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  1. Article ; Online: Phytochemical and antioxidant activities of methanolic extract of Lawsonia inermis L. Bark

    Golwala Dharmesh K. / Vaidya Santosh Kumar / Patel Timir B / Patel Darpini S. / Dholwani Kishor K.

    Current Issues in Pharmacy and Medical Sciences, Vol 33, Iss 3, Pp 132-

    2020  Volume 138

    Abstract: Many diseases are associated with oxidative stress are caused by free radicals. Current research has been directed towards finding naturally occurring antioxidants of plant origin. The aim of the present study was to evaluate the in vitro antioxidant ... ...

    Abstract Many diseases are associated with oxidative stress are caused by free radicals. Current research has been directed towards finding naturally occurring antioxidants of plant origin. The aim of the present study was to evaluate the in vitro antioxidant activities of methanolic extract of Lawsonia inermis L. bark (MELIB). The present study was carried out for determination of qualitative, quantitative phytochemical and in vitro antioxidant activity for scavenging of free radical DPPH, superoxide radical scavenging and lipid peroxidation. The bark extract is a rich source of secondary metabolites like flavonoids at a rutin equivalent 73.43±0.26%, polyphenol at a gallic acid equivalent 84.70±0.43%, tannins at a tannic acid equivalent 88.75±0.14% and terpenoids at a linalool equivalent 68.13±0.31. MELIB showed free radicals scavenging capacity by way of the DPPH method (6.93±0.51 to 62.63±0.10% inhibition), the superoxide radical scavenging method (1.82±0.41 to 57.11±0.18% inhibition) and the ferric chloride induced lipid peroxidation method (9.87±0.33 to 80.32±0.82% inhibition). The results obtained in the present study indicate that MELIB can be a potential source of natural antioxidants due to the presence of flavonoids, polyphenols, tannins and terpenoids.
    Keywords lawsonia inermis l ; flavonoids ; polyphenols ; tannins ; terpenoids ; antioxidant activity ; Medicine ; R
    Subject code 500
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: A review on plant-derived natural products and their analogs with anti-tumor activity.

    Dholwani, K K / Saluja, A K / Gupta, A R / Shah, D R

    Indian journal of pharmacology

    2011  Volume 40, Issue 2, Page(s) 49–58

    Abstract: Traditional medicines, including Chinese herbal formulations, can serve as the source of potential new drugs, and initial research focuses on the isolation of bioactive lead compound(s). The development of novel plant-derived natural products and their ... ...

    Abstract Traditional medicines, including Chinese herbal formulations, can serve as the source of potential new drugs, and initial research focuses on the isolation of bioactive lead compound(s). The development of novel plant-derived natural products and their analogs for anticancer activity details efforts to synthesize new derivatives based on bioactivity- and mechanism of action-directed isolation and characterization coupled with rational drug design - based modification. Also, the anticancer activity of certain natural products and their analogs can be enhanced by synthesizing new derivatives based on active pharmacophore models; drug resistance and solubility and metabolic limitations can be overcome by appropriate molecular modifications; and new biological properties or mechanisms of action can be added by combining other functional groups or molecules. Preclinical screening for in vitro human cell line panels and selected in vivo xenograft testing then identifies the most promising drug development targets.
    Language English
    Publishing date 2011-01-31
    Publishing country India
    Document type Journal Article
    ZDB-ID 605829-2
    ISSN 1998-3751 ; 0253-7613
    ISSN (online) 1998-3751
    ISSN 0253-7613
    DOI 10.4103/0253-7613.41038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Detection of Heavy Metal Contents and Proximate Analysis of roots of Anogeissus latifolia

    Kishor K. Dholwani / Ajay K Saluja / Vidita V. Bhargava

    Journal of Pharmacognosy and Phytochemistry, Vol 1, Iss 6, Pp 61-

    2013  Volume 65

    Abstract: The study of heavy metal contamination in plants, serve to indicate the metal concentration status of the site, where plants have grown. This is an important tool for phytoremediation. Proximate analysis in plants gives valuable information and help to ... ...

    Abstract The study of heavy metal contamination in plants, serve to indicate the metal concentration status of the site, where plants have grown. This is an important tool for phytoremediation. Proximate analysis in plants gives valuable information and help to access the quality of the sample. So studies were carried out on the roots of Anogeissus latifolia which is useful in UTI infections, skin diseases, liver complaints, fever, epileptic fits etc. for heavy metal contents and proximate analysis of the root sample was also done. The root showed the absence of heavy metals when it was subjected to analysis by Inductively Coupled Plasma Atomic Spectrometer. The ash values, extractive values, moisture content, total solid content and crude fiber content of the root sample were also determined.
    Keywords Heavy Metals ; Proximate Analysis ; Inductively Coupled Plasma Atomic Spectrometer ; Anogeissus latifolia ; Therapeutics. Pharmacology ; RM1-950 ; Medicine ; R ; DOAJ:Therapeutics ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2013-03-01T00:00:00Z
    Publisher AkiNik Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: EVALUATION OF ANTI-MICROBIAL ACTIVITY OF OCIMUM SANCTUM METHANOLIC EXTRACT

    Bhatt Mehul K / M. B. Shankar / Saluja Ajay K / Dholwani Kishor K / Captain A. D.

    Journal of Pharmaceutical and Scientific Innovation, Vol 1, Iss 4, Pp 39-

    2012  Volume 41

    Abstract: The present study was conducted to investigate anti-microbial activity of Ocimum sanctum methanolic extract against strains of gram positive and gram negative bacteria. Tulsi plant is known to possess therapeutic potentials and have been used, by ... ...

    Abstract The present study was conducted to investigate anti-microbial activity of Ocimum sanctum methanolic extract against strains of gram positive and gram negative bacteria. Tulsi plant is known to possess therapeutic potentials and have been used, by traditional medicinal practitioners, as an expectorant, analgesic, anticancer, antiasthmatic, antiemetic, diaphoretic, antidiabetic, antifertility, hepatoprotective, hypotensive, hypolipidmic, anti-microbial, antifungal activity against Asperigillus niger. The extract was tested for its antimicrobial activity against Gram-positive bacteria like Bacillus subtilis and Gram-negative bacteria like Escherichia coli. Inhibition of microbial growth was investigated using agar well diffusion method. UV-Visible and HPLC analysis of the extract was carried out for the presence of eugenol.
    Keywords Antimicrobial ; Eugenol ; Ocimum sanctum ; Well diffusion method ; HPLC. ; Pharmacy and materia medica ; RS1-441 ; Medicine ; R ; DOAJ:Pharmacy and materia medica ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 540
    Language English
    Publishing date 2012-08-01T00:00:00Z
    Publisher Moksha Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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