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Article ; Online: American Academy of Orthopaedic Surgeons Clinical Practice Guideline Case Study: Management of Anterior Cruciate Ligament Injuries.

Brophy, Robert H / Silverman, Richard M / Lowry, Kent Jason

The Journal of the American Academy of Orthopaedic Surgeons

2023 Volume 31, Issue 11, Page(s) 538–548

Abstract: Considering the frequency of anterior cruciate ligament (ACL) tears, optimal management of these injuries was the subject of a 2022 clinical practice guideline update from The American Academy of Orthopaedic Surgeons (AAOS) with input from ... ...

Abstract	Considering the frequency of anterior cruciate ligament (ACL) tears, optimal management of these injuries was the subject of a 2022 clinical practice guideline update from The American Academy of Orthopaedic Surgeons (AAOS) with input from representatives from the American Orthopaedic Society for Sports Medicine, the Pediatric Orthopaedic Society of North America, the American Orthopaedic Society for Sports Medicine, the American Medical Society for Sports Medicine, the American Academy of Physical Medicine and Rehabilitation, and the American College of Emergency Physicians. The eight recommendations and seven options to guide orthopaedic surgeons and other physicians managing patients with these anterior cruciate ligament injuries are based on the best current available evidence. The cases presented in this article are examples designed to demonstrate the clinical application of these guidelines.
MeSH term(s)	Child ; Humans ; United States ; Anterior Cruciate Ligament Injuries/surgery ; Orthopedic Surgeons ; Sports Medicine ; Orthopedics ; Physicians
Language	English
Publishing date	2023-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200524-1
ISSN	1940-5480 ; 1067-151X
ISSN (online)	1940-5480
ISSN	1067-151X
DOI	10.5435/JAAOS-D-23-00088
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Article ; Online: The 11+ injury prevention programme decreases rate of hamstring strain injuries in male collegiate soccer players.

Silvers-Granelli, Holly / Silverman, Richard / Bizzini, Mario / Thorborg, Kristian / Brophy, Robert H

British journal of sports medicine

2024

Abstract: Objectives: To investigate if the 11+ injury prevention programme decreases the risk of hamstring injury and improves recovery time and determine whether compliance with the 11+ affects hamstring injury risk.: Methods: This study is a secondary ... ...

Abstract	Objectives: To investigate if the 11+ injury prevention programme decreases the risk of hamstring injury and improves recovery time and determine whether compliance with the 11+ affects hamstring injury risk. Methods: This study is a secondary analysis from a prospective cluster randomised controlled trial that included 65 National Collegiate Athletic Association (NCAA) division I and II men's soccer teams over the fall 2012 season. Thirty-one teams were randomised to the intervention group that were using the 11+ as their warm-up and 35 teams to the control group that continued to use their traditional warm-up. Each certified athletic trainer (ATC) collected data on demographics, hamstring injury (HSI), mechanism of injury, position, playing surface, time lost due to injury and compliance to the 11+ programme. Results: The 11+ decreased the risk of HSI by 63% compared with the control group (RR=0.37, 95% CI 0.21 to 0.63). Difference in return to play after HSI between the control (9.4±11.2 days) and intervention groups (10.2±11.3 days) was not significant (p=0.8). High compliance (>2 or more doses on average per week) reduced the risk of HSI by 78% (RR=0.22, 95% CI 0.06 to 0.87) compared with low compliance (<1 dose on average per week), and moderate compliance (1 to <2 doses on average per week) decreased the risk of HSI by 67% (RR=0.33, 95% CI 0.11 to 0.97) compared with low compliance. There was no significant difference between high and moderate compliance. Conclusion: The 11+ decreased the risk of HSI by 63% but did not improve recovery time. High to moderate compliance is essential and makes the programme more effective at reducing HSI.
Language	English
Publishing date	2024-04-10
Publishing country	England
Document type	Journal Article
ZDB-ID	600592-5
ISSN	1473-0480 ; 0306-3674
ISSN (online)	1473-0480
ISSN	0306-3674
DOI	10.1136/bjsports-2023-107323
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Article ; Online: COVID-19: Coronavirus replication, pathogenesis, and therapeutic strategies.

Bergmann, Cornelia C / Silverman, Robert H

Cleveland Clinic journal of medicine

2020 Volume 87, Issue 6, Page(s) 321–327

MeSH term(s)	Animals ; Betacoronavirus/genetics ; Betacoronavirus/immunology ; Betacoronavirus/pathogenicity ; Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/therapy ; Coronavirus Infections/virology ; Disease Reservoirs/virology ; Disease Transmission, Infectious ; Host Microbial Interactions/physiology ; Humans ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/therapy ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Virus Replication/physiology ; Zoonoses/etiology ; Zoonoses/virology
Keywords	covid19
Language	English
Publishing date	2020-05-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	639116-3
ISSN	1939-2869 ; 0891-1150
ISSN (online)	1939-2869
ISSN	0891-1150
DOI	10.3949/ccjm.87a.20047
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Article: Initiation of a ZAKα-dependent Ribotoxic Stress Response by the Innate Immunity Endoribonuclease RNase L.

Xi, Jiajia / Snieckute, Goda / Asthana, Abhishek / Gaughan, Christina / Bekker-Jensen, Simon / Silverman, Robert H

bioRxiv : the preprint server for biology

2023

Abstract: RNase L is a regulated endoribonuclease in higher vertebrates that functions in antiviral innate immunity. Interferons induce OAS enzymes that sense double-stranded RNA of viral origin leading to synthesis of 2',5'-oligoadenylate (2-5A) activators of ... ...

Abstract	RNase L is a regulated endoribonuclease in higher vertebrates that functions in antiviral innate immunity. Interferons induce OAS enzymes that sense double-stranded RNA of viral origin leading to synthesis of 2',5'-oligoadenylate (2-5A) activators of RNase L. However, it is unknown precisely how RNase L inhibits viral infections. To isolate effects of RNase L from other effects of double-stranded RNA or virus, 2-5A was directly introduced into cells. Here we report that RNase L activation by 2-5A causes a ribotoxic stress response that requires the ribosome-associated MAP3K, ZAKα. Subsequently, the stress-activated protein kinases (SAPK) JNK and p38α are phosphorylated. RNase L activation profoundly altered the transcriptome by widespread depletion of mRNAs associated with different cellular functions, but also by SAPK-dependent induction of inflammatory genes. Our findings show that 2-5A is a ribotoxic stressor that causes RNA damage through RNase L triggering a ZAKα kinase cascade leading to proinflammatory signaling and apoptosis.
Language	English
Publishing date	2023-10-12
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.10.12.562082
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Caps off to poxviruses.

Silverman, Robert H

Cell host & microbe

2015 Volume 17, Issue 3, Page(s) 287–289

Abstract: In this issue of Cell Host & Microbe, Liu et al. (2015) and Burgess and Mohr (2015) describe how two poxvirus mRNA decapping enzymes hijack a host 5'-to-3'-exoribonuclease to evade antiviral innate immunity by limiting accumulation of double-stranded RNA. ...

Abstract	In this issue of Cell Host & Microbe, Liu et al. (2015) and Burgess and Mohr (2015) describe how two poxvirus mRNA decapping enzymes hijack a host 5'-to-3'-exoribonuclease to evade antiviral innate immunity by limiting accumulation of double-stranded RNA.
MeSH term(s)	Animals ; Endoribonucleases/metabolism ; Exoribonucleases/metabolism ; Host-Pathogen Interactions ; Humans ; Immunity, Innate ; Microtubule-Associated Proteins/metabolism ; RNA, Double-Stranded/metabolism ; Vaccinia virus/enzymology ; Vaccinia virus/immunology ; Vaccinia virus/physiology ; Virus Replication
Chemical Substances	Microtubule-Associated Proteins ; RNA, Double-Stranded ; Endoribonucleases (EC 3.1.-) ; Exoribonucleases (EC 3.1.-)
Language	English
Publishing date	2015-02-27
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2278004-X
ISSN	1934-6069 ; 1931-3128
ISSN (online)	1934-6069
ISSN	1931-3128
DOI	10.1016/j.chom.2015.02.013
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Zs.A 6578: Show issues

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Article: COVID-19: Coronavirus replication, pathogenesis, and therapeutic strategies

Bergmann, Cornelia C / Silverman, Robert H

Cleve Clin J Med

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #193516
Database	COVID19

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Article ; Online: Initiation of a ZAKα-dependent ribotoxic stress response by the innate immunity endoribonuclease RNase L.

Xi, Jiajia / Snieckute, Goda / Martínez, José Francisco / Arendrup, Frederic Schrøder Wenzel / Asthana, Abhishek / Gaughan, Christina / Lund, Anders H / Bekker-Jensen, Simon / Silverman, Robert H

Cell reports

2024 Volume 43, Issue 4, Page(s) 113998

Abstract: RNase L is an endoribonuclease of higher vertebrates that functions in antiviral innate immunity. Interferons induce oligoadenylate synthetase enzymes that sense double-stranded RNA of viral origin leading to the synthesis of 2',5'-oligoadenylate (2-5A) ... ...

Abstract	RNase L is an endoribonuclease of higher vertebrates that functions in antiviral innate immunity. Interferons induce oligoadenylate synthetase enzymes that sense double-stranded RNA of viral origin leading to the synthesis of 2',5'-oligoadenylate (2-5A) activators of RNase L. However, it is unknown precisely how RNase L remodels the host cell transcriptome. To isolate effects of RNase L from other effects of double-stranded RNA or virus, 2-5A is directly introduced into cells. Here, we report that RNase L activation by 2-5A causes a ribotoxic stress response involving the MAP kinase kinase kinase (MAP3K) ZAKα, MAP2Ks, and the stress-activated protein kinases JNK and p38α. RNase L activation profoundly alters the transcriptome by widespread depletion of mRNAs associated with different cellular functions but also by JNK/p38α-stimulated induction of inflammatory genes. These results show that the 2-5A/RNase L system triggers a protein kinase cascade leading to proinflammatory signaling and apoptosis.
MeSH term(s)	Endoribonucleases/metabolism ; Endoribonucleases/genetics ; Immunity, Innate ; Humans ; Adenine Nucleotides/metabolism ; Oligoribonucleotides/metabolism ; Animals ; Stress, Physiological ; Transcriptome/genetics ; RNA, Double-Stranded/metabolism
Chemical Substances	Endoribonucleases (EC 3.1.-) ; 2-5A-dependent ribonuclease (EC 3.1.26.-) ; 2',5'-oligoadenylate (61172-40-5) ; Adenine Nucleotides ; Oligoribonucleotides ; RNA, Double-Stranded
Language	English
Publishing date	2024-03-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2024.113998
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Article ; Online: Hepatitis C and HIV detection by blood RNA-sequencing in cohort of smokers.

Morrow, Jarrett D / Castaldi, Peter J / Chase, Robert P / Yun, Jeong H / Kinney, Gregory L / Silverman, Edwin K / Hersh, Craig P

Scientific reports

2023 Volume 13, Issue 1, Page(s) 1357

Abstract: Detection of viruses by RNA and DNA sequencing has improved the understanding of the human virome. We sought to identify blood viral signatures through secondary use of RNA-sequencing (RNA-seq) data in a large study cohort. The ability to reveal ... ...

Abstract	Detection of viruses by RNA and DNA sequencing has improved the understanding of the human virome. We sought to identify blood viral signatures through secondary use of RNA-sequencing (RNA-seq) data in a large study cohort. The ability to reveal undiagnosed infections with public health implications among study subjects with available sequencing data could enable epidemiologic surveys and may lead to diagnosis and therapeutic interventions, leveraging existing research data in a clinical context. We detected viral RNA in peripheral blood RNA-seq data from a COPD-enriched population of current and former smokers. Correlation between viral detection and both reported infections and relevant disease outcomes was evaluated. We identified Hepatitis C virus RNA in 228 subjects and HIV RNA in 30 subjects. Overall, we observed 31 viral species, including Epstein-Barr virus and Cytomegalovirus. We observed an enrichment of Hepatitis C and HIV infections among subjects reporting liver disease and HIV infections, respectively. Higher interferon expression scores were observed in the subjects with Hepatitis C and HIV infections. Through secondary use of RNA-seq from a cohort of current and former smokers, we detected peripheral blood viral signatures. We identified HIV and Hepatitis C virus (HCV), highlighting potential public health implications for the approach described this study. We observed correlations with reported infections, chronic infection outcomes and the host transcriptomic response, providing evidence to support the validity of the approach.
MeSH term(s)	Humans ; Hepacivirus/genetics ; HIV Infections/diagnosis ; HIV Infections/genetics ; HIV Infections/complications ; Epstein-Barr Virus Infections/complications ; Smokers ; Herpesvirus 4, Human/genetics ; Hepatitis C/diagnosis ; Hepatitis C/genetics ; Hepatitis C/complications ; RNA ; RNA, Viral/genetics
Chemical Substances	RNA (63231-63-0) ; RNA, Viral
Language	English
Publishing date	2023-01-24
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-28156-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Joint clinical and molecular subtyping of COPD with variational autoencoders.

Maiorino, Enrico / De Marzio, Margherita / Xu, Zhonghui / Yun, Jeong H / Chase, Robert P / Hersh, Craig P / Weiss, Scott T / Silverman, Edwin K / Castaldi, Peter J / Glass, Kimberly

medRxiv : the preprint server for health sciences

2024

Abstract: Chronic Obstructive Pulmonary Disease (COPD) is a complex, heterogeneous disease. Traditional subtyping methods generally focus on either the clinical manifestations or the molecular endotypes of the disease, resulting in classifications that do not ... ...

Abstract	Chronic Obstructive Pulmonary Disease (COPD) is a complex, heterogeneous disease. Traditional subtyping methods generally focus on either the clinical manifestations or the molecular endotypes of the disease, resulting in classifications that do not fully capture the disease's complexity. Here, we bridge this gap by introducing a subtyping pipeline that integrates clinical and gene expression data with variational autoencoders. We apply this methodology to the COPDGene study, a large study of current and former smoking individuals with and without COPD. Our approach generates a set of vector embeddings, called Personalized Integrated Profiles (PIPs), that recapitulate the joint clinical and molecular state of the subjects in the study. Prediction experiments show that the PIPs have a predictive accuracy comparable to or better than other embedding approaches. Using trajectory learning approaches, we analyze the main trajectories of variation in the PIP space and identify five well-separated subtypes with distinct clinical phenotypes, expression signatures, and disease outcomes. Notably, these subtypes are more robust to data resampling compared to those identified using traditional clustering approaches. Overall, our findings provide new avenues to establish fine-grained associations between the clinical characteristics, molecular processes, and disease outcomes of COPD.
Language	English
Publishing date	2024-01-10
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.08.19.23294298
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Article ; Online: Canadian Rheumatology Association Meeting Fairmont The Queen Elizabeth Montreal, Quebec, Canada February - March 2, 2019.

Silverman, Earl D

The Journal of rheumatology

2019

Abstract: ... its Mimics; Dunlop-Dottridge Lecture by Gilles Boire: The 4-H of Biomarkers in Arthritis: A lot of Help ... Comorbidities in RA - Coexisting or Complications; State of the Art Lecture by Mark Roberts: Myositis and ...

Abstract	The 73rd Annual Meeting of The Canadian Rheumatology Association was held at the Fairmont The Queen Elizabeth, Montreal, Quebec, Canada February 27 - March 2, 2019. The program consisted of presentations covering original research, symposia, awards, and lectures. Highlights of the meeting include the following 2019 Award Winners: Distinguished Rheumatologist, Edward Keystone; Distinguished Investigator, Diane Lacaille; Teacher-Educator, Shirley Tse; Emerging Investigator, Glen Hazlewood; Best Abstract on SLE Research by a Trainee - Ian Watson Award, Alexandra Legge; Best Abstract on Clinical or Epidemiology Research by a Trainee - Phil Rosen Award, Lauren King; Best Abstract on Basic Science Research by a Trainee, Remy Pollock; Best Abstract for Research by an Undergraduate Student, Andrea Carboni-Jimènez; Best Abstract on Research by a Rheumatology Resident, May Choi; Best Abstract by a Medical Student, Leonardo Calderon; Best Abstract by a Post-Graduate Research Trainee, Carolina Munoz-Grajales; Best Abstract by a Rheumatology Post-Graduate Research Trainee, Andre Luquini; Best Abstract on Quality Care Initiatives in Rheumatology, Cheryl Barnabe and Ines Colmegna; Best Abstract on Research by Young Faculty, Bindee Kuriya; Practice Reflection Award, Gold, Jason Kur; Practice Reflection Award, Silver, May Choi. Lectures and other events included Keynote Lecture by Andre Picard: Quirky Past, Uncertain Future: The State of Medicare in Canada; Keynote Address by Diane Lacaille, Distinguished Investigator Awardee: Time to Re-Label Comorbidities in RA - Coexisting or Complications; State of the Art Lecture by Mark Roberts: Myositis and its Mimics; Dunlop-Dottridge Lecture by Gilles Boire: The 4-H of Biomarkers in Arthritis: A lot of Help, Potential Harm, Some Hype, Increasing Hope; and the Great Debate: Be it Resolved that Competency-based Medical Education will Result in Improved Quality of Care for Patients vs the "Old Way" of Training Rheumatologists. Arguing for: Mercedes Chan and Marie-Paule Morin, and against: Beth Hazel and Heather McDonald-Blumer. Topics including rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, Sjögren syndrome, psoriatic arthritis, spondyloarthritis, vasculitis, osteoarthritis, fibromyalgia, and their respective diagnoses, treatments, and outcomes are reflected in the abstracts, which we are pleased to publish in this issue of
Language	English
Publishing date	2019-06-01
Publishing country	Canada
Document type	Journal Article
ZDB-ID	194928-7
ISSN	1499-2752 ; 0315-162X
ISSN (online)	1499-2752
ISSN	0315-162X
DOI	10.3899/jrheum.190333
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Zs.MO 135: Show issues

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