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Article ; Online: The Validity of Perceived Recovery Status as a Marker of Daily Recovery Following a High-Volume Back-Squat Protocol.

Tolusso, Danilo V / Dobbs, Ward C / MacDonald, Haley V / Winchester, Lee J / Laurent, C Matthew / Fedewa, Michael V / Esco, Michael R

International journal of sports physiology and performance

2022 Volume 17, Issue 6, Page(s) 886–892

Abstract: ... to evaluate the sensitivity of PRS as a subjective marker of recovery up to 72 hours after a high-volume back ...

Abstract	Although a variety of tools to monitor recovery have been developed, many are impractical for daily use due to cost, time, and challenges with interpretation. The Perceived Recovery Status (PRS) scale was recently developed as an expeditious, noninvasive tool to assess recovery status. While PRS has been strongly associated with repeated sprinting performance, a paucity of research exists relating PRS and performance recovery following resistance exercise. Purpose: The purpose of this study was to evaluate the sensitivity of PRS as a subjective marker of recovery up to 72 hours after a high-volume back-squat protocol. Methods: Eleven resistance-trained men reported to the laboratory on 5 separate occasions (1 familiarization session and 4 testing sessions). The first testing session was considered the baseline session and consisted of a nonfatiguing performance assessment (ie, countermovement jumps and back squats) and a fatiguing back-squat protocol of 8 sets of 10 at 70% 1-repetition maximum separated by 2 minutes of recovery. Participants returned 24, 48, and 72 hours following baseline to provide a PRS rating and complete the performance assessment. Results: Repeated-measures correlations revealed strong associations between PRS countermovement jump (r = .84) and mean bar velocity (r = .80) (both P < .001). Conclusions: The current findings suggest that PRS can be used as a method to effectively assess daily recovery following a fatiguing bout of resistance exercise. Practitioners are cautioned that the relationship between PRS and performance recovery is individualized, and equivalent PRS scores between individuals are not indicative of similar recovery.
MeSH term(s)	Exercise ; Fatigue ; Humans ; Male ; Monitoring, Physiologic ; Muscle, Skeletal ; Posture ; Resistance Training/methods
Language	English
Publishing date	2022-03-07
Publishing country	United States
Document type	Journal Article
ISSN	1555-0273
ISSN (online)	1555-0273
DOI	10.1123/ijspp.2021-0360
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Article: A novel bladder cancer urinary biomarker: can it go where no marker has gone before?

Dobbs, Ryan W / Abern, Michael R

Translational andrology and urology

2015 Volume 7, Issue Suppl 1, Page(s) S96–S97

Language	English
Publishing date	2015-10-05
Publishing country	China
Document type	Editorial ; Comment
ZDB-ID	2851630-8
ISSN	2223-4691 ; 2223-4691 ; 2223-4683
ISSN (online)	2223-4691
ISSN	2223-4691 ; 2223-4683
DOI	10.21037/tau.2018.01.04
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Article ; Online: An immune-based biomarker signature is associated with mortality in COVID-19 patients.

Abers, Michael S / Delmonte, Ottavia M / Ricotta, Emily E / Fintzi, Jonathan / Fink, Danielle L / de Jesus, Adriana A Almeida / Zarember, Kol A / Alehashemi, Sara / Oikonomou, Vasileios / Desai, Jigar V / Canna, Scott W / Shakoory, Bita / Dobbs, Kerry / Imberti, Luisa / Sottini, Alessandra / Quiros-Roldan, Eugenia / Castelli, Francesco / Rossi, Camillo / Brugnoni, Duilio /

Biondi, Andrea / Bettini, Laura Rachele / D'Angio', Mariella / Bonfanti, Paolo / Castagnoli, Riccardo / Montagna, Daniela / Licari, Amelia / Marseglia, Gian Luigi / Gliniewicz, Emily F / Shaw, Elana / Kahle, Dana E / Rastegar, Andre T / Stack, Michael / Myint-Hpu, Katherine / Levinson, Susan L / DiNubile, Mark J / Chertow, Daniel W / Burbelo, Peter D / Cohen, Jeffrey I / Calvo, Katherine R / Tsang, John S / Su, Helen C / Gallin, John I / Kuhns, Douglas B / Goldbach-Mansky, Raphaela / Lionakis, Michail S / Notarangelo, Luigi D

JCI insight

2021 Volume 6, Issue 1

Abstract: ... with mortality. Multivariate analyses of longitudinal biomarker trajectories identified 8 of the aforementioned ...

Abstract	Immune and inflammatory responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contribute to disease severity of coronavirus disease 2019 (COVID-19). However, the utility of specific immune-based biomarkers to predict clinical outcome remains elusive. Here, we analyzed levels of 66 soluble biomarkers in 175 Italian patients with COVID-19 ranging from mild/moderate to critical severity and assessed type I IFN-, type II IFN-, and NF-κB-dependent whole-blood transcriptional signatures. A broad inflammatory signature was observed, implicating activation of various immune and nonhematopoietic cell subsets. Discordance between IFN-α2a protein and IFNA2 transcript levels in blood suggests that type I IFNs during COVID-19 may be primarily produced by tissue-resident cells. Multivariable analysis of patients' first samples revealed 12 biomarkers (CCL2, IL-15, soluble ST2 [sST2], NGAL, sTNFRSF1A, ferritin, IL-6, S100A9, MMP-9, IL-2, sVEGFR1, IL-10) that when increased were independently associated with mortality. Multivariate analyses of longitudinal biomarker trajectories identified 8 of the aforementioned biomarkers (IL-15, IL-2, NGAL, CCL2, MMP-9, sTNFRSF1A, sST2, IL-10) and 2 additional biomarkers (lactoferrin, CXCL9) that were substantially associated with mortality when increased, while IL-1α was associated with mortality when decreased. Among these, sST2, sTNFRSF1A, IL-10, and IL-15 were consistently higher throughout the hospitalization in patients who died versus those who recovered, suggesting that these biomarkers may provide an early warning of eventual disease outcome.
MeSH term(s)	Adrenal Cortex Hormones/therapeutic use ; Adult ; Aged ; Anti-Bacterial Agents/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antiviral Agents/therapeutic use ; Azithromycin/therapeutic use ; Biomarkers ; COVID-19/genetics ; COVID-19/immunology ; COVID-19/mortality ; COVID-19/therapy ; Calgranulin B/genetics ; Calgranulin B/immunology ; Case-Control Studies ; Chemokine CCL2/genetics ; Chemokine CCL2/immunology ; Chemokine CXCL9/genetics ; Chemokine CXCL9/immunology ; Enzyme Inhibitors/therapeutic use ; Female ; Ferritins/genetics ; Ferritins/immunology ; Gene Expression Profiling ; Humans ; Hydroxychloroquine/therapeutic use ; Immunologic Factors/therapeutic use ; Interferon Type I/genetics ; Interferon Type I/immunology ; Interferon-gamma/genetics ; Interferon-gamma/immunology ; Interleukin-1 Receptor-Like 1 Protein/genetics ; Interleukin-1 Receptor-Like 1 Protein/immunology ; Interleukin-10/genetics ; Interleukin-10/immunology ; Interleukin-15/genetics ; Interleukin-15/immunology ; Interleukin-2/genetics ; Interleukin-2/immunology ; Interleukin-6/genetics ; Interleukin-6/immunology ; Lactoferrin/genetics ; Lactoferrin/immunology ; Lipocalin-2/genetics ; Lipocalin-2/immunology ; Male ; Matrix Metalloproteinase 9/genetics ; Matrix Metalloproteinase 9/immunology ; Middle Aged ; Multivariate Analysis ; NF-kappa B/genetics ; NF-kappa B/immunology ; Prognosis ; Receptors, Tumor Necrosis Factor, Type I/genetics ; Receptors, Tumor Necrosis Factor, Type I/immunology ; SARS-CoV-2 ; Severity of Illness Index ; Vascular Endothelial Growth Factor Receptor-1/genetics ; Vascular Endothelial Growth Factor Receptor-1/immunology
Chemical Substances	Adrenal Cortex Hormones ; Anti-Bacterial Agents ; Antibodies, Monoclonal, Humanized ; Antiviral Agents ; Biomarkers ; CCL2 protein, human ; CXCL9 protein, human ; Calgranulin B ; Chemokine CCL2 ; Chemokine CXCL9 ; Enzyme Inhibitors ; IL10 protein, human ; IL15 protein, human ; IL1RL1 protein, human ; IL2 protein, human ; IL6 protein, human ; Immunologic Factors ; Interferon Type I ; Interleukin-1 Receptor-Like 1 Protein ; Interleukin-15 ; Interleukin-2 ; Interleukin-6 ; LCN2 protein, human ; LTF protein, human ; Lipocalin-2 ; NF-kappa B ; Receptors, Tumor Necrosis Factor, Type I ; S100A9 protein, human ; TNFRSF1A protein, human ; Interleukin-10 (130068-27-8) ; canakinumab (37CQ2C7X93) ; Hydroxychloroquine (4QWG6N8QKH) ; Interferon-gamma (82115-62-6) ; Azithromycin (83905-01-5) ; Ferritins (9007-73-2) ; Vascular Endothelial Growth Factor Receptor-1 (EC 2.7.10.1) ; Lactoferrin (EC 3.4.21.-) ; MMP9 protein, human (EC 3.4.24.35) ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; tocilizumab (I031V2H011)
Language	English
Publishing date	2021-01-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural
ISSN	2379-3708
ISSN (online)	2379-3708
DOI	10.1172/jci.insight.144455
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Article ; Online: Congenital beta cell defects are not associated with markers of islet autoimmunity, even in the context of high genetic risk for type 1 diabetes.

Wyatt, Rebecca C / Hagopian, William A / Roep, Bart O / Patel, Kashyap A / Resnick, Brittany / Dobbs, Rebecca / Hudson, Michelle / De Franco, Elisa / Ellard, Sian / Flanagan, Sarah E / Hattersley, Andrew T / Oram, Richard A / Johnson, Matthew B

Diabetologia

2022 Volume 65, Issue 7, Page(s) 1179–1184

Abstract: Aims/hypothesis: A key unanswered question in type 1 diabetes is whether beta cells initiate their own destruction or are victims of an aberrant immune response (beta cell suicide or homicide?). To investigate this, we assessed islet autoantibodies in ... ...

Abstract	Aims/hypothesis: A key unanswered question in type 1 diabetes is whether beta cells initiate their own destruction or are victims of an aberrant immune response (beta cell suicide or homicide?). To investigate this, we assessed islet autoantibodies in individuals with congenital beta cell defects causing neonatal diabetes mellitus (NDM). Methods: We measured autoantibodies to GAD (GADA), islet antigen-2 (IA-2A) and zinc transporter 8 (ZnT8A) in 242 individuals with NDM (median age diagnosed 1.8 months [IQR 0.39-2.9 months]; median age collected 4.6 months [IQR 1.8-27.6 months]; median diabetes duration 2 months [IQR 0.6-23 months]), including 75 whose NDM resulted from severe beta cell endoplasmic reticulum (ER) stress. As a control cohort we also tested samples from 69 diabetes-free individuals (median age collected 9.9 months [IQR 9.0-48.6 months]) for autoantibodies. Results: We found low prevalence of islet autoantibodies in individuals with monogenic NDM; 13/242 (5.4% [95% CI 2.9, 9.0%]) had detectable GADA, IA-2A and/or ZnT8A. This was similar to the proportion in the control participants who did not have diabetes (1/69 positive [1.4%, 95% CI 0.03, 7.8%], p=0.3). Importantly, monogenic individuals with beta cell ER stress had a similar rate of GADA/IA-2A/ZnT8A positivity to non-ER stress aetiologies (2.7% [95% CI 0.3, 9.3%] vs 6.6% [95% CI 3.3, 11.5%] p=0.4). We observed no association between islet autoimmunity and genetic risk, age at testing (including 30 individuals >10 years at testing) or diabetes duration (p>0.4 for all). Conclusions/interpretation: Our data support the hypothesis that beta cell stress/dysfunction alone does not lead to the production of islet autoantibodies, even in the context of high-risk HLA types. This suggests that additional factors are required to trigger an autoimmune response towards beta cells.
MeSH term(s)	Autoantibodies ; Autoimmunity/genetics ; Biomarkers ; Child, Preschool ; Diabetes Mellitus, Type 1/metabolism ; Glutamate Decarboxylase ; Humans ; Infant ; Infant, Newborn ; Insulin-Secreting Cells/metabolism ; Risk Factors
Chemical Substances	Autoantibodies ; Biomarkers ; Glutamate Decarboxylase (EC 4.1.1.15)
Language	English
Publishing date	2022-04-30
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1694-9
ISSN	1432-0428 ; 0012-186X
ISSN (online)	1432-0428
ISSN	0012-186X
DOI	10.1007/s00125-022-05697-3
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Article ; Online: Distribution of nutrients and trace elements in forest soils of Singapore.

Leitgeb, Ernst / Ghosh, Subhadip / Dobbs, Marcus / Englisch, Michael / Michel, Kerstin

Chemosphere

2019 Volume 222, Page(s) 62–70

Abstract	Information on chemical fertility status and on trace element concentrations for Singapore soils is sparse. In this study, concentration and distribution of nutrients and trace elements in forest soils of Singapore, and the effect of geology on the current conditions of soils, were evaluated. Litter and mineral soil samples (0-10 cm, 10-20 cm, 20-50 cm) were divided into three groups according to geology (sedimentary rocks, Neogene-Quaternary sediments and igneous rocks). Basic soil properties, exchangeable cations including cation exchange capacity (CEC), and pseudototal concentrations of 17 elements including nutrients and potentially toxic elements (PTE; As, Cd, Cu, Cr, Ni, Pb, Zn) were determined. Results showed that the soils of Singapore were acidic (pH 3.7-6.2) and characterised by a low CEC (maximum mean value: 100 mmol
MeSH term(s)	Forests ; Geologic Sediments/chemistry ; Geology/methods ; Minerals/analysis ; Minerals/chemistry ; Nutrients/analysis ; Singapore ; Soil/chemistry ; Trace Elements/analysis
Chemical Substances	Minerals ; Nutrients ; Soil ; Trace Elements
Language	English
Publishing date	2019-01-21
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2019.01.106
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Article ; Online: An immune-based biomarker signature is associated with mortality in COVID-19 patients

Michael S. Abers / Ottavia M. Delmonte / Emily E. Ricotta / Jonathan Fintzi / Danielle L. Fink / Adriana A. Almeida de Jesus / Kol A. Zarember / Sara Alehashemi / Vasileios Oikonomou / Jigar V. Desai / Scott W. Canna / Bita Shakoory / Kerry Dobbs / Luisa Imberti / Alessandra Sottini / Eugenia Quiros-Roldan / Francesco Castelli / Camillo Rossi / Duilio Brugnoni /

Andrea Biondi / Laura Rachele Bettini / Mariella D’Angio’ / Paolo Bonfanti / Riccardo Castagnoli / Daniela Montagna / Amelia Licari / Gian Luigi Marseglia / Emily F. Gliniewicz / Elana Shaw / Dana E. Kahle / Andre T. Rastegar / Michael Stack / Katherine Myint-Hpu / Susan L. Levinson / Mark J. DiNubile / Daniel W. Chertow / Peter D. Burbelo / Jeffrey I. Cohen / Katherine R. Calvo / John S. Tsang / NIAID COVID-19 Consortium / Helen C. Su / John I. Gallin / Douglas B. Kuhns / Raphaela Goldbach-Mansky / Michail S. Lionakis / Luigi D. Notarangelo

JCI Insight, Vol 6, Iss

2021 Volume 1

Abstract: ... with mortality. Multivariate analyses of longitudinal biomarker trajectories identified 8 of the aforementioned ...

Abstract	Immune and inflammatory responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contribute to disease severity of coronavirus disease 2019 (COVID-19). However, the utility of specific immune-based biomarkers to predict clinical outcome remains elusive. Here, we analyzed levels of 66 soluble biomarkers in 175 Italian patients with COVID-19 ranging from mild/moderate to critical severity and assessed type I IFN–, type II IFN–, and NF-κB–dependent whole-blood transcriptional signatures. A broad inflammatory signature was observed, implicating activation of various immune and nonhematopoietic cell subsets. Discordance between IFN-α2a protein and IFNA2 transcript levels in blood suggests that type I IFNs during COVID-19 may be primarily produced by tissue-resident cells. Multivariable analysis of patients’ first samples revealed 12 biomarkers (CCL2, IL-15, soluble ST2 [sST2], NGAL, sTNFRSF1A, ferritin, IL-6, S100A9, MMP-9, IL-2, sVEGFR1, IL-10) that when increased were independently associated with mortality. Multivariate analyses of longitudinal biomarker trajectories identified 8 of the aforementioned biomarkers (IL-15, IL-2, NGAL, CCL2, MMP-9, sTNFRSF1A, sST2, IL-10) and 2 additional biomarkers (lactoferrin, CXCL9) that were substantially associated with mortality when increased, while IL-1α was associated with mortality when decreased. Among these, sST2, sTNFRSF1A, IL-10, and IL-15 were consistently higher throughout the hospitalization in patients who died versus those who recovered, suggesting that these biomarkers may provide an early warning of eventual disease outcome.
Keywords	COVID-19 ; Immunology ; Medicine ; R
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	American Society for Clinical investigation
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comment on "Anomalous tracer diffusion on surfaces"

Krug / Dobbs

Physical review letters

1996 Volume 76, Issue 21, Page(s) 4096

Language	English
Publishing date	1996-05-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.76.4096
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Article ; Online: Evaluation of the Performance of Three Biomarker Assays for Recent HIV Infection Using a Well-Characterized HIV-1 Subtype C Incidence Cohort.

Gonese, Elizabeth / Kilmarx, Peter H / van Schalkwyk, Cari / Grebe, Eduard / Mutasa, Kuda / Ntozini, Robert / Parekh, Bharat / Dobbs, Trudy / Duong Pottinger, Yen / Masciotra, Silvina / Owen, Michele / Nachega, Jean B / van Zyl, Gert / Hargrove, John W

AIDS research and human retroviruses

2019 Volume 35, Issue 7, Page(s) 615–627

Abstract: Biomarkers for detecting early HIV infection and estimating HIV incidence should minimize false-recent rates (FRRs) while maximizing mean duration of recent infection (MDRI). We compared HIV subtypes B, E and D (BED) capture enzyme immunoassay (BED), ... ...

Abstract	Biomarkers for detecting early HIV infection and estimating HIV incidence should minimize false-recent rates (FRRs) while maximizing mean duration of recent infection (MDRI). We compared HIV subtypes B, E and D (BED) capture enzyme immunoassay (BED), Sedia limiting antigen (LAg) avidity enzyme immunoassay, and Bio-Rad avidity incidence (BRAI) assays using samples from Zimbabwean postpartum women infected with clade C HIV. We calculated MDRIs using 590 samples from 351 seroconverting postpartum women, and FRRs using samples from 2,825 women known to be HIV positive for >12 months. Antibody kinetics were more predictable with LAg and had higher precision compared with BED or BRAI. BRAI also exhibited more variability, and avidity reversal in some cases. For BED, LAg, and BRAI, used alone or with viral load, MDRI values in days were: BED-188 and 170 at normalized optical density (ODn) 0.8; LAg-104 and 100 at ODn cutoff 1.5; BRAI-135 and 134 at avidity index cutoff 30%. Corresponding FRRs were: BRAI 1.1% and 1.0% and LAg 0.57% and 0.35%: these were 3.8-10.9 times lower than BED values of 4.8% and 3.8%. BRAI and LAg have significantly lower FRRs and MDRIs than in published studies, and much lower than BED and could be used to estimate incidence in perinatal women and to measure population-level HIV incidence in HIV control operations in Africa.
MeSH term(s)	AIDS Serodiagnosis/methods ; Africa/epidemiology ; Antibody Affinity ; Biomarkers/blood ; CD4 Lymphocyte Count ; Cohort Studies ; Female ; HIV Antibodies/blood ; HIV Antibodies/immunology ; HIV Infections/diagnosis ; HIV Infections/epidemiology ; HIV Seropositivity/diagnosis ; HIV-1/classification ; HIV-1/immunology ; HIV-1/isolation & purification ; Humans ; Immunoenzyme Techniques/methods ; Incidence ; Postpartum Period ; Viral Load
Chemical Substances	Biomarkers ; HIV Antibodies
Language	English
Publishing date	2019-05-13
Publishing country	United States
Document type	Comparative Study ; Evaluation Study ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	639130-8
ISSN	1931-8405 ; 0889-2229
ISSN (online)	1931-8405
ISSN	0889-2229
DOI	10.1089/AID.2019.0033
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Article: Distribution of nutrients and trace elements in forest soils of Singapore

Leitgeb, Ernst / Kerstin Michel / Marcus Dobbs / Michael Englisch / Subhadip Ghosh

Chemosphere. 2019 May, v. 222

2019

Abstract: Information on chemical fertility status and on trace element concentrations for Singapore soils is ... sparse. In this study, concentration and distribution of nutrients and trace elements in forest soils ... the three geological groups, the differences in nutrient status were more pronounced than in trace ...

Abstract	Information on chemical fertility status and on trace element concentrations for Singapore soils is sparse. In this study, concentration and distribution of nutrients and trace elements in forest soils of Singapore, and the effect of geology on the current conditions of soils, were evaluated. Litter and mineral soil samples (0–10 cm, 10–20 cm, 20–50 cm) were divided into three groups according to geology (sedimentary rocks, Neogene-Quaternary sediments and igneous rocks). Basic soil properties, exchangeable cations including cation exchange capacity (CEC), and pseudototal concentrations of 17 elements including nutrients and potentially toxic elements (PTE; As, Cd, Cu, Cr, Ni, Pb, Zn) were determined. Results showed that the soils of Singapore were acidic (pH 3.7–6.2) and characterised by a low CEC (maximum mean value: 100 mmolc kg−1) and low P concentrations (mean values of 0.28 g kg−1 or less) irrespective of geology. Pseudototal concentrations of PTE were also low, except for As. However, significantly (p < 0.05) higher concentrations of soil organic carbon, total P, base forming elements, exchangeable base cations and PTE (except As and Cd) were found in soils developed on sedimentary rocks and Neogene-Quaternary sediments compared to those developed on igneous rocks. Although total N and S concentrations did not differ significantly between the three geological groups, the differences in nutrient status were more pronounced than in trace element levels across geology. The properties of forest soils, which are mainly unaffected by anthropogenic activities, vary depending on the parent material, i.e. igneous or sedimentary rocks and Neogene-Quaternary sediments.
Keywords	anthropogenic activities ; arsenic ; cadmium ; cation exchange capacity ; chemical bases ; chromium ; copper ; exchangeable cations ; forest soils ; igneous rocks ; lead ; mineral soils ; nickel ; nutrients ; pH ; phosphorus ; sedimentary rocks ; sediments ; soil organic carbon ; soil sampling ; toxic substances ; zinc ; Singapore
Language	English
Dates of publication	2019-05
Size	p. 62-70.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2019.01.106
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Tracing the stemness of porcine skin-derived progenitors (pSKP) back to specific marker gene expression.

Zhao, Mingtao / Isom, S Clay / Lin, Hui / Hao, Yanhong / Zhang, Yong / Zhao, Jianguo / Whyte, Jeffrey J / Dobbs, Kyle B / Prather, Randall S

Cloning and stem cells

2009 Volume 11, Issue 1, Page(s) 111–122

Abstract: ... the cooperative expression of pluripotency related genes (POU5F1, SOX2, NANOG, STAT3) and neural crest marker ...

Abstract	Multipotent skin-derived progenitors (SKP) can produce both neural and mesodermal progeny in vitro, sharing the characteristics of embryonic neural crest stem cells. However, the molecular basis for the property of multiple lineage potential and neural crest origin of SKPs is still elusive. Here we report the cooperative expression of pluripotency related genes (POU5F1, SOX2, NANOG, STAT3) and neural crest marker genes (p75NTR, TWIST1, PAX3, SNAI2, SOX9, SOX10) in GFP-transgenic porcine skin-derived progenitors (pSKP). The proportion of cells positive for POU5F1, nestin, fibronectin, and vimentin were 12.3%, 15.1%, 67.9% and 53.7%, showing the heterogeneity of pSKP spheres. Moreover, pSKP cells can generate both neural (neurons and glia) and mesodermal cell types (smooth muscle cells and adipocytes) in vitro, indicating the multiple lineage potency. Four transcription factors (POU5F1, SNAI2, SOX9, and PAX3) were identified that were sensitive to mitogen (FBS) and/or growth factors (EGF and bFGF). We infer that POU5F1, SNAI2, SOX9, and PAX3 may be the key players for maintaining the neural crest derived multipotency of SKP cells in vitro. This study has provided new insight into the molecular mechanism of stemness for somatic-derived stem cells at the level of transcriptional regulation.
MeSH term(s)	Animals ; Cell Differentiation ; Cell Lineage/genetics ; Culture Media/pharmacology ; Gene Expression ; Genetic Markers ; Neural Crest/metabolism ; Pluripotent Stem Cells/cytology ; Pluripotent Stem Cells/drug effects ; Pluripotent Stem Cells/metabolism ; Skin/cytology ; Skin/metabolism ; Swine
Chemical Substances	Culture Media ; Genetic Markers
Language	English
Publishing date	2009-02-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2063765-2
ISSN	1557-7457 ; 1536-2302
ISSN (online)	1557-7457
ISSN	1536-2302
DOI	10.1089/clo.2008.0071
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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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