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  1. Article ; Online: A 10-point score classification for anti-VEGF response in exudative AMD.

    Monés, Jordi

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

    2021  Volume 260, Issue 6, Page(s) 2073–2074

    MeSH term(s) Angiogenesis Inhibitors/therapeutic use ; Humans ; Ranibizumab
    Chemical Substances Angiogenesis Inhibitors ; Ranibizumab (ZL1R02VT79)
    Language English
    Publishing date 2021-11-09
    Publishing country Germany
    Document type Letter
    ZDB-ID 8435-9
    ISSN 1435-702X ; 0721-832X
    ISSN (online) 1435-702X
    ISSN 0721-832X
    DOI 10.1007/s00417-021-05478-5
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  2. Article ; Online: Reply.

    Monés, Jordi

    Ophthalmology. Retina

    2017  Volume 2, Issue 1, Page(s) e1–e2

    Language English
    Publishing date 2017-11-07
    Publishing country United States
    Document type Letter ; Comment
    ISSN 2468-7219
    ISSN (online) 2468-7219
    DOI 10.1016/j.oret.2017.09.014
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  3. Article ; Online: Regression to the Mean in Measurements of Growth Rates in Geographic Atrophy.

    Biarnés, Marc / Monés, Jordi

    Ophthalmic research

    2020  Volume 63, Issue 5, Page(s) 460–465

    Abstract: Introduction: Comparison of patients with extremely high and low values of a given characteristic is a common strategy to gain insights into disease mechanisms, but this approach is particularly susceptible to regression to the mean (RTM).: Objective!# ...

    Abstract Introduction: Comparison of patients with extremely high and low values of a given characteristic is a common strategy to gain insights into disease mechanisms, but this approach is particularly susceptible to regression to the mean (RTM).
    Objective: The aim of this work was to determine RTM in growth rate measurements in patients with geographic atrophy (GA) secondary to age-related macular degeneration.
    Methods: We conducted a retrospective analysis of the GAIN (NCT01694095) and its extension study, in which individuals 50 years or older with pure GA were followed for a minimum of 6 months. Two repeated and masked measurements of area of atrophy, both at baseline and final visits, were made, and growth rates were calculated for each. RTM was determined graphically and statistically, and the percentage of eyes misclassified as having fast and slow progression rates due to RTM was determined for different definitions of "fast" and "slow" growth.
    Results: We included 112 eyes of 112 patients: 64.3% were females, the mean age was 78.1 (SD ±7.6) years, and the mean follow-up time was 3.2 (±2.2) years. There was RTM, which decreased when the mean of two measurements was used. The magnitude of RTM in growth rates ranged from 2 to 11 µm/year and led to misclassification of eyes considered to have fast and slow growth between 2.9 and 10.3% of the cases, depending on the definition of fast and slow growth.
    Conclusions: RTM was present in measurements of GA growth rate, but it had a modest impact on patient misclassification. Comparison of features between patients with extreme growth rates is a reasonable strategy, but RTM should be minimized by taking the mean of two measurements.
    MeSH term(s) Aged ; Disease Progression ; Female ; Fluorescein Angiography/methods ; Follow-Up Studies ; Fundus Oculi ; Geographic Atrophy/diagnosis ; Geographic Atrophy/epidemiology ; Humans ; Male ; Morbidity/trends ; Retina/pathology ; Retrospective Studies ; Spain/epidemiology ; Tomography, Optical Coherence/methods
    Language English
    Publishing date 2020-01-07
    Publishing country Switzerland
    Document type Comparative Study ; Journal Article ; Observational Study
    ZDB-ID 205708-6
    ISSN 1423-0259 ; 0030-3747
    ISSN (online) 1423-0259
    ISSN 0030-3747
    DOI 10.1159/000505755
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  4. Article ; Online: Intravitreal aflibercept efficacy in neovascular age-related macular degeneration with suboptimal response to anti-vascular endothelial growth factor-A therapy.

    Monés, Jordi / Biarnés, Marc

    European journal of ophthalmology

    2019  Volume 30, Issue 5, Page(s) 1082–1090

    Abstract: Importance: To provide new insights into aflibercept effect in non-naive-treated patients with neovascular age-related macular degeneration.: Purpose: To assess the efficacy of intravitreal aflibercept in patients with neovascular age-related macular ...

    Abstract Importance: To provide new insights into aflibercept effect in non-naive-treated patients with neovascular age-related macular degeneration.
    Purpose: To assess the efficacy of intravitreal aflibercept in patients with neovascular age-related macular degeneration without optimal response to previous anti-vascular endothelial growth factor A therapy.
    Design: Single-arm, multi-centre, prospective study.
    Participants: Patients ⩾50 years with active neovascular age-related macular degeneration, best-corrected visual acuity between 20/32 and 20/320 with suboptimal response to ranibizumab or bevacizumab.
    Methods: Aflibercept was administered monthly (3-first months), and bimonthly thereafter until month 8. Anatomical and functional outcomes were assessed.
    Main outcome measure: Percentage of eyes without intra or subretinal fluid on optical coherence tomography after 3-monthly loading doses of aflibercept.
    Results: A total of 46 patients were included. At week 12, 45.7% (95% confidence interval: 31.5%-60.1%) of eyes showed no fluid on optical coherence tomography. The mean (standard deviation) best-corrected visual acuity increased from 65.1 (8.3) to 69.6 (8.1) letters (+4.5 (5.8) p < 0.0001) and was stabilized at week 40 as compared to baseline. Mean central macular thickness decreased from 430 (119) µm to 323 (100) µm at week 12 (-107 (90) µm, p < 0.0001) and was reduced at week 40 (-46 (111) µm, p = 0.0056). At week 40, 21.7% (95% confidence interval: 9.8%-33.7%) had no fluid. There was a case of presumed noninfectious endophthalmitis that was successfully managed.
    Conclusion: Almost half of patients presented no fluid on optical coherence tomography at week 12, and there was a clinically significant improvement in best-corrected visual acuity. At week 40, one in five patients did not show intra or subretinal fluid, central macular thickness decreased and best-corrected visual acuity was stabilized compared to baseline.
    MeSH term(s) Aged ; Aged, 80 and over ; Angiogenesis Inhibitors/therapeutic use ; Choroidal Neovascularization/diagnostic imaging ; Choroidal Neovascularization/drug therapy ; Choroidal Neovascularization/physiopathology ; Female ; Follow-Up Studies ; Humans ; Intravitreal Injections ; Male ; Prospective Studies ; Receptors, Vascular Endothelial Growth Factor/therapeutic use ; Recombinant Fusion Proteins/therapeutic use ; Subretinal Fluid ; Tomography, Optical Coherence ; Treatment Outcome ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Visual Acuity/physiology ; Wet Macular Degeneration/diagnostic imaging ; Wet Macular Degeneration/drug therapy ; Wet Macular Degeneration/physiopathology
    Chemical Substances Angiogenesis Inhibitors ; Recombinant Fusion Proteins ; VEGFA protein, human ; Vascular Endothelial Growth Factor A ; aflibercept (15C2VL427D) ; Receptors, Vascular Endothelial Growth Factor (EC 2.7.10.1)
    Language English
    Publishing date 2019-05-14
    Publishing country United States
    Document type Clinical Trial, Phase IV ; Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 1089461-5
    ISSN 1724-6016 ; 1120-6721
    ISSN (online) 1724-6016
    ISSN 1120-6721
    DOI 10.1177/1120672119848961
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  5. Article: Kinetics of Heterogeneous Background in Stargardt's Disease over Time.

    Rodríguez-Bocanegra, Eduardo / Biarnés, Marc / Garcia, Míriam / Ferraro, Lucía Lee / Fischer, Manuel Dominik / Monés, Jordi

    Life (Basel, Switzerland)

    2022  Volume 12, Issue 3

    Abstract: Stargardt's disease (STGD1) is caused by mutations in ... ...

    Abstract Stargardt's disease (STGD1) is caused by mutations in the
    Language English
    Publishing date 2022-03-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12030381
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  6. Article ; Online: Re: Keenan et al.: Cluster Analysis and Genotype-Phenotype Assessment of Geographic Atrophy in Age-Related Macular Degeneration: AREDS2 Report 25 (Ophthalmology. 2021;5(11):1061-1073).

    Biarnés, Marc / Ferraro, Lucia L / Garcia, Míriam / Delcourt, Cécile / Lengyel, Imre / Monés, Jordi

    Ophthalmology. Retina

    2022  Volume 6, Issue 4, Page(s) 333–334

    MeSH term(s) Cluster Analysis ; Genotype ; Geographic Atrophy ; Humans ; Macular Degeneration/diagnosis ; Macular Degeneration/genetics ; Phenotype
    Language English
    Publishing date 2022-04-08
    Publishing country United States
    Document type Letter ; Comment
    ISSN 2468-6530
    ISSN (online) 2468-6530
    DOI 10.1016/j.oret.2021.12.001
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  7. Article: The Rate of Progression of Geographic Atrophy Decreases With Increasing Baseline Lesion Size Even After the Square Root Transformation.

    Monés, Jordi / Biarnés, Marc

    Translational vision science & technology

    2018  Volume 7, Issue 6, Page(s) 40

    Abstract: Purpose: To determine the relationship between the progression of geographic atrophy (GA) and its baseline area (BA) using the square root transformation (sqrt) for different atrophy sizes.: Methods: Single eyes of patients with GA visiting the ... ...

    Abstract Purpose: To determine the relationship between the progression of geographic atrophy (GA) and its baseline area (BA) using the square root transformation (sqrt) for different atrophy sizes.
    Methods: Single eyes of patients with GA visiting the Institut de la Màcula (Barcelona, Spain) between December 2009 and January 2018 with a follow-up of ≥6 months were included. The main outcome was the correlation between BA and growth after the sqrt using Pearson's
    Results: We included 128 eyes (mean follow-up, 3.1 years). The correlation between BA and progression was negative (
    Conclusions: The correlation between GA progression and BA using the sqrt is negative. This has implications for the expected prediction of progression of a given lesion and to avoid overestimating the beneficial effects of interventional therapies.
    Translational relevance: The GA progression/BA relationship using the sqrt currently is regarded as independent. Our results suggest the sqrt slope actually is negative, which should be kept in mind to avoid misinterpretation of results in advanced therapies.
    Language English
    Publishing date 2018-12-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2674602-5
    ISSN 2164-2591
    ISSN 2164-2591
    DOI 10.1167/tvst.7.6.40
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  8. Article ; Online: A review of ranibizumab clinical trial data in exudative age-related macular degeneration and how to translate it into daily practice.

    Monés, Jordi

    Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde

    2011  Volume 225, Issue 2, Page(s) 112–119

    Abstract: The results of randomized controlled clinical trials of ranibizumab for the treatment of age-related macular degeneration established a new standard of care with the prospect of improved vision in many patients. Subsequent trials have explored different ... ...

    Abstract The results of randomized controlled clinical trials of ranibizumab for the treatment of age-related macular degeneration established a new standard of care with the prospect of improved vision in many patients. Subsequent trials have explored different strategies to increase response rates and reduce treatment frequency. This review analyzes the key clinical trial data for ranibizumab on the basis of which the author proposes a new treatment regimen with the aim of rationalizing treatment frequency without compromising improvements in vision--the FUSION regimen. This consists of an initiation phase followed by pro re nata (PRN) retreatment combined with fixed injections after a period of disease inactivity of 2-4 months (depending on the time elapsed since the last injection). A randomized clinical trial is recommended for comparing monthly, PRN and the FUSION regimens.
    MeSH term(s) Angiogenesis Inhibitors/administration & dosage ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal, Humanized ; Exudates and Transudates ; Humans ; Intravitreal Injections ; Macular Degeneration/drug therapy ; Macular Degeneration/physiopathology ; Randomized Controlled Trials as Topic ; Ranibizumab ; Retreatment ; Treatment Outcome ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Visual Acuity/physiology
    Chemical Substances Angiogenesis Inhibitors ; Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; VEGFA protein, human ; Vascular Endothelial Growth Factor A ; Ranibizumab (ZL1R02VT79)
    Language English
    Publishing date 2011
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 209735-7
    ISSN 1423-0267 ; 0030-3755
    ISSN (online) 1423-0267
    ISSN 0030-3755
    DOI 10.1159/000319906
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  9. Article ; Online: Correspondence.

    Monés, Jordi / Biarnés, Marc

    Retina (Philadelphia, Pa.)

    2016  Volume 36, Issue 3, Page(s) e20

    MeSH term(s) Female ; Geographic Atrophy/diagnosis ; Humans ; Male ; Retina/pathology
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 603192-4
    ISSN 1539-2864 ; 0275-004X
    ISSN (online) 1539-2864
    ISSN 0275-004X
    DOI 10.1097/IAE.0000000000000944
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  10. Article ; Online: Geographic atrophy phenotype identification by cluster analysis.

    Monés, Jordi / Biarnés, Marc

    The British journal of ophthalmology

    2017  Volume 102, Issue 3, Page(s) 388–392

    Abstract: Background/aims: To identify ocular phenotypes in patients with geographic atrophy secondary to age-related macular degeneration (GA) using a data-driven cluster analysis.: Methods: This was a retrospective analysis of data from a prospective, ... ...

    Abstract Background/aims: To identify ocular phenotypes in patients with geographic atrophy secondary to age-related macular degeneration (GA) using a data-driven cluster analysis.
    Methods: This was a retrospective analysis of data from a prospective, natural history study of patients with GA who were followed for ≥6 months. Cluster analysis was used to identify subgroups within the population based on the presence of several phenotypic features: soft drusen, reticular pseudodrusen (RPD), primary foveal atrophy, increased fundus autofluorescence (FAF), greyish FAF appearance and subfoveal choroidal thickness (SFCT). A comparison of features between the subgroups was conducted, and a qualitative description of the new phenotypes was proposed. The atrophy growth rate between phenotypes was then compared.
    Results: Data were analysed from 77 eyes of 77 patients with GA. Cluster analysis identified three groups: phenotype 1 was characterised by high soft drusen load, foveal atrophy and slow growth; phenotype 3 showed high RPD load, extrafoveal and greyish FAF appearance and thin SFCT; the characteristics of phenotype 2 were midway between phenotypes 1 and 3. Phenotypes differed in all measured features (p≤0.013), with decreases in the presence of soft drusen, foveal atrophy and SFCT seen from phenotypes 1 to 3 and corresponding increases in high RPD load, high FAF and greyish FAF appearance. Atrophy growth rate differed between phenotypes 1, 2 and 3 (0.63, 1.91 and 1.73 mm
    Conclusion: Cluster analysis identified three distinct phenotypes in GA. One of them showed a particularly slow growth pattern.
    MeSH term(s) Aged ; Aged, 80 and over ; Atrophy ; Cluster Analysis ; Disease Progression ; Female ; Fluorescein Angiography ; Follow-Up Studies ; Fovea Centralis/pathology ; Geographic Atrophy/diagnosis ; Humans ; Male ; Middle Aged ; Phenotype ; Prospective Studies ; Retinal Drusen/diagnosis ; Retrospective Studies ; Risk Factors ; Tomography, Optical Coherence
    Language English
    Publishing date 2017-07-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80078-8
    ISSN 1468-2079 ; 0007-1161
    ISSN (online) 1468-2079
    ISSN 0007-1161
    DOI 10.1136/bjophthalmol-2017-310268
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