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Article: Biological Functions and Molecular Mechanisms of MiR-608 in Cancer.

Lu, Juan / Zhu, Danhua / Li, Lanjuan

2022 Volume 12, Page(s) 870983

Abstract: In recent years, microRNAs (miRNAs) have attracted much attention because of their prominent role in cancer. An increasing number of studies have shown that miRNAs play an important role in a variety of tumors. miR-608 has been reported to be decreased ... ...

Abstract	In recent years, microRNAs (miRNAs) have attracted much attention because of their prominent role in cancer. An increasing number of studies have shown that miRNAs play an important role in a variety of tumors. miR-608 has been reported to be decreased in cancers, especially in solid tumors. miR-608 is regarded as a tumor suppressor, which has been verified through a large number of experiments both
Language	English
Publishing date	2022-03-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.870983
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Successful pancreatoduodenectomy of

Ji, Linhua / Xu, Danhua / Zhu, Chunchao / Xu, Jia / Cao, Hui / Zhao, Gang

Frontiers in surgery

2023 Volume 9, Page(s) 1068215

Abstract: Introduction: Liver transplantation is a risk factor for premalignant and malignant changes of the duodenum. De novo duodenal malignancy is seldom reported after liver transplantation.: Case report: The present study reports a case of an asymptomatic ...

Abstract	Introduction: Liver transplantation is a risk factor for premalignant and malignant changes of the duodenum. De novo duodenal malignancy is seldom reported after liver transplantation. Case report: The present study reports a case of an asymptomatic 67-year-old male patient who underwent liver transplantation more than 10 years ago and subsequently developed duodenal malignancy. Endoscopic biopsy of the Conclusions: To the best of our knowledge, this case type has not been previously reported. The present study sheds light on the development, the treatment, the prognosis, and the management of a new type of
Language	English
Publishing date	2023-01-06
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2022.1068215
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Article ; Online: Trace determination of disinfection by-products in drinking water by cyclic ion chromatography with large-volume direct injection.

Zhu, Haibao / Ruan, Zheng / Wang, Han / Liu, Danhua / Tang, Hongfang / Wang, Jiahong

RSC advances

2023 Volume 13, Issue 31, Page(s) 21550–21557

Abstract: A novel cyclic ion chromatography (IC) system was developed for the simultaneous determination of trace disinfection by-products (DBPs) in drinking water. Five DBPs (chlorite, bromate, chlorate, dichloroacetic acid, and trichloroacetic acid) were ... ...

Abstract	A novel cyclic ion chromatography (IC) system was developed for the simultaneous determination of trace disinfection by-products (DBPs) in drinking water. Five DBPs (chlorite, bromate, chlorate, dichloroacetic acid, and trichloroacetic acid) were sensitively determined by large-volume direct injection, and the interferences of dominant inorganic anions present in water were eliminated online through the cyclic determination of the target analytes. Under optimized conditions, the obtained limits of detection (LODs) were in the range of 0.18-1.91 μg L
Language	English
Publishing date	2023-07-18
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra02471g
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Article ; Online: Evaluation of hydromechanical and functional properties of diversion-type microcapsule-suspension bioreactor for bioartificial liver.

Lu, Juan / Zhu, Danhua / Li, Lanjuan

The International journal of artificial organs

2022 Volume 45, Issue 3, Page(s) 309–321

Abstract: Aim: To evaluate the performance of a diversion-type microcapsulesuspension fluidized bed bioreactor and a choanoid fluidized bed bioreactor as bioartificial liver support systems.: Materials and methods: We evaluated the performance between the ... ...

Abstract	Aim: To evaluate the performance of a diversion-type microcapsulesuspension fluidized bed bioreactor and a choanoid fluidized bed bioreactor as bioartificial liver support systems. Materials and methods: We evaluated the performance between the modified fluidized bed bioreactor based on diversion-type microcapsule suspension (DMFBB) and choanoid fluidized bed bioreactor (CFBB). The fluidization performance, fluidized height, bed expansion, and the mechanical stability and strength of microcapsule were determined. The viability, synthetic, metabolism, and apoptosis of microcapsulated HepLi5 cells were evaluated. Finally, samples were collected for measurement of alanine aminotransferase, total bilirubin, direct bilirubin, and albumin concentrations. Results: Uniform fluidization was established in both DMFBB and CFBB. The bed expansion, shear force, retention rate, swelling rate, and breakage rate of microcapsules differed significantly between two bioreactors over 3 days. The viability of microencapsulated HepLi5 cells and the activities of cytochrome P450 1A2 and 3A4 increased on each day in DMFBB compared to the control. The albumin and urea concentrations in the DMFBB displayed obvious improvements compared to the control. Caspase3/7 activities in the DMFBB decreased compared to those in the CFBB. At 24 h, the alanine aminotransferase concentration in the DMFBB declined significantly compared to the control. The total and direct bilirubin concentrations within plasma perfusion were decreased and albumin was increased in the DMFBB at 24 h than in the CFBB. Conclusion: The DMFBB shows a promising alternative bioreactor for use in bioartificial liver support systems for application of clinical practice.
MeSH term(s)	Bilirubin ; Bioreactors ; Capsules ; Liver, Artificial ; Perfusion
Chemical Substances	Capsules ; Bilirubin (RFM9X3LJ49)
Language	English
Publishing date	2022-01-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	80456-3
ISSN	1724-6040 ; 0391-3988
ISSN (online)	1724-6040
ISSN	0391-3988
DOI	10.1177/03913988211066502
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Article ; Online: Application of the PDMS Passive Sampling Method to Assess Bioavailability and Health Risks Associated with PAH-Contaminated Soil

Xiaoyang Jia / Danhua Yang / Yandan Li / Xiaoying Zhu / Lina Zhang / Jinsheng Wang

Sustainability, Vol 15, Iss 9027, p

2023 Volume 9027

Abstract: Integrating bioavailability into risk assessments is an effective way to objectively assess human health risks. In this study, the bioavailability of 16 polycyclic aromatic hydrocarbons (PAHs) in contaminated soil from a coking plant was evaluated using ... ...

Abstract	Integrating bioavailability into risk assessments is an effective way to objectively assess human health risks. In this study, the bioavailability of 16 polycyclic aromatic hydrocarbons (PAHs) in contaminated soil from a coking plant was evaluated using the polydimethylsiloxane (PDMS) passive sampling method. The results showed that the bioavailability factor ( BAF ) of each PAH, predicted using PDMS fibers, ranged from 0.46% to 9.74%. The PDMS passive sampling method was more stable in testing the bioavailability of PAHs with more than 4 benzene rings; a preliminary relationship was established between the BAF and the log value of the octanol–water partition coefficient (log K ow ). After considering their bioavailability, the carcinogenic risks ( CR s) and non-carcinogenic hazard quotients ( HQ s) associated with the 16 PAHs were reduced by 1 to 2 orders of magnitude. Only the health risks associated with benzo(a)pyrene and dibenzo(a,h)anthracene exceeded the acceptable level. The PDMS passive sampling method provides a useful tool for estimating oral bioavailability, and incorporating its results into human exposure testing can help to refine the health risk assessment of contaminants through oral ingestion.
Keywords	passive sampling method ; PDMS fiber ; PAHs contaminated soil ; bioavailability ; health risk assessment ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	333
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article: A promising new cancer marker: Long noncoding RNA EGFR-AS1.

Zhu, Danhua / Ouyang, Xiaoxi / Zhang, Yanhong / Yu, Xiaopeng / Su, Kunkai / Li, Lanjuan

Frontiers in oncology

2023 Volume 13, Page(s) 1130472

Abstract: Cancer consists of a group of diseases with the salient properties of an uncontrolled cell cycle, metastasis, and evasion of the immune response, mainly driven by the genomic instability of somatic cells and the physicochemical environment. Long ... ...

Abstract	Cancer consists of a group of diseases with the salient properties of an uncontrolled cell cycle, metastasis, and evasion of the immune response, mainly driven by the genomic instability of somatic cells and the physicochemical environment. Long noncoding RNAs (lncRNAs) are defined as noncoding RNAs with a length of more than 200 nucleotides. LncRNA dysregulation participates in diverse disease types and is tightly associated with patient clinical features, such as age, disease stage, and prognosis. In addition, an increasing number of lncRNAs have been confirmed to regulate a series of biological and pathological processes through numerous mechanisms. The lncRNA epidermal growth factor receptor antisense RNA 1 (EGFR-AS1) was recently discovered to be aberrantly expressed in many types of diseases, particularly in cancers. A high level of EGFR-AS1 was demonstrated to correlate with multiple patient clinical characteristics. More importantly, EGFR-AS1 was found to be involved in the mediation of various cellular activities, including cell proliferation, invasion, migration, chemosensitivity, and stemness. Therefore, EGFR-AS1 is a promising marker for cancer management. In this review, we introduce the expression profile, molecular mechanisms, biological functions, and clinical value of EGFR-AS1 in cancers.
Language	English
Publishing date	2023-02-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1130472
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Article ; Online: The expression and function of miR-622 in a variety of tumors.

Lu, Juan / Xie, Zhongyang / Xiao, Zhaoying / Zhu, Danhua

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2021 Volume 146, Page(s) 112544

Abstract: Cancer is a heavy burden worldwide, with high morbidity and mortality rates. Cancer treatments currently involve surgical and nonsurgical approaches. Molecular targeted therapy is the latest breakthrough. miRNAs are small noncoding RNAs found in plants ... ...

Abstract	Cancer is a heavy burden worldwide, with high morbidity and mortality rates. Cancer treatments currently involve surgical and nonsurgical approaches. Molecular targeted therapy is the latest breakthrough. miRNAs are small noncoding RNAs found in plants and animals that play a role in cancer and various diseases through influencing numerous biological processes, such as cell proliferation, apoptosis, the immune response, and drug resistance. One miRNA, miR-622, has been shown to regulate various pathways to influence disease processes. Abnormal miR-622 expression can promote or inhibit liver, colorectal, and breast cancers and other tumors, such as glioma. Herein, we reviewed the expression levels and clinical effects of miR-622 in various tumors and summarized its mechanisms and related molecules.
MeSH term(s)	Animals ; Apoptosis/genetics ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Glioma/genetics ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Molecular Targeted Therapy ; Neoplasms/genetics ; Neoplasms/metabolism
Chemical Substances	MIRN622 microRNA, human ; MicroRNAs
Language	English
Publishing date	2021-12-20
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2021.112544
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Article ; Online: Occurrence, seasonal variations, distribution patterns, and risk assessment of volatile monoaromatic hydrocarbons in soils of industrial parks in Yangtze River Delta, China

Zhu, Haibao / Chen, Yuanchen / Ruan, Zheng / Wang, Jiahong / Liu, Danhua / Wang, Han / Zhao, Meirong

Science of the Total Environment. 2023 Sept., v. 892 p.164511-

2023

Abstract: Monoaromatic hydrocarbons (MACHs) are a ubiquitous category of volatile compounds found in various environmental media. Despite their prevalence, systematic studies of MACHs on a large regional scale are still lacking. Herein, a comprehensive ... ...

Abstract	Monoaromatic hydrocarbons (MACHs) are a ubiquitous category of volatile compounds found in various environmental media. Despite their prevalence, systematic studies of MACHs on a large regional scale are still lacking. Herein, a comprehensive investigation of the occurrence, seasonal variations, distribution characteristics, and health risks of MACHs was carried out by analyzing soil samples (372 surface soils and 96 soil columns) from 33 typical industrial parks in the Yangtze River Delta (YRD) region. MACHs were detected in all surface soil samples. BTEXS (benzene, toluene, ethylbenzene, xylene, and styrene) were the five predominant congeners with the highest detection frequencies (90.9 %–100 %), collectively accounting for >78.2 % of the total MACHs content. Higher residual levels of MACHs were observed in winter compared to summer (P < 0.01), with total concentrations of 24 MACHs ranging from 30.9 ng/g to 1536 ng/g (median: 135 ng/g) in winter and 16.3 ng/g to 931 ng/g (median: 87.9 ng/g) in summer. Soils collected from the northeast of Jiangsu Province and the southwest of Anhui Province exhibited relatively higher levels of MACHs. On the basis of principal component analysis, we proposed that industrial emissions and vehicle exhaust may be the main sources of MACHs contamination in the soils of YRD industrial parks. Vertically, the concentrations of total MACHs decreased with the soil depth. Soil organic matter (OM) content and the concentration of MACHs in the surface soil layer (0–15 cm) were significant factors influencing the vertical migration and distribution of MACHs (P < 0.05). It was verified that residual MACHs in the soils posed lower lifetime non-carcinogenic and carcinogenic risks to the inhabitants of the study area. The field study provides valuable evidence for the formulation of MACHs pollution control policies in the YRD region.
Keywords	benzene ; carcinogenicity ; environment ; ethylbenzene ; migratory behavior ; pollution control ; principal component analysis ; risk assessment ; river deltas ; soil depth ; soil organic matter ; styrene ; summer ; toluene ; winter ; xylene ; China ; Yangtze River ; MACHs ; Soils ; Industrial parks ; Seasonal variations ; Distribution patterns ; Health risks
Language	English
Dates of publication	2023-09
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.164511
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Occurrence, seasonal variations, distribution patterns, and risk assessment of volatile monoaromatic hydrocarbons in soils of industrial parks in Yangtze River Delta, China.

Zhu, Haibao / Chen, Yuanchen / Ruan, Zheng / Wang, Jiahong / Liu, Danhua / Wang, Han / Zhao, Meirong

The Science of the total environment

2023 Volume 892, Page(s) 164511

Abstract	Monoaromatic hydrocarbons (MACHs) are a ubiquitous category of volatile compounds found in various environmental media. Despite their prevalence, systematic studies of MACHs on a large regional scale are still lacking. Herein, a comprehensive investigation of the occurrence, seasonal variations, distribution characteristics, and health risks of MACHs was carried out by analyzing soil samples (372 surface soils and 96 soil columns) from 33 typical industrial parks in the Yangtze River Delta (YRD) region. MACHs were detected in all surface soil samples. BTEXS (benzene, toluene, ethylbenzene, xylene, and styrene) were the five predominant congeners with the highest detection frequencies (90.9 %-100 %), collectively accounting for >78.2 % of the total MACHs content. Higher residual levels of MACHs were observed in winter compared to summer (P < 0.01), with total concentrations of 24 MACHs ranging from 30.9 ng/g to 1536 ng/g (median: 135 ng/g) in winter and 16.3 ng/g to 931 ng/g (median: 87.9 ng/g) in summer. Soils collected from the northeast of Jiangsu Province and the southwest of Anhui Province exhibited relatively higher levels of MACHs. On the basis of principal component analysis, we proposed that industrial emissions and vehicle exhaust may be the main sources of MACHs contamination in the soils of YRD industrial parks. Vertically, the concentrations of total MACHs decreased with the soil depth. Soil organic matter (OM) content and the concentration of MACHs in the surface soil layer (0-15 cm) were significant factors influencing the vertical migration and distribution of MACHs (P < 0.05). It was verified that residual MACHs in the soils posed lower lifetime non-carcinogenic and carcinogenic risks to the inhabitants of the study area. The field study provides valuable evidence for the formulation of MACHs pollution control policies in the YRD region.
MeSH term(s)	Soil ; Environmental Monitoring ; Rivers ; Seasons ; Soil Pollutants/analysis ; China ; Risk Assessment ; Hydrocarbons/analysis ; Toluene/analysis
Chemical Substances	Soil ; Soil Pollutants ; Hydrocarbons ; Toluene (3FPU23BG52)
Language	English
Publishing date	2023-05-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.164511
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Article ; Online: CCL19/CCR7 drives regulatory T cell migration and indicates poor prognosis in gastric cancer.

Xu, Danhua / Liu, Xu / Ke, Shouyu / Guo, Yixian / Zhu, Chunchao / Cao, Hui

BMC cancer

2023 Volume 23, Issue 1, Page(s) 464

Abstract: Background: Gastric cancer is associated with significant morbidity and mortality in the world. Blocking programmed cell death protein 1 pathway have been approved for the treatment of a variety of tumors and have achieved remarkable clinical ... ...

Abstract	Background: Gastric cancer is associated with significant morbidity and mortality in the world. Blocking programmed cell death protein 1 pathway have been approved for the treatment of a variety of tumors and have achieved remarkable clinical therapeutic effects. However, immune checkpoint inhibitors failed to achieve satisfactory results in gastric cancer. There is a need to identify novel immunotherapy targets in gastric cancer. Methods: We analysed the correlation between Treg cells and CD8 + T cells in gastric cancer samples. We studied the relationship between chemokines and Treg cells or CD8 + T cells in gastric cancer. We compared CCL19/CCR7 expression in gastric cancer patients in TCGA database. We performed transwell experiments to determine the influence of CCL19 on Treg cells and CD8 + T cells migratory capacity. We conducted survival analysis of CCL19 and CCR7 in gastric cancer database. Results: Treg cells show positive correlation with CD8 + T cells in gastric cancer. Treg cell expression was significantly upregulated in tumor tissues. Patients with high FOXP3 expression had worse overall survival than those with low FOXP3 expression. CCL19 had strong correlation with FOXP3 and weak correlation with CD8A. CCL19 had strong impact on the migratory capacity of Treg cells but weak impact on the migratory capacity of CD8 + T cells. Both CCL19 and CCR7 expression were significantly upregulated in gastric cancer tissues. Survival analysis demonstrated that both CCL19 and CCR7 indicate poor prognosis in gastric cancer. Conclusions: CCL19/CCR7 may be a potential novel therapeutic target in gastric cancer.
MeSH term(s)	Humans ; T-Lymphocytes, Regulatory ; Receptors, CCR7/genetics ; Receptors, CCR7/metabolism ; Stomach Neoplasms/pathology ; Prognosis ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism ; Chemokine CCL19
Chemical Substances	Receptors, CCR7 ; Forkhead Transcription Factors ; CCR7 protein, human ; CCL19 protein, human ; Chemokine CCL19
Language	English
Publishing date	2023-05-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-023-10882-7
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