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Article ; Online: Association Between Quantitative and Qualitative Imaging Biomarkers and Geographic Atrophy Growth Rate.

de Carlo Forest, Talisa E / Gill, Zafar / Lisker-Cervantes, Andres / Gnanaraj, Ramya / Grove, Nathan / Patnaik, Jennifer L / Lynch, Anne M / Palestine, Alan G / Mathias, Marc / Manoharan, Niranjan / Mandava, Naresh

American journal of ophthalmology

2024

Abstract: Purpose: Investigate associations between geographic atrophy (GA) growth rate and multimodal imaging biomarkers and patient demographics in patients with advanced non-neovascular age-related macular degeneration (nnAMD).: Design: Prospective cohort ... ...

Abstract	Purpose: Investigate associations between geographic atrophy (GA) growth rate and multimodal imaging biomarkers and patient demographics in patients with advanced non-neovascular age-related macular degeneration (nnAMD). Design: Prospective cohort study. Methods: 121 eyes of 66 patients with advanced nnAMD with GA enrolled in the University of Colorado AMD Registry from August 2014 to June 2021, with follow-up through June 2023. Multimodal images were reviewed by two graders for imaging biomarkers at enrollment. GA growth rate and square-root transformed (SQRT) GA growth rate were measured between enrollment and final visit. Associations between the outcome SQRT GA growth rate and imaging biomarkers, baseline GA lesions characteristics, and patient demographics were evaluated. Results: Average GA growth rate was 1.430mm Conclusions: Select patient demographic factors and basic clinically-relevant imaging biomarkers were associated with GA growth rate. These biomarkers may guide patient selection when considering treating GA patients with novel therapeutics.
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	80030-2
ISSN	1879-1891 ; 0002-9394
ISSN (online)	1879-1891
ISSN	0002-9394
DOI	10.1016/j.ajo.2024.03.023
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Article ; Online: Interleukin-4 Plasma Levels Stratified by Sex in Intermediate Age-Related Macular Degeneration and Geographic Atrophy.

Rajeswaren, Vivian / Wagner, Brandie D / Patnaik, Jennifer L / Mandava, Naresh / Mathias, Marc T / Manoharan, Niranjan / De Carlo Forest, Talisa E / Gnanaraj, Ramya / Lynch, Anne M / Palestine, Alan G

Translational vision science & technology

2023 Volume 12, Issue 8, Page(s) 1

Abstract: Purpose: Chronic local inflammation underlies the pathogenesis of age-related macular degeneration (AMD) causing damage to the neurosensory retina. However, there is minimal research on systemic cell-mediated inflammation in AMD. Interleukin-4 (IL-4) is ...

Abstract	Purpose: Chronic local inflammation underlies the pathogenesis of age-related macular degeneration (AMD) causing damage to the neurosensory retina. However, there is minimal research on systemic cell-mediated inflammation in AMD. Interleukin-4 (IL-4) is an immunoregulatory cytokine with an important role in modulating inflammation in chronic immune mediated disease. The purpose of this study was to: (1) investigate the role of systemic IL-4 in patients with intermediate AMD (iAMD) and in geographic atrophy (GA), an advanced form of AMD, compared to controls without AMD, and (2) determine if IL-4 levels are moderated by sex. Methods: We examined plasma levels of IL-4 in patients with iAMD, GA, and controls without AMD included in the University of Colorado AMD registry (August 2014 to June 2021). Cases and controls were defined by multimodal imaging. IL-4 was measured by multiplex immunoassay. Data were analyzed using a nonparametric rank based linear regression model fit to IL-4. Results: There were 199 patients with iAMD, 97 patients with GA, and 139 controls, with a percentage of female patients 61%, 55%, and 66%, respectively. We demonstrated significantly higher median IL-4 levels in GA (35.3; interquartile range [IQR] = 22.8-50.5) compared to iAMD (6.1; IQR = 2.2-11.3, P < 0.01) and controls (10.7; IQR = 5.0-16.8, P < 0.01). There were no significant differences in levels of IL-4 for cases and controls when stratified by sex. Conclusions: These findings demonstrate a systemic immunological difference between iAMD and GA, indicating IL-4 may be a systemic biomarker for GA development. Translational relevance: The plasma biomarker IL-4 is significantly elevated in patients with GA.
MeSH term(s)	Humans ; Female ; Geographic Atrophy ; Interleukin-4 ; Fluorescein Angiography/methods ; Macular Degeneration/diagnosis ; Biomarkers ; Inflammation
Chemical Substances	Interleukin-4 (207137-56-2) ; Biomarkers
Language	English
Publishing date	2023-08-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2674602-5
ISSN	2164-2591 ; 2164-2591
ISSN (online)	2164-2591
ISSN	2164-2591
DOI	10.1167/tvst.12.8.1
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Article ; Online: Limited English Proficiency Is Associated With Diabetic Retinopathy in Patients Presenting for Cataract Surgery.

Gill, Zafar S / Marin, A Itzam / Caldwell, Anne Strong / Mehta, Nihaal / Grove, Nathan / Seibold, Leonard K / Puente, Michael A / De Carlo Forest, Talisa E / Oliver, Scott C N / Patnaik, Jennifer L / Manoharan, Niranjan

Translational vision science & technology

2023 Volume 12, Issue 10, Page(s) 4

Abstract: Purpose: To investigate the relationship between limited English proficiency (LEP) and diabetic retinopathy (DR) in patients presenting for cataract surgery.: Methods: This is a retrospective observational study of patients who underwent cataract ... ...

Abstract	Purpose: To investigate the relationship between limited English proficiency (LEP) and diabetic retinopathy (DR) in patients presenting for cataract surgery. Methods: This is a retrospective observational study of patients who underwent cataract surgery between January 2014 and February 2020. Patients who self-identified as needing or preferring an interpreter were defined as having LEP. Differences in demographics, characteristics, and outcomes including history of type 2 diabetes (T2DM), DR, preoperative best corrected visual acuity (BCVA), macular edema, and anti-vascular endothelial growth factor injections were analyzed. Statistical comparisons were assessed using logistic regression with generalized estimating equations. Results: We included 13,590 eyes. Of these, 868 (6.4%) were from LEP patients. Patients with LEP were more likely to be Hispanic (P < 0.001), female sex (P = 0.008), or older age (P = 0.003) and have worse mean BCVA at presentation (P < 0.001). Patients with LEP had a significantly higher rate of T2DM (P < 0.001), macular edema (P = 0.033), and DR (18.1% vs. 5.8%, P < 0.001). Findings remained significant when controlling for age, sex, race/ethnicity, and type of health insurance. Patients with LEP and DR were more likely to have had later stages of DR (P = 0.023). Conclusions: Patients with LEP presenting for cataract surgery had a higher rate of DR and associated complications compared to patients with English proficiency. Further studies are needed to understand how language disparities influence health and what measures could be taken to improve healthcare in this vulnerable population. Translational relevance: Our study highlights healthcare disparities within ophthalmology and emphasizes the importance of advocating for improved healthcare delivery for patients with LEP.
MeSH term(s)	Humans ; Female ; Diabetic Retinopathy/diagnosis ; Diabetic Retinopathy/epidemiology ; Ophthalmology ; Diabetes Mellitus, Type 2/complications ; Limited English Proficiency ; Macular Edema/epidemiology ; Macular Edema/etiology ; Cataract/complications ; Cataract/epidemiology
Language	English
Publishing date	2023-10-05
Publishing country	United States
Document type	Observational Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2674602-5
ISSN	2164-2591 ; 2164-2591
ISSN (online)	2164-2591
ISSN	2164-2591
DOI	10.1167/tvst.12.10.4
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Article: Spectral-Domain Optical Coherence Tomography Angiography for the Diagnosis and Evaluation of Polypoidal Choroidal Vasculopathy

de Carlo, Talisa E. / Kokame, Gregg T. / Shantha, Jessica G. / Lai, James C. / Wee, Raymond

Ophthalmologica

2017 Volume 239, Issue 2-3, Page(s) 103–109

Abstract: Purpose: To compare the diagnostic ability of optical coherence tomography angiography (OCTA) with indocyanine green angiography (ICGA) in polypoidal choroidal vasculopathy (PCV). Methods: Retrospective review of 47 eyes with PCV imaged with ICGA and ... ...

Institution	University of Hawaii Transitional Residency Program, Department of Medicine, University of Hawaii School of Medicine, Honolulu, Hawaii, USA John A. Burns School of Medicine, University of Hawaii School of Medicine, Honolulu, Hawaii, USA The Retina Center at Pali Momi, Aiea, Hawaii, USA Retina Consultants of Hawaii, Honolulu, Hawaii, USA Hawaii Macula and Retina Institute, Aiea, Hawaii, USA Division of Ophthalmology, Department of Surgery, University of Hawaii School of Medicine, Honolulu, Hawaii, USA
Abstract	Purpose: To compare the diagnostic ability of optical coherence tomography angiography (OCTA) with indocyanine green angiography (ICGA) in polypoidal choroidal vasculopathy (PCV). Methods: Retrospective review of 47 eyes with PCV imaged with ICGA and OCTA. For each eye, it was determined which imaging modality better delineated the PCV complex. The presence of a branching vascular network (BVN) and polyp(s) were noted. Results: PCV was better visualized with ICGA in 21 eyes (44.7%) and with OCTA in 9 eyes (19.2%). The results were comparable in 17 eyes (36.2%). Of the 44 eyes with BVN on ICGA, 41 eyes (93.2%) also showed BVN on OCTA. Of the 28 eyes with polyp(s) on ICGA, 22 eyes (78.6%) also showed polyp(s) on OCTA. Polyps were high-flow lesions or faint low-flow dilations on OCTA. Conclusion: OCTA readily detects BVNs and can detect most polyps, but in many cases ICGA is better able to detect the PCV complex.
Keywords	Polypoidal choroidal vasculopathy ; Optical coherence tomography ; Indocyanine green angiography ; Age-related macular degeneration
Language	English
Publishing date	2017-12-11
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
Note	Research Paper
ZDB-ID	209735-7
ISSN	1423-0267 ; 0030-3755
ISSN (online)	1423-0267
ISSN	0030-3755
DOI	10.1159/000481540
Database	Karger publisher's database

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Article ; Online: Automated quantitative OCTA measurements of uveal melanoma-treated eyes with and without radiation retinopathy after I-125 plaque therapy and of nonirradiated fellow eyes.

de Carlo, Talisa E / Mieler, William F

Eye (London, England)

2020 Volume 35, Issue 3, Page(s) 769–776

Abstract: Objectives: To determine if commercial OCTA measurements can provide quantitative biomarkers for detection of radiation retinopathy (RR) s/p I-125 plaque brachytherapy in patients with uveal melanoma.: Methods: Retrospective review of 6 × 6 mm OCTA ... ...

Abstract	Objectives: To determine if commercial OCTA measurements can provide quantitative biomarkers for detection of radiation retinopathy (RR) s/p I-125 plaque brachytherapy in patients with uveal melanoma. Methods: Retrospective review of 6 × 6 mm OCTA images of nonirradiated fellow eyes (group 1, 28 eyes), eyes without RR (group 2, 22 eyes), eyes with RR (group 3, 13 eyes). We used automated AngioVue AngioAnalytics OCTA software determinations of FAZ size, perimeter size, and 27 capillary density measurements (nine regions of each segmentation: full-thickness retina, superficial plexus, deep plexus). Results: Average time since irradiation was 1.9 years in group 2, and 3.7 years in group 3. FAZ size was 1.2 mm in group 3 compared with 0.2 mm in group 1 and 0.3 mm in group 2 (both p < 0.001). Capillary density was statistically significantly reduced in group 3 compared with group 1 in all 27 regions. Group 2 had significantly decreased superficial plexus capillary density compared with group 1 in three regions. Group 3 had significantly reduced capillary density compared with group 2 in 6/27 (22%) regions. Linear regression showed a change in whole-scan density of -1.5 per year after irradiation in the full-thickness retina segmentation (p = 0.008). Conclusion: Quantitative OCTA may aid in early detection of RR.
MeSH term(s)	Fluorescein Angiography ; Fundus Oculi ; Humans ; Iodine Radioisotopes ; Macula Lutea ; Melanoma ; Retinal Diseases ; Retinal Vessels ; Retrospective Studies ; Tomography, Optical Coherence ; Uveal Neoplasms ; Visual Acuity
Chemical Substances	Iodine Radioisotopes ; Iodine-125 (GVO776611R)
Language	English
Publishing date	2020-11-23
Publishing country	England
Document type	Journal Article
ZDB-ID	91001-6
ISSN	1476-5454 ; 0950-222X
ISSN (online)	1476-5454
ISSN	0950-222X
DOI	10.1038/s41433-020-01237-8
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Article ; Online: DYNAMIC ECHOGRAPHY OF VARIX OF THE VORTEX VEIN AMPULLA.

de Carlo, Talisa E / Mieler, William

Retinal cases & brief reports

2018 Volume 15, Issue 5, Page(s) 548–551

Abstract: Purpose: To describe four cases of varix of the vortex vein ampulla imaged with dynamic echography.: Methods: Observational case series of four patients with varix of the vortex vein ampulla diagnosed with ocular examination maneuvers such as digital ...

Abstract	Purpose: To describe four cases of varix of the vortex vein ampulla imaged with dynamic echography. Methods: Observational case series of four patients with varix of the vortex vein ampulla diagnosed with ocular examination maneuvers such as digital pressure or Valsalva. Dynamic echography was used to confirm the diagnosis. Results: Dynamic echography can quickly and noninvasively show the varix of the vortex vein ampulla disappear with external pressure, or engorge with a Valsalva maneuver or altered gaze directions. Conclusion: Dynamic echography is very helpful in the establishment of the diagnosis of varix of the vortex vein ampulla and differentiating this benign condition from other retinal or choroidal abnormalities.
MeSH term(s)	Choroid/blood supply ; Diagnosis, Differential ; Humans ; Ultrasonography ; Varicose Veins/diagnostic imaging
Language	English
Publishing date	2018-12-20
Publishing country	United States
Document type	Case Reports
ISSN	1937-1578
ISSN (online)	1937-1578
DOI	10.1097/ICB.0000000000000848
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Article ; Online: Optic Nerve Head Edema in a Healthy Man in His 20s.

de Carlo, Talisa E / Zahid, Sarwar / MacIntosh, Peter W

JAMA ophthalmology

2019 Volume 137, Issue 4, Page(s) 455–456

MeSH term(s)	Adult ; Cerebrovascular Disorders/complications ; Cranial Sinuses/pathology ; Humans ; Male ; Papilledema/etiology
Language	English
Publishing date	2019-01-31
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2701705-9
ISSN	2168-6173 ; 2168-6165
ISSN (online)	2168-6173
ISSN	2168-6165
DOI	10.1001/jamaophthalmol.2018.5902
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Article ; Online: OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF TYPE 3 NEOVASCULARIZATION SECONDARY TO AGE-RELATED MACULAR DEGENERATION.

Kuehlewein, Laura / Dansingani, Kunal K / de Carlo, Talisa E / Bonini Filho, Marco A / Iafe, Nicholas A / Lenis, Tamara L / Freund, K Bailey / Waheed, Nadia K / Duker, Jay S / Sadda, SriniVas R / Sarraf, David

Retina (Philadelphia, Pa.)

2015 Volume 35, Issue 11, Page(s) 2229–2235

Abstract: ... i.e., deep retinal capillary plexus). The mean (SD) size of the neovascular complex measured 0.07 (± 0 ...

Abstract	Purpose: To characterize the vascular structure of Type 3 neovascularization secondary to age-related macular degeneration using optical coherence tomography angiography. Methods: Optical coherence tomography angiography cube scans (3 mm × 3 mm) were acquired in 29 eyes of 24 patients with Type 3 lesions secondary to age-related macular degeneration using the RTVue XR Avanti with AngioVue, Split-spectrum amplitude-decorrelation, and motion correction technology. Automated layer segmentation boundaries were adjusted to best visualize the neovascular complex on en face projection images. Results: A distinct neovascular complex could be identified in 10 (34%) eyes, all of which were active on optical coherence tomography imaging. In all 10 eyes, the neovascular complex appeared as a small tuft of bright, high-flow tiny vessels with curvilinear morphology located in the outer retinal layers with a feeder vessel communicating with the inner retinal circulation (i.e., deep retinal capillary plexus). The mean (SD) size of the neovascular complex measured 0.07 (± 0.07) mm. Conclusion: With optical coherence tomography angiography, it is possible to identify small intraretinal neovascular complexes communicating with the deep retinal capillary plexus in eyes with Type 3 neovascularization secondary to age-related macular degeneration. Qualitative and quantitative analyses of Type 3 neovascular complexes can be performed using optical coherence tomography angiography.
MeSH term(s)	Aged ; Aged, 80 and over ; Angiogenesis Inhibitors/therapeutic use ; Female ; Fluorescein Angiography/methods ; Humans ; Intravitreal Injections ; Male ; Prospective Studies ; Retinal Neovascularization/diagnosis ; Retinal Neovascularization/etiology ; Retinal Vessels/pathology ; Tomography, Optical Coherence/methods ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Visual Acuity ; Wet Macular Degeneration/complications ; Wet Macular Degeneration/drug therapy
Chemical Substances	Angiogenesis Inhibitors ; VEGFA protein, human ; Vascular Endothelial Growth Factor A
Language	English
Publishing date	2015-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603192-4
ISSN	1539-2864 ; 0275-004X
ISSN (online)	1539-2864
ISSN	0275-004X
DOI	10.1097/IAE.0000000000000835
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Article: Application of Optical Coherence Tomography Angiography to Retinal Disease.

de Carlo, Talisa E / Waheed, Nadia K / Sridhar, Jayanth / Ferrara, Daniela

Journal of ophthalmology

2018 Volume 2018, Page(s) 5490592

Language	English
Publishing date	2018-08-07
Publishing country	United States
Document type	Editorial
ZDB-ID	2546525-9
ISSN	2090-0058 ; 2090-004X
ISSN (online)	2090-0058
ISSN	2090-004X
DOI	10.1155/2018/5490592
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Article ; Online: Reply.

de Carlo, Talisa E / Duker, Jay S

Retina (Philadelphia, Pa.)

2016 Volume 36, Issue 8, Page(s) e77–8

Language	English
Publishing date	2016
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	603192-4
ISSN	1539-2864 ; 0275-004X
ISSN (online)	1539-2864
ISSN	0275-004X
DOI	10.1097/IAE.0000000000001157
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