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  1. Article: The management of sepsis: science & fiction.

    Marik, Paul E

    Journal of thoracic disease

    2020  Volume 12, Issue Suppl 1, Page(s) S1–S4

    Language English
    Publishing date 2020-02-19
    Publishing country China
    Document type Editorial
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2019.12.89
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Vitamin C: an essential "stress hormone" during sepsis.

    Marik, Paul E

    Journal of thoracic disease

    2020  Volume 12, Issue Suppl 1, Page(s) S84–S88

    Abstract: The stress response is a preserved evolutionary response that functions to enhance the survival of the species. In mammals, the stress response is characterized by activation of the HPA axis and sympathoadrenal system (SAS) as well as the increased ... ...

    Abstract The stress response is a preserved evolutionary response that functions to enhance the survival of the species. In mammals, the stress response is characterized by activation of the HPA axis and sympathoadrenal system (SAS) as well as the increased synthesis and secretion of vitamin C. Cortisol, catecholamines, and vitamin C act synergistically to increase hemodynamic reserve, maintain immune function and protect the host against excessive oxidant injury. Humans (and anthropoid apes) have lost the ability to synthesize vitamin C and therefore have an impaired stress response. The inability to produce vitamin C has serious implications in septic humans. Treatment with vitamin C appears to restore the stress response and improve the survival of stressed humans.
    Language English
    Publishing date 2020-02-28
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2019.12.64
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Lactate guided resuscitation-nothing is more dangerous than conscientious foolishness.

    Marik, Paul E

    Journal of thoracic disease

    2019  Volume 11, Issue Suppl 15, Page(s) S1969–S1972

    Language English
    Publishing date 2019-10-14
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2019.07.67
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Nutritional Support Among Medical Inpatients-Feed the Cold (and Malnourished) and Starve the Febrile.

    Marik, Paul E

    JAMA network open

    2019  Volume 2, Issue 11, Page(s) e1915707

    MeSH term(s) Fever ; Humans ; Inpatients ; Nutritional Support
    Language English
    Publishing date 2019-11-01
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2019.15707
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Is intravenous vitamin C contraindicated in patients with G6PD deficiency?

    Marik, Paul E

    Critical care (London, England)

    2019  Volume 23, Issue 1, Page(s) 109

    MeSH term(s) Administration, Intravenous/methods ; Ascorbic Acid/adverse effects ; Ascorbic Acid/therapeutic use ; Contraindications, Drug ; Glucosephosphate Dehydrogenase Deficiency/blood ; Glucosephosphate Dehydrogenase Deficiency/complications ; Humans
    Chemical Substances Ascorbic Acid (PQ6CK8PD0R)
    Language English
    Publishing date 2019-04-03
    Publishing country England
    Document type Editorial
    ZDB-ID 2051256-9
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-019-2397-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Procalcitonin is an essential biomarker for hydrocortisone, ascorbic acid, and thiamine (HAT) therapy in patients with sepsis.

    Marik, Paul E

    Critical care (London, England)

    2019  Volume 23, Issue 1, Page(s) 151

    MeSH term(s) Ascorbic Acid/adverse effects ; Ascorbic Acid/therapeutic use ; Biomarkers/analysis ; Biomarkers/blood ; Humans ; Hydrocortisone/adverse effects ; Hydrocortisone/therapeutic use ; Procalcitonin/analysis ; Procalcitonin/blood ; Sepsis/complications ; Sepsis/drug therapy ; Thiamine/adverse effects ; Thiamine/therapeutic use
    Chemical Substances Biomarkers ; Procalcitonin ; Ascorbic Acid (PQ6CK8PD0R) ; Hydrocortisone (WI4X0X7BPJ) ; Thiamine (X66NSO3N35)
    Language English
    Publishing date 2019-05-02
    Publishing country England
    Document type Letter
    ZDB-ID 2051256-9
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-019-2445-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Cancer Metabolism as a Therapeutic Target and Review of Interventions.

    Halma, Matthew T J / Tuszynski, Jack A / Marik, Paul E

    Nutrients

    2023  Volume 15, Issue 19

    Abstract: Cancer is amenable to low-cost treatments, given that it has a significant metabolic component, which can be affected through diet and lifestyle change at minimal cost. The Warburg hypothesis states that cancer cells have an altered cell metabolism ... ...

    Abstract Cancer is amenable to low-cost treatments, given that it has a significant metabolic component, which can be affected through diet and lifestyle change at minimal cost. The Warburg hypothesis states that cancer cells have an altered cell metabolism towards anaerobic glycolysis. Given this metabolic reprogramming in cancer cells, it is possible to target cancers metabolically by depriving them of glucose. In addition to dietary and lifestyle modifications which work on tumors metabolically, there are a panoply of nutritional supplements and repurposed drugs associated with cancer prevention and better treatment outcomes. These interventions and their evidentiary basis are covered in the latter half of this review to guide future cancer treatment.
    MeSH term(s) Humans ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Glycolysis ; Energy Metabolism ; Treatment Outcome
    Language English
    Publishing date 2023-10-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15194245
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Ivermectin, A Reanalysis of the Data.

    Marik, Paul E / Kory, Pierre

    American journal of therapeutics

    2021  Volume 28, Issue 5, Page(s) e579–e580

    MeSH term(s) Humans ; Ivermectin
    Chemical Substances Ivermectin (70288-86-7)
    Language English
    Publishing date 2021-09-07
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1280786-2
    ISSN 1536-3686 ; 1075-2765
    ISSN (online) 1536-3686
    ISSN 1075-2765
    DOI 10.1097/MJT.0000000000001443
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4351: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Steroids for sepsis: yes, no or maybe.

    Marik, Paul E

    Journal of thoracic disease

    2018  Volume 10, Issue Suppl 9, Page(s) S1070–S1073

    Language English
    Publishing date 2018-04-19
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2018.04.35
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Response.

    Marik, Paul E

    Chest

    2018  Volume 154, Issue 1, Page(s) 229

    MeSH term(s) Ascorbic Acid ; Controlled Before-After Studies ; Humans ; Hydrocortisone ; Retrospective Studies ; Sepsis ; Shock, Septic ; Thiamine
    Chemical Substances Ascorbic Acid (PQ6CK8PD0R) ; Hydrocortisone (WI4X0X7BPJ) ; Thiamine (X66NSO3N35)
    Language English
    Publishing date 2018-07-25
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2018.03.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui III Zs.45: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 349: Show issues

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