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Article ; Online: Learning about diabetes through epidemiology.

Balkau, B / Holt, R I G

Diabetic medicine : a journal of the British Diabetic Association

2020 Volume 36, Issue 10, Page(s) 1195–1198

MeSH term(s)	Diabetes Complications/epidemiology ; Diabetes Mellitus/epidemiology ; Female ; Humans ; Male
Language	English
Publishing date	2020-02-10
Publishing country	England
Document type	Editorial ; Introductory Journal Article
ZDB-ID	605769-x
ISSN	1464-5491 ; 0742-3071 ; 1466-5468
ISSN (online)	1464-5491
ISSN	0742-3071 ; 1466-5468
DOI	10.1111/dme.14120
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Article: Comment to: Borch-Johnsen K, Colagiuri S, Balkau B et al. (2004) Creating a pandemic of prediabetes: the proposed new diagnostic criteria for impaired fasting glycaemia. Diabetologia 47:1396-1402.

Balkau, B / Hillier, T / Vierron, E / D'Hour, A / Lépinay, P / Royer, B / Born, C

Diabetologia

2005 Volume 48, Issue 4, Page(s) 801–802

MeSH term(s)	Adult ; Age Factors ; Blood Glucose/analysis ; Diabetes Mellitus/blood ; Diabetes Mellitus/diagnosis ; Fasting/blood ; Female ; Follow-Up Studies ; Humans ; Hyperglycemia/blood ; Hyperglycemia/classification ; Hyperglycemia/diagnosis ; Male ; Middle Aged ; Prediabetic State/blood ; Prediabetic State/classification ; Prediabetic State/diagnosis ; Sex Factors
Chemical Substances	Blood Glucose
Language	English
Publishing date	2005-04
Publishing country	Germany
Document type	Comment ; Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	1694-9
ISSN	1432-0428 ; 0012-186X
ISSN (online)	1432-0428
ISSN	0012-186X
DOI	10.1007/s00125-005-1695-5
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Article ; Online: Epigenetic changes associated with hyperglycaemia exposure in the longitudinal D.E.S.I.R. cohort.

Khamis, Amna / Ning, Lijiao / Balkau, Beverley / Bonnefond, Amélie / Canouil, Mickaël / Roussel, Ronan / Froguel, Philippe

Diabetes & metabolism

2022 Volume 48, Issue 4, Page(s) 101347

MeSH term(s)	CpG Islands ; DNA Methylation/genetics ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/genetics ; Epigenesis, Genetic ; Genome-Wide Association Study ; Glycated Hemoglobin A ; Humans ; Hyperglycemia/genetics
Chemical Substances	Glycated Hemoglobin A
Language	English
Publishing date	2022-04-12
Publishing country	France
Document type	Journal Article
ZDB-ID	1315751-6
ISSN	1878-1780 ; 1262-3636 ; 0338-1684
ISSN (online)	1878-1780
ISSN	1262-3636 ; 0338-1684
DOI	10.1016/j.diabet.2022.101347
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Article ; Online: Cost-effectiveness of robotic-assisted surgery vs open surgery in the context of partial nephrectomy for small kidney tumors.

Baghli, Adnan / Achit, Hamza / Audigé, Victor / Larré, Stéphane / Branchu, Benjamin / Balkau, Beverley / Eschwege, Pascal / Hubert, Jacques / Mazeaud, Charles

Journal of robotic surgery

2023 Volume 17, Issue 4, Page(s) 1571–1578

Abstract: To evaluate the cost-effectiveness of robotic-assisted surgery compared to open surgery in the context of partial nephrectomy for small kidney tumor management. This is a retrospective study using data from 395 patients operated on by either robot- ... ...

Abstract	To evaluate the cost-effectiveness of robotic-assisted surgery compared to open surgery in the context of partial nephrectomy for small kidney tumor management. This is a retrospective study using data from 395 patients operated on by either robot-assisted surgery (RAPN) or by open partial nephrectomy (OPN); one hospital performed RAPN exclusively and the second hospital, OPN exclusively. Cost-effectiveness analysis was conducted from the perspective of the National Health Insurance System (NHIS) by considering the costs of the initial hospital stay and the cost of complications. Clinical outcome was defined by the avoidance of major complications during the 12 months postoperatively. Major complications were absent in 82% of patients in the OPN group and 93% of patients in the RAPN group, with 11% in favor of robotic assistance (p < 0.001). The average cost per patient, including the costs of complications, were, respectively, 9637 € and 8305 € for the OPN and RAPN groups. Robotic assistance was associated with a 1332 € lower cost (p < 0.001). The incremental cost-effectiveness ratio (ICER) is estimated at - 12,039 €. From the perspective of the public payer, robotic assistance was associated with a lower rate of postoperative complications and a lower average cost per patient. Robotic-assisted surgery was an efficient alternative to open surgery in partial nephrectomy. Trial registration number: NCT05089006 (October 22, 2021).
MeSH term(s)	Humans ; Robotic Surgical Procedures/methods ; Retrospective Studies ; Cost-Benefit Analysis ; Kidney Neoplasms/surgery ; Kidney Neoplasms/pathology ; Nephrectomy ; Postoperative Complications/epidemiology ; Postoperative Complications/surgery ; Treatment Outcome
Language	English
Publishing date	2023-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2268283-1
ISSN	1863-2491 ; 1863-2483
ISSN (online)	1863-2491
ISSN	1863-2483
DOI	10.1007/s11701-023-01552-8
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Article ; Online: Complications after partial nephrectomy: robotics overcomes open surgery and laparoscopy: the PMSI French national database.

Bic, Antoine / Mazeaud, Charles / Salleron, Julia / Bannay, Aurélie / Balkau, Beverley / Larose, Clément / Hubert, Jacques / Eschwège, Pascal

BMC urology

2023 Volume 23, Issue 1, Page(s) 146

Abstract: Purpose: To evaluate three partial nephrectomies (PN) procedures: open (OPN), standard laparoscopy (LPN), and robot-assisted laparoscopy (RAPN), for the risk of initial complications and rehospitalization for two years after the surgery.: Materials ... ...

Abstract	Purpose: To evaluate three partial nephrectomies (PN) procedures: open (OPN), standard laparoscopy (LPN), and robot-assisted laparoscopy (RAPN), for the risk of initial complications and rehospitalization for two years after the surgery. Materials and methods: From the French national hospital database (PMSI-MCO), every hospitalization in French hospitals for renal tumor PN in 2016-2017 were extracted. Complications were documented from the initial hospitalization and any rehospitalization over two years. Chi-square and ANOVA tests compared the frequency of complications and length of initial hospitalization between the three surgical procedures. Relative risks (RR) and 95% confidence intervals were computed. Results: The 9119 initial hospitalizations included 4035 OPN, 1709 LPN, and 1900 RAPN; 1475 were excluded as the laparoscopic procedure performed was not determined. The average length of hospitalization was 8.1, 6.2, and 4.5 days for OPN, LPN, and RAPN, respectively. Compared to OPN, there were fewer complications at the time of initial hospitalization for the mini-invasive procedures: 29% for OPN vs. 20% for LPN (0.70 [0.63;0.78]) and 12% for RAPN (RR=0.43, 95%CI [0.38;0.49]). For RAPN compared to LPN, there were fewer haemorrhages (RR=0.55 [0.43;0.72]), anemia (0.69 {0.48;0.98]), and sepsis (0.51 [0.36;0.71]); during follow up, there were fewer urinary tract infections (0.64 [0.45;0.91]) but more infectious lung diseases (1.69 [1.03;2.76]). Over the two-year postoperative period, RAPN was associated with fewer acute renal failures (RR=0.73 [0.55;0.98]), renal abscesses (0.41 [0.23;0.74]), parietal complications (0.69 [0.52;0.92]) and urinary tract infections (0.54 [0.40;0.73]) than for OPN. Conclusions: Conservative renal surgery is associated with postoperative morbidity related to the surgical procedure fashion. Mini-invasive procedures, especially robot-assisted surgery, had fewer complications and shorter hospital lengths of stay.
MeSH term(s)	Humans ; Robotics ; Laparoscopy/adverse effects ; Nephrectomy/adverse effects ; Robotic Surgical Procedures/adverse effects ; Hospitalization
Language	English
Publishing date	2023-09-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2059857-9
ISSN	1471-2490 ; 1471-2490
ISSN (online)	1471-2490
ISSN	1471-2490
DOI	10.1186/s12894-023-01322-6
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Article ; Online: Comparison of surgical procedures for benign prostatic hyperplasia of medium-volume prostates: evaluation of the causes of rehospitalization from the French National Hospital Database (PMSI-MCO).

Behr, Antoine / Salleron, Julia / Mazeaud, Charles / Larose, Clément / Dagry, Andréa / Balkau, Beverley / Hubert, Jacques / Eschwège, Pascal

World journal of urology

2023 Volume 41, Issue 9, Page(s) 2481–2488

Abstract: Purpose: In France, transurethral resection of the prostate (TURP) is still the most commonly used surgical treatment for medium sized benign prostatic hyperplasia (BPH), but the Holmium Laser Enucleation of the Prostate (HoLEP) and laser vaporization ... ...

Abstract	Purpose: In France, transurethral resection of the prostate (TURP) is still the most commonly used surgical treatment for medium sized benign prostatic hyperplasia (BPH), but the Holmium Laser Enucleation of the Prostate (HoLEP) and laser vaporization procedures are becoming more common. For these three surgical procedures, we evaluate the initial complications, the short term (3 months) and the 4-12-month postoperative complications necessitating re-hospitalization. Methods: From the French national hospital data base (PMSI-MCO), all hospitalizations for BPH treatment in 2018 were extracted. We document the complications during the initial hospitalization and any subsequent rehospitalizations during the one-year postoperative period. Results: In 2018, 67,220 patients were treated for BPH: 46,242 TURP, 13,509 HoLEP and 7469 laser vaporization. Age and anticoagulation medications were similar for men treated by the three procedures, but TURP patients were more often hypertensive. Infections and hemorrhagic complications were the most common complications at the initial hospitalization: 17%, 10%, 13% for infections and 15%, 8.1%, 11% for hemorrhagic complications respectively, and TURP performed worse than the other two procedures at the initial hospitalization. During the first three months and then the subsequent nine months, there were fewer complications than initially, with little difference between the three procedures, all differences being less than 1%. Conclusion: Laser vaporization techniques led to fewer complications. However, the PMSI-MCO only registers complications during hospitalizations. This study should be extended to non-hospitalized, more minor complications.
MeSH term(s)	Male ; Humans ; Prostatic Hyperplasia/surgery ; Prostatic Hyperplasia/complications ; Prostate/surgery ; Transurethral Resection of Prostate/adverse effects ; Transurethral Resection of Prostate/methods ; Patient Readmission ; Treatment Outcome ; Laser Therapy/methods ; Hospitals ; Lasers, Solid-State/therapeutic use
Chemical Substances	MCO (56369-20-1)
Language	English
Publishing date	2023-08-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	380333-8
ISSN	1433-8726 ; 0724-4983
ISSN (online)	1433-8726
ISSN	0724-4983
DOI	10.1007/s00345-023-04509-6
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Article ; Online: The number of nephroprotection targets attained is associated with cardiorenal outcomes and mortality in patients with diabetic kidney disease. The CKD-REIN cohort study.

Bonnet, Fabrice / Balkau, Beverley / Lambert, Oriane / Diawara, Yakhara / Combe, Christian / Frimat, Luc / Laville, Maurice / Liabeuf, Sophie / Massy, Ziad A / Metzger, Marie / Stengel, Bénédicte / Alencar de Pinho, Natalia / Fouque, Denis

Diabetes, obesity & metabolism

2024 Volume 26, Issue 5, Page(s) 1908–1918

Abstract: Aim: The risk of cardiorenal events remains high among patients with diabetes and chronic kidney disease (CKD), despite the prescription of recommended treatments. We aimed to determine whether the attainment of a combination of nephroprotection targets ...

Abstract	Aim: The risk of cardiorenal events remains high among patients with diabetes and chronic kidney disease (CKD), despite the prescription of recommended treatments. We aimed to determine whether the attainment of a combination of nephroprotection targets at baseline (glycated haemoglobin <7.0%, urinary albumin-creatinine ratio <300 mg/g, blood pressure <130/80 mmHg, renin-angiotensin system inhibition) was associated with better cardiorenal outcomes and lower mortality. Materials and methods: From the prospective French CKD-REIN cohort, we studied 1260 patients with diabetes and CKD stages 3-4 (estimated glomerular filtration rate: 15-60 ml/min/1.73 m Results: In adjusted Cox regression models, the attainment of two nephroprotection targets was consistently associated with a lower risk of cardiorenal events [hazard ratio 0.70 (95% confidence interval 0.57-0.85)], incident kidney failure with replacement therapy [0.58 (0.43-0.77)], four major adverse cardiovascular events (cardiovascular death, myocardial infarction, stroke, hospitalization for heart failure) [0.75 (0.57-0.99)] and all-cause mortality [0.59 (0.42-0.82)] when compared with the attainment of zero or one target. For patients with a urinary albumin-creatinine ratio ≥300 mg/g, those who attained at least two targets had lower hazard ratios for cardiorenal events [0.61 (0.39-0.96)], four major adverse cardiovascular events [0.53 (0.28-0.98)] and all-cause mortality [0.35 (0.17-0.70)] compared with those who failed to attain any targets. Conclusions: These findings suggest that the attainment of a combination of nephroprotection targets is associated with better cardiorenal outcomes and a lower mortality rate in people with diabetic kidney disease.
MeSH term(s)	Male ; Humans ; Middle Aged ; Aged ; Aged, 80 and over ; Female ; Diabetic Nephropathies/complications ; Cohort Studies ; Prospective Studies ; Creatinine ; Renal Insufficiency, Chronic ; Heart Failure/complications ; Albumins ; Cardiovascular Diseases/etiology ; Glomerular Filtration Rate ; Diabetes Mellitus
Chemical Substances	Creatinine (AYI8EX34EU) ; Albumins
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	1454944-x
ISSN	1463-1326 ; 1462-8902
ISSN (online)	1463-1326
ISSN	1462-8902
DOI	10.1111/dom.15507
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Article ; Online: The JUBILE cohort: Quality of life after more than 40 years with type 1 diabetes.

Altman, Jean-Jacques / Niarra, Ralph / Balkau, Beverley / Vincent-Cassy, Christophe

Diabetic medicine : a journal of the British Diabetic Association

2020 Volume 38, Issue 9, Page(s) e14460

Abstract: Aim: The incidence of type 1 diabetes is increasing, and more people are going to live many years with the disease. Quality of life might become the most challenging long-term complication. The JUBILE study describes the quality of life of people living ...

Abstract	Aim: The incidence of type 1 diabetes is increasing, and more people are going to live many years with the disease. Quality of life might become the most challenging long-term complication. The JUBILE study describes the quality of life of people living with type 1 diabetes for more than 40 years. Methods: Patients were recruited from 35 French regional or university hospitals: patients and physicians completed questionnaires, validated by the Delphi method. From 1200 questionnaires circulated, 808 patients and their physicians returned questionnaires. Results: The duration of type 1 diabetes was 49 ± 6 years (mean±SD), age at diagnosis 15 ± 10 years, HbA1c 7.4 ± 0.9% [58 ± 10 mmol/mol] and 52% were men. Macrovascular disease was present in 32%, 46% had no or only mild non proliferative retinopathy. Insulin pumps were used by 25% and insulin pen/syringe users injected 3.9 ± 2.1 times per day. Blood glucose was self monitored at least five times per day by 67% of patients. Men had 1.8 ± 1.2 children, women 1.4 ± 1.0. More than half (55%) of this population was working, 38% had a university degree. Patients still had a busy life, going out (59%), eating out (82%), playing sports (38%) and travelling (66%). No differences appeared based on age, duration of diabetes, demography or social features. Conclusions: Living a long and pleasant life is possible with type 1 diabetes. Diabetes does not prevent people from having children, working at highly qualified jobs, travelling abroad: a message of hope that is comforting for patients, their family, relatives and the medical teams.
MeSH term(s)	Adolescent ; Adult ; Aged ; Blood Glucose/metabolism ; Child ; Diabetes Mellitus, Type 1/blood ; Diabetes Mellitus, Type 1/drug therapy ; Diabetes Mellitus, Type 1/psychology ; Female ; Follow-Up Studies ; Glycated Hemoglobin A/metabolism ; Humans ; Hypoglycemic Agents/therapeutic use ; Insulin/therapeutic use ; Insulin Infusion Systems ; Male ; Middle Aged ; Prognosis ; Quality of Life ; Retrospective Studies ; Young Adult
Chemical Substances	Blood Glucose ; Glycated Hemoglobin A ; Hypoglycemic Agents ; Insulin
Keywords	covid19
Language	English
Publishing date	2020-12-22
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	605769-x
ISSN	1464-5491 ; 0742-3071 ; 1466-5468
ISSN (online)	1464-5491
ISSN	0742-3071 ; 1466-5468
DOI	10.1111/dme.14460
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Article ; Online: Screening for diabetes.

Balkau, Beverley

Diabetes care

2008 Volume 31, Issue 5, Page(s) 1084–1085

MeSH term(s)	Diabetes Mellitus/epidemiology ; Diabetes Mellitus, Type 2/epidemiology ; Diabetic Angiopathies/epidemiology ; Diabetic Angiopathies/prevention & control ; Humans ; Mass Screening/methods ; Mass Screening/standards ; Risk Factors ; United Kingdom
Language	English
Publishing date	2008-04-29
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	441231-x
ISSN	1935-5548 ; 0149-5992
ISSN (online)	1935-5548
ISSN	0149-5992
DOI	10.2337/dc08-0439
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Article ; Online: Pathogenic, Total Loss-of-Function DYRK1B Variants Cause Monogenic Obesity Associated With Type 2 Diabetes.

Folon, Lise / Baron, Morgane / Scherrer, Victoria / Toussaint, Bénédicte / Vaillant, Emmanuel / Loiselle, Hélène / Dechaume, Aurélie / De Pooter, Frédérique / Boutry, Raphaël / Boissel, Mathilde / Diallo, Aboubacar / Ning, Lijiao / Balkau, Beverley / Charpentier, Guillaume / Franc, Sylvia / Marre, Michel / Derhourhi, Mehdi / Froguel, Philippe / Bonnefond, Amélie

Diabetes care

2024 Volume 47, Issue 3, Page(s) 444–451

Abstract: Objective: Rare variants in DYRK1B have been described in some patients with central obesity, type 2 diabetes, and early-onset coronary disease. Owing to the limited number of conducted studies, the broader impact of DYRK1B variants on a larger scale ... ...

Abstract	Objective: Rare variants in DYRK1B have been described in some patients with central obesity, type 2 diabetes, and early-onset coronary disease. Owing to the limited number of conducted studies, the broader impact of DYRK1B variants on a larger scale has yet to be investigated. Research design and methods: DYRK1B was sequenced in 9,353 participants from a case-control study for obesity and type 2 diabetes. Each DYRK1B variant was functionally assessed in vitro. Variant pathogenicity was determined using criteria from the American College of Medical Genetics and Genomics (ACMG). The effect of pathogenic or likely pathogenic (P/LP) variants on metabolic traits was assessed using adjusted mixed-effects score tests. Results: Sixty-five rare, heterozygous DYRK1B variants were identified and were not associated with obesity or type 2 diabetes. Following functional analyses, 20 P/LP variants were pinpointed, including 6 variants that exhibited a fully inhibitory effect (P/LP-null) on DYRK1B activity. P/LP and P/LP-null DYRK1B variants were associated with increased BMI and obesity risk; however, the impact was notably more pronounced for the P/LP-null variants (effect of 8.0 ± 3.2 and odds ratio of 7.9 [95% CI 1.2-155]). Furthermore, P/LP-null variants were associated with higher fasting glucose and type 2 diabetes risk (effect of 2.9 ± 1.0 and odds ratio of 4.8 [95% CI 0.85-37]), while P/LP variants had no effect on glucose homeostasis. Conclusions: P/LP, total loss-of-function DYRK1B variants cause monogenic obesity associated with type 2 diabetes. This study underscores the significance of conducting functional assessments in order to accurately ascertain the tangible effects of P/LP DYRK1B variants.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/genetics ; Case-Control Studies ; Obesity/complications ; Obesity/genetics ; Phenotype ; Glucose
Chemical Substances	Glucose (IY9XDZ35W2)
Language	English
Publishing date	2024-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	441231-x
ISSN	1935-5548 ; 0149-5992
ISSN (online)	1935-5548
ISSN	0149-5992
DOI	10.2337/dc23-1851
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