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  1. Article ; Online: A

    Wockenfuss, Anna / Chan, Kevin / Cooper, Jessica G / Chaya, Timothy / Mauriello, Megan A / Yannarell, Sarah M / Maresca, Julia A / Donofrio, Nicole M

    Frontiers in fungal biology

    2024  Volume 5, Page(s) 1332755

    Abstract: Biological control uses naturally occurring antagonists such as bacteria or fungi for environmentally friendly control of plant pathogens. ...

    Abstract Biological control uses naturally occurring antagonists such as bacteria or fungi for environmentally friendly control of plant pathogens.
    Language English
    Publishing date 2024-02-23
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-6128
    ISSN (online) 2673-6128
    DOI 10.3389/ffunb.2024.1332755
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A

    Todd, Kirsten L / Lai, Junyun / Sek, Kevin / Huang, Yu-Kuan / Newman, Dane M / Derrick, Emily B / Koay, Hui-Fern / Nguyen, Dat / Hoang, Thang X / Petley, Emma V / Chan, Cheok Weng / Munoz, Isabelle / House, Imran G / Lee, Joel N / Kim, Joelle S / Li, Jasmine / Tong, Junming / N de Menezes, Maria / Scheffler, Christina M /
    Yap, Kah Min / Chen, Amanda X Y / Dunbar, Phoebe A / Haugen, Brandon / Parish, Ian A / Johnstone, Ricky W / Darcy, Phillip K / Beavis, Paul A

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 6990

    Abstract: There is significant clinical interest in targeting adenosine-mediated immunosuppression, with several small molecule inhibitors having been developed for targeting the ... ...

    Abstract There is significant clinical interest in targeting adenosine-mediated immunosuppression, with several small molecule inhibitors having been developed for targeting the A
    MeSH term(s) Animals ; Mice ; Cytokines/metabolism ; Immunity ; Immunotherapy ; Lymphocytes, Tumor-Infiltrating ; Neoplasms/genetics ; Neoplasms/metabolism ; Tumor Microenvironment
    Chemical Substances Cytokines ; Adora2a protein, mouse
    Language English
    Publishing date 2023-11-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-42734-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A

    Quintal-Novelo, Carlos / Valencia-Chan, Lía / Chávez-González, Antonieta / Rangel-Méndez, Jorge / Moo-Puc, Rosa

    Iranian journal of parasitology

    2022  Volume 17, Issue 2, Page(s) 259–267

    Abstract: Background: The gastrointestinal parasite : Methods: A methanol extract was done of the root and then fractionated. The extract and fractions were tested in vitro on : Results: The hexane fraction exhibited potent activity against : Conclusion: ...

    Abstract Background: The gastrointestinal parasite
    Methods: A methanol extract was done of the root and then fractionated. The extract and fractions were tested in vitro on
    Results: The hexane fraction exhibited potent activity against
    Conclusion: The medicinal plant
    Language English
    Publishing date 2022-08-10
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2388453-8
    ISSN 2008-238X ; 1735-7020
    ISSN (online) 2008-238X
    ISSN 1735-7020
    DOI 10.18502/ijpa.v17i2.9544
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  4. Article ; Online: A

    McAfee, Alison / Chan, Queenie W T / Evans, Jay / Foster, Leonard J

    Molecular & cellular proteomics : MCP

    2017  Volume 16, Issue 12, Page(s) 2125–2137

    Abstract: ... Varroa ... ...

    Abstract Varroa destructor
    MeSH term(s) Animals ; Chromatin Assembly and Disassembly ; Gene Expression Regulation, Developmental ; Genomics/methods ; Internet ; Proteomics/methods ; Sex Determination Processes ; Sex Differentiation ; User-Computer Interface ; Varroidae/genetics ; Varroidae/growth & development ; Varroidae/metabolism ; Varroidae/physiology ; Vitellogenins/metabolism
    Chemical Substances Vitellogenins
    Language English
    Publishing date 2017-09-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2075924-1
    ISSN 1535-9484 ; 1535-9476
    ISSN (online) 1535-9484
    ISSN 1535-9476
    DOI 10.1074/mcp.RA117.000104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5599: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Book: Reassembling models of reality

    Chan, Aldrich

    theory and clinical practice

    (The Norton series on interpersonal neurobiology)

    2021  

    Author's details Aldrich Chan
    Series title The Norton series on interpersonal neurobiology
    Keywords Phenomenological psychology ; Experience/Psychological aspects ; Neuropsychology
    Subject code 150.192
    Language English
    Size xxvii, 351 Seiten, Illustrationen, 23 cm
    Edition First edition
    Publisher W.W. Norton and Company
    Publishing place New York, N.Y
    Publishing country United States
    Document type Book
    HBZ-ID HT020991455
    ISBN 978-1-324-01597-0 ; 9781324015987 ; 1-324-01597-7 ; 1324015985
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2021 A 999 available for loan (reading room) Lesesaal EG

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  6. Article ; Online: Implementing a cancer survivorship seminar course to non-healthcare professional undergraduate students.

    Chan, Alexandre

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2024  Volume 32, Issue 4, Page(s) 227

    Abstract: Background: At University of California, Irvine (UCI), a seminar course focused on cancer survivorship was developed and offered to non-healthcare professional undergraduate students. Utilizing the knowledge, attitude, and perception (KAP) framework, ... ...

    Abstract Background: At University of California, Irvine (UCI), a seminar course focused on cancer survivorship was developed and offered to non-healthcare professional undergraduate students. Utilizing the knowledge, attitude, and perception (KAP) framework, this study was designed to examine the impact on students who have taken this course, and to clarify the value of this course for undergraduate students.
    Methods: This was a cross-sectional survey. Undergraduate students enrolled in the Life After Cancer Freshmen Seminar course (Uni Stu 3) at UCI between 2021 and 2023 were invited to participate. The survey consisted of 4 main sections: (1) demographics, (2) knowledge of cancer survivorship, (3) attitude towards cancer survivorship, and (4) perception and awareness of cancer survivorship. The survey was administered prior to the implementation of the course, and the same survey was administered at the end of the course.
    Results: A total of 33 students completed the pre-implementation survey and 30 students completed the post-implementation survey. Comparing pre- and post-course implementation, there was an increase of perception and awareness of (i) resources and guidelines for cancer survivors (pre, 9.1% vs. post, 36.7%), (ii) mental health complications among cancer survivors (pre, 36.4% vs. post, 56.7%), (iii) benefits of cancer survivorship care (pre, 15.2% vs. post, 40%), latest research in cancer survivorship (pre, 0% vs. post, 23.3%), and (iv) tailoring survivors' needs according to their age groups (pre, 24.2% vs. post, 66.7%). Knowledge and attitude towards caring of cancer survivors were similar comparing pre- and post-course implementation.
    Conclusion: In an undergraduate seminar course focused on cancer survivorship, we observed an improvement of non-healthcare students' perception and awareness of cancer survivorship-related issues, advocating the value on introducing highly prevalent cancer survivorship topics early to both undergraduate STEM and non-STEM students.
    MeSH term(s) Humans ; Cancer Survivors ; Cross-Sectional Studies ; Curriculum ; Students ; Neoplasms/therapy
    Language English
    Publishing date 2024-03-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-024-08426-1
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3697: Show issues Location:
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  7. Article: A technical report on a novel robotic lower limb rehabilitation device - Is ROBERT

    Chan, Alan

    Hong Kong physiotherapy journal : official publication of the Hong Kong Physiotherapy Association Limited = Wu li chih liao

    2022  Volume 42, Issue 2, Page(s) 75–80

    Abstract: A shortage of physiotherapist (PT) manpower is a barrier for providing better rehabilitation service in Hong Kong. Quality training can benefit patients with better recovery, on the contrary, insufficient training may cause a longer length of stay, ... ...

    Abstract A shortage of physiotherapist (PT) manpower is a barrier for providing better rehabilitation service in Hong Kong. Quality training can benefit patients with better recovery, on the contrary, insufficient training may cause a longer length of stay, readmission, and thus the burden of healthcare system. The estimated cost for PT services in Hospital Authority was HK$7.0 Billion in 2020. A novel Danish robot with a 7-joint robotic arm became popular in Denmark and Germany in the last two years. The robot is designed for lower limb patient rehabilitation. It can enhance the mobility of patients. Based on the experience of a university hospital in Denmark, this robotic rehabilitation was well accepted by both patients and PTs. Function-wise, the robot provides many clinical benefits to patients, especially stroke ones. A physiotherapist's time can be saved when the robot is being used. The cost-effectiveness of ROBERT
    Language English
    Publishing date 2022-08-24
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2202255-7
    ISSN 1876-441X ; 1013-7025
    ISSN (online) 1876-441X
    ISSN 1013-7025
    DOI 10.1142/S1013702522710019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book: Neuroendocrine tumors

    Chan, Jennifer A.

    (Hematology/oncology clinics of North America ; volume 30, number 1 (February 2016))

    2016  

    Author's details editor Jennifer A. Chan, Matthew H. Kulke
    Series title Hematology/oncology clinics of North America ; volume 30, number 1 (February 2016)
    Hematology, oncology clinics of North America
    Collection Hematology, oncology clinics of North America
    Language English
    Size xiv, 232 Seiten, Illustrationen
    Publisher Elsevier
    Publishing place Philadelphia, Pennsylvania
    Publishing country United States
    Document type Book
    HBZ-ID HT018851183
    ISBN 978-0-323-41692-4 ; 0-323-41692-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 1077 -30,1- verfügbar in Königswinter Königswinter

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  9. Article ; Online: Intracellular Protein Delivery: Approaches, Challenges, and Clinical Applications.

    Chan, Alexander / Tsourkas, Andrew

    BME frontiers

    2024  Volume 5, Page(s) 35

    Abstract: Protein biologics are powerful therapeutic agents with diverse inhibitory and enzymatic functions. However, their clinical use has been limited to extracellular applications due to their inability to cross plasma membranes. Overcoming this physiological ... ...

    Abstract Protein biologics are powerful therapeutic agents with diverse inhibitory and enzymatic functions. However, their clinical use has been limited to extracellular applications due to their inability to cross plasma membranes. Overcoming this physiological barrier would unlock the potential of protein drugs for the treatment of many intractable diseases. In this review, we highlight progress made toward achieving cytosolic delivery of recombinant proteins. We start by first considering intracellular protein delivery as a drug modality compared to existing Food and Drug Administration-approved drug modalities. Then, we summarize strategies that have been reported to achieve protein internalization. These techniques can be broadly classified into 3 categories: physical methods, direct protein engineering, and nanocarrier-mediated delivery. Finally, we highlight existing challenges for cytosolic protein delivery and offer an outlook for future advances.
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2765-8031
    ISSN (online) 2765-8031
    DOI 10.34133/bmef.0035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Common pitfalls in the use of hypertonic sodium bicarbonate for cardiac toxic drug poisonings.

    Chan, Betty S / Buckley, Nicholas A

    Clinical toxicology (Philadelphia, Pa.)

    2024  , Page(s) 1–6

    Abstract: Background: Hypertonic sodium bicarbonate is advocated for the treatment of sodium channel blocker poisoning, but its efficacy varies amongst different sodium channel blockers. This Commentary addresses common pitfalls and appropriate usage of ... ...

    Abstract Background: Hypertonic sodium bicarbonate is advocated for the treatment of sodium channel blocker poisoning, but its efficacy varies amongst different sodium channel blockers. This Commentary addresses common pitfalls and appropriate usage of hypertonic sodium bicarbonate therapy in cardiotoxic drug poisonings.
    Sodium bicarbonate works synergistically with hyperventilation: Serum alkalinization is best achieved by the synergistic effect of hypertonic sodium bicarbonate and hyperventilation (PCO
    Variability in response to sodium bicarbonate treatment: Tricyclic antidepressant poisoning responds well to sodium bicarbonate therapy, but many other sodium channel blockers may not. For instance, drugs that block the intercellular gap junctions, such as bupropion, do not respond well to alkalinization. For sodium channel blocker poisonings in which the expected response is unknown, a bolus of 1-2 mmol/kg sodium bicarbonate can be used to assess the response to alkalinization.
    Sodium bicarbonate can exacerbate toxicity from drugs acting on multiple cardiac channels: Hypertonic sodium bicarbonate can cause electrolyte abnormalities such as hypokalaemia and hypocalcaemia, leading to QT interval prolongation and torsade de pointes in poisonings with drugs that have mixed sodium and potassium cardiac channel properties, such as hydroxychloroquine and flecainide.
    The goal for hypertonic sodium bicarbonate is to achieve the alkalinization target (∼ph 7.5), not complete correction of qrs complex prolongation: Excessive doses of hypertonic sodium bicarbonate commonly occur if it is administered until the QRS complex duration is < 100 ms. A prolonged QRS complex duration is not specific for sodium channel blocker toxicity. Some sodium channel blockers do not respond, and even when there is a response, it takes a few hours for the QRS complex duration to return completely to normal. In addition, QRS complex prolongation can be due to a rate-dependent bundle branch block. So, no further doses should be given after achieving serum alkalinization (pH ∼ 7.45-7.55).
    Maximal dosing for hypertonic sodium bicarbonate: A further strategy to avoid overdosing patients with hypertonic sodium bicarbonate is to set maximum doses. Exceeding 6 mmol/kg is likely to cause hypernatremia, fluid overload, metabolic alkalosis, and cerebral oedema in many patients and potentially be lethal.
    Recommendation for the use of hypertonic sodium bicarbonate in sodium channel blocker poisoning: We propose that hypertonic sodium bicarbonate therapy be used in patients with sodium channel blocker poisoning who have clinically significant toxicities such as seizures, shock (systolic blood pressure < 90 mmHg, mean arterial pressure <65 mmHg) or ventricular dysrhythmia. We recommend initial bolus dosing of hypertonic sodium bicarbonate of 1-2 mmol/kg, which can be repeated if the patient remains unstable, up to a maximum dose of 6 mmol/kg. This is recommended to be administered in conjunction with mechanical ventilation and hyperventilation to achieve serum alkalinization (PCO
    Conclusions: Hypertonic sodium bicarbonate is an effective antidote for certain sodium channel blocker poisonings, such as tricyclic antidepressants, and when used in appropriate dosing, it works synergistically with hyperventilation to achieve serum alkalinization and to reduce sodium channel blockade. However, there are many pitfalls that can lead to excessive sodium bicarbonate therapy and severe adverse effects.
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 204476-6
    ISSN 1556-9519 ; 0009-9309 ; 0731-3810 ; 1556-3650
    ISSN (online) 1556-9519
    ISSN 0009-9309 ; 0731-3810 ; 1556-3650
    DOI 10.1080/15563650.2024.2337028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 419: Show issues Location:
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