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  1. Article ; Online: Quantitative methods in the study of pulmonary pathology.

    Dunnill, M S

    Thorax

    2014  Volume 17, Issue 4, Page(s) 320–328

    MeSH term(s) Autopsy ; Emphysema/pathology ; Humans ; Lung/pathology ; Lung Volume Measurements/methods ; Models, Biological ; Specimen Handling
    Language English
    Publishing date 2014-09-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thx.17.4.320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui III Zs.83: Show issues Location:
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  2. Article ; Online: Multiplexed Live-Cell Imaging for Drug Responses in Patient-Derived Organoid Models of Cancer.

    Colling, Kaitriana E / Symons, Emily L / Buroni, Lorenzo / Sumanasiri, Hiruni K / Andrew-Udoh, Jessica / Witt, Emily / Losh, Haley A / Morrison, Abigail M / Leslie, Kimberly K / Dunnill, Christopher J / de Bono, Johann S / Thiel, Kristina W

    Journal of visualized experiments : JoVE

    2024  , Issue 203

    Abstract: Patient-derived organoid (PDO) models of cancer are a multifunctional research system that better recapitulates human disease as compared to cancer cell lines. PDO models can be generated by culturing patient tumor cells in extracellular basement ... ...

    Abstract Patient-derived organoid (PDO) models of cancer are a multifunctional research system that better recapitulates human disease as compared to cancer cell lines. PDO models can be generated by culturing patient tumor cells in extracellular basement membrane extracts (BME) and plating them as three-dimensional domes. However, commercially available reagents that have been optimized for phenotypic assays in monolayer cultures often are not compatible with BME. Herein, we describe a method to plate PDO models and assess drug effects using an automated live-cell imaging system. In addition, we apply fluorescent dyes that are compatible with kinetic measurements to quantify cell health and apoptosis simultaneously. Image capture can be customized to occur at regular time intervals over several days. Users can analyze drug effects in individual Z-plane images or a Z Projection of serial images from multiple focal planes. Using masking, specific parameters of interest are calculated, such as PDO number, area, and fluorescence intensity. We provide proof-of-concept data demonstrating the effect of cytotoxic agents on cell health, apoptosis, and viability. This automated kinetic imaging platform can be expanded to other phenotypic readouts to understand diverse therapeutic effects in PDO models of cancer.
    MeSH term(s) Humans ; Apoptosis ; Basement Membrane ; Biological Assay ; Cell Line ; Neoplasms ; Organoids
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article ; Video-Audio Media
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/66072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Victor Horsley (1857-1916) in World War I.

    Dunnill, M S

    Journal of medical biography

    2010  Volume 18, Issue 4, Page(s) 186–193

    Abstract: In 1914 Victor Horsley, 56 years old, pioneer neurosurgeon, politician and ardent supporter of the temperance movement volunteered for active service. After a brief period in France he was posted to the Middle East, initially to Egypt and then to ... ...

    Abstract In 1914 Victor Horsley, 56 years old, pioneer neurosurgeon, politician and ardent supporter of the temperance movement volunteered for active service. After a brief period in France he was posted to the Middle East, initially to Egypt and then to Mesopotamia. There he witnessed the horrors of that campaign. His attempts to alleviate the appalling conditions to which the wounded were subjected took toll of his own health and the official cause of his death in 1916 at Amara was heat stroke.
    MeSH term(s) Firearms/history ; History, 19th Century ; History, 20th Century ; Humans ; Military Medicine/history ; Neurosurgery/history ; Politics ; Temperance/history ; United Kingdom ; World War I
    Language English
    Publishing date 2010-11
    Publishing country England
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 1159267-9
    ISSN 1758-1087 ; 0967-7720
    ISSN (online) 1758-1087
    ISSN 0967-7720
    DOI 10.1258/jmb.2010.010017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Multiplexed live-cell imaging for drug responses in patient-derived organoid models of cancer.

    Colling, Kaitriana E / Symons, Emily L / Buroni, Lorenzo / Sumanisiri, Hiruni K / Andrew-Udoh, Jessica / Witt, Emily / Losh, Haley A / Morrison, Abigail M / Leslie, Kimberly K / Dunnill, Christopher J / De Bono, Johann S / Thiel, Kristina W

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Patient-derived organoid (PDO) models of cancer are a multifunctional research system that better recapitulates human disease as compared to cancer cell lines. PDO models can be generated by culturing patient tumor cells in extracellular basement ... ...

    Abstract Patient-derived organoid (PDO) models of cancer are a multifunctional research system that better recapitulates human disease as compared to cancer cell lines. PDO models can be generated by culturing patient tumor cells in extracellular basement membrane extracts (BME) and plating as three-dimensional domes. However, commercially available reagents that have been optimized for phenotypic assays in monolayer cultures often are not compatible with BME. Herein we describe a method to plate PDO models and assess drug effects using an automated live-cell imaging system. In addition, we apply fluorescent dyes that are compatible with kinetic measurements to simultaneously quantitate cell health and apoptosis. Image capture can be customized to occur at regular time intervals over several days. Users can analyze drug effects in individual Z-plane images or a Z Projection of serial images from multiple focal planes. Using masking, specific parameters of interest are calculated, such as PDO number, area, and fluorescence intensity. We provide proof-of-concept data demonstrating the effect of cytotoxic agents on cell health, apoptosis and viability. This automated kinetic imaging platform can be expanded to other phenotypic readouts to understand diverse therapeutic effects in PDO models of cancer.
    Language English
    Publishing date 2023-11-17
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.11.15.567243
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Mild clinical presentation of a patient with a mutation in the NSDHL gene.

    Ormerod, E / Bownass, L / Smithson, S / Zhang, Y / Dunnill, M G S

    Clinical and experimental dermatology

    2018  Volume 44, Issue 4, Page(s) 456–458

    MeSH term(s) 3-Hydroxysteroid Dehydrogenases/genetics ; Abnormalities, Multiple/diagnosis ; Abnormalities, Multiple/genetics ; Adult ; Diagnostic Errors ; Female ; Genetic Diseases, X-Linked/diagnosis ; Genetic Diseases, X-Linked/genetics ; Humans ; Ichthyosiform Erythroderma, Congenital/diagnosis ; Ichthyosiform Erythroderma, Congenital/genetics ; Limb Deformities, Congenital/diagnosis ; Limb Deformities, Congenital/genetics ; Mutation, Missense ; Nevus, Sebaceous of Jadassohn/diagnosis ; Phenotype ; Severity of Illness Index
    Chemical Substances 3-Hydroxysteroid Dehydrogenases (EC 1.1.-) ; Nsdhl protein, human (EC 1.1.1.170)
    Language English
    Publishing date 2018-11-28
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 195504-4
    ISSN 1365-2230 ; 0307-6938
    ISSN (online) 1365-2230
    ISSN 0307-6938
    DOI 10.1111/ced.13845
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  6. Article: Metaplastic changes in the visceral pleura in a case of fibrocystic disease of the pancreas.

    DUNNILL, M S

    The Journal of pathology and bacteriology

    2003  Volume 77, Issue 1, Page(s) 299–302

    MeSH term(s) Cystic Fibrosis/pathology ; Female ; Fibrocystic Breast Disease ; Humans ; Metaplasia ; Pancreas ; Pleura/pathology ; Thorax
    Language English
    Publishing date 2003-08-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 3101-x
    ISSN 1555-2039 ; 0368-3494
    ISSN (online) 1555-2039
    ISSN 0368-3494
    DOI 10.1002/path.1700770129
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  7. Book: William Budd

    Dunnill, M. S

    Bristol's most famous physician : pioneer of preventive medicine and epidemiology

    2006  

    Author's details Michael Dunnill
    MeSH term(s) Preventive Medicine/history ; Epidemiology/history ; History, 19th Century
    Keywords Great Britain
    Language English
    Size ix, 158 p., [16] p. of plates :, ill., maps, ports. ;, 24 cm.
    Publisher Redcliffe
    Publishing place Bristol
    Document type Book
    ISBN 9781904537489 ; 1904537480
    Database Catalogue of the US National Library of Medicine (NLM)

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  8. Article: Absent right pulmonary artery as an isolated congenital defect.

    DUNNILL, M S / ROSS, H B

    Lancet (London, England)

    2003  Volume 2, Issue 7195, Page(s) 185–187

    MeSH term(s) Humans ; Pulmonary Artery/abnormalities ; Vascular Malformations
    Language English
    Publishing date 2003-03-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0140-6736 ; 0023-7507
    ISSN (online) 1474-547X
    ISSN 0140-6736 ; 0023-7507
    DOI 10.1016/s0140-6736(61)90466-4
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  9. Book: The Plato of Praed Street

    Dunnill, M. S

    the life and times of Almroth Wright

    2000  

    Author's details by Michael Dunnill
    MeSH term(s) Physicians ; History, 19th Century ; History, 20th Century ; Vaccination/history
    Keywords Great Britain
    Language English
    Size xiii, 269 p. :, ill., ports.
    Publisher Royal Society of Medicine Press
    Publishing place London ; Lake Forest, IL
    Document type Book
    ISBN 9781853154775 ; 1853154776
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Article: Pulmonary granulomatosis and angiitis.

    Dunnill, M S

    Histopathology

    1991  Volume 19, Issue 4, Page(s) 297–301

    Abstract: A wide variety of disease processes, each requiring different therapy, may give rise to granulomatous and vasculitic pulmonary lesions, making accurate aetiological diagnosis essential. For this, adequate sampling of tissue is necessary, and this usually ...

    Abstract A wide variety of disease processes, each requiring different therapy, may give rise to granulomatous and vasculitic pulmonary lesions, making accurate aetiological diagnosis essential. For this, adequate sampling of tissue is necessary, and this usually requires open lung biopsy in order to obtain sufficient material for microbiological, immunocytochemical and ultrastructural as well as histopathological investigation. Many cases diagnosed as lymphomatoid granulomatosis are examples of extranodal lymphoma. It is suggested that this is an inappropriate name and that such cases should be referred to as pulmonary lymphomas and the phenotype specified.
    MeSH term(s) Churg-Strauss Syndrome/diagnosis ; Diagnosis, Differential ; Granuloma/diagnosis ; Granulomatosis with Polyangiitis/diagnosis ; Humans ; Lung Diseases/diagnosis ; Lymphatic Diseases/diagnosis ; Rheumatic Diseases/diagnosis ; Sarcoidosis/diagnosis ; Vasculitis/diagnosis
    Language English
    Publishing date 1991-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 131914-0
    ISSN 1365-2559 ; 0309-0167
    ISSN (online) 1365-2559
    ISSN 0309-0167
    DOI 10.1111/j.1365-2559.1991.tb00043.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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