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Article ; Online: Entrapped Megakaryocytes in the Microvasculature of Brain Tissues are not Specific to COVID-19 but can be Seen Across a Spectrum of Acute Lung Injuries.

McMullen, Phillip / Smith, Heather / Pytel, Peter

Journal of neuropathology and experimental neurology

2021 Volume 80, Issue 11, Page(s) 1078–1080

MeSH term(s)	Acute Lung Injury/epidemiology ; Acute Lung Injury/pathology ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Brain/blood supply ; Brain/pathology ; COVID-19/epidemiology ; COVID-19/pathology ; Cell Count/methods ; Female ; Humans ; Male ; Megakaryocytes/pathology ; Microvessels/pathology ; Middle Aged ; Young Adult
Language	English
Publishing date	2021-08-17
Publishing country	England
Document type	Letter
ZDB-ID	3088-0
ISSN	1554-6578 ; 0022-3069
ISSN (online)	1554-6578
ISSN	0022-3069
DOI	10.1093/jnen/nlab048
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Article ; Online: Effects of corneoconjunctival transposition, posterior lamellar keratoplasty and modified deep lamellar endothelial keratoplasty on streak retinoscopy in equine cadaver eyes.

Charnock, Lauren N / Boveland, Shannon D / Groover, Erin S / Moore, Phillip A / McMullen, Richard J

Veterinary ophthalmology

2022 Volume 25, Issue 6, Page(s) 483–492

Abstract: Objective: Evaluate the effects of corneoconjunctival transposition (CCT), posterior lamellar keratoplasty (PLK) and modified deep lamellar endothelial keratoplasty (DLEK) on streak retinoscopy in equine cadaver eyes.: Methods: Intraocular pressure ( ... ...

Abstract	Objective: Evaluate the effects of corneoconjunctival transposition (CCT), posterior lamellar keratoplasty (PLK) and modified deep lamellar endothelial keratoplasty (DLEK) on streak retinoscopy in equine cadaver eyes. Methods: Intraocular pressure (IOP) was maintained at 25 ± 3 mmHg in 35 equine cadaver eyes. Streak retinoscopy was performed prior to (NO VISCO) and following (VISCO) intracameral injection of 1.0 ml of viscoelastic. Following optical coherence tomography (OCT), an axial CCT [n = 11] or PLK [n = 12], or peripheral DLEK [n = 12] was performed. Streak retinoscopy and OCT were repeated postoperatively. Results: Postsurgical net meridional and spherical refraction for CCT [Horizontal (H): 3.4 (95% CI 2.4-4.4) diopters (D), p < .001, Vertical (V): 3.5 (95% CI 2.7-4.4) D, p < .001, Spherical: 3.5 (95% CI 2.6-4.3) D, p < .001] and PLK [H: 3.2 (95% CI 2.2-4.1) D, p < .001, V: 2.8 (95% CI 2.0-3.6) D, p < .001, Spherical: 3.0 (95% CI 2.2-3.8) D, p < .001] were significantly increased from presurgical (VISCO) values. No difference between presurgical (VISCO) and postsurgical values were identified for the DLEK. Postoperative OCT revealed space between anterior and posterior corneal grafts and corneal undulation associated with suture placement. Conclusion: Meridional and spherical refraction had a hyperopic shift following CCT and PLK, with a significantly higher value in the vertical meridian for the CCT. Pre- and postoperative refraction was not significantly different for the DLEK. This supports that the DLEK has a lesser effect on immediate postoperative refraction compared with CCT or PLK.
MeSH term(s)	Horses ; Animals ; Endothelium, Corneal ; Retinoscopy ; Visual Acuity ; Corneal Transplantation/veterinary ; Corneal Transplantation/methods ; Cadaver ; Horse Diseases/surgery
Language	English
Publishing date	2022-09-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2011043-1
ISSN	1463-5224 ; 1463-5216
ISSN (online)	1463-5224
ISSN	1463-5216
DOI	10.1111/vop.13025
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Article ; Online: Platelet-rich aggregates in MNC collection circuit.

Amin, Nisar / Cho, Joseph H / McMullen, Phillip / Uraizee, Imran / Wool, Geoffrey / Su, Leon

Transfusion

2021 Volume 61, Issue 4, Page(s) 1010–1011

MeSH term(s)	Adult ; Blood Specimen Collection/methods ; Cell Separation/methods ; Cytapheresis/methods ; Filtration/methods ; Humans ; Immunotherapy, Adoptive/adverse effects ; Immunotherapy, Adoptive/methods ; Leukocytes, Mononuclear/cytology ; Leukocytes, Mononuclear/immunology ; Leukocytes, Mononuclear/metabolism ; Lymphoma, Large B-Cell, Diffuse/blood ; Lymphoma, Large B-Cell, Diffuse/immunology ; Lymphoma, Large B-Cell, Diffuse/therapy ; Male ; Platelet Aggregation/immunology
Language	English
Publishing date	2021-03-04
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	208417-x
ISSN	1537-2995 ; 0041-1132
ISSN (online)	1537-2995
ISSN	0041-1132
DOI	10.1111/trf.16288
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Article ; Online: Printculture of Surgical Pathology and Autopsy Specimens.

McMullen, Phillip D / Tesic, Vera / Pytel, Peter

American journal of clinical pathology

2019 Volume 152, Issue 6, Page(s) 747–756

Abstract: Objectives: Printculture is a method of microbiologic assessment previously described for use in the autopsy setting. We sought to compare printculture of surgical and autopsy pathology specimens to standard microbiology culture using matrix-assisted ... ...

Abstract	Objectives: Printculture is a method of microbiologic assessment previously described for use in the autopsy setting. We sought to compare printculture of surgical and autopsy pathology specimens to standard microbiology culture using matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF)-based colony identification. Methods: Printculture was performed on 18 frozen samples with corresponding standard culture results. The results of MALDI-TOF identification of colonies recovered by printculture were compared with standard cultures, and percent concordance was calculated. Results: There was 95.8% concordance to standard culture methods for cases with infections and 100% concordance for cases without infection. The pattern of growth was found to aid in the distinction between contamination and true infection. Conclusions: Printculture allows the identification of microorganisms from routinely frozen tissues and provides a bridge between microbiology and histomorphology through the identification of associated histologic features of infection. This technique can be successfully integrated into autopsy and surgical pathology workup of potentially infected tissues.
MeSH term(s)	Autopsy/methods ; Frozen Sections ; Humans ; Infections/diagnosis ; Infections/microbiology ; Microbiological Techniques/methods ; Pathology, Surgical/methods
Language	English
Publishing date	2019-07-22
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	2944-0
ISSN	1943-7722 ; 0002-9173
ISSN (online)	1943-7722
ISSN	0002-9173
DOI	10.1093/ajcp/aqz090
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Article: Carotid Intimal Sarcoma Presenting as Large Vessel Occlusion and Diagnosed by Embolus Histopathology: Case Report.

Johnson, Mahlon D / Rogers, Eli J / Khan, Muhammad Waqas / McMullen, Phillip D / Akkipeddi, Sajal Medha K / Mattingly, Thomas / Benesch, Curtis G / Bender, Matthew T

Neurology. Clinical practice

2023 Volume 13, Issue 1, Page(s) e200129

Abstract: Objective: The objective of this study was to present the clinical, histopathologic, and radiographic findings of a unique case of intimal sarcoma (IS) embolus presenting as a large vessel occlusion causing an ischemic stroke without a detectable ... ...

Abstract	Objective: The objective of this study was to present the clinical, histopathologic, and radiographic findings of a unique case of intimal sarcoma (IS) embolus presenting as a large vessel occlusion causing an ischemic stroke without a detectable primary tumor site. Methods: Extensive examinations, multimodal imaging, laboratory testing, and histopathologic analysis were used in evaluation. Results: We report the case of a patient who presented with acute embolic ischemic stroke and was found to have IS based on a histopathologic evaluation of his embolectomy specimen. Subsequent comprehensive imaging studies failed to detect a primary tumor site. Multidisciplinary interventions including a course of radiotherapy were performed. The patient died of recurrent multifocal strokes 92 days after diagnosis. Discussion: Meticulous histopathologic analysis should be conducted on cerebral embolectomy specimens. Histopathology may be useful in diagnosing IS.
Language	English
Publishing date	2023-01-19
Publishing country	United States
Document type	Case Reports
ZDB-ID	2645818-4
ISSN	2163-0933 ; 2163-0402
ISSN (online)	2163-0933
ISSN	2163-0402
DOI	10.1212/CPJ.0000000000200129
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Article ; Online: Comparison of image quality of corneal and retinal optical coherence tomography using sedation and general anesthesia protocols with or without retrobulbar anesthesia in horses.

Hefner, Ethan M / Lin, Hui-Chu / Cole, Robert C / Moore, Phillip A / McMullen, Richard J

American journal of veterinary research

2021 Volume 83, Issue 1, Page(s) 72–79

Abstract: Objective: To compare image quality and acquisition time of corneal and retinal spectral domain optical coherence tomography (SD-OCT) under 3 different sedation-anesthesia conditions in horses.: Animals: 6 middle-aged geldings free of ocular disease.! ...

Abstract	Objective: To compare image quality and acquisition time of corneal and retinal spectral domain optical coherence tomography (SD-OCT) under 3 different sedation-anesthesia conditions in horses. Animals: 6 middle-aged geldings free of ocular disease. Procedures: 1 randomly selected eye of each horse was evaluated via SD-OCT under the following 3 conditions: standing sedation without retrobulbar anesthetic block (RB), standing sedation with RB, and general anesthesia with RB. Five regions of interest were evaluated in the cornea (axial and 12, 3, 6, and 9 o'clock positions) and fundus (optic nerve head). Three diagnostic scans of predetermined quality were obtained per anatomical region. Image acquisition times and total scans per site were recorded. Corneal and retinal SD-OCT image quality was graded on a subjective scale from 0 (nondiagnostic) to 4 (excellent). Results: Mean values for the standing sedation without RB, standing sedation with RB, and general anesthesia conditions were 24, 23, and 17, respectively, for total cornea scan attempts; 23, 19, and 19 for total retina-scan attempts; 14.6, 13.2, and 9.2 minutes for total cornea scan time; 19.1, 9.2, and 13.0 for total retina scan time; 2.0, 2.3, and 2.5 for cornea grade; and 2.7, 2.9, and 2.5 for retina grade. Conclusions and clinical relevance: The RB facilitated globe akinesia and improved the percentage of scans in frame and region of interest accuracy for retinal imaging via OCT in horses. Retrobulbar blocks improved clinical image acquisition while minimizing motion artifact.
MeSH term(s)	Anesthesia, General/veterinary ; Animals ; Cornea/diagnostic imaging ; Horses ; Retina/diagnostic imaging ; Tomography, Optical Coherence/veterinary
Language	English
Publishing date	2021-11-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	390796-x
ISSN	1943-5681 ; 0002-9645
ISSN (online)	1943-5681
ISSN	0002-9645
DOI	10.2460/ajvr.21.02.0029
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Zs.A 422: Show issues

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Article ; Online: ATTR Cardiomyopathy Meets Multiple Myeloma: The Importance of Cardiac Biopsy.

Kanelidis, Anthony J / Miller, Patrick / Prabhu, Nicole / Dela Cruz, Mark Joshua / Alenghat, Francis J / McMullen, Phillip / Sarswat, Nitasha / Derman, Benjamin A / Polonsky, Tamar S / DeCara, Jeanne M

JACC. CardioOncology

2021 Volume 3, Issue 4, Page(s) 598–601

Language	English
Publishing date	2021-10-19
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2666-0873
ISSN (online)	2666-0873
DOI	10.1016/j.jaccao.2021.07.007
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Article ; Online: Lymphatic coagulation and neutrophil extracellular traps in lung-draining lymph nodes of COVID-19 decedents.

Blood advances

2024 Volume 6, Issue 24, Page(s) 6249–6262

Abstract: Clinical manifestations of severe COVID-19 include coagulopathies that are exacerbated by the formation of neutrophil extracellular traps (NETs). Here, we report that pulmonary lymphatic vessels, which traffic neutrophils and other immune cells to the ... ...

Abstract	Clinical manifestations of severe COVID-19 include coagulopathies that are exacerbated by the formation of neutrophil extracellular traps (NETs). Here, we report that pulmonary lymphatic vessels, which traffic neutrophils and other immune cells to the lung-draining lymph node (LDLN), can also be blocked by fibrin clots in severe COVID-19. Immunostained tissue sections from COVID-19 decedents revealed widespread lymphatic clotting not only in the lung but also in the LDLN, where the extent of clotting correlated with the presence of abnormal, regressed, or missing germinal centers (GCs). It strongly correlated with the presence of intralymphatic NETs. In mice, tumor necrosis factor α induced intralymphatic fibrin clots; this could be inhibited by DNase I, which degrades NETs. In vitro, TNF-α induced lymphatic endothelial cell upregulation of ICAM-1 and CXCL8, among other neutrophil-recruiting factors, as well as thrombomodulin downregulation; in decedents, lymphatic clotting in LDLNs. In a separate cohort of hospitalized patients, serum levels of Myeloperoxidase-DNA (MPO-DNA, a NET marker) inversely correlated with antiviral antibody titers, but D-dimer levels, indicative of blood thrombosis, did not correlate with either. Patients with high MPO-DNA but low D-dimer levels generated poor antiviral antibody titers. This study introduces lymphatic coagulation in lungs and LDLNs as a clinical manifestation of severe COVID-19 and suggests the involvement of NETosis of lymphatic-trafficking neutrophils. It further suggests that lymphatic clotting may correlate with impaired formation or maintenance of GCs necessary for robust antiviral antibody responses, although further studies are needed to determine whether and how lymphatic coagulation affects adaptive immune responses.
MeSH term(s)	Mice ; Animals ; Extracellular Traps ; COVID-19 ; Thrombosis/metabolism ; Lung/metabolism ; DNA/metabolism ; Lymph Nodes
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2022007798
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Article ; Online: Effects of corneoconjunctival transposition, posterior lamellar keratoplasty and modified deep lamellar endothelial keratoplasty on streak retinoscopy in equine cadaver eyes

Charnock, Lauren N. / Boveland, Shannon D. / Groover, Erin S. / Moore, Phillip A. / McMullen, Richard J., Jr

Veterinary Ophthalmology. 2022 Nov., v. 25, no. 6 p.483-492

2022

Abstract: OBJECTIVE: Evaluate the effects of corneoconjunctival transposition (CCT), posterior lamellar keratoplasty (PLK) and modified deep lamellar endothelial keratoplasty (DLEK) on streak retinoscopy in equine cadaver eyes. METHODS: Intraocular pressure (IOP) ... ...

Abstract	OBJECTIVE: Evaluate the effects of corneoconjunctival transposition (CCT), posterior lamellar keratoplasty (PLK) and modified deep lamellar endothelial keratoplasty (DLEK) on streak retinoscopy in equine cadaver eyes. METHODS: Intraocular pressure (IOP) was maintained at 25 ± 3 mmHg in 35 equine cadaver eyes. Streak retinoscopy was performed prior to (NO VISCO) and following (VISCO) intracameral injection of 1.0 ml of viscoelastic. Following optical coherence tomography (OCT), an axial CCT [n = 11] or PLK [n = 12], or peripheral DLEK [n = 12] was performed. Streak retinoscopy and OCT were repeated postoperatively. RESULTS: Postsurgical net meridional and spherical refraction for CCT [Horizontal (H): 3.4 (95% CI 2.4–4.4) diopters (D), p < .001, Vertical (V): 3.5 (95% CI 2.7–4.4) D, p < .001, Spherical: 3.5 (95% CI 2.6–4.3) D, p < .001] and PLK [H: 3.2 (95% CI 2.2–4.1) D, p < .001, V: 2.8 (95% CI 2.0–3.6) D, p < .001, Spherical: 3.0 (95% CI 2.2–3.8) D, p < .001] were significantly increased from presurgical (VISCO) values. No difference between presurgical (VISCO) and postsurgical values were identified for the DLEK. Postoperative OCT revealed space between anterior and posterior corneal grafts and corneal undulation associated with suture placement. CONCLUSION: Meridional and spherical refraction had a hyperopic shift following CCT and PLK, with a significantly higher value in the vertical meridian for the CCT. Pre‐ and postoperative refraction was not significantly different for the DLEK. This supports that the DLEK has a lesser effect on immediate postoperative refraction compared with CCT or PLK.
Keywords	cadaver ; cornea ; horses ; ophthalmology ; tomography ; viscoelasticity
Language	English
Dates of publication	2022-11
Size	p. 483-492.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	2011043-1
ISSN	1463-5224 ; 1463-5216
ISSN (online)	1463-5224
ISSN	1463-5216
DOI	10.1111/vop.13025
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A Descriptive and Quantitative Immunohistochemical Study Demonstrating a Spectrum of Platelet Recruitment Patterns Across Pulmonary Infections Including COVID-19.

McMullen, Phillip D / Cho, Joseph H / Miller, Jonathan L / Husain, Aliya N / Pytel, Peter / Krausz, Thomas

American journal of clinical pathology

2020 Volume 155, Issue 3, Page(s) 354–363

Abstract: Objectives: Pulmonary platelet deposition and microangiopathy are increasingly recognized components of coronavirus disease 2019 (COVID-19) infection. Thrombosis is a known component of sepsis and disseminated intravascular coagulation. We sought to ... ...

Abstract	Objectives: Pulmonary platelet deposition and microangiopathy are increasingly recognized components of coronavirus disease 2019 (COVID-19) infection. Thrombosis is a known component of sepsis and disseminated intravascular coagulation. We sought to compare the level of platelet deposition in the pulmonary vasculature in cases of confirmed COVID-19 infection to other lung injuries and infections. Methods: Immunohistochemistry was performed on 27 autopsy cases and 2 surgical pathology cases targeting CD61. Multiple cases of normal lung, diffuse alveolar damage, COVID-19, influenza, and bacterial and fungal infections, as well as one case of pulmonary emboli, were included. The levels of CD61 staining were compared quantitatively in the autopsy cases, and patterns of staining were described. Results: Nearly all specimens exhibited an increase in CD61 staining relative to control lung tissue. The area of CD61 staining in COVID-19 infection was higher than influenza but still comparable to many other infectious diseases. Cases of aspiration pneumonia, Staphylococcus aureus infection, and blastomycosis exhibited the highest levels of CD61 staining. Conclusions: Platelet deposition is a phenomenon common to many pulmonary insults. A spectrum of staining patterns was observed, suggestive of pathogen-specific mechanisms of platelet deposition. Further study into the mechanisms driving platelet deposition in pulmonary injuries and infections is warranted.
MeSH term(s)	Blood Platelets/pathology ; COVID-19/pathology ; Humans ; Immunohistochemistry ; Integrin beta3/analysis ; Respiratory Tract Infections/pathology ; SARS-CoV-2
Chemical Substances	ITGB3 protein, human ; Integrin beta3
Keywords	covid19
Language	English
Publishing date	2020-12-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2944-0
ISSN	1943-7722 ; 0002-9173
ISSN (online)	1943-7722
ISSN	0002-9173
DOI	10.1093/ajcp/aqaa230
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