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Article: Remark on "Establishment and Validation of the Risk Nomogram of Poor Prognosis in Patients with Severe Pulmonary Infection Complicated with Respiratory Failure" by Qiang et al [Letter].

Liang, Dongrui / Li, Xiaodong

International journal of general medicine

2023 Volume 16, Page(s) 3081–3082

Language	English
Publishing date	2023-07-20
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2452220-X
ISSN	1178-7074
ISSN	1178-7074
DOI	10.2147/IJGM.S429537
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Article ; Online: Levels of vitamin A and selenium of children with cystic echinococcosis in Aba Tibetan and Qiang and Garze Tibetan Autonomous Prefecture, Sichuan, China.

Zheng, Qinxin / Gong, Yao / Wang, Qian / Jin, Chuan / Guo, Qulian / Zeng, Mingcai / Luo, Yong / Luorong, Chumu / Li, Cheng

Nutrition (Burbank, Los Angeles County, Calif.)

2023 Volume 111, Page(s) 112023

Abstract: Objective: The aim of this study was to review the levels of vitamin A and selenium in children with echinococcosis in Ganzi and Aba.: Methods: Twenty-six children with cystic echinococcosis and 104 apparently healthy controls from the Aba and Garze ... ...

Abstract	Objective: The aim of this study was to review the levels of vitamin A and selenium in children with echinococcosis in Ganzi and Aba. Methods: Twenty-six children with cystic echinococcosis and 104 apparently healthy controls from the Aba and Garze Tibetan Autonomous Prefecture of Sichuan province in China were recruited. The serum levels of selenium and vitamin A of the cases and controls were detected and stratified by sex and age. Results: The results showed that the ratio of boys to girls was 1:1.36. Compared with the healthy controls, the vitamin A serum levels of the cases significantly declined. The rate of selenium deficiency was high in the cases, but there was no significant difference compared with the control group. Additionally, the lower the vitamin A serum level, the higher the risk for developing echinococcosis. Conclusions: To improve management strategies in children with cystic echinococcosis, or possibly to prevent the disease, children living in high-risk areas for cystic echinococcosis should be given supplemental vitamin A and encouraged to consume a vitamin A-rich diet containing paw-paw, carrot, palm oil, or fish. Children with vitamin A deficiency in high-risk areas should be screened for cystic echinococcosis.
MeSH term(s)	Animals ; Selenium ; Vitamin A ; Tibet ; Prevalence ; Echinococcosis ; China/epidemiology
Chemical Substances	Selenium (H6241UJ22B) ; Vitamin A (11103-57-4)
Language	English
Publishing date	2023-03-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639259-3
ISSN	1873-1244 ; 0899-9007
ISSN (online)	1873-1244
ISSN	0899-9007
DOI	10.1016/j.nut.2023.112023
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Article ; Online: Erratum: SHENGBO ZHOU (), LI HE (), SIYU MA (), SHUJUN XU (), QIANG ZHAI (), PING GUAN (), HUI WANG ()amp; JINGSONG SHI () (2022)Taxonomic status of Rana nigromaculata mongolia and the validity of Pelophylax tenggerensis (Anura, Ranidae) Zootaxa 5165 (4): 486500.

Zhou, Shengbo / He, L I / Ma, Siyu / Xu, Shujun / Zhai, Qiang / Guan, Ping / Wang, Hui / Shi, Jingsong

Zootaxa

2022 Volume 5174, Issue 5, Page(s) 600

Language	English
Publishing date	2022-08-12
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.5174.5.8
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Article ; Online: Confidence Charms: How Superstition Influences Overconfidence Bias in Han and the Qiang Ethnic Minority Chinese.

Li, Heng

The Journal of psychology

2021 Volume 155, Issue 5, Page(s) 473–488

Abstract: ... of Chinese Qiang people. Moreover, Experiments 1 through 3 consistently show that self-efficacy mediates ...

Abstract	The overconfidence effect is a cognitive bias in which individuals' subjective confidence in their judgements is greater than their actual performance. Extending beyond a range of contributing factors in the emergence of the overconfidence bias, the present research examines whether superstition, an under-explored yet important factor, can influence people's perceived level of confidence. Drawing on previous findings regarding the consequences of superstitions, we propose that activating the good-luck-related superstitions can increase overconfidence in one's judgment. Specifically, Experiments 1 and 2 show that Chinese Han student and non-student participants, who were activated by different types of superstitions, displayed a higher level of overconfidence than those in the absence of superstition. Experiment 3 fully replicated the causal effect of superstition beliefs on the heightened overconfidence bias in a traditional population of Chinese Qiang people. Moreover, Experiments 1 through 3 consistently show that self-efficacy mediates the relationship between superstition and overconfidence. Taken together, these findings suggest that superstition strengthens people's belief in their own performance ability, which in turn boosts overconfidence.
MeSH term(s)	China ; Ethnic Groups ; Humans ; Minority Groups ; Students ; Superstitions
Language	English
Publishing date	2021-05-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	3126-4
ISSN	1940-1019 ; 0022-3980
ISSN (online)	1940-1019
ISSN	0022-3980
DOI	10.1080/00223980.2021.1902918
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Article ; Online: Remark on “Establishment and Validation of the Risk Nomogram of Poor Prognosis in Patients with Severe Pulmonary Infection Complicated with Respiratory Failure” by Qiang et al [Letter]

Liang D / Li X

International Journal of General Medicine, Vol Volume 16, Pp 3081-

2023 Volume 3082

Abstract: ... Xiaodong Li, Department of Nephrology, Baoding No. 1 Central Hospital of Hebei Medical Universtiy, Baoding ...

Abstract	Dongrui Liang,1 Xiaodong Li2 1Department of Ophthalmology, Baoding No. 1 Central Hospital of Hebei Medical Universtiy, Baoding, Hebei, People’s Republic of China; 2Department of Nephrology, Baoding No. 1 Central Hospital of Hebei Medical Universtiy, Baoding, Hebei, People’s Republic of ChinaCorrespondence: Xiaodong Li, Department of Nephrology, Baoding No. 1 Central Hospital of Hebei Medical Universtiy, Baoding Great Wall North Street No 320, Baoding, Hebei, 071000, People’s Republic of China, Tel +8618617789590, Email lxd_765@sina.com
Keywords	hemoglobin ; c-reactive proteins ; procalcitonin ; Medicine (General) ; R5-920
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Dove Medical Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Homotherapy for heteropathy active components and mechanisms of Qiang-Huo-Sheng-Shi decoction for treatment of rheumatoid arthritis and osteoarthritis.

Shi, Yuan-Yuan / Li, Ying-Qi / Xie, Xiang / Zhou, Yu-Ting / Zhang, Qian / Yu, Jia-Lin / Li, Ping / Mi, Na / Li, Fei

Computational biology and chemistry

2020 Volume 89, Page(s) 107397

Abstract: Qiang-Huo-Sheng-Shi decoction (QHSSD), a classic traditional Chinese herbal formula, which has been ...

Abstract	Qiang-Huo-Sheng-Shi decoction (QHSSD), a classic traditional Chinese herbal formula, which has been reported to be effective in rheumatoid arthritis (RA) and osteoarthritis (OA). However, the concurrent targeting mechanism of how the aforementioned formula is valid in the two distinct diseases OA and RA, which represents the homotherapy-for-heteropathy principle in traditional Chinese medicine (TCM), have not yet been clarified. In the present study, network pharmacology was adopted to analyze the potential molecular mechanism, and therapeutic effective components of QHSSD on both OA and RA. A total of 153 active ingredients in QHSSD were identified, 142 of which associated with 59 potential targets for the two diseases were identified. By constructing the protein-protein interaction network and the compound-target-disease network, 72 compounds and 10 proteins were obtained as the hub targets of QHSSD against OA and RA. The hub genes of ESR1, PTGS2, PPARG, IL1B, TNF, MMP2, IL6, CYP3A4, MAPK8, and ALB were mainly involved in osteoclast differentiation, the NF-κB and TNF signaling pathways. Moreover, molecular docking results showed that the screened active compounds had a high affinity for the hub genes. This study provides new insight into the molecular mechanisms behind how QHSSD presents homotherapy-for-heteropathy therapeutic efficacy in both OA and RA. For the first time, a two-disease model was linked with a TCM formula using network pharmacology to identify the key active components and understand the common mechanisms of its multi-pathway regulation. This study will inspire more innovative and important studies on the modern research of TCM formulas.
MeSH term(s)	Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/genetics ; Cell Differentiation/drug effects ; Databases, Pharmaceutical/statistics & numerical data ; Drugs, Chinese Herbal/metabolism ; Drugs, Chinese Herbal/pharmacology ; Gene Expression/drug effects ; Humans ; Molecular Docking Simulation ; Osteoarthritis/drug therapy ; Osteoarthritis/genetics ; Osteoclasts/cytology ; Pharmacology/methods ; Protein Interaction Maps
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2020-10-01
Publishing country	England
Document type	Journal Article
ISSN	1476-928X
ISSN (online)	1476-928X
DOI	10.1016/j.compbiolchem.2020.107397
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Article ; Online: Novel Compound-Target Interactions Prediction for the Herbal Formula Hua-Yu-Qiang-Shen-Tong-Bi-Fang.

Wang, Zihao / Lin, Hui-Heng / Linghu, Kegang / Huang, Run-Yue / Li, Guangyao / Zuo, Huali / Yu, Hua / Chan, Ging / Hu, Yuanjia

Chemical & pharmaceutical bulletin

2019 Volume 67, Issue 8, Page(s) 778–785

Abstract: ... For example, the Hua-Yu-Qiang-Shen-Tong-Bi-Fang (TBF), an herbal formula of Chinese medicine, has been used ...

Abstract	Herbal formulae have a long history in clinical medicine in Asia. While the complexity of the formulae leads to the complex compound-target interactions and the resultant multi-target therapeutic effects, it is difficult to elucidate the molecular/therapeutic mechanism of action for the many formulae. For example, the Hua-Yu-Qiang-Shen-Tong-Bi-Fang (TBF), an herbal formula of Chinese medicine, has been used for treating rheumatoid arthritis. However, the target information of a great number of compounds from the TBF formula is missing. In this study, we predicted the targets of the compounds from the TBF formula via network analysis and in silico computing. Initially, the information of the phytochemicals contained in the plants of the herbal formula was collected, and subsequently computed to their corresponding fingerprints for the sake of structural similarity calculation. Then a compound structural similarity network infused with available target information was constructed. Five local similarity indices were used and compared for their performance on predicting the potential new targets of the compounds. Finally, the Preferential Attachment Index was selected for it having an area under curve (AUC) of 0.886, which outperforms the other four algorithms in predicting the compound-target interactions. This method could provide a promising direction for identifying the compound-target interactions of herbal formulae in silico.
MeSH term(s)	Algorithms ; Arthritis, Rheumatoid/drug therapy ; Drug Compounding ; Drug Interactions ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Medicine, Chinese Traditional
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2019-07-31
Publishing country	Japan
Document type	Journal Article
ZDB-ID	213307-6
ISSN	1347-5223 ; 0009-2363
ISSN (online)	1347-5223
ISSN	0009-2363
DOI	10.1248/cpb.c18-00808
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Article ; Online: Qiang-Gan formula extract improves non-alcoholic steatohepatitis via regulating bile acid metabolism and gut microbiota in mice.

Li, Qiong / Li, Meng / Li, Fenghua / Zhou, Wenjun / Dang, Yanqi / Zhang, Li / Ji, Guang

Journal of ethnopharmacology

2020 Volume 258, Page(s) 112896

Abstract: Ethnopharmacological relevance: Qiang-Gan formula is a traditional Chinese medicine formula ... the effect of Qiang-Gan formula extract (QGE) on non-alcoholic steatohepatitis (NASH) and its underlying ...

Abstract	Ethnopharmacological relevance: Qiang-Gan formula is a traditional Chinese medicine formula, which has been widely used in treating liver diseases in China. Aim of the study: To investigate the effect of Qiang-Gan formula extract (QGE) on non-alcoholic steatohepatitis (NASH) and its underlying possible mechanisms. Materials and methods: The high-performance liquid chromatography finger-print method was used for the quality control of chemical components in QGE. Methionine- and choline-deficient diet-induced NASH mice were administrated with QGE via gavage for four weeks. Phenotypic parameters including liver histological change as well as serum levels of alanine transaminase (ALT), aspartate transaminase (AST) were detected. Bile acid profile in the serum, liver and fecal samples was analyzed by gas chromatography-mass spectrometer technique, and fecal microbiota was detected by 16S rDNA sequencing. Expression of liver G protein-coupled bile acid receptor 1 (TGR5), farnesiod X receptor (FXR), tumor necrosis factor-α (TNF-α), interleukin 1β (IL-1β) as well as molecules in nuclear factor kappa B (NF-κB) pathway was assayed by immunohistochemistry staining, RT-qPCR, or Western blot, respectively. Results: QGE alleviated liver inflammation, reduced serum ALT and AST levels and liver TNF-α and IL-1β expression in NASH mice. It also decreased liver and serum BA concentration and increased fecal lithocholicacid (LCA) production in this animal model. QGE altered the structure of gut microbiota, predominantly increased LCA-producing bacteria Bacteroides and Clostridium in NASH mice. In addition, the expression of liver TGR5 but not FXR was increased, and the molecules in NF-κB pathway were decreased in QGE-treated NASH mice. Conclusions: QGE was effective in preventing NASH, possibly by regulation of gut microbiota-mediated LCA production, promotion of TGR5 expression and suppression of the NF-κB activation.
MeSH term(s)	Animals ; Bile Acids and Salts/metabolism ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Gastrointestinal Microbiome/drug effects ; Lithocholic Acid/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; NF-kappa B/metabolism ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/physiopathology ; Receptors, G-Protein-Coupled/genetics
Chemical Substances	Bile Acids and Salts ; Drugs, Chinese Herbal ; Gpbar1 protein, mouse ; NF-kappa B ; Receptors, G-Protein-Coupled ; qianggan ; Lithocholic Acid (5QU0I8393U)
Language	English
Publishing date	2020-04-20
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2020.112896
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Article ; Online: Pharmacokinetics, hepatic disposition, and heart tissue distribution of 14 compounds in rat after oral administration of Qi-Li-Qiang-Xin capsule via ultra-high-performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry.

Tang, Xi-Yang / Dai, Zi-Qin / Zeng, Jia-Xing / Li, Zi-Ting / Fan, Cai-Lian / Yao, Zhi-Hong / Yao, Xin-Sheng / Dai, Yi

Journal of separation science

2022 Volume 45, Issue 13, Page(s) 2177–2189

Abstract: ... compounds after the oral administration of Qi-Li-Qiang-Xin capsule. Ginsenoside Rb1, alisol A, astragaloside ... of Qi-Li-Qiang-Xin capsule. ...

Abstract	In the present study, a specific and sensitive approach using ultra-high-performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry was developed and validated for the quantitative analysis of 14 constituents in rat plasma, liver, and heart. The method was fully validated and successfully applied to pharmacokinetic, hepatic disposition, and heart tissue distribution studies of 14 compounds after the oral administration of Qi-Li-Qiang-Xin capsule. Ginsenoside Rb1, alisol A, astragaloside IV, and periplocymarin were found to be highly exposed in rat plasma, while toxic components such as hypaconitine, mesaconitine, and periplocin had low circulation levels in vivo. Moreover, sinapine thiocyanate, neoline, formononetin, calycosin, and alisol A exhibited significant liver first-pass effects. Notably, high levels of alisol A, periplocymarin, benzoylmesaconine, and benzoylhypaconine were observed in the heart. Based on high exposure and appropriate pharmacokinetic features in the systemic plasma and heart, astragaloside IV, ginsenoside Rb1, periplocymarin, benzoylmesaconine, benzoylhypaconine, and alisol A can be considered as the main potentially effective components. Ultimately, the results provide relevant information for discovery of effective substances, as well as further anti-heart failure action mechanism investigations of Qi-Li-Qiang-Xin capsule.
MeSH term(s)	Administration, Oral ; Animals ; Chromatography, High Pressure Liquid/methods ; Drugs, Chinese Herbal/analysis ; Liver/chemistry ; Rats ; Tandem Mass Spectrometry/methods ; Tissue Distribution
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2022-05-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2047990-6
ISSN	1615-9314 ; 1615-9306
ISSN (online)	1615-9314
ISSN	1615-9306
DOI	10.1002/jssc.202101008
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Article ; Online: Ancient DNA reveals genetic connections between early Di-Qiang and Han Chinese.

Li, Jiawei / Zeng, Wen / Zhang, Ye / Ko, Albert Min-Shan / Li, Chunxiang / Zhu, Hong / Fu, Qiaomei / Zhou, Hui

BMC evolutionary biology

2017 Volume 17, Issue 1, Page(s) 239

Abstract: Background: Ancient Di-Qiang people once resided in the Ganqing region of China, adjacent ... to the Central Plain area from where Han Chinese originated. While gene flow between the Di-Qiang and Han Chinese ... from an early Di-Qiang site (Mogou site dated ~4000 years old) and compared them to other ancient DNA across ...

Abstract	Background: Ancient Di-Qiang people once resided in the Ganqing region of China, adjacent to the Central Plain area from where Han Chinese originated. While gene flow between the Di-Qiang and Han Chinese has been proposed, there is no evidence to support this view. Here we analyzed the human remains from an early Di-Qiang site (Mogou site dated ~4000 years old) and compared them to other ancient DNA across China, including an early Han-related site (Hengbei site dated ~3000 years old) to establish the underlying genetic relationship between the Di-Qiang and ancestors of Han Chinese. Results: We found Mogou mtDNA haplogroups were highly diverse, comprising 14 haplogroups: A, B, C, D (D, D4, D5), F, G, M7, M8, M10, M13, M25, N, N9a, and Z. In contrast, Mogou males were all Y-DNA haplogroup O3a2/P201; specifically one male was further assigned to O3a2c1a/M117 using targeted unique regions on the non-recombining region of the Y-chromosome. We compared Mogou to 7 other ancient and 38 modern Chinese groups, in a total of 1793 individuals, and found that Mogou shared close genetic distances with Taojiazhai (a more recent Di-Qiang population), Hengbei, and Northern Han. We modeled their interactions using Approximate Bayesian Computation, and support was given to a potential admixture of ~13-18% between the Mogou and Northern Han around 3300-3800 years ago. Conclusions: Mogou harbors the earliest genetically identifiable Di-Qiang, ancestral to the Taojiazhai, and up to ~33% paternal and ~70% of its maternal haplogroups could be found in present-day Northern Han Chinese.
MeSH term(s)	Asian Continental Ancestry Group/genetics ; Bayes Theorem ; China ; Chromosomes, Human, Y/genetics ; Computer Simulation ; DNA, Ancient ; DNA, Mitochondrial/genetics ; Ethnic Groups/genetics ; Genetics, Population ; Geography ; Haplotypes/genetics ; Humans ; Male ; Models, Genetic ; Phylogeny ; Polymorphism, Single Nucleotide/genetics ; Principal Component Analysis ; Probability ; Time Factors
Chemical Substances	DNA, Ancient ; DNA, Mitochondrial
Language	English
Publishing date	2017-12-04
Publishing country	England
Document type	Journal Article
ISSN	1471-2148
ISSN (online)	1471-2148
DOI	10.1186/s12862-017-1082-0
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