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  1. Book: Tissue engineering for artificial organs / Volume 1

    Hasan, Anwarul

    regenerative medicine, smart diagnostics and personalized medicine

    2017  

    Author's details edited by Anwarul Hasan
    Collection Tissue engineering for artificial organs
    Language English
    Size xxvi, 361 Seiten, Illustrationen
    Publishing country Germany
    Document type Book
    HBZ-ID HT019311411
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2017 A 814 available for loan (reading room) Lesesaal EG

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  2. Book: Tissue engineering for artificial organs / Volume 2

    Hasan, Anwarul

    regenerative medicine, smart diagnostics and personalized medicine

    2017  

    Author's details edited by Anwarul Hasan
    Collection Tissue engineering for artificial organs
    Language English
    Size xviii Seiten, Seite 363-717, Illustrationen, Diagramme
    Publishing country Germany
    Document type Book
    HBZ-ID HT019311433
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2017 A 815 available for loan (reading room) Lesesaal EG

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  3. Book ; Collection: Tissue engineering for artificial organs

    Hasan, Anwarul

    regenerative medicine, smart diagnostics and personalized medicine

    2017  

    Author's details edited by Anwarul Hasan
    Keywords Künstliches Organ ; Tissue Engineering
    Subject Tissue-Engineering ; Gewebezucht ; Organplastik
    Language English
    Dates of publication 2017-9999
    Size 2 Bände
    Publisher Wiley-VCH
    Publishing place Weinheim
    Publishing country Germany
    Document type Book ; Collection (display volumes)
    HBZ-ID HT019137086
    ISBN 978-3-527-33863-4 ; 9783527689941 ; 9783527689965 ; 9783527689958 ; 9783527689934 ; 3-527-33863-2 ; 352768994X ; 3527689966 ; 3527689958 ; 3527689931
    Database Catalogue ZB MED Medicine, Health

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  4. Book ; Online: Developing Successful Neuroprotective Treatments for TBI: Translational Approaches, Novel Directions, Opportunities and Challenges

    Mondello, Stefania / Hasan, Anwarul / Shear, Deborah

    2020  

    Keywords Medicine ; Neurology & clinical neurophysiology ; traumatic brain injury (TBI) ; neuroprotection ; therapy ; translational research ; drug development ; clinical trial design ; mesenchymal stem cells ; phenotyping
    Size 1 electronic resource (281 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021229927
    ISBN 9782889634491 ; 2889634493
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Autophagy and Its Lineage-Specific Roles in the Hematopoietic System.

    Hasan, Kazi Md Mahmudul / Haque, Md Anwarul

    Oxidative medicine and cellular longevity

    2023  Volume 2023, Page(s) 8257217

    Abstract: Autophagy is a dynamic process that regulates the selective and nonselective degradation of cytoplasmic components, such as damaged organelles and protein aggregates inside lysosomes to maintain tissue homeostasis. Different types of autophagy including ... ...

    Abstract Autophagy is a dynamic process that regulates the selective and nonselective degradation of cytoplasmic components, such as damaged organelles and protein aggregates inside lysosomes to maintain tissue homeostasis. Different types of autophagy including macroautophagy, microautophagy, and chaperon-mediated autophagy (CMA) have been implicated in a variety of pathological conditions, such as cancer, aging, neurodegeneration, and developmental disorders. Furthermore, the molecular mechanism and biological functions of autophagy have been extensively studied in vertebrate hematopoiesis and human blood malignancies. In recent years, the hematopoietic lineage-specific roles of different autophagy-related (
    MeSH term(s) Humans ; Autophagy/genetics ; Neoplasms ; Organelles ; Lysosomes ; Aging/physiology
    Language English
    Publishing date 2023-05-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2455981-7
    ISSN 1942-0994 ; 1942-0994
    ISSN (online) 1942-0994
    ISSN 1942-0994
    DOI 10.1155/2023/8257217
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Potential use of iPSCs for disease modeling, drug screening, and cell-based therapy for Alzheimer's disease.

    Marei, Hany E / Khan, Muhammad Umar Aslam / Hasan, Anwarul

    Cellular & molecular biology letters

    2023  Volume 28, Issue 1, Page(s) 98

    Abstract: Alzheimer's disease (AD) is a chronic illness marked by increasing cognitive decline and nervous system deterioration. At this time, there is no known medication that will stop the course of Alzheimer's disease; instead, most symptoms are treated. ... ...

    Abstract Alzheimer's disease (AD) is a chronic illness marked by increasing cognitive decline and nervous system deterioration. At this time, there is no known medication that will stop the course of Alzheimer's disease; instead, most symptoms are treated. Clinical trial failure rates for new drugs remain high, highlighting the urgent need for improved AD modeling for improving understanding of the underlying pathophysiology of disease and improving drug development. The development of induced pluripotent stem cells (iPSCs) has made it possible to model neurological diseases like AD, giving access to an infinite number of patient-derived cells capable of differentiating neuronal fates. This advance will accelerate Alzheimer's disease research and provide an opportunity to create more accurate patient-specific models of Alzheimer's disease to support pathophysiological research, drug development, and the potential application of stem cell-based therapeutics. This review article provides a complete summary of research done to date on the potential use of iPSCs from AD patients for disease modeling, drug discovery, and cell-based therapeutics. Current technological developments in AD research including 3D modeling, genome editing, gene therapy for AD, and research on familial (FAD) and sporadic (SAD) forms of the disease are discussed. Finally, we outline the issues that need to be elucidated and future directions for iPSC modeling in AD.
    MeSH term(s) Humans ; Alzheimer Disease/drug therapy ; Alzheimer Disease/genetics ; Induced Pluripotent Stem Cells/physiology ; Drug Evaluation, Preclinical ; Neurons ; Drug Discovery
    Language English
    Publishing date 2023-11-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2108724-6
    ISSN 1689-1392 ; 1689-1392
    ISSN (online) 1689-1392
    ISSN 1689-1392
    DOI 10.1186/s11658-023-00504-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Recent advances in biosensors for real time monitoring of pH, temperature, and oxygen in chronic wounds.

    Youssef, Khaled / Ullah, Asad / Rezai, Pouya / Hasan, Anwarul / Amirfazli, Alidad

    Materials today. Bio

    2023  Volume 22, Page(s) 100764

    Abstract: Chronic wounds are among the major healthcare issues affecting millions of people worldwide with high rates of morbidity, losses of limbs and mortality. Microbial infection in wounds is a severe problem that can impede healing of chronic wounds. Accurate, ...

    Abstract Chronic wounds are among the major healthcare issues affecting millions of people worldwide with high rates of morbidity, losses of limbs and mortality. Microbial infection in wounds is a severe problem that can impede healing of chronic wounds. Accurate, timely and early detection of infections, and real time monitoring of various wound healing biomarkers related to infection can be significantly helpful in the treatment and care of chronic wounds. However, clinical methodologies of periodic assessment and care of wounds require physical visit to wound care clinics or hospitals and time-consuming frequent replacement of wound dressing patches, which also often adversely affect the healing process. Besides, frequent replacements of wound dressings are highly expensive, causing a huge amount of burden on the national health care systems. Smart bandages have emerged to provide
    Language English
    Publishing date 2023-08-19
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2590-0064
    ISSN (online) 2590-0064
    DOI 10.1016/j.mtbio.2023.100764
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Inter-library loan at ZB MED

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  8. Article: Cancer immunotherapy with immune checkpoint inhibitors (ICIs): potential, mechanisms of resistance, and strategies for reinvigorating T cell responsiveness when resistance is acquired.

    Marei, Hany E / Hasan, Anwarul / Pozzoli, Giacomo / Cenciarelli, Carlo

    Cancer cell international

    2023  Volume 23, Issue 1, Page(s) 64

    Abstract: Cancer is still the leading cause of death globally. The approval of the therapeutic use of monoclonal antibodies against immune checkpoint molecules, notably those that target the proteins PD-1 and PD-L1, has changed the landscape of cancer treatment. ... ...

    Abstract Cancer is still the leading cause of death globally. The approval of the therapeutic use of monoclonal antibodies against immune checkpoint molecules, notably those that target the proteins PD-1 and PD-L1, has changed the landscape of cancer treatment. In particular, first-line PD-1/PD-L1 inhibitor drugs are increasingly common for the treatment of metastatic cancer, significantly prolonging patient survival. Despite the benefits brought by immune checkpoint inhibitors (ICIs)-based therapy, the majority of patients had their diseases worsen following a promising initial response. To increase the effectiveness of ICIs and advance our understanding of the mechanisms causing cancer resistance, it is crucial to find new, effective, and tolerable combination treatments. In this article, we addressed the potential of ICIs for the treatment of solid tumors and offer some insight into the molecular pathways behind therapeutic resistance to ICIs. We also discuss cutting-edge therapeutic methods for reactivating T-cell responsiveness after resistance has been established.
    Language English
    Publishing date 2023-04-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2091573-1
    ISSN 1475-2867
    ISSN 1475-2867
    DOI 10.1186/s12935-023-02902-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: [No title information]

    Mahgoub, Elham Omer / Cho, William C / Sharifi, Majid / Falahati, Mojtaba / Zeinabad, Hojjat Alizadeh / Mare, Hany E / Hasan, Anwarul

    Heliyon

    2023  Volume 10, Issue 1, Page(s) e22095

    Title translation Role of functional genomics in identifying cancer drug resistance and overcoming cancer relapse.
    Language English
    Publishing date 2023-11-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e22095
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Potential of antibody-drug conjugates (ADCs) for cancer therapy.

    Marei, Hany E / Cenciarelli, Carlo / Hasan, Anwarul

    Cancer cell international

    2022  Volume 22, Issue 1, Page(s) 255

    Abstract: The primary purpose of ADCs is to increase the efficacy of anticancer medications by minimizing systemic drug distribution and targeting specific cells. Antibody conjugates (ADCs) have changed the way cancer is treated. However, because only a tiny ... ...

    Abstract The primary purpose of ADCs is to increase the efficacy of anticancer medications by minimizing systemic drug distribution and targeting specific cells. Antibody conjugates (ADCs) have changed the way cancer is treated. However, because only a tiny fraction of patients experienced long-term advantages, current cancer preclinical and clinical research has been focused on combination trials. The complex interaction of ADCs with the tumor and its microenvironment appear to be reliant on the efficacy of a certain ADC, all of which have significant therapeutic consequences. Several clinical trials in various tumor types are now underway to examine the potential ADC therapy, based on encouraging preclinical results. This review tackles the potential use of ADCs in cancer therapy, emphasizing the essential processes underlying their positive therapeutic impacts on solid and hematological malignancies. Additionally, opportunities are explored to understand the mechanisms of ADCs action, the mechanism of resistance against ADCs, and how to overcome potential resistance following ADCs administration. Recent clinical findings have aroused interest, leading to a large increase in the number of ADCs in clinical trials. The rationale behind ADCs, as well as their primary features and recent research breakthroughs, will be discussed. We then offer an approach for maximizing the potential value that ADCs can bring to cancer patients by highlighting key ideas and distinct strategies.
    Language English
    Publishing date 2022-08-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2091573-1
    ISSN 1475-2867
    ISSN 1475-2867
    DOI 10.1186/s12935-022-02679-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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