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Article: Investigating the Prevalence of Contrast-associated Nephropathy and the Related Risk Factors in Patients Undergoing Elective Angioplasty.

Dianatkhah, Mehrnoush / Poursaeid, Samira / Shirvani, Ehsan / Badri, Shirinsadat

Journal of research in pharmacy practice

2024 Volume 12, Issue 2, Page(s) 64–67

Abstract: Objective: Contrast-associated nephropathy (CAN) is a sudden decrease in kidney function following contrast media administration. Considering the importance of CAN in the patient's outcome and the high prevalence of this complication in cardiac ... ...

Abstract	Objective: Contrast-associated nephropathy (CAN) is a sudden decrease in kidney function following contrast media administration. Considering the importance of CAN in the patient's outcome and the high prevalence of this complication in cardiac catheterizing centers, this study was designed to investigate the prevalence and the related risk factors of CAN in patients undergoing angioplasty in Chamran Heart Hospital, Isfahan, Iran, from January 2022 to June 2022. Methods: The inclusion criteria were adult patients above 18 admitted for elective percutaneous coronary intervention (PCI). Patient demographic information, underlying diseases and medications, dehydration state, type and amount of contrast media, and serum levels of blood urea nitrogen (BUN) and serum creatinine (SrCr) at 24 and 72 h after contrast injection were all recorded. Findings: Out of 340, 128 patients developed CAN after PCI, giving an incidence of 37.64%. Adjusted analysis showed a significant relation between age over 65, the amount of contrast media administered, and the use of furosemide with the incidence of CAN. However, adjusted logistic regression analysis failed to show any significant relationship between the risk of CAN and the hydration status of the patients at 24 and 48 h after receiving contrast media as diagnosed by BUN/SrCr >20. Conclusion: The prevalence of CAN in this study was higher than in other studies since this high-risk population was under risk factors such as arterial injection of contrast material and a higher amount of contrast material administration. In addition, advanced age, volume of contrast material, and previous or concurrent furosemide administration were associated with an increased risk of CAN.
Language	English
Publishing date	2024-01-31
Publishing country	India
Document type	Journal Article
ZDB-ID	2734861-1
ISSN	2279-042X ; 2319-9644
ISSN (online)	2279-042X
ISSN	2319-9644
DOI	10.4103/jrpp.jrpp_1_24
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Effect of Selenium Supplementation on Lipid Profile, Anemia, and Inflammation Indices in Hemodialysis Patients.

Assarzadeh, Samaneh / Vahdat, Sahar / Seirafian, Shiva / Pourfarzam, Morteza / Badri, Shirinsadat

Journal of research in pharmacy practice

2023 Volume 11, Issue 3, Page(s) 103–108

Abstract: Objective: Trace elements deficiency is common among end-stage renal disease (ESRD) patients due to excessive loss during dialysis and the lower intake secondary to loss of appetite. Selenium (Se) is a trace element that plays an important role in the ... ...

Abstract	Objective: Trace elements deficiency is common among end-stage renal disease (ESRD) patients due to excessive loss during dialysis and the lower intake secondary to loss of appetite. Selenium (Se) is a trace element that plays an important role in the radical scavenging system and helps the body defend against oxidative stress. This study aims to evaluate the effects of Se supplementation on lipid profile, anemia, and inflammation indices in ESRD patients. Methods: Fifty-nine hemodialysis patients enrolled and were randomly divided into two groups. Two hundred microgram Se capsules once daily for the case group and matching placebo for the control group were administered for three months. Demographic data were collected at the study beginning. Uric acid (UA), anemia and inflammation indices, and lipid profiles were recorded at the beginning and the end of the study. Findings: UA and UA-to-HDL (high-density lipoprotein) ratio decreased significantly in the case group ( Conclusion: According to the results of this study, selenium supplementation in ESRD patients could reduce some risk factors related to their mortality, such as the ratio of uric acid to HDL. However, the changes related to lipid profile, hemoglobin level and hs-CRP biomarker were not significant.
Language	English
Publishing date	2023-03-24
Publishing country	India
Document type	Journal Article
ZDB-ID	2734861-1
ISSN	2279-042X ; 2319-9644
ISSN (online)	2279-042X
ISSN	2319-9644
DOI	10.4103/jrpp.jrpp_68_22
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Article: Potential Benefits of Selenium Supplementation in Patients with Kidney Disease.

Badri, Shirinsadat / Vahdat, Sahar / Pourfarzam, Morteza / Assarzadeh, Samaneh / Seirafian, Shiva / Ataei, Sara

Journal of research in pharmacy practice

2022 Volume 10, Issue 4, Page(s) 149–158

Abstract: Trace element deficiency is common among patients with end-stage renal disease (ESRD); the reason is that since these patients undergo dialysis, they lose these elements more than healthy people, and also the use of trace elements is restricted due to ... ...

Abstract	Trace element deficiency is common among patients with end-stage renal disease (ESRD); the reason is that since these patients undergo dialysis, they lose these elements more than healthy people, and also the use of trace elements is restricted due to loss of appetite. Selenium (Se) is a trace element that is essential for the oxidative stress defense system. Se deficiency leads to some complications similar to those often seen in ESRD patients, such as all-cause mortality due to cardiovascular diseases, bone loss, uric acid elevation, and anemia. This article aims to review the evidence on consequences of Se deficiency in ESRD patients, as well as effects of Se supplementation in hemodialysis patients. Multiple databases were searched to summarize the available evidence on selenium's role in kidney diseases. Since the complications of ESRD and those of Se deficiency are mostly similar, this triggers the idea that Se deficiency may be considered as a cause of these problems, but it needs to be more assessed that Se deficiency is a single factor or there are other factors participated in. Also the role of Se supplementation on resolving the mentioned complications, needs to be more studied through welldesigned clinical studies.
Language	English
Publishing date	2022-05-25
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2734861-1
ISSN	2279-042X ; 2319-9644
ISSN (online)	2279-042X
ISSN	2319-9644
DOI	10.4103/jrpp.jrpp_3_22
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Article: Effect of Omega-3 Fatty Acids Supplementation on Homocysteine Level in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis.

Gholipur-Shahraki, Tahereh / Vahdat, Sahar / Seirafian, Shiva / Pourfarzam, Morteza / Badri, Shirinsadat

Journal of research in pharmacy practice

2022 Volume 11, Issue 2, Page(s) 80–86

Abstract: Objective: One of the most common diseases with high morbidity and mortality rates is chronic kidney disease. Cardiovascular disease affects most patients with chronic kidney disorders, particularly patients undergoing dialysis; hence, appropriate ... ...

Abstract	Objective: One of the most common diseases with high morbidity and mortality rates is chronic kidney disease. Cardiovascular disease affects most patients with chronic kidney disorders, particularly patients undergoing dialysis; hence, appropriate prevention and management approaches are essential. This study aimed to evaluate the reduction of inflammatory biomarkers, especially homocysteine, by omega-3 fatty acids in peritoneal dialysis patients. Methods: This study enrolled 60 peritoneal dialysis patients who met specified inclusion and exclusion criteria and were randomized to intervention or placebo groups. Omega-3 capsules were given at a dose of 3 g/d for 8 weeks. Inflammatory markers, including high-sensitivity C-reactive protein (hs-CRP), homocysteine, albumin, and lipid profile measured before and after the study. Findings: Results of this trial revealed that the levels of homocysteine, hs-CRP, and albumin did not change significantly during the study. Analysis of lipid profiles before and after intervention showed omega-3 has no significant effect on the level of total cholesterol or low-density lipoprotein cholesterol; However, the level of triglyceride reduced remarkably ( Conclusion: Omega-3 does not seem to be able to change the inflammatory markers significantly, particularly homocysteine. More extensive trials must be conducted to better understand the impact of omega-3 on inflammatory and nutritional markers, particularly in peritoneal dialysis patients.
Language	English
Publishing date	2022-12-14
Publishing country	India
Document type	Journal Article
ZDB-ID	2734861-1
ISSN	2279-042X ; 2319-9644
ISSN (online)	2279-042X
ISSN	2319-9644
DOI	10.4103/jrpp.jrpp_67_22
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Article ; Online: The Effect of Herbal Extracts Containing Punica granatum, Mentha spicata, and Honey on Weight and Cachexia Indices in Peritoneal Dialysis Patients

Niloofar Fazel / Firouzeh Moeinzadeh / Mohammad Hossein Rouhani / Shirinsadat Badri / Leila Mohammad Taghizadeh Kashani

مجله دانشکده پزشکی اصفهان, Vol 40, Iss 688, Pp 729-

2022 Volume 737

Abstract: Background: Chronic kidney disease (CKD) is defined as a gradual decline in kidney function. CKD could be manifested by nausea, vomiting, and loss of appetite. Cachexia results from systemic inflammation and oxidative stress in CKD patients. Some drugs ... ...

Abstract	Background: Chronic kidney disease (CKD) is defined as a gradual decline in kidney function. CKD could be manifested by nausea, vomiting, and loss of appetite. Cachexia results from systemic inflammation and oxidative stress in CKD patients. Some drugs used for cachexia have adverse effects like increased risk of death due to edema, thromboembolism, and sarcopenia with long-term uses. Nowadays, Appetizer Barij Essence Syrup®, which contains the extract of Punica granatum, Mentha spicata, and honey, has been used to enhance appetite. In this paper, we studied the effect of this syrup on weight, anthropometric markers, and cachexia in peritoneal dialysis patients. Methods: Fifty-four patients were enrolled in this randomized clinical trial. The 5ml syrup was administered 3 times a day before meals to the patients in the intervention group for two months. Biomarkers like serum triglycerides and albumin levels, as well as muscle mass, appetite score, and actual weight were recorded at the beginning and the end of the intervention. Findings: The appetite score, serum albumin, and average muscle mass increased significantly in the intervention group after two months. Also, serum triglyceride levels decreased significantly in this group. Conclusion: Using Appetizer Barij Essence Syrup® in peritoneal dialysis patients with cachexia improved the appetite, as well as cachexia indices, like serum albumin and muscle mass. However, the impact of these interventions on these indices must be evaluated over a longer period so, long-term studies may yield more reliable results.
Keywords	cachexia ; appetite ; peritoneal dialysis ; herbal extract ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	610
Language	Persian
Publishing date	2022-11-01T00:00:00Z
Publisher	Vesnu Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Premedication drugs’ evaluation and incidence of infusion-related reactions in patients receiving amphotericin B

Shirinsadat Badri / Sara Etemadi-Moghaddam / Azadeh Moghaddas

Tehran University Medical Journal, Vol 77, Iss 12, Pp 760-

2020 Volume 766

Abstract: Background: Amphotericin B is one of the most useful therapeutic modalities for the treatment of patients with invasive fungal infections, in spite of serious side effects, namely kidney injury, electrolyte imbalances, and infusion-related reactions. The ...

Abstract	Background: Amphotericin B is one of the most useful therapeutic modalities for the treatment of patients with invasive fungal infections, in spite of serious side effects, namely kidney injury, electrolyte imbalances, and infusion-related reactions. The goal of this study was to assess the different aspects of premedication practice and the incidence and types of infusion-related reactions in patients receiving amphotericin B. Methods: This observational study was performed on 70 hospitalized patients who received amphotericin B in different departments of two university hospitals, affiliated to Isfahan University of Medical Sciences, Isfahan, Iran, from January 2017 to February 2018. Information on physicians’ performance regarding premedication administration for amphotericin B, including the types and doses of medications administered prior to amphotericin B infusion, as well as patients’ clinical data including infusion-related side effects were collected and then analyzed in comparison with the standard practice guidelines. Results: The study population consisted of 70 patients with the mean age of 51.6±18.3 years, who received amphotericin B for 8.2±3.5 days. From 70 evaluated patients, 21 patients (30%) had encountered the infusion-related reactions, including chills, fever, urticaria, headache, and hypotension. These side effects were evident in 19 patients (27%) who received no premedication and 2 patients (3%) who received only one drug as premedication, before amphotericin B administration. Twenty patients (28%) experienced chills, fever and headache, while 7 patients (10%) had nausea and vomiting during amphotericin B infusion. Hydrocortisone 50-200 mg, was the most prescribed agent for premedication (in 67% of patients), while chlorpheniramine 10 mg (in 50% of patients) and promethazine 10 mg (in 35% of patients) were the second and third prescribed ones, respectively. Conclusion: In this study, the patients who received no or only one drug as premedication experienced infusion-related side ...
Keywords	amphotericin b ; observational study ; premedication ; transfusion reaction ; Medicine (General) ; R5-920
Subject code	610
Language	Persian
Publishing date	2020-02-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
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Article: Potential of Drug Interactions as a Cause of Adverse Drug Reactions in Patients with Kidney Diseases.

Shahraki, Tahereh Gholipur / Yari, Fatemeh / Seirafian, Shiva / Badri, Shirinsadat

Journal of research in pharmacy practice

2020 Volume 9, Issue 2, Page(s) 121–124

Abstract: Objective: Adverse drug reactions (ADRs) are one of the major causes of mortality. One of the major causes of ADR is drug-drug interactions. The purpose of this study was to evaluate the prevalence and characteristics of ADRs caused by the drug ... ...

Abstract	Objective: Adverse drug reactions (ADRs) are one of the major causes of mortality. One of the major causes of ADR is drug-drug interactions. The purpose of this study was to evaluate the prevalence and characteristics of ADRs caused by the drug interactions in the nephrology departments. Methods: This cross-sectional prospective study was carried out in the nephrology department on 117 patients who received at least two medicines. Drug interactions were determined, and the patients were evaluated for the presence of a drug complication. Findings: A total of fifty ADRs were observed in 39 patients, whereas 26% of total ADRs (13 drug complications) were due to drug interactions. About 69% and 31% of complications were classified in terms of severity, in the category of "severe" and "moderate" complications, respectively. Warfarin had the highest contribution to major interactions (33.33%). Conclusion: ADRs, which specially occurred due to drug interactions, are particularly important for patients taking multiple medications (e.g., patient with renal insufficiency). Therefore, special attention should be paid to preventing and reducing ADRs in these patients' population.
Language	English
Publishing date	2020-06-26
Publishing country	India
Document type	Journal Article
ZDB-ID	2734861-1
ISSN	2279-042X ; 2319-9644
ISSN (online)	2279-042X
ISSN	2319-9644
DOI	10.4103/jrpp.JRPP_20_38
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Article: Homocysteine-Lowering Interventions in Chronic Kidney Disease.

Badri, Shirinsadat / Vahdat, Sahar / Seirafian, Shiva / Pourfarzam, Morteza / Gholipur-Shahraki, Tahereh / Ataei, Sara

Journal of research in pharmacy practice

2021 Volume 10, Issue 3, Page(s) 114–124

Abstract: The incidence of cardiovascular events and mortality is higher in patients with chronic kidney disease (CKD) compared to the general population. Homocysteine (Hcy) appears to be an independent risk factor for cardiovascular diseases in general ... ...

Abstract	The incidence of cardiovascular events and mortality is higher in patients with chronic kidney disease (CKD) compared to the general population. Homocysteine (Hcy) appears to be an independent risk factor for cardiovascular diseases in general populations and patients with CKD. Further, hyperhomocysteinemia can cause endothelial damage and increase the activity and production of coagulation factors, and its prevalence among patients with end-stage renal disease is approximately 85%-100%. Most treatments, which lower Hcy levels and have been considered in previous studies, include folic acid, B vitamins, omega-3 fatty acids, and N-acetylcysteine. However, the effect of therapies that can decrease Hcy levels and thus cardiovascular events in these patients is still unclear. The results are conflicting and require further investigation. To guide treatment decisions and improve patient outcomes, multiple databases were searched, including Web of Science, PubMed, and Medline to summarize the available evidence (i.e., clinical trial and meta-analyses) on Hcy-lowering interventions and cardiovascular events.
Language	English
Publishing date	2021-12-25
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2734861-1
ISSN	2279-042X ; 2319-9644
ISSN (online)	2279-042X
ISSN	2319-9644
DOI	10.4103/jrpp.jrpp_75_21
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Article: Therapeutic drug monitoring of vancomycin by AUC

Khoei, Ahmad / Soltani, Rasool / Emami, Jaber / Badri, Shirinsadat / Taheri, Shahram

Research in pharmaceutical sciences

2019 Volume 14, Issue 1, Page(s) 84–92

Abstract: In this study which was conducted in Alzahra University Hospital (Isfahan, I.R. Iran), the therapeutic drug monitoring of vancomycin focused on determining area under the concentration-time curve at dosing interval (τ) at steady state/minimum inhibitory ... ...

Abstract	In this study which was conducted in Alzahra University Hospital (Isfahan, I.R. Iran), the therapeutic drug monitoring of vancomycin focused on determining area under the concentration-time curve at dosing interval (τ) at steady state/minimum inhibitory concentration (AUC
Language	English
Publishing date	2019-02-26
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2400156-9
ISSN	1735-9414 ; 1735-5362
ISSN (online)	1735-9414
ISSN	1735-5362
DOI	10.4103/1735-5362.251856
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Article ; Online: Effect of pentoxifylline on anemia in patients with chronic kidney disease

Awat Feizi / Mojgan Mortazavi / Shirinsadat Badri / Mohammad Javad Norouzi

Tehran University Medical Journal, Vol 78, Iss 4, Pp 212-

an updated systematic review and meta-analysis

2020 Volume 220

Abstract: Background: Pentoxifylline, a valuable medication with promising clinical characteristics and considerable profile of safety is used in many conditions namely chronic kidney diseases (CKD). However, the decision to prescribe pentoxifylline for anemia in ... ...

Abstract	Background: Pentoxifylline, a valuable medication with promising clinical characteristics and considerable profile of safety is used in many conditions namely chronic kidney diseases (CKD). However, the decision to prescribe pentoxifylline for anemia in CKD should be based on evidence accrued from randomized controlled trials (RCTs). Yet, substantial heterogeneity exists in studies performed to evaluate pentoxifylline therapy, particularly in relation to classification of patients, the different quality and research design, sample size, baseline parameters, clinical outcome measures, and definition of endpoints and clinically meaningful improvements. As a result, assessment of pentoxifylline in treating anemia of CKD by conducting a systematic review and meta-analysis of the published relevant clinical studies seems rational and promising. Methods: The present systematic review was done in accordance with the PRISMA guideline for systematic reviews and meta-analysis. Peer-reviewed RCTs with at least four weeks of follow-up were including in the meta-analysis. Online databases (PubMed/Medline, ISI Web of Science, Embase, and Scopus) were searched to December 2017 using selected MeSH terms related to the studied topic. Data was extracted independently by two reviewers using a standard form and then cross-checked. Statistical analyses were carrying out with Stata Software, version 7.0 (Stata Corp., College Station, TX, USA). P value of less than 0.05 was considered statistically significant. Data are presented as standard mean difference (SMD) and confidence interval (CI) 95%. Results: According to the predefined criteria, a total of ten studies (parallel group or cross-over trials, and case-control studies) were included and screened for data extraction by two reviewers, separately. The preliminary results extracted from meta-analysis have shown that pentoxifylline can significantly increase transferrin saturation (SMD: 0.348; CI95%: 0.008, 0.688), but there were no conclusive effects of pentoxifylline on ...
Keywords	anemia ; chronic kidney disease ; pentoxifylline ; systematic review ; Medicine (General) ; R5-920
Subject code	610
Language	Persian
Publishing date	2020-06-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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