LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 4 of total 4

Search options

  1. Article ; Online: A stress response pathway involving sirtuins, forkheads and 14-3-3 proteins.

    Berdichevsky, Ala / Guarente, Leonard

    Cell cycle (Georgetown, Tex.)

    2006  Volume 5, Issue 22, Page(s) 2588–2591

    Abstract: A conserved sir2 deacetylase gene can determine longevity of yeast, flies and worms. Recently we have reported a molecular mechanism of action of the C. elegans homologue sir-2.1. Our study revealed a novel stress-dependent pathway for lifespan ... ...

    Abstract A conserved sir2 deacetylase gene can determine longevity of yeast, flies and worms. Recently we have reported a molecular mechanism of action of the C. elegans homologue sir-2.1. Our study revealed a novel stress-dependent pathway for lifespan determination in which SIR-2.1 binds to 14-3-3 proteins and a forkhead transcription factor DAF-16 to activate transcription of DAF-16 target genes. DAF-16 has long been known as a central protein in the regulation of lifespan that interfaces with multiple pathways. Recent studies by us and other laboratories suggest that DAF-16 requires co-factors for full activity. In this prospective we review recent literature highlighting the role of SIR-2.1, 14-3-3 and other DAF-16 co-factors in DAF-16 activation.
    MeSH term(s) 14-3-3 Proteins/metabolism ; Animals ; Caenorhabditis elegans/physiology ; Caenorhabditis elegans Proteins/metabolism ; Forkhead Transcription Factors/metabolism ; Humans ; Models, Biological ; Oxidative Stress ; Signal Transduction ; Sirtuins/metabolism ; Transcription Factors/metabolism
    Chemical Substances 14-3-3 Proteins ; Caenorhabditis elegans Proteins ; Forkhead Transcription Factors ; Transcription Factors ; daf-16 protein, C elegans ; SIR-2.1 protein, C elegans (EC 3.5.1.-) ; Sirtuins (EC 3.5.1.-)
    Language English
    Publishing date 2006-11-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2146183-1
    ISSN 1551-4005 ; 1538-4101 ; 1554-8627
    ISSN (online) 1551-4005
    ISSN 1538-4101 ; 1554-8627
    DOI 10.4161/cc.5.22.3513
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5881: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span.

    Berdichevsky, Ala / Viswanathan, Mohan / Horvitz, H Robert / Guarente, Leonard

    Cell

    2006  Volume 125, Issue 6, Page(s) 1165–1177

    Abstract: The longevity of Caenorhabditis elegans is promoted by extra copies of the sir-2.1 gene in a manner dependent on the forkhead transcription factor DAF-16. We identify two C. elegans 14-3-3 proteins as SIR-2.1 binding partners and show that 14-3-3 genes ... ...

    Abstract The longevity of Caenorhabditis elegans is promoted by extra copies of the sir-2.1 gene in a manner dependent on the forkhead transcription factor DAF-16. We identify two C. elegans 14-3-3 proteins as SIR-2.1 binding partners and show that 14-3-3 genes are required for the life-span extension conferred by extra copies of sir-2.1. 14-3-3 proteins are also required for SIR-2.1-induced transcriptional activation of DAF-16 and stress resistance. Following heat stress, SIR-2.1 can bind DAF-16 in a 14-3-3-dependent manner. By contrast, low insulin-like signaling does not promote SIR-2.1/DAF-16 interaction, and sir-2.1 and the 14-3-3 genes are not required for the regulation of life span by the insulin-like signaling pathway. We propose the existence of a stress-dependent pathway in which SIR-2.1 and 14-3-3 act in parallel to the insulin-like pathway to activate DAF-16 and extend life span.
    MeSH term(s) 14-3-3 Proteins/physiology ; Animals ; Caenorhabditis elegans/physiology ; Caenorhabditis elegans Proteins/physiology ; Forkhead Transcription Factors ; Heat-Shock Response ; Insulin/physiology ; Longevity ; Oxidative Stress ; Protein Binding ; Signal Transduction ; Sirtuins/physiology ; Transcription Factors/physiology
    Chemical Substances 14-3-3 Proteins ; Caenorhabditis elegans Proteins ; Forkhead Transcription Factors ; Insulin ; Transcription Factors ; daf-16 protein, C elegans ; par-5 protein, C elegans ; SIR-2.1 protein, C elegans (EC 3.5.1.-) ; Sirtuins (EC 3.5.1.-)
    Language English
    Publishing date 2006-01-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2006.04.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1167: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 58: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Error-free recombinational repair predominates over mutagenic translesion replication in E. coli.

    Berdichevsky, Ala / Izhar, Lior / Livneh, Zvi

    Molecular cell

    2002  Volume 10, Issue 4, Page(s) 917–924

    Abstract: Tolerance mechanisms are important in the ability of cells to cope with DNA damage. In E. coli, the two main damage tolerance mechanisms are recombinational repair (RR) and translesion replication (TLR). Here we show that RR effectively repairs gaps ... ...

    Abstract Tolerance mechanisms are important in the ability of cells to cope with DNA damage. In E. coli, the two main damage tolerance mechanisms are recombinational repair (RR) and translesion replication (TLR). Here we show that RR effectively repairs gaps opposite DNA lesions. When both mechanisms are functional, RR predominates over TLR, being responsible for 86% of the repair events. This predominance of RR is determined by the high concentration of RecA present under SOS conditions, which causes a differential inhibition of TLR. Further inhibition of TLR is caused by the RecA-catalyzed strand exchange reaction of RR. This molecular hierarchy in the tolerance of DNA lesions ensures that the nonmutagenic RR predominates over the mutagenic TLR, thereby contributing to genetic stability.
    MeSH term(s) Bacterial Proteins/metabolism ; DNA Damage/genetics ; DNA Repair/genetics ; DNA Replication/genetics ; DNA, Bacterial/genetics ; DNA-Directed DNA Polymerase/metabolism ; Escherichia coli/enzymology ; Escherichia coli/genetics ; Escherichia coli Proteins/metabolism ; Mutagenesis ; Rec A Recombinases/metabolism ; Recombination, Genetic/genetics ; SOS Response (Genetics)
    Chemical Substances Bacterial Proteins ; DNA, Bacterial ; Escherichia coli Proteins ; Rec A Recombinases (EC 2.7.7.-) ; DNA polymerase V, E coli (EC 2.7.7.7) ; DNA-Directed DNA Polymerase (EC 2.7.7.7) ; UmuD protein, E coli (EC 2.7.7.7)
    Language English
    Publishing date 2002-11-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/s1097-2765(02)00679-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5055: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span.

    Viswanathan, Mohan / Kim, Stuart K / Berdichevsky, Ala / Guarente, Leonard

    Developmental cell

    2005  Volume 9, Issue 5, Page(s) 605–615

    Abstract: C. elegans SIR-2.1, a member of the Sir-2 family of NAD(+)-dependent protein deacetylases, has been shown to regulate nematode aging via the insulin/IGF pathway transcription factor daf-16. Treatment of C. elegans with the small molecule resveratrol, ... ...

    Abstract C. elegans SIR-2.1, a member of the Sir-2 family of NAD(+)-dependent protein deacetylases, has been shown to regulate nematode aging via the insulin/IGF pathway transcription factor daf-16. Treatment of C. elegans with the small molecule resveratrol, however, extends life span in a manner fully dependent upon sir-2.1, but independent of daf-16. Microarray analysis of worms treated with resveratrol demonstrates the transcriptional induction of a family of genes encoding prion-like glutamine/asparagine-rich proteins involved in endoplasmic reticulum (ER) stress response to unfolded proteins. RNA interference of abu-11, a member of this ER stress gene family, abolishes resveratrol-mediated life span extension, and overexpression of abu-11 extends the life span of transgenic animals. Furthermore, SIR-2.1 normally represses transcription of abu-11 and other ER stress gene family members, indicating that resveratrol extends life span by inhibiting sir-2.1-mediated repression of ER stress genes. Our findings demonstrate that abu-11 and other members of its ER stress gene family are positive determinants of C. elegans life span.
    MeSH term(s) Animals ; Asparagine/chemistry ; Caenorhabditis elegans/drug effects ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/physiology ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Endoplasmic Reticulum/drug effects ; Endoplasmic Reticulum/genetics ; Endoplasmic Reticulum/metabolism ; Fungal Proteins/metabolism ; Gene Expression Profiling ; Glutamine/chemistry ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/metabolism ; Longevity/drug effects ; Longevity/genetics ; RNA Interference/drug effects ; RNA Interference/physiology ; Sirtuins/metabolism ; Stilbenes/pharmacology ; Transcription, Genetic/drug effects ; Transcription, Genetic/genetics
    Chemical Substances Abu-11 protein, C elegans ; Caenorhabditis elegans Proteins ; Fungal Proteins ; Heat-Shock Proteins ; Stilbenes ; Glutamine (0RH81L854J) ; Asparagine (7006-34-0) ; SIR-2.1 protein, C elegans (EC 3.5.1.-) ; Sirtuins (EC 3.5.1.-) ; resveratrol (Q369O8926L)
    Language English
    Publishing date 2005-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2005.09.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5742: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 76: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top