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  1. Article ; Online: Erythropoietin-producing cells in the kidney: Novel insights in their long-term fate during hypoxaemia and renal tissue remodelling.

    Scholz, Holger

    Acta physiologica (Oxford, England)

    2022  Volume 234, Issue 3, Page(s) e13786

    MeSH term(s) Animals ; Erythropoietin ; Hypoxia ; Kidney ; Mice
    Chemical Substances Erythropoietin (11096-26-7)
    Language English
    Publishing date 2022-01-19
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2218636-0
    ISSN 1748-1716 ; 1748-1708
    ISSN (online) 1748-1716
    ISSN 1748-1708
    DOI 10.1111/apha.13786
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs 229: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: WT1 in Adipose Tissue: From Development to Adult Physiology.

    Kirschner, Karin M / Scholz, Holger

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 854120

    Abstract: Much of the fascination of the Wilms tumor protein (WT1) emanates from its unique roles in development and disease. ... ...

    Abstract Much of the fascination of the Wilms tumor protein (WT1) emanates from its unique roles in development and disease. Ubiquitous
    Language English
    Publishing date 2022-03-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.854120
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  3. Article: Editorial: Pathogenomics of the genus

    Cloeckaert, Axel / Roop, R Martin / Scholz, Holger C / Whatmore, Adrian M / Zygmunt, Michel S

    Frontiers in microbiology

    2024  Volume 15, Page(s) 1370330

    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2024.1370330
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  4. Book ; Thesis: "Einfluß mechanischer Stimulation des Knochengewebes auf die Serumkonzentration verschiedener Parameter des Knochenumbaus in vivo"

    Scholz, Holger

    2000  

    Author's details vorgelegt von Holger Scholz
    Keywords Knochen ; Mechanische Beanspruchung ; Marker ; Knochenumbau
    Subject Knochentransformation ; Markierungssubstanz ; Bone ; Bones ; Os ; Knochengewebe
    Language German
    Size 77 Bl. : graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Münster (Westfalen), Univ., Diss., 2000
    HBZ-ID HT013263390
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2002 MB 845 order for loan Magazin

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  5. Article ; Online: WT1 in Adipose Tissue

    Karin M. Kirschner / Holger Scholz

    Frontiers in Cell and Developmental Biology, Vol

    From Development to Adult Physiology

    2022  Volume 10

    Abstract: Much of the fascination of the Wilms tumor protein (WT1) emanates from its unique roles in development and disease. Ubiquitous Wt1 deletion in adult mice causes multiple organ failure including a reduction of body fat. WT1 is expressed in fat cell ... ...

    Abstract Much of the fascination of the Wilms tumor protein (WT1) emanates from its unique roles in development and disease. Ubiquitous Wt1 deletion in adult mice causes multiple organ failure including a reduction of body fat. WT1 is expressed in fat cell progenitors in visceral white adipose tissue (WAT) but detected neither in energy storing subcutaneous WAT nor in heat producing brown adipose tissue (BAT). Our recent findings indicate that WT1 represses thermogenic genes and maintains the white adipose identity of visceral fat. Wt1 heterozygosity in mice is associated with molecular and morphological signs of browning including elevated levels of uncoupling protein 1 (UCP1) in epididymal WAT. Compared to their wild-type littermates, Wt1 heterozygous mice exhibit significantly improved whole-body glucose tolerance and alleviated hepatic steatosis under high-fat diet. Partial protection of heterozygous Wt1 knockout mice against metabolic dysfunction is presumably related to browning of their epididymal WAT. In the light of recent advancements, this article reviews the role of WT1 in the development of visceral WAT and its supposed function as a regulator of white adipose identity.
    Keywords white adipocyte ; brown adipocyte differentiation ; thermogenesis ; uncoupling protein (UCP) ; WAT browning ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Virulence and resistance patterns of

    Schmidt, Katarzyna / Scholz, Holger C / Appelt, Sandra / Michel, Jana / Jacob, Daniela / Dupke, Susann

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1282135

    Abstract: Global warming has caused an increase in the emergence ... ...

    Abstract Global warming has caused an increase in the emergence of
    Language English
    Publishing date 2023-11-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1282135
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  7. Book ; Collection: Bikablo

    Scholz, Holger / Haussmann, Martin

    2006  

    Institution Kommunikationslotsen Scholz & Vesper GmbH & Co. KG
    bikablo® akademie GmbH & Co.KG
    Author's details [Vorw. Holger Scholz .... Text, Gestaltung und Ill.: Martin Haußmann. Kommunikationslotsen]
    Language German ; English
    Dates of publication 2006-9999
    Publisher Neuland
    Publishing place Eichenzell
    Publishing country Germany
    Document type Book ; Collection (display volumes)
    Note Teilw. mit Erscheinungsvermerk Köln, Bikablo-Akademie ; Bikablo = Bilder-Karten-Block
    HBZ-ID HT016850707
    Database Catalogue ZB MED Medicine, Health

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  8. Article ; Online: On the Parametrization of Epidemiologic Models-Lessons from Modelling COVID-19 Epidemic.

    Kheifetz, Yuri / Kirsten, Holger / Scholz, Markus

    Viruses

    2022  Volume 14, Issue 7

    Abstract: Numerous prediction models of SARS-CoV-2 pandemic were proposed in the past. Unknown parameters of these models are often estimated based on observational data. However, lag in case-reporting, changing testing policy or incompleteness of data lead to ... ...

    Abstract Numerous prediction models of SARS-CoV-2 pandemic were proposed in the past. Unknown parameters of these models are often estimated based on observational data. However, lag in case-reporting, changing testing policy or incompleteness of data lead to biased estimates. Moreover, parametrization is time-dependent due to changing age-structures, emerging virus variants, non-pharmaceutical interventions, and vaccination programs. To cover these aspects, we propose a principled approach to parametrize a SIR-type epidemiologic model by embedding it as a hidden layer into an input-output non-linear dynamical system (IO-NLDS). Observable data are coupled to hidden states of the model by appropriate data models considering possible biases of the data. This includes data issues such as known delays or biases in reporting. We estimate model parameters including their time-dependence by a Bayesian knowledge synthesis process considering parameter ranges derived from external studies as prior information. We applied this approach on a specific SIR-type model and data of Germany and Saxony demonstrating good prediction performances. Our approach can estimate and compare the relative effectiveness of non-pharmaceutical interventions and provide scenarios of the future course of the epidemic under specified conditions. It can be translated to other data sets, i.e., other countries and other SIR-type models.
    MeSH term(s) Bayes Theorem ; COVID-19/epidemiology ; COVID-19/prevention & control ; Forecasting ; Humans ; Pandemics/prevention & control ; SARS-CoV-2
    Language English
    Publishing date 2022-07-02
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14071468
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  9. Article ; Online: Bacterial Chaperone Domain Insertions Convert Human FKBP12 into an Excellent Protein-Folding Catalyst-A Structural and Functional Analysis.

    Žoldák, Gabriel / Knappe, Thomas A / Geitner, Anne-Juliane / Scholz, Christian / Dobbek, Holger / Schmid, Franz X / Jakob, Roman P

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 7

    Abstract: Many folding enzymes use separate domains for the binding of substrate proteins and for the catalysis of slow folding reactions such as prolyl isomerization. FKBP12 is a small prolyl isomerase without a chaperone domain. Its folding activity is low, but ... ...

    Abstract Many folding enzymes use separate domains for the binding of substrate proteins and for the catalysis of slow folding reactions such as prolyl isomerization. FKBP12 is a small prolyl isomerase without a chaperone domain. Its folding activity is low, but it could be increased by inserting the chaperone domain from the homolog SlyD of
    MeSH term(s) Humans ; Tacrolimus Binding Protein 1A ; Escherichia coli/genetics ; Molecular Chaperones ; Peptidylprolyl Isomerase/genetics ; Catalysis ; Escherichia coli Proteins
    Chemical Substances Tacrolimus Binding Protein 1A (EC 5.2.1.-) ; Molecular Chaperones ; Peptidylprolyl Isomerase (EC 5.2.1.8) ; SlyD protein, E coli ; Escherichia coli Proteins
    Language English
    Publishing date 2024-03-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29071440
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  10. Article: Analysis of Sporulation in

    Gummelt, Constanze / Dupke, Susann / Howaldt, Sabine / Zimmermann, Fee / Scholz, Holger C / Laue, Michael / Klee, Silke R

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 12

    Abstract: ... Bacillus ... ...

    Abstract Bacillus cereus
    Language English
    Publishing date 2023-12-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12121442
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