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  1. Article ; Online: Eugenol alleviates acrylamide-induced rat testicular toxicity by modulating AMPK/p-AKT/mTOR signaling pathway and blood-testis barrier remodeling.

    Saleh, Dalia O / Baraka, Sara M / Jaleel, Gehad A Abdel / Hassan, Azza / Ahmed-Farid, Omar A

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 1910

    Abstract: This study aimed to investigate the effects of eugenol treatment on reproductive parameters in acrylamide (ACR)-intoxicated rats. The study evaluated alterations in relative testes and epididymides weights, sperm quality, serum hormonal status, seminal ... ...

    Abstract This study aimed to investigate the effects of eugenol treatment on reproductive parameters in acrylamide (ACR)-intoxicated rats. The study evaluated alterations in relative testes and epididymides weights, sperm quality, serum hormonal status, seminal plasma amino acids, testicular cell energy and phospholipids content, oxidative and nitrosative stress parameters, adenosine monophosphate-activated protein kinase/ phosphoinositide 3-kinase/phosphor-protein kinase B/mammalian target of rapamycin (AMPK/PI3K/p-AKT/mTOR) signaling pathway, blood-testis barrier (BTB) remodeling markers, testicular autophagy and apoptotic markers, as well as histopathological alterations in testicular tissues. The results revealed that eugenol treatment demonstrated a significant improvement in sperm quality parameters, with increased sperm cell concentration, progressive motility live sperm, and a reduction in abnormal sperm, compared to the ACR-intoxicated group. Furthermore, eugenol administration increased the levels of seminal plasma amino acids in a dose-dependent manner. In addition, eugenol treatment dose-dependently improved testicular oxidative/nitrosative stress biomarkers by increasing oxidized and reduced glutathione levels and reducing malondialdehyde and nitric oxide contents as compared to ACRgroup. However, eugenol treatment at a high dose restored the expression of AMPK, PI3K, and mTOR genes, to levels comparable to the control group, while significantly increasing p-AKT content compared to the ACRgroup. In conclusion, the obtained findings suggest the potential of eugenol as a therapeutic agent in mitigating ACR-induced detrimental effects on the male reproductive system via amelioration of ROS-mediated autophagy, apoptosis, AMPK/p-AKT/mTOR signaling pathways and BTB remodeling.
    MeSH term(s) Male ; Animals ; Rats ; Testis ; AMP-Activated Protein Kinases ; Eugenol/pharmacology ; Proto-Oncogene Proteins c-akt ; Blood-Testis Barrier ; Phosphatidylinositol 3-Kinases ; Semen ; Signal Transduction ; TOR Serine-Threonine Kinases ; Acrylamide/toxicity ; Amino Acids ; Antifibrinolytic Agents ; Mammals
    Chemical Substances AMP-Activated Protein Kinases (EC 2.7.11.31) ; Eugenol (3T8H1794QW) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Acrylamide (20R035KLCI) ; Amino Acids ; Antifibrinolytic Agents ; mTOR protein, rat (EC 2.7.1.1)
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-52259-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Neuromodulatory role of L-arginine: nitric oxide precursor against thioacetamide-induced-hepatic encephalopathy in rats via downregulation of NF-κB-mediated apoptosis.

    Sedik, Ahmed A / Hassan, Azza / Saleh, Dalia O

    Environmental science and pollution research international

    2023  Volume 30, Issue 35, Page(s) 84791–84804

    Abstract: ... kg; p.o.) concurrently with TAA for the six consecutive weeks. Blood samples were withdrawn, and rats ...

    Abstract The aim of the present study was to investigate the impact of arginine (ARG), a nitric oxide (NO) precursor, on thioacetamide (TAA)-induced hepatic encephalopathy (HE) in rats by injection of TAA (100 mg/kg, i.p) three times per week for six consecutive weeks. TAA-injected rats were administered ARG (100 mg/kg; p.o.) concurrently with TAA for the six consecutive weeks. Blood samples were withdrawn, and rats were sacrificed; liver and brain tissues were isolated. Results of the present study demonstrated that ARG administration to TAA-injected rats revealed a restoration in the serum and brain ammonia levels as well as serum aspartate transaminase, alanine transaminase, and alkaline phosphatase and total bilirubin levels as well as behavioral alterations evidenced by restoration in locomotor activity, motor skill performance, and memory impairment. ARG showed also improvement in the hepatic and neuro-biochemical values, pro-inflammatory cytokines, and oxidative stress biomarkers. All these results were confirmed by histopathological evaluation as well as ultrastructural imaging of the cerebellum using a transmission electron microscope. Furthermore, treatment with ARG could ameliorate the immunological reactivity of nuclear factor erythroid-2-related factor 2 (Nrf2) and cleaved caspase-3 proteins in the cerebellum and hepatic tissues. From all the previous results, it can be fulfilled that ARG showed a beneficial role in modulating the adverse complications associated with TAA-induced HE in rats via reducing hyperammonemia and downregulating nuclear factor kappa B (NF-κB)-mediated apoptosis.
    MeSH term(s) Rats ; Animals ; Hepatic Encephalopathy/chemically induced ; NF-kappa B/metabolism ; Thioacetamide/toxicity ; Nitric Oxide/metabolism ; Down-Regulation ; Liver/metabolism ; Arginine/adverse effects ; Arginine/metabolism ; Oxidative Stress
    Chemical Substances NF-kappa B ; Thioacetamide (075T165X8M) ; Nitric Oxide (31C4KY9ESH) ; Arginine (94ZLA3W45F)
    Language English
    Publishing date 2023-06-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-28184-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 5915: Show issues

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  3. Article ; Online: Irinotecan-gut microbiota interactions and the capability of probiotics to mitigate Irinotecan-associated toxicity.

    Mahdy, Marwa S / Azmy, Ahmed F / Dishisha, Tarek / Mohamed, Wafaa R / Ahmed, Kawkab A / Hassan, Ahmed / Aidy, Sahar El / El-Gendy, Ahmed O

    BMC microbiology

    2023  Volume 23, Issue 1, Page(s) 53

    Abstract: Background: Irinotecan is a chemotherapeutic agent used to treat a variety of tumors, including colorectal cancer (CRC). In the intestine, it is transformed into SN-38 by gut microbial enzymes, which is responsible for its toxicity during excretion.: ... ...

    Abstract Background: Irinotecan is a chemotherapeutic agent used to treat a variety of tumors, including colorectal cancer (CRC). In the intestine, it is transformed into SN-38 by gut microbial enzymes, which is responsible for its toxicity during excretion.
    Objective: Our study highlights the impact of Irinotecan on gut microbiota composition and the role of probiotics in limiting Irinotecan-associated diarrhea and suppressing gut bacterial β-glucuronidase enzymes.
    Material and methods: To investigate the effect of Irinotecan on the gut microbiota composition, we applied 16S rRNA gene sequencing in three groups of stool samples from healthy individuals, colon cancer, and Irinotecan treated patients (n = 5/group). Furthermore, three Lactobacillus spp.; Lactiplantibacillus plantarum (L. plantarum), Lactobacillus acidophilus (L. acidophilus), Lacticaseibacillus rhamnosus (L. rhamnosus) were used in a single and mixed form to in-vitro explore the effect of probiotics on the expression of β-glucuronidase gene from E. coli. Also, probiotics were introduced in single and mixed forms in groups of mice before the administration of Irinotecan, and their protective effects were explored by assessing the level of reactive oxidative species (ROS) as well as studying the concomitant intestinal inflammation and apoptosis.
    Results: The gut microbiota was disturbed in individuals with colon cancer and after Irinotecan treatment. In the healthy group, Firmicutes were more abundant than Bacteriodetes, which was the opposite in the case of colon-cancer or Irinotecan treated groups. Actinobacteria and Verrucomicrobia were markedly present within the healthy group, while Cyanobacteria were noted in colon-cancer and the Irinotecan-treated groups. Enterobacteriaceae and genus Dialister were more abundant in the colon-cancer group than in other groups. The abundance of Veillonella, Clostridium, Butryicicoccus, and Prevotella were increased in Irinotecan-treated groups compared to other groups. Using Lactobacillus spp. mixture in mice models significantly relieved Irinotecan-induced diarrhea through the reduction of both β-glucuronidase expression and ROS, in addition to guarding gut epithelium against microbial dysbiosis and proliferative crypt injury.
    Conclusions: Irinotecan-based chemotherapy altered intestinal microbiota. The gut microbiota participates greatly in determining both the efficacy and toxicity of chemotherapies, of which the toxicity of Irinotecan is caused by the bacterial ß-glucuronidase enzymes. The gut microbiota can now be aimed and modulated to promote efficacy and decrease the toxicity of chemotherapeutics. The used probiotic regimen in this study lowered mucositis, oxidative stress, cellular inflammation, and apoptotic cascade induction of Irinotecan.
    MeSH term(s) Animals ; Mice ; Irinotecan/adverse effects ; Gastrointestinal Microbiome ; Escherichia coli ; RNA, Ribosomal, 16S/genetics ; Reactive Oxygen Species ; Colonic Neoplasms ; Glucuronidase/genetics ; Diarrhea/chemically induced ; Diarrhea/prevention & control
    Chemical Substances Irinotecan (7673326042) ; RNA, Ribosomal, 16S ; Reactive Oxygen Species ; Glucuronidase (EC 3.2.1.31)
    Language English
    Publishing date 2023-03-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041505-9
    ISSN 1471-2180 ; 1471-2180
    ISSN (online) 1471-2180
    ISSN 1471-2180
    DOI 10.1186/s12866-023-02791-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Diagnosis of Idiopathic Granulomatous Mastitis in a Sudanese Woman.

    Almobarak, Ahmed O / Siddig, Samar B / Hassan, Ahmed / Ahmed, Mohamed H

    Journal of microscopy and ultrastructure

    2021  Volume 10, Issue 1, Page(s) 33–35

    Abstract: Idiopathic granulomatous mastitis (IGM) is a relatively rare specific chronic inflammatory process of unknown etiology, that diagnostically overlaps with common breast pathologies in Sudan, namely breast cancer (BC) and tuberculous mastitis (TBM). We ... ...

    Abstract Idiopathic granulomatous mastitis (IGM) is a relatively rare specific chronic inflammatory process of unknown etiology, that diagnostically overlaps with common breast pathologies in Sudan, namely breast cancer (BC) and tuberculous mastitis (TBM). We report the case of a 34-year-old female who presented with a 1-month history of a painful lump in the lower outer quadrant of her left breast. A tru-cut biopsy showed features of granulomatous inflammation suggestive of IGM. Four months later, she presented with similar features and fine-needle aspiration cytology (FNAC) confirmed the presence of IGM and excluded the presence of both, BC and TBM. Histology once again confirmed the diagnosis of granulomatous mastitis with no evidence of breast cancer. Grocott's Methenamine Silver, Ziehl-Neelsen stain, and polymerase chain reaction were negative and accordingly the possibility of fungal infection and TBM were excluded. To our knowledge, this is the first case report of IGM in Sudan. FNAC helped in correct diagnosis of our case and importantly, conditions such as BC and TBM were both excluded as common mimickers of IGM. Although breast biopsy is the main golden approach in the diagnosis of IGM in addition to the usefulness of adjunct ancillary microbiological techniques, still further research is needed to establish whether FNAC can be a reliable tool in the diagnosis of IGM with the common practice of this diagnostic tool in Sudan.
    Language English
    Publishing date 2021-12-02
    Publishing country India
    Document type Case Reports
    ISSN 2213-8803
    ISSN (online) 2213-8803
    DOI 10.4103/JMAU.JMAU_51_20
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  5. Article ; Online: Periconceptional folic acid usage and its associated factors in eastern Sudan: A cross-sectional study.

    Hassan, Ahmed Ali / Hassan, Albagir M / Bashir, Amal O / Adam, Gamal K / AlHabardi, Nadiah / Adam, Ishag

    Women's health (London, England)

    2024  Volume 20, Page(s) 17455057231224176

    Abstract: Background: Several countries poorly adhere to the World Health Organization's recommendation of folic acid supplementation in the periconceptional period, especially in limited-resource settings.: Objective: The objective of this study was to ... ...

    Abstract Background: Several countries poorly adhere to the World Health Organization's recommendation of folic acid supplementation in the periconceptional period, especially in limited-resource settings.
    Objective: The objective of this study was to investigate the prevalence of and the factors associated with folic acid usage in the periconceptional period among pregnant women at Gadarif Maternity Hospital in eastern Sudan.
    Study design: This is a cross-sectional study.
    Methods: This study was conducted in eastern Sudan from April to September 2022. A total of 720 pregnant women in their first trimester were enrolled. The sociodemographic characteristics and clinical and obstetrical data of pregnant women in their first trimester were assessed using a face-to-face questionnaire. In addition, multivariate regression analysis was performed.
    Results: In this study, the median (interquartile range) of the age and gravidity of the enrolled women was 26.3 (24.14-29.52) years and 2 (1-4), respectively. Of these 720 women, 423 (58.8%) used folic acid during the periconceptional period, while 27 (3.7%) women used folic acid in the preconceptional period. None of the investigated factors (age, residence, education, employment, body mass index, or gravidity) were associated with periconceptional use of folic acid.
    Conclusion: The study revealed a low prevalence of folic acid usage in preconceptional period among pregnant women in eastern Sudan. Additional efforts are needed to promote folic acid usage in the preconceptional period as well as in the first trimester.
    MeSH term(s) Female ; Pregnancy ; Humans ; Male ; Folic Acid/therapeutic use ; Cross-Sectional Studies ; Dietary Supplements ; Sudan/epidemiology ; Surveys and Questionnaires ; Neural Tube Defects/epidemiology ; Neural Tube Defects/prevention & control
    Chemical Substances Folic Acid (935E97BOY8)
    Language English
    Publishing date 2024-01-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2274503-8
    ISSN 1745-5065 ; 1745-5057
    ISSN (online) 1745-5065
    ISSN 1745-5057
    DOI 10.1177/17455057231224176
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6629: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: The association between red cell distribution width and newly diagnosed hypertension among adults in Northern Sudan: a case-control study.

    Hassan, Ahmed A / Musa, Shaza M / Omer, Husam-Eldin O / Adam, Ishag

    The Libyan journal of medicine

    2023  Volume 18, Issue 1, Page(s) 2254502

    Abstract: The existing data have shown inconsistency about the association between red cell distribution width (RDW) and hypertension. Thus, the aim of the present study was to investigate the association between RDW and newly diagnosed hypertension among adults ... ...

    Abstract The existing data have shown inconsistency about the association between red cell distribution width (RDW) and hypertension. Thus, the aim of the present study was to investigate the association between RDW and newly diagnosed hypertension among adults in Sudan. This was a case-control study conducted in Northern Sudan from July to September 2022. The cases were patients with newly diagnosed hypertension (
    MeSH term(s) Humans ; Adult ; Case-Control Studies ; Erythrocyte Indices ; Sudan/epidemiology ; Hypertension/epidemiology ; Body Mass Index
    Language English
    Publishing date 2023-01-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2273005-9
    ISSN 1819-6357 ; 1819-6357
    ISSN (online) 1819-6357
    ISSN 1819-6357
    DOI 10.1080/19932820.2023.2254502
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: A Closed-Loop Clinical Audit of Surgical Documentation of Inpatient Records at a Tertiary Level Hospital in Egypt.

    Hassan, Ahmed G / Elqaffas, Eyad O / Elbouridy, Ahmed M / Shawky, Mazen M / El-Fayoumi, Tarek A

    Cureus

    2023  Volume 15, Issue 12, Page(s) e49862

    Abstract: Background: Optimal record keeping is a very essential component in health care provision especially in the surgical setting. This study aimed to evaluate the quality of surgical records in wards of a surgical department at Alexandria Main University ... ...

    Abstract Background: Optimal record keeping is a very essential component in health care provision especially in the surgical setting. This study aimed to evaluate the quality of surgical records in wards of a surgical department at Alexandria Main University Hospital, Egypt.
    Methods: We created a systematically designed checklist using standard hospital protocol and universal guidelines presented in the previously validated STAR and CRABEL auditing tools as a basis for Yes/No questions. This checklist was then used to prospectively evaluate the quality of surgical records of patients who underwent surgery in the surgical oncology department from July 2023 to October 2023. Total STAR and section-specific STAR scores were then calculated and compared statistically.
    Results: A total of 80 records were randomly selected and evaluated using the STAR questionnaire. All domains showed improvement compared to the baseline except for the discharge summary which did not change from an already relatively high baseline of 96±0.0. The highest improvements were observed in the anesthetic record and operative record domains which increased from 90.65±4.3 and 86.15±5.347 to 100±0.0 and 95.6±3.365, respectively.
    Conclusion: Our study demonstrates that significant improvements in the quality of surgical records can be achieved by simply using preprepared templates, personnel education, and systematic auditing.
    Language English
    Publishing date 2023-12-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.49862
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  8. Article: The Antimicrobial Effect of Gold Quantum Dots and Femtosecond Laser Irradiation on the Growth Kinetics of Common Infectious Eye Pathogens: An In Vitro Study.

    El-Gendy, Ahmed O / Obaid, Yousif / Ahmed, Esraa / Enwemeka, Chukuka S / Hassan, Mansour / Mohamed, Tarek

    Nanomaterials (Basel, Switzerland)

    2022  Volume 12, Issue 21

    Abstract: We studied the antimicrobial effect of gold quantum dots (AuQDs), femtosecond laser irradiation, and the combined effect of laser irradiation and AuQD treatment against common infectious eye pathogens. The INSPIRE HF100 laser system (Spectra Physics) ... ...

    Abstract We studied the antimicrobial effect of gold quantum dots (AuQDs), femtosecond laser irradiation, and the combined effect of laser irradiation and AuQD treatment against common infectious eye pathogens. The INSPIRE HF100 laser system (Spectra Physics) provided a femtosecond laser, which was pumped by a mode-locked femtosecond Ti: sapphire laser MAI TAI HP (Spectra Physics), while a Quanta-Ray nanosecond Nd: YAG laser (Spectra-Physics) was used to precisely synthesize 7.8, 8.7, and 11.6 nm spherical AuQDs. Then, the in vitro growth kinetics and growth rate analysis of
    Language English
    Publishing date 2022-10-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano12213757
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  9. Article: Dense Cover, but Not Allelopathic Potential, of Naturalized Alien

    Hassan, Mahmoud O / Mohamed, Howida Y / Okla, Mohammad K / Kiani, Bushra Hafeez / Amro, Ahmed

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 21

    Abstract: Exotic plants usually exhibit problems for native species where they coexist. This study evaluated the effect of naturalized ... ...

    Abstract Exotic plants usually exhibit problems for native species where they coexist. This study evaluated the effect of naturalized alien
    Language English
    Publishing date 2023-10-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12213736
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  10. Article ; Online: Corrigendum to "Supplementing rabbit diets with butylated hydroxyanisole affects oxidative stress, growth performance, and meat quality" [Animal 15(9) (2021) 100339].

    Imbabi, T / Hassan, A / Ahmed-Farid, O / El-Garhy, O / Sabeq, I / Moustafa, M / Mohammadein, A / Hassan, N / Osman, A / Sitohy, M

    Animal : an international journal of animal bioscience

    2023  Volume 17, Issue 7, Page(s) 100859

    Language English
    Publishing date 2023-07-14
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2257920-5
    ISSN 1751-732X ; 1751-7311
    ISSN (online) 1751-732X
    ISSN 1751-7311
    DOI 10.1016/j.animal.2023.100859
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    In stock of ZB MED Bonn / Germany

    Z 7718: Show issues

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