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  1. Article ; Online: Exosomes: from biology to immunotherapy in infectious diseases.

    Rangel-Ramírez, Velia Verónica / González-Sánchez, Hilda Minerva / Lucio-García, César

    Infectious diseases (London, England)

    2022  Volume 55, Issue 2, Page(s) 79–107

    Abstract: Exosomes are extracellular vesicles derived from the endosomal compartment, which are released by all kinds of eukaryotic and prokaryotic organisms. These vesicles contain a variety of biomolecules that differ both in quantity and type depending on the ... ...

    Abstract Exosomes are extracellular vesicles derived from the endosomal compartment, which are released by all kinds of eukaryotic and prokaryotic organisms. These vesicles contain a variety of biomolecules that differ both in quantity and type depending on the origin and cellular state. Exosomes are internalized by recipient cells, delivering their content and thus contributing to cell-cell communication in health and disease. During infections exosomes may exert a dual role, on one hand, they can transmit pathogen-related molecules mediating further infection and damage, and on the other hand, they can protect the host by activating the immune response and reducing pathogen spread. Selective packaging of pathogenic components may mediate these effects. Recently, quantitative analysis of samples by omics technologies has allowed a deep characterization of the proteins, lipids, RNA, and metabolite cargoes of exosomes. Knowledge about the content of these vesicles may facilitate their therapeutic application. Furthermore, as exosomes have been detected in almost all biological fluids, pathogenic or host-derived components can be identified in liquid biopsies, making them suitable for diagnosis and prognosis. This review attempts to organize the recent findings on exosome composition and function during viral, bacterial, fungal, and protozoan infections, and their contribution to host defense or to pathogen spread. Moreover, we summarize the current perspectives and future directions regarding the potential application of exosomes for prophylactic and therapeutic purposes.
    MeSH term(s) Humans ; Exosomes/metabolism ; Cell Communication ; Communicable Diseases/therapy ; Immunotherapy ; Biology
    Language English
    Publishing date 2022-12-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2839775-7
    ISSN 2374-4243 ; 2374-4235
    ISSN (online) 2374-4243
    ISSN 2374-4235
    DOI 10.1080/23744235.2022.2149852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A systematic review and meta-analysis of the IgA seroprevalence in COVID-19 patients: Is there a role for IgA in COVID-19 diagnosis or severity?

    Rangel-Ramírez, Velia Verónica / Macías-Piña, Karen Alondra / Servin-Garrido, Roberto Raúl / de Alba-Aguayo, David R. / Moreno-Fierros, Leticia / Rubio-Infante, Nestor

    Microbiological research. 2022 Oct., v. 263

    2022  

    Abstract: Nowadays, Coronavirus disease (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the most important health problems. The dynamics and nature of humoral responses are relevant to determine the efficacy of both, ...

    Abstract Nowadays, Coronavirus disease (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the most important health problems. The dynamics and nature of humoral responses are relevant to determine the efficacy of both, diagnostic tests and developed vaccines. Since the role of IgA in the COVID-19 disease is not fully understood, we have systematically reviewed the scientific literature on antibody IgA immunity to SARS-CoV-2 to determine if IgA could be useful as a diagnostic tool or as a biomarker of severity. We systematically reviewed 736 abstracts and identified 38 manuscripts relevant to include in the meta-analysis. The seroprevalence of IgA in SARS-CoV-2 PCR (+) confirmed patients was 86.47% (CI: 5.27–178.21). Furthermore, we found out that IgA can be produced on the first days of infection (10 days) and IgA is detected until 75 days after symptomatic onset in some studies. We also observe that IgA production is stronger in severe patients compared with mild or asymptomatic patients. Our research noticed a possible association between IgA and protection; however, the possible role of IgA as a biomarker of protection or severity remains unclear.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; antibodies ; biomarkers ; diagnostic techniques ; meta-analysis ; research ; seroprevalence ; systematic review
    Language English
    Dates of publication 2022-10
    Publishing place Elsevier GmbH
    Document type Article
    ZDB-ID 1189614-0
    ISSN 1618-0623 ; 0944-5013
    ISSN (online) 1618-0623
    ISSN 0944-5013
    DOI 10.1016/j.micres.2022.127105
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: A systematic review and meta-analysis of the IgA seroprevalence in COVID-19 patients: Is there a role for IgA in COVID-19 diagnosis or severity?

    Rangel-Ramírez, Velia Verónica / Macías-Piña, Karen Alondra / Servin-Garrido, Roberto Raúl / de Alba-Aguayo, David R / Moreno-Fierros, Leticia / Rubio-Infante, Nestor

    Microbiological research

    2022  Volume 263, Page(s) 127105

    Abstract: Nowadays, Coronavirus disease (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the most important health problems. The dynamics and nature of humoral responses are relevant to determine the efficacy of both, ...

    Abstract Nowadays, Coronavirus disease (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the most important health problems. The dynamics and nature of humoral responses are relevant to determine the efficacy of both, diagnostic tests and developed vaccines. Since the role of IgA in the COVID-19 disease is not fully understood, we have systematically reviewed the scientific literature on antibody IgA immunity to SARS-CoV-2 to determine if IgA could be useful as a diagnostic tool or as a biomarker of severity. We systematically reviewed 736 abstracts and identified 38 manuscripts relevant to include in the meta-analysis. The seroprevalence of IgA in SARS-CoV-2 PCR (+) confirmed patients was 86.47% (CI: 5.27-178.21). Furthermore, we found out that IgA can be produced on the first days of infection (10 days) and IgA is detected until 75 days after symptomatic onset in some studies. We also observe that IgA production is stronger in severe patients compared with mild or asymptomatic patients. Our research noticed a possible association between IgA and protection; however, the possible role of IgA as a biomarker of protection or severity remains unclear.
    MeSH term(s) Antibodies, Viral ; Biomarkers ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19 Testing ; Humans ; Immunoglobulin A ; SARS-CoV-2 ; Seroepidemiologic Studies
    Chemical Substances Antibodies, Viral ; Biomarkers ; Immunoglobulin A
    Language English
    Publishing date 2022-06-30
    Publishing country Germany
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 1189614-0
    ISSN 1618-0623 ; 0944-5013
    ISSN (online) 1618-0623
    ISSN 0944-5013
    DOI 10.1016/j.micres.2022.127105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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