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Article: Seroprevalence of IgM/IgG and Neutralizing Antibodies against SARS-CoV-2 in Unvaccinated Young Adults from Mexico Who Reported Not Having Had a Previous COVID-19 Infection.

Padilla-Bórquez, Diana Lourdes / Matuz-Flores, Mónica Guadalupe / Hernández-Bello, Jorge / Sánchez-Zuno, Gabriela Athziri / García-Arellano, Samuel / Oregon-Romero, Edith / Herrera-Godina, Melva Guadalupe / González-Estevez, Guillermo / Adan-Bante, Norma Patricia / Rosas-Rodríguez, Jesús Alfredo / Muñoz-Valle, José Francisco

The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale

2024 Volume 2024, Page(s) 8871439

Abstract: Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus that causes coronavirus disease 2019 (COVID-19). It is estimated that more than half of new infections are transmitted by asymptomatic people; therefore, the isolation ...

Abstract	Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus that causes coronavirus disease 2019 (COVID-19). It is estimated that more than half of new infections are transmitted by asymptomatic people; therefore, the isolation of symptomatic people is not enough to control the spread of the disease. Methods: A total of 171 unvaccinated young adults (18-35 years) from Sonora, Mexico, who underwent a structured survey to identify prior COVID-19 infections, were included in this study. A qualitative determination of anti-SARS-CoV-2 antibodies in serum was performed by lateral flow immunoassay (Certum IgG/IgM Rapid Test™ cassette kit) and neutralizing antibodies were also determined (GenScript cPass assay). Results: A total of 36 people reported a history of COVID-19 infection, and 135 reported no history of COVID-19. In contrast, 49.6% (67/135) of individuals who had not reported a previous SARS-CoV-2 infection were seropositive to the rapid anti-SARS-CoV-2 antibody test, and 48.1% (65/135) of them had neutralizing antibodies. Conclusions: These results suggest that in young adults, SARS-CoV-2 infections could be asymptomatic in a high percentage of individuals, which could contribute in part to the slow control of the current pandemic due to the large number of asymptomatic cases that are contagious and that could be a silent spread of the virus.
Language	English
Publishing date	2024-02-14
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	1057056-1
ISSN	1712-9532 ; 1180-2332
ISSN	1712-9532 ; 1180-2332
DOI	10.1155/2024/8871439
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Article ; Online: Potential immunomodulatory effects of vitamin D in the prevention of severe coronavirus disease 2019: An ally for Latin America (Review).

Turrubiates-Hernández, Francisco Javier / Sánchez-Zuno, Gabriela Athziri / González-Estevez, Guillermo / Hernández-Bello, Jorge / Macedo-Ojeda, Gabriela / Muñoz-Valle, José Francisco

International journal of molecular medicine

2021 Volume 47, Issue 4

Abstract: Currently, the world is under a pandemic of severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2), responsible for coronavirus disease 2019 (COVID‑19). This disease is characterized by a respiratory syndrome that can progress to an acute ... ...

Abstract	Currently, the world is under a pandemic of severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2), responsible for coronavirus disease 2019 (COVID‑19). This disease is characterized by a respiratory syndrome that can progress to an acute respiratory distress syndrome. To date, limited effective therapies are available for the prevention or treatment of COVID‑19; therefore, it is necessary to propose novel treatment options with immunomodulatory effects. Vitamin D serves functions in bone health and has been recently reported to exert protective effects against respiratory infections. Observational studies have demonstrated an association between vitamin D deficiency and a poor prognosis of COVID‑19; this is alarming as vitamin D deficiency is a global health problem. In Latin America, the prevalence of vitamin D deficiency is unknown, and currently, this region is in the top 10 according to the number of confirmed COVID‑19 cases. Supplementation with vitamin D may be a useful adjunctive treatment for the prevention of COVID‑19 complications. The present review provides an overview of the current knowledge of the potential immunomodulatory effects of vitamin D in the prevention of COVID‑19 and sets out vitamin D recommendations for the Latin American population.
MeSH term(s)	Bone and Bones ; COVID-19/complications ; COVID-19/prevention & control ; Dietary Supplements ; Humans ; Immunologic Factors/therapeutic use ; Latin America ; Prevalence ; Renin-Angiotensin System ; Respiratory Tract Infections/virology ; Vitamin D/therapeutic use ; Vitamin D Deficiency/complications
Chemical Substances	Immunologic Factors ; Vitamin D (1406-16-2)
Language	English
Publishing date	2021-02-04
Publishing country	Greece
Document type	Journal Article ; Review
ZDB-ID	1444428-8
ISSN	1791-244X ; 1107-3756
ISSN (online)	1791-244X
ISSN	1107-3756
DOI	10.3892/ijmm.2021.4865
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Zs.A 4942: Show issues

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Article: Enfermedades reumáticas y alergias, la dualidad del sistema inmunológico.

Sánchez-Zuno, Gabriela Athziri / Oregón-Romero, Edith / Hernández-Bello, Jorge / González-Estevez, Guillermo / Vargas-Rosales, Rodrigo / Muñoz-Valle, José Francisco

Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)

2021 Volume 68, Issue 4, Page(s) 264–275

Abstract: Autoimmune rheumatic diseases are multisystemic disorders that mainly affect joints and muscles; some examples of these conditions are: rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and Sjögren's syndrome (SS). In general, autoimmune ... ...

Title translation	Rheumatic diseases and allergies, the duality of the immune system.
Abstract	Autoimmune rheumatic diseases are multisystemic disorders that mainly affect joints and muscles; some examples of these conditions are: rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and Sjögren's syndrome (SS). In general, autoimmune rheumatic diseases have a high prevalence worldwide and are highly disabling for those who have them. At present, one of the main limitations for the management of these diseases is that their triggering factor continues to be unknown in most cases and the knowledge of the factors associated with their exacerbation is limited. In this review, the possible link of allergies as a possible trigger for autoimmune rheumatic diseases will be explored. We will also analyze the basic and general aspects of both diseases and the development of allergic processes and hypersensitivity reactions to drugs used in the treatment of rheumatic diseases.
MeSH term(s)	Autoimmune Diseases/epidemiology ; Humans ; Hypersensitivity/epidemiology ; Hypersensitivity/etiology ; Immune System ; Rheumatic Diseases/epidemiology ; Sjogren's Syndrome/epidemiology
Language	Spanish
Publishing date	2021-12-14
Publishing country	Mexico
Document type	Journal Article ; Review
ZDB-ID	639125-4
ISSN	0002-5151
ISSN	0002-5151
DOI	10.29262/ram.v68i4.984
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Article ; Online: The Novel Role of MIF in the Secretion of IL-25, IL-31, and IL-33 from PBMC of Patients with Rheumatoid Arthritis.

García-Arellano, Samuel / Hernández-Palma, Luis Alexis / Cerpa-Cruz, Sergio / Sánchez-Zuno, Gabriela Athziri / Herrera-Godina, Melva Guadalupe / Muñoz-Valle, José Francisco

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 16

Abstract: Rheumatoid arthritis (RA) is an autoimmune inflammatory joint disease with complex pathogenesis associated with cytokine dysregulation. Macrophage migration inhibitory factor (MIF) plays a role in systemic inflammation and joint destruction in RA and ... ...

Abstract	Rheumatoid arthritis (RA) is an autoimmune inflammatory joint disease with complex pathogenesis associated with cytokine dysregulation. Macrophage migration inhibitory factor (MIF) plays a role in systemic inflammation and joint destruction in RA and could be associated with the secretion of other immune-modulatory cytokines such as IL-25, IL-31, and IL-33. For the above, our main aim was to evaluate the IL-25, IL-31, and IL-33 secretion from recombinant human MIF (rhMIF)-stimulated peripheral blood mononuclear cells (PBMC) of RA patients. The rhMIF and lipopolysaccharide (LPS) plus rhMIF stimuli promote the secretion of IL-25, IL-31, and IL-33 (
MeSH term(s)	Adult ; Arthritis, Rheumatoid/immunology ; Arthritis, Rheumatoid/metabolism ; Female ; Humans ; Immunomodulation/drug effects ; Interleukin-17/metabolism ; Interleukin-33/metabolism ; Interleukins/metabolism ; Intramolecular Oxidoreductases/metabolism ; Intramolecular Oxidoreductases/pharmacology ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/immunology ; Leukocytes, Mononuclear/metabolism ; Macrophage Migration-Inhibitory Factors/metabolism ; Macrophage Migration-Inhibitory Factors/pharmacology ; Male ; Middle Aged ; Recombinant Proteins/pharmacology
Chemical Substances	IL25 protein, human ; IL31 protein, human ; Interleukin-17 ; Interleukin-33 ; Interleukins ; Macrophage Migration-Inhibitory Factors ; Recombinant Proteins ; Intramolecular Oxidoreductases (EC 5.3.-) ; MIF protein, human (EC 5.3.2.1)
Language	English
Publishing date	2021-08-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26164968
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Article: Efficacy and Safety of Heterologous Booster Vaccination after Ad5-nCoV (CanSino Biologics) Vaccine: A Preliminary Descriptive Study.

Muñoz-Valle, José Francisco / Sánchez-Zuno, Gabriela Athziri / Matuz-Flores, Mónica Guadalupe / Hernández-Ramírez, Cristian Oswaldo / Díaz-Pérez, Saúl Alberto / Baños-Hernández, Christian Johana / Turrubiates-Hernández, Francisco Javier / Vega-Magaña, Alejandra Natali / Hernández-Bello, Jorge

Vaccines

2022 Volume 10, Issue 3

Abstract: Several studies have reported the benefits and safety of heterologous vaccination among different approved vaccines; however, there are no specific reports on the effects of vaccination with the Ad5-nCoV and other vaccines of the same or different ... ...

Abstract	Several studies have reported the benefits and safety of heterologous vaccination among different approved vaccines; however, there are no specific reports on the effects of vaccination with the Ad5-nCoV and other vaccines of the same or different technologies. In the present study, we evaluated the neutralizing antibodies percentage against SARS-CoV-2 in Mexican patients immunized with the Ad5-nCoV vaccine six months after its application. Moreover, the effect of the heterologous vaccination with the Ad5-nCoV vaccine and a booster dose of ChAdOx1-S-Nov-19, Ad26.COV2.S, BNT162b2, or mRNA-127 were determined. Our results suggest that a heterologous regimen of one dose with Ad5-nCoV vaccine followed by a booster dose of a different vaccine is safe and induces a stronger humoral immune response.
Language	English
Publishing date	2022-03-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines10030400
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Article ; Online: ICOS

García-Espinoza, José Antonio / Muñoz-Valle, José Francisco / García-Chagollán, Mariel / Hernández-Bello, Jorge / Palafox-Sánchez, Claudia Azucena / López-Villalobos, Erika Fabiola / Sánchez-Zuno, Gabriela Athziri / Martínez-Bonilla, Gloria Esther / Cerpa-Cruz, Sergio / Carrillo-Ballesteros, Francisco Josue / Oregon-Romero, Edith

Current issues in molecular biology

2022 Volume 44, Issue 2, Page(s) 764–776

Abstract: Background: Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease, which affects exocrine glands. T cell activation is a trigger mechanism in the immune response. Hyperreactivity of T cells and antibody production are features in pSS. ICOS ... ...

Abstract	Background: Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease, which affects exocrine glands. T cell activation is a trigger mechanism in the immune response. Hyperreactivity of T cells and antibody production are features in pSS. ICOS can be critical in the pathogenesis of pSS. Methods: A total of 134 pSS patients and 134 control subjects (CS) were included. Genotyping was performed by PCR-RFLP. ICOS mRNA expression was quantified by real-time PCR, and CD4+ ICOS+ T cells were determined by flow cytometry. Results: The ICOS IVS1 + 173 T>C polymorphisms were not associated with susceptibility to pSS (p = 0.393, CI = 0.503−1.311). However, the c.1624 C>T polymorphism was associated with a reduction in the risk of development of pSS (p = 0.015, CI = 0.294−0.884). An increase in ICOS mRNA expression in patients was observed (3.7-fold). Furthermore, pSS patients showed an increase in membranal-ICOS expression (mICOS). High expression of mICOS (MFI) was associated with lymphocytic infiltration. Conclusions: The IVS1 + 173 polymorphism is not a genetic marker for the development of pSS, while c.1624 T allele was associated with a low risk. However, elevated mICOS expression in pSS patients with high lymphocytic infiltration was found. ICOS may have an important role in the immunopathogenesis of pSS and should be analyzed in T cell subsets in pSS patients as a possible disease marker.
Language	English
Publishing date	2022-02-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2000024-8
ISSN	1467-3045 ; 1467-3037
ISSN (online)	1467-3045
ISSN	1467-3037
DOI	10.3390/cimb44020053
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Article ; Online: A review: Antibody-dependent enhancement in COVID-19: The not so friendly side of antibodies.

Sánchez-Zuno, Gabriela Athziri / Matuz-Flores, Mónica Guadalupe / González-Estevez, Guillermo / Nicoletti, Ferdinando / Turrubiates-Hernández, Francisco Javier / Mangano, Katia / Muñoz-Valle, José Francisco

International journal of immunopathology and pharmacology

2021 Volume 35, Page(s) 20587384211050199

Abstract: The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represents an unprecedented global public health emergency with economic and social consequences. One of the main concerns in the ... ...

Abstract	The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represents an unprecedented global public health emergency with economic and social consequences. One of the main concerns in the development of vaccines is the antibody-dependent enhancement phenomenon, better known as ADE. In this review, we provide an overview of SARS-CoV-2 infection as well as the immune response generated by the host. On the bases of this principle, we also describe what is known about the ADE phenomenon in various viral infections and its possible role as a limiting factor in the development of new vaccines and therapeutic strategies.
MeSH term(s)	Adaptive Immunity ; Antibodies, Viral/immunology ; Antibody-Dependent Enhancement ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19/virology ; COVID-19 Vaccines/therapeutic use ; Host-Pathogen Interactions ; Humans ; Immunity, Innate ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; Vaccination
Chemical Substances	Antibodies, Viral ; COVID-19 Vaccines
Language	English
Publishing date	2021-10-10
Publishing country	England
Document type	Letter ; Review
ZDB-ID	645171-8
ISSN	2058-7384 ; 0394-6320
ISSN (online)	2058-7384
ISSN	0394-6320
DOI	10.1177/20587384211050199
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Article ; Online: Steroid Resistance Associated with High MIF and P-gp Serum Levels in SLE Patients.

Beltrán-Ramírez, Alberto / Muñoz-Valle, José Francisco / Gamez-Nava, Jorge I / Saldaña-Cruz, Ana Miriam / Gonzalez-Lopez, Laura / Padilla-Ortega, Alejandro / Arias-García, Francisco I / Sánchez-Zuno, Gabriela Athziri / Nava-Valdivia, Cesar Arturo / Ponce-Guarneros, Juan Manuel / García-Galindo, Jesús Jonathan / Perez-Guerrero, Edsaúl Emilio

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 19

Abstract: Approximately 30% of patients with systemic lupus erythematosus (SLE) present steroid resistance (SR). Macrophage migration inhibition factor (MIF) and P-glycoprotein (P-gp) could be related to SR. This work aims to evaluate the relationship between MIF ... ...

Abstract	Approximately 30% of patients with systemic lupus erythematosus (SLE) present steroid resistance (SR). Macrophage migration inhibition factor (MIF) and P-glycoprotein (P-gp) could be related to SR. This work aims to evaluate the relationship between MIF and P-pg serum levels in SR in SLE. Methods: Case−control study including 188 SLE patients who were divided into two groups (90 in the steroid-resistant group and 98 in the steroid-sensitive (SS) group) and 35 healthy controls. MIF and P-gp serum levels were determined by ELISA. Multivariable logistic regression and chi-squared automatic interaction detection (CHAID) were used to explore risk factors for SR. Results: The steroid-resistant group presented higher MIF and P-gp serum levels in comparison with the SS (p < 0.001) and reference (p < 0.001) groups. MIF correlated positively with P-gp (rho = 0.41, p < 0.001). MIF (≥15.75 ng/mL) and P-gp (≥15.22 ng/mL) were a risk factor for SR (OR = 2.29, OR = 5.27). CHAID identified high P-gp as the main risk factor for SR and high MIF as the second risk factor in those patients with low P-gp. Conclusions: An association between MIF and P-gp serum levels was observed in SR. CHAID identified P-gp ≥ 15.22 ng/mL as the main risk factor for SR. More studies are needed to validate these results.
MeSH term(s)	ATP Binding Cassette Transporter, Subfamily B, Member 1 ; Case-Control Studies ; Humans ; Intramolecular Oxidoreductases ; Lupus Erythematosus, Systemic/drug therapy ; Macrophage Migration-Inhibitory Factors/metabolism ; Steroids
Chemical Substances	ATP Binding Cassette Transporter, Subfamily B, Member 1 ; Macrophage Migration-Inhibitory Factors ; Steroids ; Intramolecular Oxidoreductases (EC 5.3.-) ; MIF protein, human (EC 5.3.2.1)
Language	English
Publishing date	2022-10-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27196741
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Article ; Online: Association of Food Intake Quality with Vitamin D in SARS-CoV-2 Positive Patients from Mexico: A Cross-Sectional Study.

González-Estevez, Guillermo / Turrubiates-Hernández, Francisco Javier / Herrera-Jiménez, Laura Elena / Sánchez-Zuno, Gabriela Athziri / Herrera-Godina, Melva Guadalupe / Muñoz-Valle, José Francisco

International journal of environmental research and public health

2021 Volume 18, Issue 14

Abstract: One of the micronutrients that has attracted the most attention in relation to COVID-19 is vitamin D. Although several factors affect its sufficiency; it has been argued that an optimal diet can ensure the intake of micronutrients with effects on immune ... ...

Abstract	One of the micronutrients that has attracted the most attention in relation to COVID-19 is vitamin D. Although several factors affect its sufficiency; it has been argued that an optimal diet can ensure the intake of micronutrients with effects on immune response. Therefore, in this work we aimed to evaluate the food intake quality of SARS-CoV-2 positive Mexican patients and some of the common factors related to vitamin D deficiency. We conducted a cross-sectional study in 40 SARS-CoV-2 positive patients. Serum samples and clinical parameters were collected. Micronutrient intake and food intake quality were assessed with a 24-h dietary recall and the Mini-ECCA v.2, respectively. Thirty-eight percent of the sample had a healthy food intake. The median 25(OH)D concentration was 22.7 ng/mL. A considerable insufficient intake of micronutrients with immunomodulatory effects such as vitamin D (
MeSH term(s)	COVID-19 ; Cross-Sectional Studies ; Eating ; Humans ; Mexico/epidemiology ; Micronutrients ; SARS-CoV-2 ; Vitamin D ; Vitamin D Deficiency
Chemical Substances	Micronutrients ; Vitamin D (1406-16-2)
Language	English
Publishing date	2021-07-07
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph18147266
Database	MEDical Literature Analysis and Retrieval System OnLINE

2022 Volume 44, Issue 9, Page(s) 4268–4281

Abstract: Citrullination is catalyzed by the peptidyl arginine deiminase 4 (PAD4) enzyme, encoded by the PADI4 gene. Increased PAD4 activity promotes the onset and progression of rheumatoid arthritis (RA). This study aimed to evaluate the association of PADI4 ... ...

Abstract	Citrullination is catalyzed by the peptidyl arginine deiminase 4 (PAD4) enzyme, encoded by the PADI4 gene. Increased PAD4 activity promotes the onset and progression of rheumatoid arthritis (RA). This study aimed to evaluate the association of PADI4 haplotypes with RA risk, mRNA expression, and the PAD4 activity in patients with RA from Mexico. Methodology: 100 RA patients and 100 control subjects (CS) were included. Genotyping was performed by PCR-RFLP method, PADI4 mRNA expression was quantified by real-time PCR, the contribution of PADI4 alleles (PADI4_89 G>A, PADI4_90 T>C, and PADI4_92 G>C) to mRNA expression by the ASTQ method, and PAD4 activity by HPLC. Also, the anti-CCP and anti-PADI4 antibodies were quantified by ELISA. Results: The three PADI4 polymorphisms were associated with RA susceptibility (OR = 1.72, p = 0.005; OR = 1.62; p = 0.014; OR = 1.69; p = 0.009; respectively). The 89G, 90T, and 92G alleles have a higher relative contribution to PADI4 mRNA expression from RA patients than 89A, 90C, and 92C alleles in RA patients. Moreover, the GTG/GTG haplotype was associated with RA susceptibility (OR = 2.86; p = 0.024). The GTG haplotype was associated with higher PADI4 mRNA expression (p = 0.04) and higher PAD4 enzymatic activity (p = 0.007) in RA patients. Conclusions: The evaluated polymorphisms contribute to PADI4 mRNA expression and the enzymatic activity of PAD4 in leukocytes. Therefore, the GTG haplotype is a genetic risk factor for RA in western Mexico, and is associated with increased PADI4 mRNA expression and higher PAD4 activity in these patients.
Language	English
Publishing date	2022-09-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2000024-8
ISSN	1467-3045 ; 1467-3037
ISSN (online)	1467-3045
ISSN	1467-3037
DOI	10.3390/cimb44090293
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