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Article ; Online: A review on histotechnology practices in COVID-19 pathology investigations.

Malloy, Seth / Wang, Yongfu

2020 Volume 43, Issue 3, Page(s) 153–158

Abstract: COVID-19 disease in humans, caused by the novel SARS-CoV-2 virus, was first reported in the city of Wuhan, China in December 2019. This disease has quickly developed into a global pandemic, resulting in over 350,000 deaths worldwide and over 5 million ... ...

Abstract	COVID-19 disease in humans, caused by the novel SARS-CoV-2 virus, was first reported in the city of Wuhan, China in December 2019. This disease has quickly developed into a global pandemic, resulting in over 350,000 deaths worldwide and over 5 million confirmed infections in a matter of 6 months. Although the genome of this novel viral RNA was sequenced quickly and testing kits were manufactured to assist in combatting COVID-19, the diagnosis and treatment will remain relatively unsuccessful until the pathology of this disease is fully understood. Histotechnology plays an important role in understanding the pathology of many diseases, including COVID-19. The first postmortem biopsy of a COVID-19 patient was collected on 27 January 2020, and the pathology finding was published in mid-February 2020. Since then, more studies have been published in scientific literatures as the global outbreak continues. This mini-review summarizes the published articles in which histotechnology aspects were utilized with the intent to understand the pathology of COVID-19. In addition, it is anticipated there will be more molecular and immunohistochemical studies to further understand the mechanism of the disease in the near future.
MeSH term(s)	Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Disease Outbreaks/prevention & control ; Humans ; Immunohistochemistry/methods ; Pandemics ; Pneumonia, Viral/pathology ; Pneumonia, Viral/virology ; RNA, Viral/genetics ; SARS-CoV-2
Chemical Substances	RNA, Viral
Keywords	covid19
Language	English
Publishing date	2020-07-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	604634-4
ISSN	2046-0236 ; 0147-8885
ISSN (online)	2046-0236
ISSN	0147-8885
DOI	10.1080/01478885.2020.1779484
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Article ; Online: A review on histotechnology practices in COVID-19 pathology investigations

Malloy, Seth / Wang, Yongfu

Journal of Histotechnology

2020 Volume 43, Issue 3, Page(s) 153–158

Keywords	Anatomy ; Medical Laboratory Technology ; Histology ; covid19
Language	English
Publisher	Informa UK Limited
Publishing country	uk
Document type	Article ; Online
ZDB-ID	604634-4
ISSN	2046-0236 ; 0147-8885
ISSN (online)	2046-0236
ISSN	0147-8885
DOI	10.1080/01478885.2020.1779484
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A review on histotechnology practices in COVID-19 pathology investigations

Malloy, Seth / Wang, Yongfu

J Histotechnol

Abstract	COVID-19 disease in humans, caused by the novel SARS-CoV-2 virus, was first reported in the city of Wuhan, China in December 2019. This disease has quickly developed into a global pandemic, resulting in over 350,000 deaths worldwide and over 5 million confirmed infections in a matter of 6 months. Although the genome of this novel viral RNA was sequenced quickly and testing kits were manufactured to assist in combatting COVID-19, the diagnosis and treatment will remain relatively unsuccessful until the pathology of this disease is fully understood. Histotechnology plays an important role in understanding the pathology of many diseases, including COVID-19. The first postmortem biopsy of a COVID-19 patient was collected on 27 January 2020, and the pathology finding was published in mid-February 2020. Since then, more studies have been published in scientific literatures as the global outbreak continues. This mini-review summarizes the published articles in which histotechnology aspects were utilized with the intent to understand the pathology of COVID-19. In addition, it is anticipated there will be more molecular and immunohistochemical studies to further understand the mechanism of the disease in the near future.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #640187
Database	COVID19

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Article ; Online: A freeze-substitution approach with solvent-based glyoxal fixative to prevent distortion of ocular structures.

Pang, Ji / Zhao, Xia / Deng, Fengyan / Tsuchiya, Dai / Malloy, Seth / Parmely, Tari / Xie, Ting / Wang, Yongfu

Journal of histotechnology

2022 Volume 45, Issue 4, Page(s) 172–181

Abstract: Investigating the function of delicate mammalian eyes often requires chemical fixation, histological sectioning, immunohistochemistry (IHC) ... ...

Abstract	Investigating the function of delicate mammalian eyes often requires chemical fixation, histological sectioning, immunohistochemistry (IHC) and
MeSH term(s)	Animals ; Mice ; Fixatives/pharmacology ; Glyoxal/pharmacology ; Solvents ; Paraffin ; In Situ Hybridization ; Mammals
Chemical Substances	Fixatives ; Glyoxal (50NP6JJ975) ; Solvents ; Paraffin (8002-74-2)
Language	English
Publishing date	2022-09-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604634-4
ISSN	2046-0236 ; 0147-8885
ISSN (online)	2046-0236
ISSN	0147-8885
DOI	10.1080/01478885.2022.2111744
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Article ; Online: Correction to: Identification and Localization of Cell Types in the Mouse Olfactory Bulb Using Slide-SeqV2.

Fang, Ai / Petentler, Kaitlyn / Price, Andrew / Malloy, Seth / Peterson, Michael / Maddera, Lucinda / Russell, Jonathon / Treese, McKenzie / Li, Hua / Wang, Yongfu / McKinney, Sean / Perera, Anoja / Yu, C Ron

Methods in molecular biology (Clifton, N.J.)

2023 Volume 2710, Page(s) C1

Language	English
Publishing date	2023-10-11
Publishing country	United States
Document type	Published Erratum
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-3425-7_17
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Article ; Online: Identification and Localization of Cell Types in the Mouse Olfactory Bulb Using Slide-SeqV2.

Methods in molecular biology (Clifton, N.J.)

2023 Volume 2710, Page(s) 171–183

Abstract: Spatial transcriptomics maps RNA molecules to the location in a tissue where they are expressed. Here we document the use of Slide-SeqV2 to visualize gene expression in the mouse olfactory bulb (OB). This approach relies on spatially identified beads to ... ...

Abstract	Spatial transcriptomics maps RNA molecules to the location in a tissue where they are expressed. Here we document the use of Slide-SeqV2 to visualize gene expression in the mouse olfactory bulb (OB). This approach relies on spatially identified beads to locate and quantify individual transcripts. The expression profiles associated with the beads are used to identify and localize individual cell types in an unbiased manner. We demonstrate the various cell types and subtypes with distinct spatial locations in the olfactory bulb that are identified using Slide-SeqV2.
MeSH term(s)	Animals ; Mice ; Olfactory Bulb ; Gene Expression Profiling
Language	English
Publishing date	2023-09-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-3425-7_13
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Article ; Online: Compartmentalized ocular lymphatic system mediates eye-brain immunity.

Yin, Xiangyun / Zhang, Sophia / Lee, Ju Hyun / Dong, Huiping / Mourgkos, George / Terwilliger, Gordon / Kraus, Aurora / Geraldo, Luiz Henrique / Poulet, Mathilde / Fischer, Suzanne / Zhou, Ting / Mohammed, Farrah Shalima / Zhou, Jiangbing / Wang, Yongfu / Malloy, Seth / Rohner, Nicolas / Sharma, Lokesh / Salinas, Irene / Eichmann, Anne /

Thomas, Jean-Leon / Saltzman, W Mark / Huttner, Anita / Zeiss, Caroline / Ring, Aaron / Iwasaki, Akiko / Song, Eric

Nature

2024 Volume 628, Issue 8006, Page(s) 204–211

Abstract: The eye, an anatomical extension of the central nervous system (CNS), exhibits many molecular and cellular parallels to the brain. Emerging research demonstrates that changes in the brain are often reflected in the eye, particularly in the ... ...

Abstract	The eye, an anatomical extension of the central nervous system (CNS), exhibits many molecular and cellular parallels to the brain. Emerging research demonstrates that changes in the brain are often reflected in the eye, particularly in the retina
MeSH term(s)	Animals ; Female ; Humans ; Male ; Mice ; Rabbits ; Bacteria/immunology ; Brain/anatomy & histology ; Brain/immunology ; Dependovirus/immunology ; Eye/anatomy & histology ; Eye/immunology ; Glioblastoma/immunology ; Herpesvirus 2, Human/immunology ; Intravitreal Injections ; Lymphatic System/anatomy & histology ; Lymphatic System/immunology ; Lymphatic Vessels/anatomy & histology ; Lymphatic Vessels/immunology ; Macaca mulatta ; Meninges/immunology ; Optic Nerve/immunology ; Swine ; Zebrafish ; Vascular Endothelial Growth Factor C/immunology ; Vascular Endothelial Growth Factor C/metabolism ; Vascular Endothelial Growth Factor C/pharmacology
Chemical Substances	Vascular Endothelial Growth Factor C
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-024-07130-8
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Confirmed rare copy number variants implicate novel genes in schizophrenia.

Tam, Gloria W C / van de Lagemaat, Louie N / Redon, Richard / Strathdee, Karen E / Croning, Mike D R / Malloy, Mary P / Muir, Walter J / Pickard, Ben S / Deary, Ian J / Blackwood, Douglas H R / Carter, Nigel P / Grant, Seth G N

Biochemical Society transactions

2010 Volume 38, Issue 2, Page(s) 445–451

Abstract: Understanding how cognitive processes including learning, memory, decision making and ideation are encoded by the genome is a key question in biology. Identification of sets of genes underlying human mental disorders is a path towards this objective. ... ...

Abstract	Understanding how cognitive processes including learning, memory, decision making and ideation are encoded by the genome is a key question in biology. Identification of sets of genes underlying human mental disorders is a path towards this objective. Schizophrenia is a common disease with cognitive symptoms, high heritability and complex genetics. We have identified genes involved with schizophrenia by measuring differences in DNA copy number across the entire genome in 91 schizophrenia cases and 92 controls in the Scottish population. Our data reproduce rare and common variants observed in public domain data from >3000 schizophrenia cases, confirming known disease loci as well as identifying novel loci. We found copy number variants in PDE10A (phosphodiesterase 10A), CYFIP1 [cytoplasmic FMR1 (Fragile X mental retardation 1)-interacting protein 1], K(+) channel genes KCNE1 and KCNE2, the Down's syndrome critical region 1 gene RCAN1 (regulator of calcineurin 1), cell-recognition protein CHL1 (cell adhesion molecule with homology with L1CAM), the transcription factor SP4 (specificity protein 4) and histone deacetylase HDAC9, among others (see http://www.genes2cognition.org/SCZ-CNV). Integrating the function of these many genes into a coherent model of schizophrenia and cognition is a major unanswered challenge.
MeSH term(s)	Case-Control Studies ; Cognition/physiology ; DNA Copy Number Variations/physiology ; DNA Mutational Analysis ; Genes/physiology ; Genome-Wide Association Study ; Humans ; Schizophrenia/genetics ; Validation Studies as Topic
Language	English
Publishing date	2010-03-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	184237-7
ISSN	1470-8752 ; 0300-5127
ISSN (online)	1470-8752
ISSN	0300-5127
DOI	10.1042/BST0380445
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Article: Indoramin in heart failure: possible adverse effects on hemodynamics and exercise capacity.

Seth, L / Galiè, N / Casebolt, P / Gimenez, H / Malloy, M / Franciosa, J A

Clinical pharmacology and therapeutics

1986 Volume 40, Issue 5, Page(s) 567–574

Abstract: Indoramin is an alpha 1-adrenergic antagonist vasodilator of potential value in heart failure. We measured hemodynamics and exercise capacity in 12 patients with heart failure, before and after 1 week of indoramin dosing, 75 mg b.i.d. Maximal hemodynamic ...

Abstract	Indoramin is an alpha 1-adrenergic antagonist vasodilator of potential value in heart failure. We measured hemodynamics and exercise capacity in 12 patients with heart failure, before and after 1 week of indoramin dosing, 75 mg b.i.d. Maximal hemodynamic effects 2 hours after the first dose of indoramin consisted of reduced mean systemic arterial pressure from 96.0 +/- 15.3 to 87.9 +/- 15.3 mm Hg (P less than 0.05) and pulmonary wedge pressure from 23.6 +/- 7.8 to 16.9 +/- 6.6 mm Hg (P less than 0.001). Heart rate, cardiac index, and total systemic resistance did not change acutely after indoramin, but after 1 week mean systemic arterial pressure was still reduced whereas cardiac index fell from 2.69 +/- 0.38 to 2.32 +/- 0.44 L/min/m2 (P less than 0.05) and total systemic resistance rose from 20.4 +/- 2.8 to 21.9 +/- 4.0 U (P less than 0.1). After 1 week maximal exercise oxygen uptake fell from 16.8 +/- 5.6 to 12.5 +/- 3.5 ml/min/kg (P less than 0.02). This limited observation suggests that indoramin is a predominant venodilator acutely in patients with heart failure but that despite this effect it may worsen functional capacity and hemodynamics during continuous dosing in these patients.
MeSH term(s)	Adult ; Aged ; Blood Pressure/drug effects ; Cardiac Output/drug effects ; Chronic Disease ; Female ; Heart Failure/drug therapy ; Hemodynamics/drug effects ; Humans ; Indoles/adverse effects ; Indoramin/adverse effects ; Indoramin/therapeutic use ; Male ; Middle Aged ; Physical Exertion ; Pulmonary Wedge Pressure/drug effects ; Time Factors ; Vascular Resistance/drug effects
Chemical Substances	Indoles ; Indoramin (0Z802HMY7H)
Language	English
Publishing date	1986-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	123793-7
ISSN	1532-6535 ; 0009-9236
ISSN (online)	1532-6535
ISSN	0009-9236
DOI	10.1038/clpt.1986.225
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Article ; Online: Clustered coding variants in the glutamate receptor complexes of individuals with schizophrenia and bipolar disorder.

Frank, René A W / McRae, Allan F / Pocklington, Andrew J / van de Lagemaat, Louie N / Navarro, Pau / Croning, Mike D R / Komiyama, Noboru H / Bradley, Sophie J / Challiss, R A John / Armstrong, J Douglas / Finn, Robert D / Malloy, Mary P / MacLean, Alan W / Harris, Sarah E / Starr, John M / Bhaskar, Sanjeev S / Howard, Eleanor K / Hunt, Sarah E / Coffey, Alison J /

Ranganath, Venkatesh / Deloukas, Panos / Rogers, Jane / Muir, Walter J / Deary, Ian J / Blackwood, Douglas H / Visscher, Peter M / Grant, Seth G N

PloS one

2011 Volume 6, Issue 4, Page(s) e19011

Abstract: Current models of schizophrenia and bipolar disorder implicate multiple genes, however their biological relationships remain elusive. To test the genetic role of glutamate receptors and their interacting scaffold proteins, the exons of ten glutamatergic ' ...

Abstract	Current models of schizophrenia and bipolar disorder implicate multiple genes, however their biological relationships remain elusive. To test the genetic role of glutamate receptors and their interacting scaffold proteins, the exons of ten glutamatergic 'hub' genes in 1304 individuals were re-sequenced in case and control samples. No significant difference in the overall number of non-synonymous single nucleotide polymorphisms (nsSNPs) was observed between cases and controls. However, cluster analysis of nsSNPs identified two exons encoding the cysteine-rich domain and first transmembrane helix of GRM1 as a risk locus with five mutations highly enriched within these domains. A new splice variant lacking the transmembrane GPCR domain of GRM1 was discovered in the human brain and the GRM1 mutation cluster could perturb the regulation of this variant. The predicted effect on individuals harbouring multiple mutations distributed in their ten hub genes was also examined. Diseased individuals possessed an increased load of deleteriousness from multiple concurrent rare and common coding variants. Together, these data suggest a disease model in which the interplay of compound genetic coding variants, distributed among glutamate receptors and their interacting proteins, contribute to the pathogenesis of schizophrenia and bipolar disorders.
MeSH term(s)	Bipolar Disorder/genetics ; Case-Control Studies ; Cluster Analysis ; Exons ; Genetic Predisposition to Disease ; Genetic Variation ; Genotype ; Humans ; Mutation ; Polymorphism, Single Nucleotide ; Protein Structure, Tertiary ; Receptors, Glutamate/genetics ; Schizophrenia/genetics ; Sequence Analysis, DNA
Chemical Substances	Receptors, Glutamate
Language	English
Publishing date	2011-04-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0019011
Database	MEDical Literature Analysis and Retrieval System OnLINE

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