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Article: C=C-Ene-Reductases Reduce the C=N Bond of Oximes.

Velikogne, Stefan / Breukelaar, Willem B / Hamm, Florian / Glabonjat, Ronald A / Kroutil, Wolfgang

ACS catalysis

2020 Volume 10, Issue 22, Page(s) 13377–13382

Abstract: ... enzyme is known. For instance, not a single defined enzyme has been described for the reduction of the C ...

Abstract	Although enzymes have been found for many reactions, there are still transformations for which no enzyme is known. For instance, not a single defined enzyme has been described for the reduction of the C=N bond of an oxime, only whole organisms. Such an enzymatic reduction of an oxime may give access to (chiral) amines. By serendipity, we found that the oxime moiety adjacent to a ketone as well as an ester group can be reduced by ene-reductases (ERs) to an intermediate amino group. ERs are well-known enzymes for the reduction of activated alkenes, as of α,β-unsaturated ketones. For the specific substrate used here, the amine intermediate spontaneously reacts further to tetrasubstituted pyrazines. This reduction reaction represents an unexpected promiscuous activity of ERs expanding the toolkit of transformations using enzymes.
Language	English
Publishing date	2020-11-03
Publishing country	United States
Document type	Journal Article
ISSN	2155-5435
ISSN	2155-5435
DOI	10.1021/acscatal.0c03755
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Article: Untersuchungen zur Wirksamkeit eines UV-C-Roboters zur Keimreduktion im klinischen Umfeld

Buhl, S. / Humig, N. / Hartig, J. / Stich, A. / Hamm, S. / Bulitta, C.

Hygiene & Medizin

2023 Volume 48, Issue 4, Page(s) D27

Language	German
Document type	Article
ZDB-ID	518696-1
ISSN	0172-3790
Database	Current Contents Medicine

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Article: Untersuchungen zur Wirksamkeit eines UV-C-Roboters zur Keimreduktion im klinischen Umfeld

Buhl*, S. / Humig, N. / Hartig, J. / Stich, A. / Hamm, S. / Bulitta, C.

Hygienemanagement Praxis

2023 Volume 13, Issue 1, Page(s) D27

Language	German
Document type	Article
ZDB-ID	3049317-1
Database	Current Contents Medicine

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Article ; Online: Stabilization of c-Myc by the atypical cell cycle regulator, Spy1, decreases efficacy of breast cancer treatments.

Ferraiuolo, Rosa-Maria / Fifield, Bre-Anne / Hamm, Caroline / Porter, Lisa A

Breast cancer research and treatment

2022 Volume 196, Issue 1, Page(s) 17–30

Abstract: Purpose: c-Myc is frequently upregulated in breast cancers, however, targeting c-Myc has proven ... to be a challenge. Targeting of downstream mediators of c-Myc, such as the 'cyclin-like' cell cycle ... samples from TNBC patients were obtained and constructed into a TMA and stained for c-Myc and Spy1 protein ...

Abstract	Purpose: c-Myc is frequently upregulated in breast cancers, however, targeting c-Myc has proven to be a challenge. Targeting of downstream mediators of c-Myc, such as the 'cyclin-like' cell cycle regulator Spy1, may be a viable therapeutic option in a subset of breast cancer subtypes. Methods: Mouse mammary tumor cells isolated from MMTV-Myc mice and human breast cancer cell lines were used to manipulate Spy1 levels followed by tamoxifen or chemotherapeutic treatment with a variety of endpoints. Patient samples from TNBC patients were obtained and constructed into a TMA and stained for c-Myc and Spy1 protein levels. Results: Over time, MMTV-Myc cells show a decreased response to tamoxifen treatment with increasing levels of Spy1 in the tamoxifen-resistant cells. shRNA against Spy1 re-establishes tamoxifen sensitivity. Spy1 was found to be highly elevated in human TNBC cell and patient samples, correlating to c-Myc protein levels. c-Myc was found to be stabilized by Spy1 and knocking down Spy1 in TNBC cells shows a significant increase in response to chemotherapy treatments. Conclusion: Understanding the interplay between protein expression level and response to treatment is a critical factor in developing novel treatment options for breast cancer patients. These data have shown a connection between Spy1 and c-Myc protein levels in more aggressive breast cancer cells and patient samples. Furthermore, targeting c-Myc has proven difficult, these data suggest targeting Spy1 even when c-Myc is elevated can confer an advantage to current chemotherapies.
MeSH term(s)	Animals ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Cell Cycle ; Cell Cycle Checkpoints ; Cell Line, Tumor ; Cell Proliferation ; Cyclins ; Female ; Humans ; Mice ; RNA, Small Interfering ; Tamoxifen/pharmacology ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/genetics ; Triple Negative Breast Neoplasms/metabolism
Chemical Substances	Cyclins ; RNA, Small Interfering ; Tamoxifen (094ZI81Y45)
Language	English
Publishing date	2022-08-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	604563-7
ISSN	1573-7217 ; 0167-6806
ISSN (online)	1573-7217
ISSN	0167-6806
DOI	10.1007/s10549-022-06715-z
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Article: Experiences and Perspectives From Women Taking Investigational Therapy for Hepatitis C Virus During Pregnancy.

Kislovskiy, Yasaswi / Chappell, Catherine / Flaherty, Emily / Hamm, Megan E / Cameron, Flor de Abril / Krans, Elizabeth E / Chang, Judy C

Substance abuse : research and treatment

2021 Volume 15, Page(s) 11782218211046261

Abstract: Objective: Describe the experiences and perspectives among pregnant people with chronic HCV infection receiving ledipasvir/sofosbuvir (LDV/SOF) therapy during pregnancy.: Methods: We conducted semi-structured, in-depth interviews within an open-label, ...

Abstract	Objective: Describe the experiences and perspectives among pregnant people with chronic HCV infection receiving ledipasvir/sofosbuvir (LDV/SOF) therapy during pregnancy. Methods: We conducted semi-structured, in-depth interviews within an open-label, phase 1 study of LDV/SOF therapy among pregnant people with chronic HCV infection. Participants took 12 weeks of LDV/SOF and were interviewed at enrollment and again at the end of treatment. We transcribed the interviews verbatim and coded them with NVivo software for subsequent inductive thematic analysis. Results: Nine pregnant people completed the study, leading to 18 interview transcripts. All participants identified as women. Eight women acquired HCV through injection drug use, and 1 through perinatal transmission. We identified 3 themes. (1) Treatment for HCV during pregnancy with LDV/SOF was tolerable and convenient. (2) Women described that taking investigational LDV/SOF increased their self-esteem and sense of well-being due to possible cure from HCV, and they felt that the experience of working hard to achieve cure may potentially prevent return to drug abuse in the future. (3) Women appreciated researchers and providers that gave non-judgmental care and communicated honestly, and preferred person-centered care that acknowledges women's individual needs. Conclusions: Women stated that cure from HCV would be "life-changing," and described antepartum treatment for HCV with LDV/SOF as tolerable and desired, when provided by non-judgmental providers. Antepartum treatment was found to be acceptable by study participants and should be further evaluated to combat the increasing HCV epidemic among young persons, including pregnant people.
Language	English
Publishing date	2021-09-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1458030-5
ISSN	1547-0164 ; 1178-2218 ; 0889-7077
ISSN (online)	1547-0164
ISSN	1178-2218 ; 0889-7077
DOI	10.1177/11782218211046261
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Article ; Online: The C0-C1f Region of Cardiac Myosin Binding Protein-C Induces Pro-Inflammatory Responses in Fibroblasts via TLR4 Signaling.

Yogeswaran, Athiththan / Troidl, Christian / McNamara, James W / Wilhelm, Jochen / Truschel, Theresa / Widmann, Laila / Aslam, Muhammad / Hamm, Christian W / Sadayappan, Sakthivel / Lipps, Christoph

Cells

2021 Volume 10, Issue 6

Abstract: Myocardial injury is associated with inflammation and fibrosis. Cardiac myosin-binding protein-C ... cMyBP-C) is cleaved by µ-calpain upon myocardial injury, releasing C0-C1f, an ...

Abstract	Myocardial injury is associated with inflammation and fibrosis. Cardiac myosin-binding protein-C (cMyBP-C) is cleaved by µ-calpain upon myocardial injury, releasing C0-C1f, an
MeSH term(s)	Actins/metabolism ; Cytoskeletal Proteins/metabolism ; Fibroblasts/metabolism ; Humans ; Myofibroblasts/metabolism ; Sarcomeres/metabolism ; Toll-Like Receptor 4/metabolism
Chemical Substances	Actins ; Cytoskeletal Proteins ; Toll-Like Receptor 4
Language	English
Publishing date	2021-05-26
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells10061326
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Article ; Online: C-Reactive Protein as a Possible Predictor of Trail-Making Performance in Individuals with Psychiatric Disorders.

Dalkner, Nina / Reininghaus, Eva / Schwalsberger, Karin / Rieger, Alexandra / Hamm, Carlo / Pilz, René / Lenger, Melanie / Queissner, Robert / Falzberger, Valerie S / Platzer, Martina / Fellendorf, Frederike T / Birner, Armin / Bengesser, Susanne A / Weiss, Elisabeth M / McIntyre, Roger S / Mangge, Harald / Reininghaus, Bernd

Nutrients

2020 Volume 12, Issue 10

Abstract: ... A/B. Multiple linear regression models were calculated to assess the predictive value of C-reactive ... disorders, C-reactive protein serum concentration is a relevant and important predictor of Trail-Making Test ... ratio was not related to cognitive test scores. The involvement of C-reactive protein as a peripheral ...

Abstract	Cognitive dysfunction is a prominent feature of psychiatric disorders. Studies have shown that systemic low-grade inflammation is crucial in the development of cognitive deficits across psychiatric disorders. The aim of this study was to further examine the role of inflammation and inflammatory mediators in cognitive function in psychiatric disorders. This study included 364 inpatients (53% females) with International Classification of Diseases (ICD)-10 F3 (affective disorders) and F4 (neurotic, stress-related, and somatoform disorders) diagnoses. The mean age was 52 years (22 to 69 years) and the median body mass index was 27.6. Cognitive function was assessed with the Color-Word Interference Test after Stroop and the Trail-Making Test A/B. Multiple linear regression models were calculated to assess the predictive value of C-reactive protein and the kynurenine/tryptophan ratio on cognitive function controlling for age, sex, education, premorbid verbal intelligence quotient illness duration, depressive symptoms, and obesity-related parameters (e.g., body mass index, high-density lipoprotein). Our data confirm that in patients with psychiatric disorders, C-reactive protein serum concentration is a relevant and important predictor of Trail-Making Test B performance, measuring cognitive flexibility. The effect size of this association did not change much after adding clinical and metabolic variables into the regression model. The kynurenine/tryptophan ratio was not related to cognitive test scores. The involvement of C-reactive protein as a peripheral inflammatory marker in cognitive flexibility and psychomotor processing speed in psychiatric illness can be concluded.
MeSH term(s)	Adult ; Aged ; Biomarkers/blood ; C-Reactive Protein/analysis ; Cognitive Dysfunction/blood ; Cognitive Dysfunction/psychology ; Female ; Humans ; Inflammation ; Inflammation Mediators/blood ; Kynurenine/blood ; Linear Models ; Male ; Mental Disorders/blood ; Mental Disorders/psychology ; Middle Aged ; Neuropsychological Tests ; Predictive Value of Tests ; Psychomotor Performance ; Reaction Time ; Stroop Test ; Trail Making Test ; Tryptophan/blood ; Young Adult
Chemical Substances	Biomarkers ; Inflammation Mediators ; Kynurenine (343-65-7) ; Tryptophan (8DUH1N11BX) ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2020-10-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu12103019
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Checkliste EKG

Hamm, Christian / Willems, Stephan

(Checklisten der aktuellen Medizin)

2023

Author's details	Christian Hamm, Stephan Willems unter Mitarbeit von Jens Hartmann und Shibu Mathew
Series title	Checklisten der aktuellen Medizin
Keywords	Herzdiagnostik ; Elektrokardiografie ; EKG ; Belastungs-EKG ; Notfallversorgung ; Zentrale Notaufnahme ; Schrittmachertherapie ; Reanimationsalgorithmen ; Ersteinschätzung ; Leitwege ; Arrhythmien ; Defibrillation ; Triage ; Rettungsleitstelle ; Schockraum ; 128 ; Hardcover, Softcover / Medizin/Klinische Fächer ; Elektrokardiogramm
Subject	EKG
Language	German
Size	261 Seiten, Illustrationen, 18 cm x 11 cm, 259 g
Edition	5., überarbeitete Auflage
Publisher	Thieme
Publishing place	Stuttgart
Publishing country	Germany
Document type	Book
Accompanying material	Zugang zu Online-Ausgabe über Code
Old title	Vorangegangen ist
HBZ-ID	HT030355180
ISBN	978-3-13-245303-6 ; 3-13-245303-X ; 9783132453043 ; 9783132453050 ; 3132453048 ; 3132453056
Database	Catalogue ZB MED Medicine, Health

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2023 A 979	available for loan (reading room)	Lesesaal EG
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Article ; Online: Experiences and Perspectives From Women Taking Investigational Therapy for Hepatitis C Virus During Pregnancy

Yasaswi Kislovskiy / Catherine Chappell / Emily Flaherty / Megan E Hamm / Flor de Abril Cameron / Elizabeth E Krans / Judy C Chang

Substance Abuse: Research and Treatment, Vol

2021 Volume 15

Abstract: Objective: Describe the experiences and perspectives among pregnant people with chronic HCV infection receiving ledipasvir/sofosbuvir (LDV/SOF) therapy during pregnancy. Methods: We conducted semi-structured, in-depth interviews within an open-label, ... ...

Abstract	Objective: Describe the experiences and perspectives among pregnant people with chronic HCV infection receiving ledipasvir/sofosbuvir (LDV/SOF) therapy during pregnancy. Methods: We conducted semi-structured, in-depth interviews within an open-label, phase 1 study of LDV/SOF therapy among pregnant people with chronic HCV infection. Participants took 12 weeks of LDV/SOF and were interviewed at enrollment and again at the end of treatment. We transcribed the interviews verbatim and coded them with NVivo software for subsequent inductive thematic analysis. Results: Nine pregnant people completed the study, leading to 18 interview transcripts. All participants identified as women. Eight women acquired HCV through injection drug use, and 1 through perinatal transmission. We identified 3 themes. (1) Treatment for HCV during pregnancy with LDV/SOF was tolerable and convenient. (2) Women described that taking investigational LDV/SOF increased their self-esteem and sense of well-being due to possible cure from HCV, and they felt that the experience of working hard to achieve cure may potentially prevent return to drug abuse in the future. (3) Women appreciated researchers and providers that gave non-judgmental care and communicated honestly, and preferred person-centered care that acknowledges women’s individual needs. Conclusions: Women stated that cure from HCV would be “life-changing,” and described antepartum treatment for HCV with LDV/SOF as tolerable and desired, when provided by non-judgmental providers. Antepartum treatment was found to be acceptable by study participants and should be further evaluated to combat the increasing HCV epidemic among young persons, including pregnant people.
Keywords	Public aspects of medicine ; RA1-1270
Subject code	360
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Development of an ADP-ribosylation assay for residual toxicity in C. difficile binary toxin CDTa using automated capillary western blot.

Rustandi, Richard R / Hamm, Melissa

Journal of pharmaceutical and biomedical analysis

2020 Volume 182, Page(s) 113125

Abstract: CDTa, an actin ADP-ribosylation transferase, is a binary toxin produced by the bacterium Clostridium difficile which is commonly associated with the hypervirulent strain present in Clostridium difficile infections. The mutated form of CDTa, 4mCDTa, is ... ...

Abstract	CDTa, an actin ADP-ribosylation transferase, is a binary toxin produced by the bacterium Clostridium difficile which is commonly associated with the hypervirulent strain present in Clostridium difficile infections. The mutated form of CDTa, 4mCDTa, is one of the components in the tetravalent Clostridium difficile vaccine in which the residual toxicity of the ADP-ribosylation activity needs to be monitored for safety reasons. There are several ADP- ribosylation activity methods employing techniques such as ELISA, manual Western blot, or SDS PAGE, but all these methods are usually time consuming and labor intensive. Here we describe the development of new quantitative capillary based western for monitoring the presence of ADP-ribosylation activity in CDTa and 4mCDTa using novel, automated Simple Western™ technology. Furthermore, we have measured for the first time the enzyme's kinetic parameters, K
MeSH term(s)	ADP Ribose Transferases/genetics ; ADP-Ribosylation/physiology ; Bacterial Proteins/genetics ; Blotting, Western ; Clostridioides difficile/enzymology
Chemical Substances	Bacterial Proteins ; ADP Ribose Transferases (EC 2.4.2.-) ; actin-specific ADP-ribosyltransferase, Clostridium (EC 2.4.2.31)
Language	English
Publishing date	2020-01-23
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2020.113125
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