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  1. Book ; Thesis: Mechanisms of insulin exocytosis and release

    Barg, Sebastian

    2001  

    Author's details Sebastian Barg
    Language English ; Swedish
    Size Getr. Zählung : Ill., graph. Darst.
    Publisher Lund University
    Publishing place Lund
    Publishing country Sweden
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Lund, Univ., Diss., 2001
    Note Zsfassung in schwed. Sprache
    HBZ-ID HT013258488
    ISBN 91-628-4676-0 ; 978-91-628-4676-3
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Local PI(4,5)P

    Omar-Hmeadi, Muhmmad / Guček, Alenka / Barg, Sebastian

    Cell reports

    2023  Volume 42, Issue 2, Page(s) 112036

    Abstract: Phosphatidylinositol(4,5)bisphosphate (PI(4,5) ... ...

    Abstract Phosphatidylinositol(4,5)bisphosphate (PI(4,5)P
    MeSH term(s) Cell Membrane ; Exocytosis ; Endocytosis ; Insulin ; Clathrin ; Phosphatidylinositols ; Membrane Fusion
    Chemical Substances Insulin ; Clathrin ; Phosphatidylinositols
    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.112036
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  3. Article ; Online: Quantification of Secretory Granule Exocytosis by TIRF Imaging and Capacitance Measurements.

    Omar-Hmeadi, Muhmmad / Liu, Liangwen / Echeverry, Santiago / Barg, Sebastian

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2565, Page(s) 179–186

    Abstract: Hormones and neurotransmitters are released from (neuro)endocrine cells by regulated exocytosis of secretory granules. During exocytosis, the granule membrane fuses with the plasma membrane, which allows release of the stored content into the bloodstream ...

    Abstract Hormones and neurotransmitters are released from (neuro)endocrine cells by regulated exocytosis of secretory granules. During exocytosis, the granule membrane fuses with the plasma membrane, which allows release of the stored content into the bloodstream or the surrounding tissue. Here, we give a detailed description of two complementary methods to observe and quantify exocytosis in single cells: high-resolution TIRF microscopy and patch-clamp capacitance recordings. Precise stimulation of exocytosis is achieved by local pressure application or voltage-clamp depolarizations. While the chapter is focused on insulin-secreting cells as an accessible and disease-relevant model system, the methodology is applicable to a wide variety of secretory cells including chromaffin and PC12 cells.
    MeSH term(s) Animals ; Cell Membrane/metabolism ; Exocytosis/physiology ; Hormones/metabolism ; Insulin-Secreting Cells/metabolism ; Neurotransmitter Agents/metabolism ; Rats ; Secretory Vesicles/metabolism
    Chemical Substances Hormones ; Neurotransmitter Agents
    Language English
    Publishing date 2022-10-07
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2671-9_12
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Open Reduction and Internal Fixation of the Posterior Malleolus Fragment in Ankle Fractures Improves the Patient-Rated Outcome: A Systematic Review.

    Miksch, Rainer Christoph / Herterich, Viktoria / Barg, Alexej / Böcker, Wolfgang / Polzer, Hans / Baumbach, Sebastian Felix

    Foot & ankle international

    2023  Volume 44, Issue 8, Page(s) 727–737

    Abstract: Background: The best treatment strategy for fractures to the posterior malleolus (PM) is still intensively debated. The aim of this systematic review was to compare the patient-rated outcome following open reduction and internal fixation (ORIF) for ... ...

    Abstract Background: The best treatment strategy for fractures to the posterior malleolus (PM) is still intensively debated. The aim of this systematic review was to compare the patient-rated outcome following open reduction and internal fixation (ORIF) for fractures of the PM to either closed reduction using AP screws (CRIF) or no treatment in bi- or trimalleolar ankle fractures.
    Methods: Systematic literature research (MEDLINE (PubMed), CINAHL, Scopus, Central and EMBASE) according to the PICOS and PRISMA guidelines. Eligible were studies comparing the outcome following ORIF to any other treatment strategy for fractures to the posterior malleolus in isolated bi- or trimalleolar ankle fractures.
    Results: Twelve studies were eligible for a qualitative analysis and 6 for a quantitative analysis. Overall, a considerable heterogeneity among the studies was observed. The most commonly used outcome score was the American Orthopaedic Foot & Ankle Society ankle-hindfoot score (AOFAS). The final follow-up ranged from 12 to 160 months. Four studies compared ORIF to CRIF of the PM. The quantitative analysis revealed significantly better AOFAS scores for ORIF (90.9 vs 83.4 points;
    Conclusion: Despite a considerable heterogeneity, the data available point to a superior outcome following ORIF for fractures to the PM when compared to CRIF or no treatment.
    MeSH term(s) Humans ; Ankle Fractures/surgery ; Treatment Outcome ; Fracture Fixation, Internal ; Open Fracture Reduction ; Ankle Joint/surgery ; Retrospective Studies
    Language English
    Publishing date 2023-04-26
    Publishing country United States
    Document type Systematic Review ; Journal Article
    ZDB-ID 1183283-6
    ISSN 1944-7876 ; 1071-1007
    ISSN (online) 1944-7876
    ISSN 1071-1007
    DOI 10.1177/10711007231165771
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  5. Article ; Online: How Kiss-and-Run Can Make Us Sick: SOX4 Puts a Break on the Pore.

    Barg, Sebastian / Guček, Alenka

    Diabetes

    2016  Volume 65, Issue 7, Page(s) 1791–1793

    Language English
    Publishing date 2016-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80085-5
    ISSN 1939-327X ; 0012-1797
    ISSN (online) 1939-327X
    ISSN 0012-1797
    DOI 10.2337/dbi16-0019
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  6. Conference proceedings: Ergebnisse nach offener Reposition und interne Fixierung (ORIF) des posterioren Malleolus (PM) im Rahmen von Sprunggelenkfrakturen – eine systematische Literaturrecherche

    Miksch, Rainer Christoph / Herterich, Viktoria / Barg, Alexej / Böcker, Wolfgang / Polzer, Hans / Baumbach, Sebastian Felix

    2022  , Page(s) AB69–1191

    Event/congress Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2022); Berlin; ; Berufsverband für Orthopädie und Unfallchirurgie; 2022
    Keywords Medizin, Gesundheit ; Sprunggelenkfraktur ; posteriorer Malleolus ; Volkmann ; ORIF
    Publishing date 2022-10-25
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/22dkou551
    Database German Medical Science

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  7. Article ; Online: Clinical Routine and Necessary Advances in Soft Tissue Tumor Imaging Based on the ESSR Guideline: Initial Findings.

    Korthaus, Alexander / Weiss, Sebastian / Barg, Alexej / Salamon, Johannes / Schlickewei, Carsten / Frosch, Karl-Heinz / Priemel, Matthias

    Tomography (Ann Arbor, Mich.)

    2022  Volume 8, Issue 3, Page(s) 1586–1594

    Abstract: Soft tissue sarcomas are malignant diseases with a complex classification and various histological subtypes, mostly clinically inconspicuous appearance, and a rare occurrence. To ensure safe patient care, the European Society of Musculoskeletal Radiology ...

    Abstract Soft tissue sarcomas are malignant diseases with a complex classification and various histological subtypes, mostly clinically inconspicuous appearance, and a rare occurrence. To ensure safe patient care, the European Society of Musculoskeletal Radiology (ESSR) issued a guideline for diagnostic imaging of soft tissue tumors in adults in 2015. In this study, we investigated whether implementation of these guidelines resulted in improved MRI protocol and report quality in patients with soft tissue sarcomas in our cancer center. All cases of histologically confirmed soft tissue sarcomas that were treated at our study center from 2006 to 2018 were evaluated retrospectively. The radiological reports were examined for their compliance with the recommendations of the ESSR. Patients were divided into two groups, before and after the introduction of the 2015 ESSR guidelines. In total, 103 cases of histologically confirmed sarcomas were studied. The distribution of, age, gender, number of subjects, performing radiology, and MRI indication on both groups did not show any significant differences. Only using the required MRI sequences showed a significant improvement after the introduction of the guidelines (
    MeSH term(s) Adult ; Humans ; Radiography ; Radiology ; Retrospective Studies ; Sarcoma/diagnostic imaging ; Soft Tissue Neoplasms/diagnostic imaging
    Language English
    Publishing date 2022-06-17
    Publishing country Switzerland
    Document type Journal Article ; Multicenter Study
    ISSN 2379-139X
    ISSN (online) 2379-139X
    DOI 10.3390/tomography8030131
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  8. Article: Clinical Presentation and MRI Characteristics of Appendicular Soft Tissue Lymphoma: A Systematic Review.

    Weiss, Sebastian / Weisse, Valentin / Korthaus, Alexander / Bannas, Peter / Frosch, Karl-Heinz / Schlickewei, Carsten / Barg, Alexej / Priemel, Matthias

    Diagnostics (Basel, Switzerland)

    2022  Volume 12, Issue 7

    Abstract: Appendicular soft tissue lymphoma (ASTL) is rare and is frequently misinterpreted as soft tissue sarcoma (STS). Studies investigating magnet resonance imaging (MRI) characteristics of ASTL are scarce and showed heterogenous investigation criteria and ... ...

    Abstract Appendicular soft tissue lymphoma (ASTL) is rare and is frequently misinterpreted as soft tissue sarcoma (STS). Studies investigating magnet resonance imaging (MRI) characteristics of ASTL are scarce and showed heterogenous investigation criteria and results. The purpose of this study was to systematically review clinical presentations and MRI characteristics of ASTL as described in the current literature. For that purpose, we performed a systematic literature review in compliance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Patient demographics, clinical presentation and MRI imaging characteristics of ASTL were investigated, resulting in a total of nine included studies reporting a total of 77 patients. Signal intensity of lymphoma compared to muscle tissue was mostly described as isointense (53%) or slightly hyperintense (39%) in T1-weighted images and always as hyperintense in proton-and T2-weighted images. Multicompartmental involvement was reported in 59% of cases and subcutaneous stranding in 74%. Long segmental involvement was present in 80% of investigated cases. Involvement of neurovascular structures was reported in 41% of cases and the presence of traversing vessels in 83% of patients. The presence of these findings should lead to the inclusion of ASTL in the differential diagnosis of soft tissue masses.
    Language English
    Publishing date 2022-07-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics12071623
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  9. Article ; Online: PtdIns(4,5)P

    Omar-Hmeadi, Muhmmad / Gandasi, Nikhil R / Barg, Sebastian

    Traffic (Copenhagen, Denmark)

    2018  Volume 19, Issue 6, Page(s) 436–445

    Abstract: Phosphoinositides (PtdIns) play important roles in exocytosis and are thought to regulate secretory granule docking by co-clustering with the SNARE protein syntaxin to form a docking receptor in the plasma membrane. Here we tested this idea by high- ... ...

    Abstract Phosphoinositides (PtdIns) play important roles in exocytosis and are thought to regulate secretory granule docking by co-clustering with the SNARE protein syntaxin to form a docking receptor in the plasma membrane. Here we tested this idea by high-resolution total internal reflection imaging of EGFP-labeled PtdIns markers or syntaxin-1 at secretory granule release sites in live insulin-secreting cells. In intact cells, PtdIns markers distributed evenly across the plasma membrane with no preference for granule docking sites. In contrast, syntaxin-1 was found clustered in the plasma membrane, mostly beneath docked granules. We also observed rapid accumulation of syntaxin-1 at sites where granules arrived to dock. Acute depletion of plasma membrane phosphatidylinositol (4,5) bisphosphate (PtdIns(4,5)P
    MeSH term(s) Animals ; Cell Line ; Cell Line, Tumor ; Cell Membrane/metabolism ; Exocytosis/physiology ; Humans ; Insulin-Secreting Cells/metabolism ; PC12 Cells ; Phosphatidylinositol 4,5-Diphosphate/metabolism ; Rats ; SNARE Proteins/metabolism ; Secretory Vesicles/metabolism ; Syntaxin 1/metabolism ; Trypsin/metabolism
    Chemical Substances Phosphatidylinositol 4,5-Diphosphate ; SNARE Proteins ; Syntaxin 1 ; Trypsin (EC 3.4.21.4)
    Language English
    Publishing date 2018-04-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1483852-7
    ISSN 1600-0854 ; 1398-9219
    ISSN (online) 1600-0854
    ISSN 1398-9219
    DOI 10.1111/tra.12562
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  10. Article: Outcomes and prognostic factors after surgery for bone metastases in the extremities and pelvis: A retrospective analysis of 140 patients.

    Raschka, Thore / Weiss, Sebastian / Reiter, Alonja / Barg, Alexej / Schlickewei, Carsten / Frosch, Karl-Heinz / Priemel, Matthias

    Journal of bone oncology

    2022  Volume 34, Page(s) 100427

    Abstract: Background: Surgical therapy of bone metastases is becoming increasingly important due to prolonged life expectancy and improved oncological treatment options. In a mostly palliative approach, it is necessary to identify those patients who might benefit ...

    Abstract Background: Surgical therapy of bone metastases is becoming increasingly important due to prolonged life expectancy and improved oncological treatment options. In a mostly palliative approach, it is necessary to identify those patients who might benefit from surgery. The shorter the remaining lifetime, the more restricted the indication and the less radical the intervention should be. The aim of this study was to evaluate the postoperative outcomes and prognostic factors for survival of patients with surgically treated bone metastases.
    Methods: We retrospectively included 140 patients who underwent surgery for 151 bone metastases in the extremities and pelvis at our hospital between 2010 and 2020. We examined patient demographics, surgical procedures, 30-day complications, local tumour progression, and reoperations. Survival was calculated using Kaplan-Meier analysis. Prognostic factors were investigated by univariate analysis using the log-rank test and multivariate analysis using the Cox regression hazard model.
    Results: In 138 patients, the median survival time was 12.3 months. The overall survival rates at one, two, three and five years were 52.3%, 37.6%, 28.0%, and 18.0%, respectively. In univariate analysis, lung cancer, renal cell carcinoma, pathological fracture, visceral metastasis and multiple bone metastases were significantly associated with prognosis. No significant influence was determined for gender, age, location of bone metastasis, type of surgical procedure and time between diagnosis of primary tumour and surgery for bone metastasis. Multivariate analysis confirmed that pathological fracture, visceral metastasis and lung cancer were negative prognostic variables in terms of survival. Within 30 days, the incidence of complications was 25.0% and mortality was 9.3%. The most common complications were urinary tract infections (5.0%), pneumonia (4.3%), and delirium (2.9%). Local tumour progression occurred in 12 patients (8.7%) and five reoperations (3.6%) were performed. There were no significant differences between patients treated with endoprosthetic replacement (n = 47) and those treated with internal fixation (n = 91) in terms of 30-day complications and mortality as well as local tumour progression.
    Conclusions: Survival of patients after surgery for bone metastases in the extremities or pelvis is very limited. The presence of a pathological fracture, visceral metastasis and lung cancer were independent prognostic factors for poor survival. Both internal fixation and endoprosthetic replacement achieved similar outcomes.
    Language English
    Publishing date 2022-04-06
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2212-1366
    ISSN 2212-1366
    DOI 10.1016/j.jbo.2022.100427
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