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  1. Article ; Online: A summary of the diagnostic and prognostic value of hemocytometry markers in COVID-19 patients.

    Khartabil, T A / Russcher, H / van der Ven, Ajam / de Rijke, Y B

    Critical reviews in clinical laboratory sciences

    2020  Volume 57, Issue 6, Page(s) 415–431

    Abstract: Many studies have reported hemocytometric changes in COVID-19 infection at admission and during the course of disease, but an overview is lacking. We provide a summary of the literature of hemocytometric changes and evaluate whether these changes may ... ...

    Abstract Many studies have reported hemocytometric changes in COVID-19 infection at admission and during the course of disease, but an overview is lacking. We provide a summary of the literature of hemocytometric changes and evaluate whether these changes may assist clinicians in diagnosing and predicting disease progression of COVID-19. Eighty-three out of 250 articles from December 2019 to 20 May 2020 were included from the databases, PubMed, Web of Science Core Collection, Embase, Cochrane and MedRxiv. Our review of the literature indicates that lymphopenia and an elevated neutrophil/lymphocyte ratio are the most consistent abnormal hemocytometric findings and that these alterations may augment in the course of time, especially in those with severe disease.
    MeSH term(s) Betacoronavirus/physiology ; Biomarkers/blood ; COVID-19 ; Coronavirus Infections/blood ; Coronavirus Infections/diagnosis ; Erythropoiesis ; Humans ; Inflammation/blood ; Inflammation/pathology ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/diagnosis ; Prognosis ; SARS-CoV-2
    Chemical Substances Biomarkers
    Keywords covid19
    Language English
    Publishing date 2020-06-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 280641-1
    ISSN 1549-781X ; 1040-8363 ; 0590-8191
    ISSN (online) 1549-781X
    ISSN 1040-8363 ; 0590-8191
    DOI 10.1080/10408363.2020.1774736
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 771: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: A summary of the diagnostic and prognostic value of hemocytometry markers in COVID-19 patients

    Khartabil, T. A. / Russcher, H. / van der Ven, Ajam / de Rijke, Y. B.

    Critical Reviews in Clinical Laboratory Sciences

    2020  Volume 57, Issue 6, Page(s) 415–431

    Keywords General Biochemistry, Genetics and Molecular Biology ; Clinical Biochemistry ; Biochemistry, medical ; covid19
    Language English
    Publisher Informa UK Limited
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 280641-1
    ISSN 1549-781X ; 1040-8363 ; 0590-8191
    ISSN (online) 1549-781X
    ISSN 1040-8363 ; 0590-8191
    DOI 10.1080/10408363.2020.1774736
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 771: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: A summary of the diagnostic and prognostic value of hemocytometry markers in COVID-19 patients

    Khartabil, T A / Russcher, H / van der Ven, Ajam / de Rijke, Y B

    Crit Rev Clin Lab Sci

    Abstract: Many studies have reported hemocytometric changes in COVID-19 infection at admission and during the course of disease, but an overview is lacking. We provide a summary of the literature of hemocytometric changes and evaluate whether these changes may ... ...

    Abstract Many studies have reported hemocytometric changes in COVID-19 infection at admission and during the course of disease, but an overview is lacking. We provide a summary of the literature of hemocytometric changes and evaluate whether these changes may assist clinicians in diagnosing and predicting disease progression of COVID-19. Eighty-three out of 250 articles from December 2019 to 20 May 2020 were included from the databases, PubMed, Web of Science Core Collection, Embase, Cochrane and MedRxiv. Our review of the literature indicates that lymphopenia and an elevated neutrophil/lymphocyte ratio are the most consistent abnormal hemocytometric findings and that these alterations may augment in the course of time, especially in those with severe disease.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #610440
    Database COVID19

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  4. Article ; Online: A summary of the diagnostic and prognostic value of hemocytometry markers in COVID-19 patients

    Khartabil, T.A.T. (T A Tania) / Russcher, H. (Henk) / van der Ven, A.A. (Ajam Andre) / Rijke, Y.B. (Yolanda) de

    Critical reviews in clinical laboratory sciences, pp. 1-17

    2020  

    Abstract: Many studies have reported hemocytometric changes in COVID-19 infection at admission and during the course of disease, but an overview is lacking. We provide a summary of the literature of hemocytometric changes and evaluate whether these changes may ... ...

    Abstract Many studies have reported hemocytometric changes in COVID-19 infection at admission and during the course of disease, but an overview is lacking. We provide a summary of the literature of hemocytometric changes and evaluate whether these changes may assist clinicians in diagnosing and predicting disease progression of COVID-19. Eighty-three out of 250 articles from December 2019 to 20 May 2020 were included from the databases, PubMed, Web of Science Core Collection, Embase, Cochrane and MedRxiv. Our review of the literature indicates that lymphopenia and an elevated neutrophil/lymphocyte ratio are the most consistent abnormal hemocytometric findings and that these alterations may augment in the course of time, especially in those with severe disease.
    Keywords COVID-19 ; hemocytometry ; platelets ; red blood cells ; white blood cells ; covid19
    Language English
    Publishing date 2020-06-22
    Publishing country nl
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Structure of mixed alkyllithium/lithium alkoxide aggregates in ethereal solvents. Insights from combined QM/MM molecular dynamics simulations.

    Khartabil, Hassan K / Martins-Costa, Marilia T C / Gros, Philippe C / Fort, Yves / Ruiz-López, Manuel F

    The journal of physical chemistry. B

    2009  Volume 113, Issue 18, Page(s) 6459–6467

    Abstract: Mixed alkyllithium/lithium alkoxides aggregates are important species in synthetic organic chemistry, but their electronic and geometric properties have not been extensively studied yet. The main objective of this work was to analyze the structure of ... ...

    Abstract Mixed alkyllithium/lithium alkoxides aggregates are important species in synthetic organic chemistry, but their electronic and geometric properties have not been extensively studied yet. The main objective of this work was to analyze the structure of simple prototypical aggregates in a coordinating solvent with the help of elaborated theoretical chemistry calculations. Within this aim, we have carried out molecular dynamics simulations for MeOLi, (EtLi)(MeOLi), and (EtLi)(2)(MeOLi)(2) systems in dimethyl ether solution. We use a combined QM/MM (quantum mechanics/molecular mechanics) force field that allows an appropriate description of the aggregate structure and of its interactions with the solvent. In the simulations, the aggregates are described at the B3LYP/6-31G(d) level while the solvent is described using the classical OPLS potential. For completeness, the influence of the chemical environment on the C-O-Li bond structure has been analyzed in some detail. The discussion focuses on (1) the distinctive properties of the alkoxide C-O-Li bond pattern, (2) the coordination of solvent molecules to the aggregates (number, stability), and (3) the time fluctuations of main structural parameters (Li-C and Li-O distances). We also show that nonclassical C-H...O hydrogen bonds involving H atoms of the solvent methyl groups and the O atom of the alkoxide are formed in the solvated MeOLi monomer and (EtLi)(MeOLi) dimer. Owing to these specific interactions, the monomer exhibits a nonlinear C-O-Li bond in solution.
    Language English
    Publishing date 2009-05-07
    Publishing country United States
    Document type Journal Article
    ISSN 1520-6106
    ISSN 1520-6106
    DOI 10.1021/jp809211y
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  6. Article: Torasemide for diuretic treatment of advanced chronic renal failure.

    Clasen, W / Khartabil, T / Imm, S / Kindler, J

    Arzneimittel-Forschung

    1988  Volume 38, Issue 1A, Page(s) 209–211

    Abstract: ... isopropyl-3- ([4-(3-methyl-phenylamino)pyridine]-3-sulfonyl)urea, T) therapy was compared ... evaluated. Patients were randomly allocated to either 500 mg F/d (group 1) or 200 mg T/d (group 2). After 14 ... lower dose of T the clinical effect of both drugs on edema, fluid and sodium excretion was equipotent ...

    Abstract In a double-blind randomized clinical trial the efficacy and safety of oral high-dose torasemide (1-isopropyl-3- ([4-(3-methyl-phenylamino)pyridine]-3-sulfonyl)urea, T) therapy was compared with that of furosemide (F) in 10 patients with advanced chronic renal failure. The efficacy on edema, fluid and electrolyte balance including the influence on renin-angiotensin-aldosterone system and cochlear function was evaluated. Patients were randomly allocated to either 500 mg F/d (group 1) or 200 mg T/d (group 2). After 14 days of treatment doses were doubled in each group for further 14 days. With respect to the 2.5 times lower dose of T the clinical effect of both drugs on edema, fluid and sodium excretion was equipotent. Significant differences were noted on calciuresis. Serum calcium levels were reduced with F, while T had no influence on calcium balance. A significant increase in plasma renin activity (PRA) was observed after F, whereas T had no raising effect on PRA. No significant alteration of plasma aldosterone concentration occurred with T or F. No adverse effects were noted in both groups. Serial audiometries showed no significant impairment of cochlear function with both drugs. In conclusion, these results indicate that high-dose T is efficient and safe in the treatment of advanced chronic renal failure. The lack of a calciuric effect with T can be regarded as an advantage in patients with hypocalcemia in chronic renal failure.
    MeSH term(s) Adult ; Calcium/urine ; Clinical Trials as Topic ; Cochlea/drug effects ; Diuresis/drug effects ; Diuretics/therapeutic use ; Double-Blind Method ; Female ; Humans ; Kidney Failure, Chronic/drug therapy ; Male ; Middle Aged ; Natriuresis/drug effects ; Random Allocation ; Renin-Angiotensin System/drug effects ; Sulfonamides/therapeutic use
    Chemical Substances Diuretics ; Sulfonamides ; Calcium (SY7Q814VUP) ; torsemide (W31X2H97FB)
    Language English
    Publishing date 1988-01
    Publishing country Germany
    Document type Clinical Trial ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 502081-5
    ISSN 1616-7066 ; 0004-4172
    ISSN (online) 1616-7066
    ISSN 0004-4172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uf I Zs.151: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    1990 A 260: Show issues

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