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  1. Article: Reference Values for the German Version of the Quality of Life after Brain Injury in Children and Adolescents (QOLIBRI-KID/ADO) from a General Population Sample.

    Krol, Leonie / Hagmayer, York / Steinbuechel, Nicole von / Cunitz, Katrin / Buchheim, Anna / Koerte, Inga K / Zeldovich, Marina

    Journal of personalized medicine

    2024  Volume 14, Issue 4

    Abstract: Assessment of health-related quality of life (HRQoL) after pediatric traumatic brain injury (TBI) has been limited in children and adolescents due to a lack of disease-specific instruments. To fill this gap, the Quality of Life after Traumatic Brain ... ...

    Abstract Assessment of health-related quality of life (HRQoL) after pediatric traumatic brain injury (TBI) has been limited in children and adolescents due to a lack of disease-specific instruments. To fill this gap, the Quality of Life after Traumatic Brain Injury for Children and Adolescents (QOLIBRI-KID/ADO) Questionnaire was developed for the German-speaking population. Reference values from a comparable general population are essential for comprehending the impact of TBI on health and well-being. This study examines the validity of the German QOLIBRI-KID/ADO in a general pediatric population in Germany and provides reference values for use in clinical practice. Overall, 1997 children and adolescents aged 8-17 years from the general population and 300 from the TBI population participated in this study. The questionnaire was tested for reliability and validity. A measurement invariance (MI) approach was used to assess the comparability of the HRQoL construct between both samples. Reference values were determined by percentile-based stratification according to factors that significantly influenced HRQoL in regression analyses. The QOLIBRI-KID/ADO demonstrated strong psychometric properties. The HRQoL construct was measured largely equivalently in both samples, and reference values could be provided. The QOLIBRI-KID/ADO was considered reliable and valid for assessing HRQoL in a general German-speaking pediatric population, allowing for clinically meaningful comparisons between general and TBI populations.
    Language English
    Publishing date 2024-03-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm14040336
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: ChatGPT Passes German State Examination in Medicine With Picture Questions Omitted.

    Jung, Leonard B / Gudera, Jonas A / Wiegand, Tim L T / Allmendinger, Simeon / Dimitriadis, Konstantinos / Koerte, Inga K

    Deutsches Arzteblatt international

    2023  Volume 120, Issue 21, Page(s) 373–374

    Language English
    Publishing date 2023-08-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.m2023.0113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Corrigendum: Psychometric evaluation and reference values for the German Postconcussion Symptom Inventory (PCSI-SR8) in children aged 8-12 years.

    Zeldovich, Marina / Krol, Leonie / Timmermann, Dagmar / Krenz, Ugne / Arango-Lasprilla, Juan Carlos / Gioia, Gerard / Brockmann, Knut / Koerte, Inga K / Buchheim, Anna / Roediger, Maike / Kieslich, Matthias / von Steinbuechel, Nicole / Cunitz, Katrin

    Frontiers in neurology

    2024  Volume 15, Page(s) 1372640

    Abstract: This corrects the article DOI: 10.3389/fneur.2023.1266828.]. ...

    Abstract [This corrects the article DOI: 10.3389/fneur.2023.1266828.].
    Language English
    Publishing date 2024-03-11
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2024.1372640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Posttraumatic Stress and Traumatic Brain Injury: Cognition, Behavior, and Neuroimaging Markers in Vietnam Veterans.

    Marcolini, Sofia / Rojczyk, Philine / Seitz-Holland, Johanna / Koerte, Inga K / Alosco, Michael L / Bouix, Sylvain

    Journal of Alzheimer's disease : JAD

    2023  Volume 95, Issue 4, Page(s) 1427–1448

    Abstract: Background: Posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) are common in Veterans and linked to behavioral disturbances, increased risk of cognitive decline, and Alzheimer's disease.: Objective: We studied the synergistic ... ...

    Abstract Background: Posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) are common in Veterans and linked to behavioral disturbances, increased risk of cognitive decline, and Alzheimer's disease.
    Objective: We studied the synergistic effects of PTSD and TBI on behavioral, cognitive, and neuroimaging measures in Vietnam war Veterans.
    Methods: Data were acquired at baseline and after about one-year from male Veterans categorized into: PTSD, TBI, PTSD+TBI, and Veteran controls without PTSD or TBI. We applied manual tractography to examine white matter microstructure of three fiber tracts: uncinate fasciculus (N = 91), cingulum (N = 87), and inferior longitudinal fasciculus (N = 95). ANCOVAs were used to compare Veterans' baseline behavioral and cognitive functioning (N = 285), white matter microstructure, amyloid-β (N = 230), and tau PET (N = 120). Additional ANCOVAs examined scores' differences from baseline to follow-up.
    Results: Veterans with PTSD and PTSD+TBI, but not Veterans with TBI only, exhibited poorer behavioral and cognitive functioning at baseline than controls. The groups did not differ in baseline white matter, amyloid-β, or tau, nor in behavioral and cognitive functioning, and tau accumulation change. Progression of white matter abnormalities of the uncinate fasciculus in Veterans with PTSD compared to controls was observed; analyses in TBI and PTSD+TBI were not run due to insufficient sample size.
    Conclusions: PTSD and PTSD+TBI negatively affect behavioral and cognitive functioning, while TBI does not contribute independently. Whether progressive decline in uncinate fasciculus microstructure in Veterans with PTSD might account for cognitive decline should be further studied. Findings did not support an association between PTSD, TBI, and Alzheimer's disease pathology based on amyloid and tau PET.
    MeSH term(s) Humans ; Male ; Veterans ; Stress Disorders, Post-Traumatic/complications ; Stress Disorders, Post-Traumatic/diagnostic imaging ; Alzheimer Disease/complications ; Vietnam ; Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/diagnostic imaging ; Cognition ; Neuroimaging ; Amyloid beta-Peptides
    Chemical Substances Amyloid beta-Peptides
    Language English
    Publishing date 2023-09-11
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-221304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Instrumented Balance Error Scoring System in Children and Adolescents-A Cross Sectional Study.

    Schönberg, Nils K T / Poppel, Julius / Howell, David / Wagner, Johanna / Höfinger, Michael / Fabri, Nicole / Bonke, Elena M / Rojczyk, Philine / Hösl, Matthias / Kiwull, Lorenz / Schröder, Sebastian A / Blaschek, Astrid / Vill, Katharina / Koerte, Inga K / Huppert, Doreen / Heinen, Florian / Bonfert, Michaela V

    Diagnostics (Basel, Switzerland)

    2024  Volume 14, Issue 5

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics14050513
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  6. Article ; Online: Social problems and brain structure development following childhood mild traumatic brain injury.

    Dégeilh, Fanny / von Soest, Tilmann / Ferschmann, Lia / Beer, Joanne C / Gaubert, Malo / Koerte, Inga K / Tamnes, Christian K

    Cortex; a journal devoted to the study of the nervous system and behavior

    2023  Volume 162, Page(s) 26–37

    Abstract: Childhood mild traumatic brain injury (mTBI) is associated with elevated risk of developing social problems, which may be underpinned by changes in the structural developmental trajectory of the social brain, a network of cortical regions supporting ... ...

    Abstract Childhood mild traumatic brain injury (mTBI) is associated with elevated risk of developing social problems, which may be underpinned by changes in the structural developmental trajectory of the social brain, a network of cortical regions supporting social cognition and behavior. However, limited sample sizes and cross-sectional designs generally used in neuroimaging studies of pediatric TBI have prevented explorations of this hypothesis. This longitudinal retrospective study examined the development of parent-reported social problems and cortical thickness in social brain regions following childhood mTBI using data from the large population-based Adolescent Brain Cognitive Development (ABCD) Study. Two-group latent change score models revealed different developmental trajectories from ages 10-12 years in the level of social problems between children with (n = 345) and without (n = 7,089) mTBI. Children with mTBI showed higher, but non-clinical, levels of social problems than controls at age 10. Then, social problems decreased over 2 years, but still remained higher, but non-clinical, than in controls in which they stayed stable. Both groups showed similar decreases in social brain cortical thickness between ages 10 and 12 years. Further studies providing detailed information on the injury mechanism and acute symptoms are needed to better understand individual differences in social functioning and brain development in pediatric TBI.
    MeSH term(s) Adolescent ; Child ; Humans ; Brain Concussion/diagnostic imaging ; Brain Concussion/psychology ; Retrospective Studies ; Cross-Sectional Studies ; Brain/diagnostic imaging ; Social Problems ; Brain Injuries, Traumatic/diagnostic imaging
    Language English
    Publishing date 2023-02-27
    Publishing country Italy
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 280622-8
    ISSN 1973-8102 ; 0010-9452
    ISSN (online) 1973-8102
    ISSN 0010-9452
    DOI 10.1016/j.cortex.2023.02.003
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  7. Article ; Online: Executive functioning, behavior, and white matter microstructure in the chronic phase after pediatric mild traumatic brain injury: results from the adolescent brain cognitive development study.

    Betz, Anja K / Cetin-Karayumak, Suheyla / Bonke, Elena M / Seitz-Holland, Johanna / Zhang, Fan / Pieper, Steve / O'Donnell, Lauren J / Tripodis, Yorghos / Rathi, Yogesh / Shenton, Martha E / Koerte, Inga K

    Psychological medicine

    2024  , Page(s) 1–11

    Abstract: Background: Mild traumatic brain injury (mTBI) is common in children. Long-term cognitive and behavioral outcomes as well as underlying structural brain alterations following pediatric mTBI have yet to be determined. In addition, the effect of age-at- ... ...

    Abstract Background: Mild traumatic brain injury (mTBI) is common in children. Long-term cognitive and behavioral outcomes as well as underlying structural brain alterations following pediatric mTBI have yet to be determined. In addition, the effect of age-at-injury on long-term outcomes is largely unknown.
    Methods: Children with a history of mTBI (
    Results: Children with a history of mTBI displayed higher parent-rated executive dysfunction, higher impulsivity, and poorer self-regulation compared to both control groups. At closer investigation, these differences to TDC were only present in one respective age-at-injury group. No alterations were found in task-based executive functioning or white matter microstructure.
    Conclusions: Findings suggest that everyday executive function, impulsivity, and emotion-regulation are affected years after pediatric mTBI. Outcomes were specific to the age at which the injury occurred, suggesting that functioning is differently affected by pediatric mTBI during vulnerable periods. Groups did not differ in white matter microstructure.
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 217420-0
    ISSN 1469-8978 ; 0033-2917
    ISSN (online) 1469-8978
    ISSN 0033-2917
    DOI 10.1017/S0033291724000229
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  8. Article ; Online: Diffusion Imaging of Sport-related Repetitive Head Impacts-A Systematic Review.

    Koerte, Inga K / Wiegand, Tim L T / Bonke, Elena M / Kochsiek, Janna / Shenton, Martha E

    Neuropsychology review

    2022  Volume 33, Issue 1, Page(s) 122–143

    Abstract: Repetitive head impacts (RHI) are commonly observed in athletes participating in contact sports such as American football, ice hockey, and soccer. RHI usually do not result in acute symptoms and are therefore often referred to as subclinical or " ... ...

    Abstract Repetitive head impacts (RHI) are commonly observed in athletes participating in contact sports such as American football, ice hockey, and soccer. RHI usually do not result in acute symptoms and are therefore often referred to as subclinical or "subconcussive" head impacts. Epidemiological studies report an association between exposure to RHI and an increased risk for the development of neurodegenerative diseases. Diffusion magnetic resonance imaging (dMRI) has emerged as particularly promising for the detection of subtle alterations in brain microstructure following exposure to sport-related RHI. The purpose of this study was to perform a systematic review of studies investigating the effects of exposure to RHI on brain microstructure using dMRI. We used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) to determine studies that met inclusion and exclusion criteria across three databases. Seventeen studies were identified and critically evaluated. Results from these studies suggest an association between white matter alterations and RHI exposure in youth and young adult athletes. The most consistent finding across studies was lower or decreased fractional anisotropy (FA), a measure of the directionality of the diffusion of water molecules, associated with greater exposure to sport-related RHI. Whether decreased FA is associated with functional outcome (e.g., cognition) in those exposed to RHI is yet to be determined. This review further identified areas of importance for future research to increase the diagnostic and prognostic value of dMRI in RHI and to improve our understanding of the effects of RHI on brain physiology and microstructure.
    MeSH term(s) Adolescent ; Humans ; Young Adult ; Athletes ; Athletic Injuries/diagnostic imaging ; Athletic Injuries/complications ; Brain/diagnostic imaging ; Brain Concussion/diagnostic imaging ; Cognition ; Football ; Soccer
    Language English
    Publishing date 2022-12-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
    ZDB-ID 1062572-0
    ISSN 1573-6660 ; 1040-7308
    ISSN (online) 1573-6660
    ISSN 1040-7308
    DOI 10.1007/s11065-022-09566-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: CME-Fortbildung. Künstliche Intelligenz in der Neurologie. / CME-Fragen

    Wiegand, Tim L. T. / Velezmoro, Laura I. / Jung, Leonard B. / Wimbauer, Felix / Dimitriadis, Konstantinos / Koerte, Inga K.

    Nervenheilkunde

    2023  Volume 42, Issue 9, Page(s) 591 / 600

    Language German
    Document type Article
    ZDB-ID 604504-2
    ISSN 0722-1541
    Database Current Contents Medicine

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  10. Article ; Online: Applicability and clinical utility of the German rivermead post-concussion symptoms questionnaire in proxies of children after traumatic brain injury: an instrument validation study.

    Bockhop, Fabian / Greving, Sven / Zeldovich, Marina / Krenz, Ugne / Cunitz, Katrin / Timmermann, Dagmar / Kieslich, Matthias / Andelic, Nada / Buchheim, Anna / Koerte, Inga K / Roediger, Maike / Brockmann, Knut / Bonfert, Michaela V / Berweck, Steffen / Lendt, Michael / Staebler, Michael / von Steinbuechel, Nicole

    BMC neurology

    2024  Volume 24, Issue 1, Page(s) 133

    Abstract: Background: The German Rivermead Post-Concussion Symptoms Questionnaire (RPQ) can be used to assess post-concussion symptoms (PCS) after traumatic brain injury (TBI) in adults, adolescents, and children.: Methods: In this study, we examined the ... ...

    Abstract Background: The German Rivermead Post-Concussion Symptoms Questionnaire (RPQ) can be used to assess post-concussion symptoms (PCS) after traumatic brain injury (TBI) in adults, adolescents, and children.
    Methods: In this study, we examined the psychometric properties of the German RPQ proxy version (N = 146) for children (8-12 years) after TBI at the item, total and scale score level. Construct validity was analyzed using rank correlations with the proxy-assessed Post-Concussion Symptoms Inventory (PCSI-P), the Patient Health Questionnaire 9 (PHQ-9), and the Generalized Anxiety Disorder Scale 7 (GAD-7). Furthermore, sensitivity testing was performed concerning subjects' sociodemographic and injury-related characteristics. Differential item functioning (DIF) was analyzed to assess the comparability of RPQ proxy ratings for children with those for adolescents.
    Results: Good internal consistency was demonstrated regarding Cronbach's α (0.81-0.90) and McDonald's ω (0.84-0.92). The factorial validity of a three-factor model was superior to the original one-factor model. Proxy ratings of the RPQ total and scale scores were strongly correlated with the PCSI-P (ϱ = 0.50-0.69), as well as moderately to strongly correlated with the PHQ-9 (ϱ = 0.49-0.65) and the GAD-7 (ϱ = 0.44-0.64). The DIF analysis revealed no relevant differences between the child and adolescent proxy versions.
    Conclusions: The German RPQ proxy is a psychometrically reliable and valid instrument for assessing PCS in children after TBI. Therefore, RPQ self- and proxy-ratings can be used to assess PCS in childhood as well as along the lifespan of an individual after TBI.
    MeSH term(s) Adult ; Adolescent ; Child ; Humans ; Post-Concussion Syndrome/diagnosis ; Post-Concussion Syndrome/epidemiology ; Brain Concussion/diagnosis ; Surveys and Questionnaires ; Brain Injuries, Traumatic/diagnosis ; Brain Injuries, Traumatic/epidemiology ; Patient Health Questionnaire
    Language English
    Publishing date 2024-04-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041347-6
    ISSN 1471-2377 ; 1471-2377
    ISSN (online) 1471-2377
    ISSN 1471-2377
    DOI 10.1186/s12883-024-03587-2
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