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Article: The impact of genetic variants related to vitamin D and autoimmunity: A systematic review.

Trefilio, Luisa Menezes / Bottino, Letícia / de Carvalho Cardoso, Rafaella / Montes, Guilherme Carneiro / Fontes-Dantas, Fabrícia Lima

Heliyon

2024 Volume 10, Issue 7, Page(s) e27700

Abstract: ... at unraveling the genetic foundations of vitamin D signaling and its implications for susceptibility ... of genetic variants related to vitamin D and autoimmune diseases and we discussed the current landscape ... of susceptibility and outcomes. Of 65 studies analyzed, most variants cited are in vitamin D binding protein ( ...

Abstract	Over the past few years, there has been a notable increment in scientific literature aimed at unraveling the genetic foundations of vitamin D signaling and its implications for susceptibility to autoimmunity, however, most of them address isolated diseases. Here, we conducted a systematic review of genetic variants related to vitamin D and autoimmune diseases and we discussed the current landscape of susceptibility and outcomes. Of 65 studies analyzed, most variants cited are in vitamin D binding protein (
Language	English
Publishing date	2024-03-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e27700
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Book ; Online: Visual Odometry for RGB-D Cameras

Fontes, Afonso / Maia, Jose Everardo Bessa

2022

Abstract: ... RGB-D camera navigating on a static environment. The proposed algorithm uses SURF (Speeded Up Robust ...

Abstract	Visual odometry is the process of estimating the position and orientation of a camera by analyzing the images associated to it. This paper develops a quick and accurate approach to visual odometry of a moving RGB-D camera navigating on a static environment. The proposed algorithm uses SURF (Speeded Up Robust Features) as feature extractor, RANSAC (Random Sample Consensus) to filter the results and Minimum Mean Square to estimate the rigid transformation of six parameters between successive video frames. Data from a Kinect camera were used in the tests. The results show that this approach is feasible and promising, surpassing in performance the algorithms ICP (Interactive Closest Point) and SfM (Structure from Motion) in tests using a publicly available dataset.
Keywords	Computer Science - Computer Vision and Pattern Recognition
Publishing date	2022-03-28
Publishing country	us
Document type	Book ; Online
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Article ; Online: Efficient Conversion of Agroindustrial Waste into D(-) Lactic Acid by

Beitel, Susan Michelz / Coelho, Luciana Fontes / Contiero, Jonas

BioMed research international

2020 Volume 2020, Page(s) 4194052

Abstract: ... such as molasses and corn steep liquor, into large amounts of D(-) lactic acid using a facilitated multipulse fed ... A high titer of D(-) lactic acid (162g/liter) was achieved after 48 hours of fermentation. Productivity ... by the addition of Ca(OH): Conclusion: The production of high optical purity D(-) lactic acid through ...

Abstract	Purpose: The goal of this paper is to describe the green conversion of agricultural waste products, such as molasses and corn steep liquor, into large amounts of D(-) lactic acid using a facilitated multipulse fed-batch strategy and affordable pH neutralizer. This is a very low-cost process because there is no need for hydrolysis of the waste products. The fed-batch strategy increases lactic acid productivity by avoiding inhibition caused by a high initial substrate concentration, and the selected controlling agent prevents cell stress that could be caused by high osmotic pressure of the culture media. Methods: The effects of different carbon and nitrogen sources on lactic acid production were investigated, and the best concentrations of the medium components were determined. To optimize the culture conditions of the Result: A high titer of D(-) lactic acid (162g/liter) was achieved after 48 hours of fermentation. Productivity at this point was 3.37 g/L·h. The optimum conditions were a temperature of 39°C, pH 5.5 controlled by the addition of Ca(OH) Conclusion: The production of high optical purity D(-) lactic acid through
MeSH term(s)	Batch Cell Culture Techniques ; Hydrogen-Ion Concentration ; Lactic Acid/biosynthesis ; Lactobacillus delbrueckii/growth & development ; Molasses ; Waste Products
Chemical Substances	Waste Products ; Lactic Acid (33X04XA5AT)
Language	English
Publishing date	2020-04-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2020/4194052
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Article ; Online: L’intervalle de quarte dans la musique d’Astor Piazzolla

Thomas Fontes Saboga Cardoso

Diacrítica, Vol 35, Iss

2021 Volume 2

Abstract: ... soit mélodique ou harmonique, et d’en constater un emploi conscient et systématique. Une œuvre de jeunesse ... de cette période révélant elle-aussi d’importants usages de ces techniques quartales. Finalement, la fascination ...

Abstract	Nous examinons dans cet article l’utilisation et l’origine de l’intervalle de quarte comme élément organisateur des hauteurs dans la musique du compositeur et bandonéoniste argentin Astor Piazzolla (1921–1992). Des exemples nous permettront de prendre contact avec une utilisation diversifiée de cet intervalle, soit mélodique ou harmonique, et d’en constater un emploi conscient et systématique. Une œuvre de jeunesse du compositeur où l’emploi de ces quartes est abondant nous permet de tisser un lien avec les leçons de Piazzolla avec Alberto Ginastera qui eurent lieu pendant l’élaboration de cette pièce, la musique de son professeur de cette période révélant elle-aussi d’importants usages de ces techniques quartales. Finalement, la fascination des deux compositeurs argentins pour Stravinski, et la présence de ces techniques quartales dans la musique du compositeur russe nous permet de déceler l’origine de ces techniques quartales dans la musique savante moderne.
Keywords	Piazzolla ; Quartes ; Ginastera ; Stravinsky ; Musique savante moderne ; History of scholarship and learning. The humanities ; AZ20-999 ; Philology. Linguistics ; P1-1091 ; Language. Linguistic theory. Comparative grammar ; P101-410
Language	Portuguese
Publishing date	2021-08-01T00:00:00Z
Publisher	Universidade do Minho
Document type	Article ; Online
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Article ; Online: Relative bioavailability of manganese in relation to proteinate and sulfate sources for broiler chickens from one to 20 d of age.

Saldanha, Mariana M / Araújo, Itallo C S / Triguineli, Marcela V / Vaz, Diego P / Ferreira, Felipe N A / Albergaria, Juliano D S / Fontes, Dalton O / Lara, Leonardo J C

Poultry science

2020 Volume 99, Issue 11, Page(s) 5647–5652

Abstract: ... proteinate compared to Mn sulfate for broilers fed a diet based on corn and soybean meal for 20 d. The diets ...

Abstract	The objective of this study was to evaluate the relative bioavailability (RB) of manganese (Mn) proteinate compared to Mn sulfate for broilers fed a diet based on corn and soybean meal for 20 d. The diets of 1,350 male Cobb broilers were supplemented with 0, 35, 70, 105, or 140 mg of Mn/kg of feed in the form of Mn sulfate or Mn proteinate. Weight gain, feed intake, feed conversion, bone strength, and Mn concentration in the tibia and liver, as well as the concentration of type I collagen in the tibia, were evaluated. No differences were observed for performance variables (P > 0.05) or for type I collage concentration in broiler tibia (P > 0.05), regardless of the source and level of supplementation used. Relative bioavailability was determined using bone strength values and Mn concentration in the tibia and liver, assuming Mn sulfate as the standard source (100%) by the slope-ratio method. The RB of Mn proteinate based on bone strength was 111%, based on liver Mn concentration was 128%, and based on tibia Mn concentration was 105%. Manganese proteinate was more bioavailable than Mn sulfate; it can be an important source of supplementation to improve bone quality in broilers.
MeSH term(s)	Animal Feed/analysis ; Animals ; Biological Availability ; Chickens ; Diet/veterinary ; Dietary Supplements ; Liver/chemistry ; Male ; Manganese/pharmacokinetics ; Manganese Compounds/analysis ; Sulfates/analysis ; Tibia/chemistry
Chemical Substances	Manganese Compounds ; Sulfates ; Manganese (42Z2K6ZL8P) ; manganese sulfate (W00LYS4T26)
Language	English
Publishing date	2020-08-26
Publishing country	England
Document type	Journal Article
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.1016/j.psj.2020.05.006
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Article ; Online: Association among 25-hydroxyvitamin D levels, hypertriglyceridemic-waist phenotype, and cardiometabolic markers in individuals with type 2 diabetes mellitus from regions with high solar incidence.

Oliveira, Juliana de Souza / Santos, Beatriz da Cruz / Santos, Ramara Kadija Fonseca / Santos, Cynthia Batista / Reis, Aline Rocha / Santos, Cinthia Fontes da Silva / de Carvalho, Gabrielli Barbosa / Brandão-Lima, Paula Nascimento / Rocha, Vivianne de Sousa / Pires, Liliane Viana

American journal of human biology : the official journal of the Human Biology Council

2023 Volume 36, Issue 2, Page(s) e23999

Abstract: Objective: To evaluate the relationship between vitamin D status and hypertriglyceridemic-waist ... Measurements included serum 25-hydroxyvitamin D (25[OH]D), glucose, insulin, total cholesterol, LDL-c, HDL-c ... among the concentration of 25(OH)D, HTW phenotype, and lipid profile variables.: Results: Triacylglycerols ...

Abstract	Objective: To evaluate the relationship between vitamin D status and hypertriglyceridemic-waist (HTW) phenotype and cardiometabolic markers in individuals with type 2 diabetes mellitus (T2DM) living in regions with high solar incidence (10° south). Methods: An observational, cross-sectional study, with 122 individuals with T2DM, of both sexes, aged between 19 and 59 years, residing in Sergipe/Brazil. Measurements included serum 25-hydroxyvitamin D (25[OH]D), glucose, insulin, total cholesterol, LDL-c, HDL-c, triacylglycerols, blood pressure, body mass index, %body fat, and waist circumference. Participants were classified by the presence or absence of the HTW phenotype, according to increased waist circumference and triacylglycerols concentrations. Logistic and linear regression models were applied to verify the association among the concentration of 25(OH)D, HTW phenotype, and lipid profile variables. Results: Triacylglycerols concentrations (p = .013) and %body fat (p = .011) were higher in women with serum 25(OH)D insufficient/deficient than in those with adequate 25(OH)D levels. Individuals with serum 25(OH)D insufficiency/deficiency were 2.595 times more likely to present the HTW phenotype than those with adequate 25(OH)D levels (p = .021). Additionally, a negative association was observed between the concentration of 25(OH)D and total cholesterol (Beta = -0.204, p = .049). Conclusion: Insufficiency/deficiency of serum 25(OH)D in individuals with T2DM increases the chances of developing the HTW phenotype.
MeSH term(s)	Male ; Humans ; Female ; Young Adult ; Adult ; Middle Aged ; Diabetes Mellitus, Type 2/epidemiology ; Cross-Sectional Studies ; Incidence ; Vitamin D ; Triglycerides ; Calcifediol ; Phenotype ; Body Mass Index ; Cardiovascular Diseases/etiology ; Vitamin D Deficiency/epidemiology
Chemical Substances	25-hydroxyvitamin D (A288AR3C9H) ; Vitamin D (1406-16-2) ; Triglycerides ; Calcifediol (P6YZ13C99Q)
Language	English
Publishing date	2023-10-11
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	1025339-7
ISSN	1520-6300 ; 1042-0533
ISSN (online)	1520-6300
ISSN	1042-0533
DOI	10.1002/ajhb.23999
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Article: New multienzymatic complex formed between human cathepsin D and snake venom phospholipase A

Moraes, Jeane do Nascimento / Francisco, Aleff Ferreira / Dill, Leandro Moreira / Diniz, Rafaela Souza / de Oliveira, Claudia Siqueira / da Silva, Tainara Maiane Rodrigues / Caldeira, Cleópatra Alves da Silva / Corrêa, Edailson de Alcântara / Coutinho-Neto, Antônio / Zanchi, Fernando Berton / Fontes, Marcos Roberto de Mattos / Soares, Andreimar Martins / Calderon, Leonardo de Azevedo

The journal of venomous animals and toxins including tropical diseases

2022 Volume 28, Page(s) e20220002

Abstract: Background: Cathepsin D (CatD) is a lysosomal proteolytic enzyme expressed in almost all tissues ...

Abstract	Background: Cathepsin D (CatD) is a lysosomal proteolytic enzyme expressed in almost all tissues and organs. This protease is a multifunctional enzyme responsible for essential biological processes such as cell cycle regulation, differentiation, migration, tissue remodeling, neuronal growth, ovulation, and apoptosis. The overexpression and hypersecretion of CatD have been correlated with cancer aggressiveness and tumor progression, stimulating cancer cell proliferation, fibroblast growth, and angiogenesis. In addition, some studies report its participation in neurodegenerative diseases and inflammatory processes. In this regard, the search for new inhibitors from natural products could be an alternative against the harmful effects of this enzyme. Methods: An investigation was carried out to analyze CatD interaction with snake venom toxins in an attempt to find inhibitory molecules. Interestingly, human CatD shows the ability to bind strongly to snake venom phospholipases A Conclusion: The present study suggests the versatility of human CatD and svPLA
Language	English
Publishing date	2022-11-04
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2031021-3
ISSN	1678-9199
ISSN	1678-9199
DOI	10.1590/1678-9199-JVATITD-2022-0002
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Article ; Online: Surgical Considerations for Vitamin D Deficiency in Foot and Ankle Surgery.

DeFontes, Kenneth / Smith, Jeremy T

The Orthopedic clinics of North America

2019 Volume 50, Issue 2, Page(s) 259–267

Abstract: Vitamin D deficiency affects nearly one-sixth of the world's population and is common in patients ... undergoing foot and ankle surgery. Vitamin D is critical for calcium homeostasis and plays an important role ... with vitamin D level testing, and deficiencies can be addressed with either preoperative or postoperative ...

Abstract	Vitamin D deficiency affects nearly one-sixth of the world's population and is common in patients undergoing foot and ankle surgery. Vitamin D is critical for calcium homeostasis and plays an important role in the maintenance of bone health. Patients undergoing foot and ankle procedures can be evaluated preoperatively with vitamin D level testing, and deficiencies can be addressed with either preoperative or postoperative supplementation. Current data suggest that patients with adequate vitamin D levels may have better outcomes, but the details are not yet clear. Vitamin D supplementation is well tolerated with rare side effects.
MeSH term(s)	Ankle/diagnostic imaging ; Ankle/surgery ; Ankle Joint/diagnostic imaging ; Ankle Joint/surgery ; Elective Surgical Procedures/methods ; Foot/diagnostic imaging ; Foot/surgery ; Humans ; Prospective Studies ; Retrospective Studies ; Vitamin D/administration & dosage ; Vitamin D/metabolism ; Vitamin D/supply & distribution ; Vitamin D Deficiency/complications
Chemical Substances	Vitamin D (1406-16-2)
Language	English
Publishing date	2019-02-12
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Review
ZDB-ID	417389-2
ISSN	1558-1373 ; 0030-5898
ISSN (online)	1558-1373
ISSN	0030-5898
DOI	10.1016/j.ocl.2018.10.008
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Article ; Online: Prostaglandin F2α 7 d prior to initiation of the 7-d CO-synch + CIDR protocol failed to enhance estrus response and pregnancy rates in beef heifers.

Oosthuizen, Nicola / Canal, Luara B / Fontes, Pedro L P / Sanford, Carla D / DiLorenzo, Nicolas / Dahlen, Carl R / Seidel, George E / Lamb, G Cliff

Journal of animal science

2018 Volume 96, Issue 4, Page(s) 1466–1473

Abstract: To determine the effects of administration of 25 mg of PGF2α 7 d prior to the initiation of the 7-d ... of GnRH and a CIDR insert for 7 d [day 7], administration of 25 mg of PGF2α at CIDR removal [day 0 ... but heifers received an additional injection of 25 mg of PGF2α 7 d prior [day 14] to CIDR insertion ...

Abstract	To determine the effects of administration of 25 mg of PGF2α 7 d prior to the initiation of the 7-d CO-Synch + controlled internal drug release (CIDR) fixed-time AI (TAI) protocol, 985 Bos taurus beef heifers were enrolled in a completely randomized design at 9 locations from April to July of 2016. Within location, all heifers were randomly assigned to 1 of 2 treatments: 1) CONTROL (n = 496); 100 µg injection of GnRH and a CIDR insert for 7 d [day 7], administration of 25 mg of PGF2α at CIDR removal [day 0], followed by a second injection of GnRH and TAI 54 ± 2 h later; or 2) PRESYNCH (n = 489); same as CONTROL but heifers received an additional injection of 25 mg of PGF2α 7 d prior [day 14] to CIDR insertion. Estrous detection patches were applied to all heifers on day 14 and were evaluated for estrual activity on day 7. Similarly, estrus alert patches were placed on all heifers on day 0 and evaluated for estrual activity at the time of TAI. Pregnancy was diagnosed via transrectal ultrasonography between 35 and 55 d after TAI. The percentage of heifers exhibiting estrus between days 14 and 7 was greater (P < 0.001) for the PRESYNCH (70.1 ± 2.4%) than the CONTROL (41.1 ± 2.3%) treatment, whereas the percentage of heifers exhibiting estrus between day 0 and TAI was greater (P < 0.001) for the CONTROL (55.6 ± 2.4%) than the PRESYNCH (39.7 ± 2.5%) treatment. Estrus response rates differed (P < 0.001) among locations. Pregnancy rates to TAI differed (P = 0.023) among locations; however, they did not differ (P = 0.739) between CONTROL and PRESYNCH treatments (45.4 ± 2.5 vs. 43.2 ± 2.5%, respectively). Final breeding season pregnancy rates did not differ (P = 0.811) between treatments. Therefore, an injection of PGF2α 7 d prior to initiation of the 7-d CO-Synch + CIDR protocol failed to improve pregnancy rates to TAI in replacement beef heifers.
MeSH term(s)	Animals ; Breeding ; Cattle/physiology ; Delayed-Action Preparations/administration & dosage ; Dinoprost/administration & dosage ; Estrus/drug effects ; Estrus Synchronization/drug effects ; Female ; Gonadotropin-Releasing Hormone/administration & dosage ; Insemination, Artificial/veterinary ; Pregnancy ; Pregnancy Rate ; Random Allocation ; Ultrasonography/veterinary
Chemical Substances	Delayed-Action Preparations ; Gonadotropin-Releasing Hormone (33515-09-2) ; Dinoprost (B7IN85G1HY)
Language	English
Publishing date	2018-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	390959-1
ISSN	1525-3163 ; 0021-8812
ISSN (online)	1525-3163
ISSN	0021-8812
DOI	10.1093/jas/sky058
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Article ; Online: Bioactivity and molecular properties of Phenoxyacetic Acids Derived from Eugenol and Guaiacol compared to the herbicide 2,4-D.

Alves, Thammyres A / Pinheiro, Patrícia F / Praça-Fontes, Milene M / Andrade-Vieira, Larissa F / Lourenço, Maicon P / Lage, Mateus R / Alves, Thayllon A / Cruz, Franceli A / Carneiro, José W M / Ferreira, Adésio / Soares, Taís C B

Anais da Academia Brasileira de Ciencias

2021 Volume 93, Issue 4, Page(s) e20191368

Abstract: ... to the commercial 2,4-D herbicide. Molecular properties of the phenols and their derivatives phenoxyacetic acids ... were compared with the ones obtained for the herbicide 2,4-D, where it was found a correlation between ...

Abstract	Herbicides are agrochemicals applied in the control of weeds. With the frequent and repetitive use of these substances, serious problems have been reported. Compounds of natural origin and their derivatives are attractive options to obtain new compounds with herbicidal properties. By aiming to develop compounds with potentiated herbicidal activity, phenoxyacetic acids were synthesized from eugenol and guaiacol. The synthesized compounds were characterized and the herbicidal potential of phenoxyacetic acids and precursors was evaluated through bioassays regarding the germination and initial development of Lactuca sativa and Sorghum bicolor seedlings, with the induction of DNA damage. The induction of changes in the mitotic cycle of meristematic cells of roots of L. sativa was also analyzed. At the concentration of 3 mmol L-1, phenols and their respective phenoxyacetic acids presented phytotoxic and cytotoxic activities in L. sativa and S. bicolor. Eugenol and guaiacol also presented genotoxic action in L. sativa. The toxic effect of eugenoxyacetic acid was more pronounced in L. sativa than in S. bicolor, similar to the commercial 2,4-D herbicide. Molecular properties of the phenols and their derivatives phenoxyacetic acids were compared with the ones obtained for the herbicide 2,4-D, where it was found a correlation between their molecular properties and bioactivity.
MeSH term(s)	2,4-Dichlorophenoxyacetic Acid/toxicity ; Eugenol/toxicity ; Germination ; Guaiacol ; Herbicides/toxicity
Chemical Substances	Herbicides ; 2,4-Dichlorophenoxyacetic Acid (2577AQ9262) ; Eugenol (3T8H1794QW) ; Guaiacol (6JKA7MAH9C)
Language	English
Publishing date	2021-10-22
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2046885-4
ISSN	1678-2690 ; 0001-3765
ISSN (online)	1678-2690
ISSN	0001-3765
DOI	10.1590/0001-3765202120191368
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