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  1. Article ; Online: Editorial comment on: "Developing a prediction model of children's asthma risk using population-based family history health records".

    Kamga, Audrey / Manca, Enrica / Caimmi, Davide / Eigenmann, Philippe / Akenroye, Ayobami

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2023  Volume 34, Issue 12, Page(s) e14063

    MeSH term(s) Child ; Humans ; Asthma/epidemiology ; Medical History Taking ; Risk Assessment
    Language English
    Publishing date 2023-12-26
    Publishing country England
    Document type Editorial
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.14063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3096: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Riding the waves of COVID-19 pandemics - A call for a multiobjective compromise.

    Bignami, Elena / Manca, Davide / Bellini, Valentina

    Trends in anaesthesia & critical care

    2021  Volume 38, Page(s) 13–15

    Language English
    Publishing date 2021-04-25
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2210-8467
    ISSN (online) 2210-8467
    DOI 10.1016/j.tacc.2021.04.004
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  3. Article: The Genetic Landscape of Systemic Rheumatic Diseases: A Comprehensive Multigene-Panel Study Identifying Key Gene Polymorphisms.

    Simula, Elena Rita / Jasemi, Seyedesomaye / Cossu, Davide / Manca, Pietro Carmelo / Sanna, Daria / Scarpa, Fabio / Meloni, Gianfranco / Cusano, Roberto / Sechi, Leonardo Antonio

    Pharmaceuticals (Basel, Switzerland)

    2024  Volume 17, Issue 4

    Abstract: Systemic rheumatic diseases, including conditions such as rheumatoid arthritis, Sjögren's syndrome, systemic sclerosis, and systemic lupus erythematosus, represent a complex array of autoimmune disorders characterized by chronic inflammation and diverse ... ...

    Abstract Systemic rheumatic diseases, including conditions such as rheumatoid arthritis, Sjögren's syndrome, systemic sclerosis, and systemic lupus erythematosus, represent a complex array of autoimmune disorders characterized by chronic inflammation and diverse clinical manifestations. This study focuses on unraveling the genetic underpinnings of these diseases by examining polymorphisms in key genes related to their pathology. Utilizing a comprehensive genetic analysis, we have documented the involvement of these genetic variations in the pathogenesis of rheumatic diseases. Our study has identified several key polymorphisms with notable implications in rheumatic diseases. Polymorphism at chr11_112020916 within the
    Language English
    Publishing date 2024-03-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph17040438
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  4. Article ; Online: Physiologically-based pharmacokinetic simulations in pharmacotherapy: selection of the optimal administration route for exogenous melatonin.

    Savoca, Adriana / Manca, Davide

    ADMET & DMPK

    2019  Volume 7, Issue 1, Page(s) 44–59

    Abstract: The benefits of melatonin on human body are drawing increasing attention from several researchers in different fields. While its role as cure for sleep disturbances (e.g., jet lag, insomnia) is well documented and established, new functions in ... ...

    Abstract The benefits of melatonin on human body are drawing increasing attention from several researchers in different fields. While its role as cure for sleep disturbances (e.g., jet lag, insomnia) is well documented and established, new functions in physiological and pathophysiological processes are emerging. To investigate these effects, there is need for the characterization of melatonin transport processes in the body and resulting pharmacokinetics. Although recent works propose physiologically-based pharmacokinetic modelling of melatonin, no work has yet highlighted the potential of PBPK simulations to shed light on melatonin pharmacokinetic aspects and discrimination among administration routes. This paper presents, validates, and discusses a versatile PBPK model featuring different ways of administration and compares the resulting pharmacokinetic profiles of intravenous, oral, and transdermal administration, with the goal of understanding which is the optimal route to achieve either physiological and/or supraphysiological melatonin levels.
    Language English
    Publishing date 2019-02-23
    Publishing country Croatia
    Document type Journal Article
    ISSN 1848-7718
    ISSN (online) 1848-7718
    DOI 10.5599/admet.625
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  5. Article ; Online: A minimal physiologically based pharmacokinetic model for high-dose methotrexate.

    Pesenti, Giuseppe / Foppoli, Marco / Manca, Davide

    Cancer chemotherapy and pharmacology

    2021  Volume 88, Issue 4, Page(s) 595–606

    Abstract: Purpose: High-dose methotrexate (HDMTX) is administered for the treatment of a variety of malignant tumors. Wide intra- and inter-individual variabilities characterize the pharmacokinetics of MTX, which is mostly excreted renally. HDMTX dosages are ... ...

    Abstract Purpose: High-dose methotrexate (HDMTX) is administered for the treatment of a variety of malignant tumors. Wide intra- and inter-individual variabilities characterize the pharmacokinetics of MTX, which is mostly excreted renally. HDMTX dosages are prescribed as a function of body surface area whereas dose adjustments depending on renal function are not well defined. We develop a population pharmacokinetic model with a physiological description of renal excretion as the basis for clinical tools able to suggest model-informed dosages and support therapeutic monitoring.
    Methods: This article presents a minimal physiologically based pharmacokinetic (PBPK) model for HDMTX, which specifically accounts for individual characteristics such as body weight, height, gender, age, hematocrit, and serum creatinine to provide individualized predictions. The model supplies a detailed and mechanistic description of capillary and cellular exchanges between plasma, interstitial fluid, and intracellular fluid compartments, and focuses on an individualized description of renal excretion.
    Results: The minimal PBPK model is identified and validated with a literature dataset based on Chinese patients suffering from primary central nervous system lymphoma. A comparison with a pharmacokinetic model from the literature suggests that the proposed model provides improved predictions. Remarkably, the model does not present any significant bias in a wide range of degrees of renal function.
    Conclusion: Results show that model predictions can capture the wide intra- and inter-individual variability of HDMTX, and highlight the role played by the individual degree of renal function. The proposed model can be the basis for the development of clinical decision-support systems for individualized dosages and therapeutic monitoring.
    MeSH term(s) Antimetabolites, Antineoplastic/administration & dosage ; Antimetabolites, Antineoplastic/pharmacokinetics ; Dose-Response Relationship, Drug ; Drug Monitoring/methods ; Female ; Humans ; Kidney/metabolism ; Male ; Methotrexate/administration & dosage ; Methotrexate/pharmacokinetics ; Models, Biological ; Neoplasms/drug therapy
    Chemical Substances Antimetabolites, Antineoplastic ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2021-06-13
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Validation Study
    ZDB-ID 6820-2
    ISSN 1432-0843 ; 0344-5704 ; 0943-9404
    ISSN (online) 1432-0843
    ISSN 0344-5704 ; 0943-9404
    DOI 10.1007/s00280-021-04305-2
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1420: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article: A simplified math approach to predict ICU beds and mortality rate for hospital emergency planning under Covid-19 pandemic.

    Manca, Davide / Caldiroli, Dario / Storti, Enrico

    Computers & chemical engineering

    2020  Volume 140, Page(s) 106945

    Abstract: The different stages of Covid-19 pandemic can be described by two key-variables: ICU patients and deaths in hospitals. We propose simple models that can be used by medical doctors and decision makers to predict the trends on both short-term and long-term ...

    Abstract The different stages of Covid-19 pandemic can be described by two key-variables: ICU patients and deaths in hospitals. We propose simple models that can be used by medical doctors and decision makers to predict the trends on both short-term and long-term horizons. Daily updates of the models with real data allow forecasting some key indicators for decision-making (an Excel file in the Supplemental material allows computing them). These are beds allocation, residence time, doubling time, rate of renewal, maximum daily rate of change (positive/negative), halfway points, maximum plateaus, asymptotic conditions, and dates and time intervals when some key thresholds are overtaken. Doubling time of ICU beds for Covid-19 emergency can be as low as 2-3 days at the outbreak of the pandemic. The models allow identifying the possible departure of the phenomenon from the predicted trend and thus can play the role of early warning systems and describe further outbreaks.
    Keywords covid19
    Language English
    Publishing date 2020-06-04
    Publishing country England
    Document type Journal Article
    ISSN 0098-1354
    ISSN 0098-1354
    DOI 10.1016/j.compchemeng.2020.106945
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  7. Article ; Online: How molecular allergology can shape the management of allergic airways diseases.

    Caimmi, Davide / Manca, Enrica / Carboni, Elena / Demoly, Pascal

    Current opinion in allergy and clinical immunology

    2020  Volume 20, Issue 2, Page(s) 149–154

    Abstract: Purpose of review: In allergy, personalized medicine passes through the assessment of molecular allergens sensitization profiles. Such technique may help to better diagnose and treat patients suffering from allergic respiratory diseases.: Recent ... ...

    Abstract Purpose of review: In allergy, personalized medicine passes through the assessment of molecular allergens sensitization profiles. Such technique may help to better diagnose and treat patients suffering from allergic respiratory diseases.
    Recent findings: Different laboratory tests are available today to assess sensitization to molecular allergens, from singleplex assays, to unspecific, screening multiplex assays, mainly performed through microarrays or macroarrays. It is important to collect both results from specific IgE toward allergen extracts and toward molecular allergens, to collect the most complete information on the patient's profile, and therefore to highlight genuine sensitization, and exclude cross-reaction and sensitization because of pan-allergens. Being able to know the exact molecular sensitization profile of the patient, also helps predicting the possible evolution of the disease, and targeting the most appropriate allergen immunotherapy treatment to prescribe.
    Summary: Even though a cost-effective analysis of running multiple assays in allergic patients has not been performed yet, such technique proved to be more efficient in detecting the appropriate treatment in each patient and in analyzing the true sensitization profile in patients suffering from allergic rhinitis, conjunctivitis, and asthma.
    MeSH term(s) Allergens/administration & dosage ; Allergens/immunology ; Asthma/diagnosis ; Asthma/immunology ; Asthma/therapy ; Cross Reactions ; Desensitization, Immunologic/adverse effects ; Desensitization, Immunologic/methods ; Humans ; Immunoglobulin E/immunology ; Immunologic Tests/methods ; Molecular Diagnostic Techniques/methods ; Rhinitis, Allergic/diagnosis ; Rhinitis, Allergic/immunology ; Rhinitis, Allergic/therapy ; Treatment Outcome
    Chemical Substances Allergens ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2020-01-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2088710-3
    ISSN 1473-6322 ; 1528-4050
    ISSN (online) 1473-6322
    ISSN 1528-4050
    DOI 10.1097/ACI.0000000000000630
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5666: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Association of HLA-A*11:01, -A*24:02, and -B*18:01 with Prostate Cancer Risk: A Case-Control Study.

    Manca, Maria Antonietta / Simula, Elena Rita / Cossu, Davide / Solinas, Tatiana / Madonia, Massimo / Cusano, Roberto / Sechi, Leonardo Antonio

    International journal of molecular sciences

    2023  Volume 24, Issue 20

    Abstract: The major histocompatibility complex (MHC) loci, the most polymorphic regions within the human genome, encode protein complexes responsible for antigen presentation and CD4+ and CD8+ cell activation. In prostate cancer (PCa), the second most diagnosed ... ...

    Abstract The major histocompatibility complex (MHC) loci, the most polymorphic regions within the human genome, encode protein complexes responsible for antigen presentation and CD4+ and CD8+ cell activation. In prostate cancer (PCa), the second most diagnosed cancer in the male population, MHC loci undergo significant changes in their expression patterns, which affect the ability of the immune system to attack and eliminate malignant cells. The purpose of this study was to explore the genetic diversity of human leukocyte antigen (HLA)-A and HLA-B in patients with PCa and healthy controls (HCs) by performing HLA genotyping using NGS technology. The analysis highlighted statistically significant differences (
    MeSH term(s) Humans ; Male ; Case-Control Studies ; HLA-A Antigens ; HLA-B Antigens ; Major Histocompatibility Complex ; Histocompatibility Antigens ; Alleles ; Haplotypes ; Neoplasms/genetics
    Chemical Substances HLA-A Antigens ; HLA-B Antigens ; Histocompatibility Antigens
    Language English
    Publishing date 2023-10-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242015398
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  9. Article: Correlation between Polymorphisms of Vitamin D Metabolism Genes and Perianal Disease in Crohn's Disease.

    Cusato, Jessica / Cafasso, Carla / Antonucci, Miriam / Palermiti, Alice / Manca, Alessandra / Caviglia, Gian Paolo / Vernero, Marta / Armandi, Angelo / Saracco, Giorgio Maria / D'Avolio, Antonio / Ribaldone, Davide Giuseppe

    Biomedicines

    2024  Volume 12, Issue 2

    Abstract: Although the role of vitamin D (VD) in the pathogenesis and progression of Crohn's disease (CD) is known, the association between single-nucleotide polymorphisms (SNPs) of genes linked to vitamin D pathway and CD risk is still under study. Furthermore, ... ...

    Abstract Although the role of vitamin D (VD) in the pathogenesis and progression of Crohn's disease (CD) is known, the association between single-nucleotide polymorphisms (SNPs) of genes linked to vitamin D pathway and CD risk is still under study. Furthermore, no significant association has been previously found between these SNPs and perianal CD (pCD), a severe phenotypic manifestation of CD that may present as perianal fistula, abscess, and recto-vaginal fistula. Among the mechanisms involved in its pathogenesis, local inflammation and intestinal microbiota alteration are recognized. VD seems to act on these elements. The aim of this study was to evaluate the presence of an association between SNPs of genes coding for enzymes, transporters, and receptors involved in the VD pathway and the occurrence of pCD. Blood samples of 206 patients with CD, including 34 with pCD, were analyzed for
    Language English
    Publishing date 2024-01-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12020320
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  10. Article: Therapeutic Drug Monitoring as a Tool for the Clinical Outcome Prediction in Vedolizumab-Treated Patients: An Italian Pilot Study.

    Cusato, Jessica / Ribaldone, Davide Giuseppe / Falzone, Michela Helga / Manca, Alessandra / Antonucci, Miriam / Palermiti, Alice / Saracco, Giorgio Maria / Ceccarelli, Linda / Costa, Francesco / Bottari, Andrea / Fornaroli, Ginevra / Caviglia, Gian Paolo / D'Avolio, Antonio / Bertani, Lorenzo

    Biomedicines

    2024  Volume 12, Issue 4

    Abstract: Over the years, vedolizumab (VDZ) has emerged as a more effective target therapy for inflammatory bowel disease. The aim of this work was to analyze a cohort of inflammatory bowel disease patients, evaluating the association between VDZ serum ... ...

    Abstract Over the years, vedolizumab (VDZ) has emerged as a more effective target therapy for inflammatory bowel disease. The aim of this work was to analyze a cohort of inflammatory bowel disease patients, evaluating the association between VDZ serum concentrations at 6 months from starting therapy and their clinical and biochemical indexes within one year of treatment, correlating drug levels with response and clinical remission. Forty patients treated with VDZ were enrolled. Drug concentrations were quantified through ELISA methods. VDZ levels correlated with hemoglobin levels at twelve months of therapy (
    Language English
    Publishing date 2024-04-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12040824
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