to determine the evaluation of mortality trend before and after the onset of Corona crisis in Jahrom County, south of Iran. Methods: This descriptive study was performed by secondary data analysis death certificate during 2016-2020. The studied variables were collected based on a checklist from the data of the death registration system of the health center and also mortality statistics announced by the organization for civil registration. Results: In a total of 3785 deaths occurred during the study period, of which 2250 (59.5%) were in male and the rest were female. The average annual number of deaths before and after the Corona epidemic was 701 and 981, respectively. Cardiovascular disease, cerebral infarction, and cancer were the three leading causes of death before the onset of Corona crisis, respectively, and cardiovascular disease, Covid-19, and cerebrovascular disease were the most common causes of death after the onset of Corona crisis, respectively. After the Corona crisis, the cause of death from road accidents and cancer was reduced by 32.60% to 48.61% and the Influenza-like illness was increased by 110.25%. Conclusion: The average number of deaths occurred after the Corona epidemic has increased by 39% compared to before the epidemic. Cardiovascular diseases are the first and most common causes of death in Jahrom before and after the Corona epidemic.
Keywords	pandemic ; covid-19 ; cause of death ; iran ; Medicine ; R
Subject code	630
Language	Persian
Publishing date	2021-03-01T00:00:00Z
Publisher	Jahrom University of Medical Sciences
Document type	Article ; Online
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Article ; Online: Shedding light on function of long non-coding RNAs (lncRNAs) in glioblastoma.

Hashemi, Mehrdad / Mousavian Roshanzamir, Sophie / Orouei, Sima / Daneii, Pouria / Raesi, Rasoul / Zokaee, Haleh / Bikarannejad, Pooria / Salmani, Kiana / Khorrami, Ramin / Deldar Abad Paskeh, Mahshid / Salimimoghadam, Shokooh / Rashidi, Mohsen / Hushmandi, Kiavash / Taheriazam, Afshin / Entezari, Maliheh

Non-coding RNA research

2024 Volume 9, Issue 2, Page(s) 508–522

Abstract: The brain tumors and especially glioblastoma, are affecting life of many people worldwide and due to their high mortality and morbidity, their treatment is of importance and has gained attention in recent years. The abnormal expression of genes is ... ...

Abstract	The brain tumors and especially glioblastoma, are affecting life of many people worldwide and due to their high mortality and morbidity, their treatment is of importance and has gained attention in recent years. The abnormal expression of genes is commonly observed in GBM and long non-coding RNAs (lncRNAs) have demonstrated dysregulation in this tumor. LncRNAs have length more than 200 nucleotides and they have been located in cytoplasm and nucleus. The current review focuses on the role of lncRNAs in GBM. There two types of lncRNAs in GBM including tumor-promoting and tumor-suppressor lncRNAs and overexpression of oncogenic lncRNAs increases progression of GBM. LncRNAs can regulate proliferation, cell cycle arrest and metastasis of GBM cells. Wnt, STAT3 and EZH2 are among the molecular pathways affected by lncRNAs in GBM and for regulating metastasis of GBM cells, these RNA molecules mainly affect EMT mechanism. LncRNAs are involved in drug resistance and can induce resistance of GBM cells to temozolomide chemotherapy. Furthermore, lncRNAs stimulate radio-resistance in GBM cells. LncRNAs increase PD-1 expression to mediate immune evasion. LncRNAs can be considered as diagnostic and prognostic tools in GBM and researchers have developed signature from lncRNAs in GBM.
Language	English
Publishing date	2024-02-06
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2468-0540
ISSN (online)	2468-0540
DOI	10.1016/j.ncrna.2024.02.002
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Article: Quercetin and Its Nano-Scale Delivery Systems in Prostate Cancer Therapy: Paving the Way for Cancer Elimination and Reversing Chemoresistance.

Hussain, Yaseen / Mirzaei, Sepideh / Ashrafizadeh, Milad / Zarrabi, Ali / Hushmandi, Kiavash / Khan, Haroon / Daglia, Maria

Cancers

2021 Volume 13, Issue 7

Abstract: Prostate cancer is the second most leading and prevalent malignancy around the world, following lung cancer. Prostate cancer is characterized by the uncontrolled growth of cells in the prostate gland. Prostate cancer morbidity and mortality have grown ... ...

Abstract	Prostate cancer is the second most leading and prevalent malignancy around the world, following lung cancer. Prostate cancer is characterized by the uncontrolled growth of cells in the prostate gland. Prostate cancer morbidity and mortality have grown drastically, and intensive prostate cancer care is unlikely to produce adequate outcomes. The synthetic drugs for the treatment of prostate cancer in clinical practice face several challenges. Quercetin is a natural flavonoid found in fruits and vegetables. Apart from its beneficial effects, its plays a key role as an anti-cancer agent. Quercetin has shown anticancer potential, both alone and in combination. Therefore, the current study was designed to collect information from the literature regarding its therapeutic significance in the treatment of prostate cancer. Studies performed both in vitro and in vivo have confirmed that quercetin effectively prevents prostate cancer through different underlying mechanisms. Promising findings have also been achieved in clinical trials regarding the pharmacokinetics and human applications of quercetin. In the meantime, epidemiological studies have shown a negative correlation between the consumption of quercetin and the incidence of prostate cancer, and have indicated a chemopreventive effect of quercetin on prostate cancer in animal models. The major issues associated with quercetin are its low bioavailability and rapid metabolism, and these require priority attention. Chemoresistance is another main negative feature concerning prostate cancer treatment. This review highlights the chemotherapeutic effect, chemo preventive effect, and chemoresistance elimination potential of quercetin in prostate cancer. The underlying mechanisms for elimination of prostate cancer and eradication of resistance, either alone or in combination with other agents, are also discussed. In addition, the nanoscale delivery of quercetin is underpinned along with possible directions for future study.
Language	English
Publishing date	2021-03-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13071602
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