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Article ; Online: Electromyogram Power Spectrum and Cardiac Function Changes After Combined Aerobic Interval Training and Inspiratory Muscle Training in Chronic Heart Failure Patients.

Sadek, Zahra / Ramadan, Wiam / Ahmaidi, Said / Youness, Mahmoud / Joumaa, Wissam H

2024 Volume 65, Issue 1, Page(s) 71–83

Abstract: Exercise intolerance and dyspnea are the major symptoms of patients with chronic heart failure (CHF) and are associated with a poor quality of life. In addition to impaired central hemodynamics, symptoms may be attributed to changes in peripheral ... ...

Abstract	Exercise intolerance and dyspnea are the major symptoms of patients with chronic heart failure (CHF) and are associated with a poor quality of life. In addition to impaired central hemodynamics, symptoms may be attributed to changes in peripheral skeletal muscles. This study aimed to evaluate the effects of aerobic interval training (AIT) combined with inspiratory muscle training (IMT) on cardiac and skeletal muscle function and on functional capacity and dyspnea in patients with CHF and inspiratory muscle weakness.Left ventricle ejection fraction was improved significantly after AIT and AIT & IMT with a high percentage of amelioration (17%, P < 0.042) in the combined group compared to the control group. Therefore, we showed a significant improvement in maximal voluntary isometric force, isometric endurance time, root mean square, and frequency median in both strength and endurance manipulations in the aerobic and combined group; however, the improvement was superior in the combined group compared to the control group. Significant amelioration was proved in functional capacity and dyspnea after all types of training but was performed at 18% higher in 6 minutes' walk test and 43% lower in dyspnea for the combined group compared to the control group.Combining AIT to IMT had optimized exercise training benefits in reversing the cardiac remodeling process and improving skeletal muscle function, functional capacity, and dyspnea in patients with CHF.
MeSH term(s)	Humans ; Breathing Exercises ; Electromyography ; Quality of Life ; Respiratory Muscles/physiology ; Heart Failure/complications ; Heart Failure/therapy ; Chronic Disease ; Dyspnea/etiology ; Exercise Tolerance/physiology
Language	English
Publishing date	2024-01-31
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2187806-7
ISSN	1349-3299 ; 1349-2365
ISSN (online)	1349-3299
ISSN	1349-2365
DOI	10.1536/ihj.23-326
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Article: A case report of molybdenum cofactor deficiency type A: the first case diagnosed in Syria.

Kardah, Haidara / Al-Zoubi, Hamza / Odeh, Zahra / Joumaa, Ranim / Alasmar, Diana

Annals of medicine and surgery (2012)

2024 Volume 86, Issue 3, Page(s) 1762–1765

Abstract: Introduction: Molybdenum cofactor deficiency (MoCD) type A, a rare mitochondrial disorder with characteristic clinical presentation and imaging findings, is one of the forms of molybdenum cofactor deficiency. It presents with seizures, psychomotor delay, ...

Abstract	Introduction: Molybdenum cofactor deficiency (MoCD) type A, a rare mitochondrial disorder with characteristic clinical presentation and imaging findings, is one of the forms of molybdenum cofactor deficiency. It presents with seizures, psychomotor delay, and breastfeeding difficulties. Seizures are especially prominent in patients with MoCD. Case presentation: A 3-month-old girl presented with refractory generalized tonic-clonic seizures since the third day of life. Her parents were third-degree relatives. On physical examination, she demonstrated psychomotor delay, breastfeeding difficulties, seizures, doll-like facial features, and other neurological abnormalities. Her brain MRI scan revealed cortical and white matter atrophy of the cerebral hemispheres. Metabolic workup revealed elevated levels of liver enzymes, lactic acid, and ammonia. These results were inconclusive. She received anticonvulsants and vitamin therapy to manage her seizures. Based on a suspicion of mitochondrial disease, genetic analysis was performed, revealing a homozygous variant of uncertain significance in the MOCS1 gene associated with autosomal recessive molybdenum cofactor deficiency type A. Conclusion: MoCD is a rare disease. Early diagnosis should be considered based on the patient's medical history and MRI findings, after excluding other possible diagnoses. The definitive diagnosis relies on genetic testing results.
Language	English
Publishing date	2024-01-30
Publishing country	England
Document type	Case Reports
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1097/MS9.0000000000001778
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Article ; Online: Impact of GSM-EMW exposure on the markers of oxidative stress in fetal rat liver.

Salameh, Mariam / Zeitoun-Ghandour, Sukaina / Sabra, Lina / Daher, Ahmad / Khalil, Mahmoud / Joumaa, Wissam H

Scientific reports

2023 Volume 13, Issue 1, Page(s) 17806

Abstract: The current study investigated the effects of 24 h/day prenatal exposure to global system ...

Abstract	The current study investigated the effects of 24 h/day prenatal exposure to global system for mobile communication electromagnetic fields (GSM-EMFs), 900 MHZ-induced electromagnetic radiation (EMR), on oxidative stress (OS) status, apoptotic, and inflammatory changes in liver of rats during their fetal development period. Fifty-two Sprague-Dawley pregnant rats were equally divided into control and exposed groups. Whole embryos were removed at 7.5 dpc (days post coitus), while liver tissues were extracted from embryos at 11.5, 15.5, and 19.5 dpc. For exposed animals, results showed an increased OS reflected by high levels of malondialdehyde (MDA), a decrease in cytosolic superoxide dismutase (cytoSOD) activity, in mitochondrial superoxide dismutase (mitoSOD) levels and catalase (CAT) mRNA expression but also in hepatic nuclear factor erythroïd 2-related Factor 2 (Nrf-2), protein kinase B (Akt1), and intercellular adhesion molecule-1 (ICAM-1) mRNA expression at 15.5 dpc. Moreover, GSM-EMR exposure was shown to significantly decrease mitoSOD and CAT activities at almost all studied ages. Thus, rat embryos may be protected by their mothers from OS, apoptotic, and pro-inflammatory responses till a sensitive developmental stage, during a continuous prenatal EMR exposure. This protection could be then created from the embryos themselves.
MeSH term(s)	Pregnancy ; Female ; Rats ; Animals ; Rats, Sprague-Dawley ; Oxidative Stress ; Electromagnetic Fields/adverse effects ; Superoxide Dismutase/metabolism ; Liver/metabolism ; RNA, Messenger/metabolism ; Cell Phone
Chemical Substances	Superoxide Dismutase (EC 1.15.1.1) ; RNA, Messenger
Language	English
Publishing date	2023-10-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-44814-z
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Article ; Online: « Tu viens d’où ? »

Ayman Al Joumaa

Cahiers du MIMMOC, Vol

réponses, mémoires et identités de réfugiés syriens

2020 Volume 22

Abstract: Dans un contexte multiculturel, les questions sur les origines sont inévitables. Dans notre ère caractérisée par les migrations (inter)nationales et la mondialisation, la rencontre avec l’Autre qui vient d’ailleurs est de plus en plus fréquente et ... ...

Abstract	Dans un contexte multiculturel, les questions sur les origines sont inévitables. Dans notre ère caractérisée par les migrations (inter)nationales et la mondialisation, la rencontre avec l’Autre qui vient d’ailleurs est de plus en plus fréquente et possible. Du côté du migrant, la question ne passe pas inaperçue. Certains trouvent cette question banale alors que d’autres la considèrent gênante ou même raciste. Prenant en compte les stéréotypes et l’hostilité montante vis-à-vis des migrations, devant cette question une hésitation peut être éprouvée chez le migrant par crainte d’un jugement. Chez les réfugié.e.s, la question est d’autant plus problématique car les discussions qui suivront contiendront des interrogations qui sollicitent éventuellement la mémoire très possiblement chargée de souvenirs et des mémoires traumatiques. Dans le cadre de notre Master, nous réalisons un mémoire intitulé « la Mémoire et l’oubli dans le contexte migratoire : l’exemple des réfugiés syriens au Canada et en Europe ». Cet article est issu de la recherche que nous effectuons. Il propose de chercher à comprendre comment la question « tu viens d’où ? » est perçue par des réfugié.e.s syrien.ne.s vivant en Europe et au Canada et quel en est l’impact, tout en prenant en compte les particularités des conditions de l’exode des Syriens.
Keywords	mémoire ; traumatisme ; témoignage ; réfugiés ; identité ; Social Sciences ; H ; Social sciences (General) ; H1-99
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	Université de Poitiers
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Contrasting offspring dependence periods and diving development rates in two closely related marine mammal species.

Jouma'a, Joffrey / Orgeret, Florian / Picard, Baptiste / Robinson, Patrick W / Weimerskirch, Henri / Guinet, Christophe / Costa, Daniel P / Beltran, Roxanne S

Royal Society open science

2024 Volume 11, Issue 1, Page(s) 230666

Abstract: Understanding the ontogeny of diving behaviour in marine megafauna is crucial owing to its influence on foraging success, energy budgets, and mortality. We compared the ontogeny of diving behaviour in two closely related species-northern elephant seals ( ...

Abstract	Understanding the ontogeny of diving behaviour in marine megafauna is crucial owing to its influence on foraging success, energy budgets, and mortality. We compared the ontogeny of diving behaviour in two closely related species-northern elephant seals (
Language	English
Publishing date	2024-01-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2787755-3
ISSN	2054-5703
ISSN	2054-5703
DOI	10.1098/rsos.230666
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Article: Novel Missense and Splice Site Mutations in

Jaffal, Lama / Akhdar, Hanane / Joumaa, Hawraa / Ibrahim, Mariam / Chhouri, Zahraa / Assi, Alexandre / Helou, Charles / Lee, Hane / Seo, Go Hun / Joumaa, Wissam H / El Shamieh, Said

Frontiers in genetics

2022 Volume 13, Page(s) 864228

Abstract: The purpose of this study was to expand the mutation spectrum by searching the causative mutations in nine Lebanese families with Usher syndrome (USH) using whole-exome sequencing. The pathogenicity of candidate mutations was first evaluated according to ...

Abstract	The purpose of this study was to expand the mutation spectrum by searching the causative mutations in nine Lebanese families with Usher syndrome (USH) using whole-exome sequencing. The pathogenicity of candidate mutations was first evaluated according to their frequency, conservation, and
Language	English
Publishing date	2022-05-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2022.864228
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Article ; Online: Artificial intelligence to differentiate asthma from COPD in medico-administrative databases.

Joumaa, Hassan / Sigogne, Raphaël / Maravic, Milka / Perray, Lucas / Bourdin, Arnaud / Roche, Nicolas

BMC pulmonary medicine

2022 Volume 22, Issue 1, Page(s) 357

Abstract: Introduction: Discriminating asthma from chronic obstructive pulmonary disease (COPD) using medico-administrative databases is challenging but necessary for medico-economic analyses focusing on respiratory diseases. Artificial intelligence (AI) may ... ...

Abstract	Introduction: Discriminating asthma from chronic obstructive pulmonary disease (COPD) using medico-administrative databases is challenging but necessary for medico-economic analyses focusing on respiratory diseases. Artificial intelligence (AI) may improve dedicated algorithms. Objectives: To assess performance of different AI-based approaches to distinguish asthmatics from COPD patients in medico-administrative databases where the clinical diagnosis is absent. An "Asthma COPD Overlap" category was defined to further test whether AI can detect complexity. Methods: This study included 178,962 patients treated by two "R03" treatment prescriptions at least from January 2016 to December 2018 and managed by either a general practitioner and/or a pulmonologist participating in a permanent longitudinal observatory of prescription in ambulatory medicine (LPD). Clinical diagnoses are available in this database and were used as gold standards to develop diagnostic rules. Three types of AI approaches were explored using data restricted to demographics and treatment dispensations: multinomial regression, gradient boosting and recurrent neural networks (RNN). The best performing model (based on metric properties) was then applied to estimate the size of asthma and COPD populations based on a database (LRx) of treatment dispensations between July, 2018 and June, 2019. Results: The best models were obtained with the boosting approach and RNN, with an overall accuracy of 68%. Performance metrics were better for asthma than COPD. Based on LRx data, the extrapolated numbers of patients treated for asthma and COPD in France were 3.7 and 1.2 million, respectively. Asthma patients were younger than COPD patients (mean, 49.9 vs. 72.1 years); COPD occurred mostly in men (68%) compared to asthma (33%). Conclusion: AI can provide models with acceptable accuracy to distinguish between asthma, ACO and COPD in medico-administrative databases where the clinical diagnosis is absent. Deep learning and machine learning (RNN) had similar performances in this regard.
MeSH term(s)	Algorithms ; Artificial Intelligence ; Asthma/drug therapy ; Databases, Factual ; Humans ; Male ; Pulmonary Disease, Chronic Obstructive
Language	English
Publishing date	2022-09-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2059871-3
ISSN	1471-2466 ; 1471-2466
ISSN (online)	1471-2466
ISSN	1471-2466
DOI	10.1186/s12890-022-02144-2
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Article ; Online: Treatment of heavily calcified coronary artery stenosis using 3.5 mm peripheral intravascular lithotripsy balloon: case series.

Mekala, Karthik / Mehta, Rajendra H / Joumaa, Mouhammed / Yamasaki, Hiroshi

European heart journal. Case reports

2020 Volume 4, Issue 5, Page(s) 1–5

Abstract: Background: Prevalence of coronary artery calcification is high among patients with advanced age, chronic kidney disease, and diabetes. Percutaneous coronary intervention of heavily calcified coronary artery remains a significant challenge for ... ...

Abstract	Background: Prevalence of coronary artery calcification is high among patients with advanced age, chronic kidney disease, and diabetes. Percutaneous coronary intervention of heavily calcified coronary artery remains a significant challenge for interventional cardiologists. Although there are several modalities available in treating calcified coronary arteries, lesion preparation of certain heavily calcified vessels remains inadequate prior to stent deployment and/or often associated with worse periprocedural adverse outcomes. Case summary: We report feasibility and safety of 3.5 mm peripheral intravascular lithotripsy (IVL) for the treatment of severely calcified coronary stenosis in two patients after orbital atherectomy failed to debulk calcified plaque to enable stent deployment. Discussion: Intravascular lithotripsy has recently emerged as a therapeutic option in treating calcified peripheral artery disease. However, coronary IVL is currently available only in a few centres in the USA. Studies are ongoing in the safety and efficacy of this technology in treating coronaries.
Language	English
Publishing date	2020-09-10
Publishing country	England
Document type	Journal Article
ISSN	2514-2119
ISSN (online)	2514-2119
DOI	10.1093/ehjcr/ytaa211
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Article ; Online: The impact of exposure of diabetic rats to 900 MHz electromagnetic radiation emitted from mobile phone antenna on hepatic oxidative stress.

Ismaiil, Lina A / Joumaa, Wissam H / Moustafa, Mohamed E

Electromagnetic biology and medicine

2019 Volume 38, Issue 4, Page(s) 287–296

Abstract: The excessive exposure of patients with type 2 diabetes mellitus (T2DM) to electromagnetic radiation (EMR) from mobile phones or their base stations antenna may influence oxidative stress and development of diabetic complications. Here, we investigated ... ...

Abstract	The excessive exposure of patients with type 2 diabetes mellitus (T2DM) to electromagnetic radiation (EMR) from mobile phones or their base stations antenna may influence oxidative stress and development of diabetic complications. Here, we investigated the effects of exposing type 2 diabetic rats to EMR of 900 MHz emitted from GSM mobile phone antenna for 24 hours/day over a period of 28 days on hyperglycemia and hepatic oxidative stress. Male Sprague-Dawley rats were divided into 4 groups (12 rats/group): control rats, normal rats exposed to EMR, T2DM rats generated by nicotinamide/streptozotocin administration, and T2DM rats exposed to EMR. Our results showed that the exposure of T2DM rats to EMR nonsignificantly reduced the hyperglycemia and hyperinsulinemia compared to unexposed T2DM rats. The exposure of T2DM rats to EMR for 28 days increased the hepatic levels of MDA and Nrf-2 as well as the activities of superoxide dismutase (SOD) and catalase but decreased phosphorylated Akt-2 (pAkt-2) as compared to unexposed T2DM rats. Therefore, the decrease in the hepatic pAkt-2 in T2DM rats after the exposure to EMR may result in elevated level of hepatic MDA, even though the level of Nrf-2 and the activities of SOD and catalase were increased.
MeSH term(s)	Animals ; Male ; Rats ; Catalase/metabolism ; Cell Phone ; Diabetes Mellitus, Type 2/metabolism ; Electromagnetic Radiation ; Liver/metabolism ; Liver/radiation effects ; Malondialdehyde/metabolism ; Oxidative Stress/radiation effects ; Phosphorylation/radiation effects ; Proto-Oncogene Proteins c-akt/metabolism ; Rats, Sprague-Dawley ; Superoxide Dismutase/metabolism ; Time Factors ; NF-E2-Related Factor 2/metabolism
Chemical Substances	Catalase (EC 1.11.1.6) ; Malondialdehyde (4Y8F71G49Q) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Superoxide Dismutase (EC 1.15.1.1) ; NF-E2-Related Factor 2
Language	English
Publishing date	2019-07-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2588120-6
ISSN	1536-8386 ; 1536-8378
ISSN (online)	1536-8386
ISSN	1536-8378
DOI	10.1080/15368378.2019.1641722
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Article ; Online: The genetic landscape of inherited retinal dystrophies in Arabs.

Jaffal, Lama / Joumaa, Hawraa / Noureldine, Jinane / Banjak, Malak / Ibrahim, Mariam / Mrad, Zamzam / Salami, Ali / Shamieh, Said El

BMC medical genomics

2023 Volume 16, Issue 1, Page(s) 89

Abstract: Inherited retinal dystrophies (IRDs) are a major cause of vision loss. Altogether are highly heterogeneous genotypically and phenotypically, exhibiting substantial differences worldwide. To shed more light on these conditions, we investigated the genetic ...

Abstract	Inherited retinal dystrophies (IRDs) are a major cause of vision loss. Altogether are highly heterogeneous genotypically and phenotypically, exhibiting substantial differences worldwide. To shed more light on these conditions, we investigated the genetic and phenotypic landscape of IRDs in the Arabs globally and per country.We analyzed 1,621 affected individuals from 16 Arabic countries reported in 198 articles. At the phenotypic level, rod-cone dystrophy (RCD) and Usher syndrome were the most prevalent conditions among non-syndromic and syndromic IRDs. At the gene level, TULP1, ABCA4, RP1, CRB1, MYO7A, RPE65, KCNV2, and IMPG2 were the most mutated genes. Interestingly, all except CRB1 were highly prevalent because they harbored founder mutations, implying that consanguinity is a major determinant in Arab countries. Of note, ~ 93% of the investigated individuals carried homozygous mutations. The country analysis for the IRDs conditions and their associated genotypes revealed that whereas Leber Congenital Amaurosis, RCD, and USHER syndrome were widely distributed, bestrophinopathies and non-syndromic hearing loss were restricted to specific countries (till now).This study could be a starting point for initiating suitable health policies towards IRDs in the Arab world. The high degree of homozygosity urges the need for genetic counsellors to provide personalized information and support the affected individuals.
MeSH term(s)	Humans ; Arabs ; Usher Syndromes ; Retinal Dystrophies/genetics ; Leber Congenital Amaurosis/genetics ; Mutation ; ATP-Binding Cassette Transporters/genetics ; Eye Proteins/genetics ; Membrane Proteins/genetics ; Nerve Tissue Proteins/genetics ; Potassium Channels, Voltage-Gated/genetics
Chemical Substances	ABCA4 protein, human ; ATP-Binding Cassette Transporters ; CRB1 protein, human ; Eye Proteins ; Membrane Proteins ; Nerve Tissue Proteins ; KCNV2 protein, human ; Potassium Channels, Voltage-Gated
Language	English
Publishing date	2023-05-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2411865-5
ISSN	1755-8794 ; 1755-8794
ISSN (online)	1755-8794
ISSN	1755-8794
DOI	10.1186/s12920-023-01518-7
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