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Article ; Online: Effectiveness of Calcitonin Gene-Related Peptide Monoclonal Antibodies in the Prevention of Migraine: A Systematic Review and Meta-Analysis of Observational Cohort Studies.

Ferreira, Vinicius L / Mainka, Felipe F / Wiens, Astrid / Pontarolo, Roberto

2023 Volume 43, Issue 9, Page(s) 669–680

Abstract: Background and objective: Migraine is a neurological disorder characterized by episodes of moderate-to-severe headache. The emergence of drugs derived from monoclonal antibodies specific for the calcitonin gene has brought forth a therapeutic option for ...

Abstract	Background and objective: Migraine is a neurological disorder characterized by episodes of moderate-to-severe headache. The emergence of drugs derived from monoclonal antibodies specific for the calcitonin gene has brought forth a therapeutic option for patients in whom the traditional treatments have failed. This study aimed to evaluate the clinical effectiveness of calcitonin gene-related peptide antibodies in the prevention of migraine through a systematic review and meta-analysis of observational cohort studies. Methods: A literature search for evidence was performed in electronic databases for observational studies that evaluated adult patients with migraine receiving calcitonin gene-related peptide receptor antagonists (e.g. erenumab, fremanezumab, galcanezumab and eptinezumab) and reported effectiveness outcomes (mean reduction in monthly migraine/headache days, and proportion of patients with 50% or greater reduction in migraine/headache days). Results: During the screening process, 47 records were included for data extraction and qualitative and quantitative analyses. The overall rate of patients with a reduction of at least 50% of mean monthly migraine days was 54% (95% CI 49-59%), and overall mean monthly migraine reduction was about 7.7 days (95% CI 8.4-7.0 days). Regarding the outcome ≥ 50% reduction in mean monthly headache reduction, the overall rate of patients with a reduction of at least 50% was 57% (95% CI 48-64%), and the overall mean monthly headache reduction was approximately 8.8 days (95% CI 10.1-7.5 days). Subgroup analyses considering the drug treatment used and type of migraine were consistent with previous results. Conclusions: The use of calcitonin gene-related peptide antibodies in real-world studies to prevent migraine demonstrates promising effectiveness outcomes, in agreement with those reported in previously published randomized clinical trial reports.
MeSH term(s)	Adult ; Humans ; Calcitonin ; Calcitonin Gene-Related Peptide ; Migraine Disorders/drug therapy ; Migraine Disorders/prevention & control ; Antibodies, Monoclonal/therapeutic use ; Headache ; Cohort Studies ; Observational Studies as Topic ; Randomized Controlled Trials as Topic
Chemical Substances	Calcitonin (9007-12-9) ; Calcitonin Gene-Related Peptide (JHB2QIZ69Z) ; Antibodies, Monoclonal
Language	English
Publishing date	2023-09-04
Publishing country	New Zealand
Document type	Meta-Analysis ; Systematic Review
ZDB-ID	1220136-4
ISSN	1179-1918 ; 0114-2402 ; 1173-2563
ISSN (online)	1179-1918
ISSN	0114-2402 ; 1173-2563
DOI	10.1007/s40261-023-01301-7
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Zs.A 2807: Show issues

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Article ; Online: Optimization of solid oral dosage form administration to patients with swallowing difficulties: An integrative review.

Ferreira-Neto, Carolina Justus Buhrer / de Lara, Janaina Aparecida Amaral / Cominato, Alanis / Tonin, Fernanda Stumpf / Wiens, Astrid

Journal of advanced nursing

2023 Volume 80, Issue 4, Page(s) 1335–1354

Abstract: Aim: To appraise and synthesize research investigating optimizing the administration of solid oral dosage forms (SODFs) to adults with swallowing difficulties.: Design: An integrative review.: Methods: An electronic search was conducted on Medical ...

Abstract	Aim: To appraise and synthesize research investigating optimizing the administration of solid oral dosage forms (SODFs) to adults with swallowing difficulties. Design: An integrative review. Methods: An electronic search was conducted on Medical Literature Analysis and Retrieval System Online (Public Medline interface), Elsevier SciVerse Scopus and Scientific Electronic Library Online (updated February 2023). Restriction regarding the publication date was not considered for the inclusion of records. Studies addressing risks, general aspects, recommendations about patient postural adjustments, swallowing techniques, swallowing aids and aspects of concealment of SODFs were included. Results: Fifty-three records published between 2002 and 2021 were included. The main administration risks were aspiration, asphyxia and solid oral dosage form-induced oral/oesophageal mucosal lesions. The most frequent general aspect reported was administering one oral dosage form at a time. The sitting position was the most patient postural adjustment mentioned. The most frequently reported solid oral dosage form swallowing technique was the lean-forward method for capsules. Solid oral dosage form swallowing aids cited: tongue and throat lubricant and solid oral dosage form coating device, swallowing cup and swallowing straw. Conclusion: The literature data on administering SODFs for adults with swallowing difficulties were appraised and synthesized. Some aspects, for example, not administering SODFs simultaneously, can make swallowing safer. Postural adjustments and solid oral dosage form swallowing aids are important to avoid administration risks. Swallowing SODFs can be easier if learned by techniques. Liquid and food are helpful as vehicles, and several of these have been listed. Implications for the profession and/or patient care: By optimizing the contributing factors of administering oral pharmacotherapy, the nurse can use appropriate practices to improve patient safety. Additionally, knowing and establishing the administration aspects are reasonable steps for standardizing care for patients with swallowing oral dosage form difficulties. Impact: This study addressed administering SODFs to adult patients with swallowing difficulties. The administration of SODFs to adult patients with swallowing difficulties can be optimized if only one oral dosage form at a time is administrated and if patient postural adjustments, swallowing techniques and swallowing aids are used. This investigation will impact the care of patients with swallowing difficulties. Reporting method: The authors declare they adhered to the relevant EQUATOR guidelines and report following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 Statement. Patient or public contribution: No patient or public contribution.
MeSH term(s)	Humans ; Administration, Oral ; Capsules ; Deglutition ; Deglutition Disorders
Chemical Substances	Capsules
Language	English
Publishing date	2023-10-31
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	197634-5
ISSN	1365-2648 ; 0309-2402
ISSN (online)	1365-2648
ISSN	0309-2402
DOI	10.1111/jan.15910
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Zs.B 1851: Show issues

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Article ; Online: Solid Oral Dosage Forms Use in Adults with Neurological Disorders and Swallowing Difficulties: A Scoping Review.

Ferreira-Neto, Carolina Justus Buhrer / de Andrade, Rayza Assis / Tonin, Fernanda Stumpf / Wiens, Astrid

Dysphagia

2021 Volume 37, Issue 4, Page(s) 909–922

Abstract: Swallowing difficulties affects the deglutition of solid oral dosage forms (SODFs) and it is a common problem among neurological disorders. Interventions may improve the use of SODFs in healthcare settings. The aim of this study was to map the available ... ...

Abstract	Swallowing difficulties affects the deglutition of solid oral dosage forms (SODFs) and it is a common problem among neurological disorders. Interventions may improve the use of SODFs in healthcare settings. The aim of this study was to map the available research about the interventions aiming the effective and safe use of SODFs in adults with neurological disorders and swallowing difficulties and to identify potential literature gaps in this scientific field. A scoping review was carried out based on Joanna Briggs Institute guidelines and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews, in PubMed, Scopus, and SciELO databases (March 2021). Peer-reviewed observational studies assessed the effectiveness and safety of SODFs in adults with neurological disorders and swallowing difficulties in the healthcare organizations setting were included. 11 studies were included (three case reports, two mixed-methods intervention studies, and six analytic studies). The frequency of women ranged from 49 to 67%, and the age from 57 to 91 years. Most studies (n = 7) included elderly patients, Parkinson (n = 6) and dementia (n = 3). Medication review was the most frequently reported intervention, 35% (9/26). In most studies, interventions were targeted to patients during hospitalization (n = 7) and performed by physicians (n = 8). At least 20 different outcomes were evaluated in the studies. Implementing specific protocols for using SODFs aimed at the swallowing difficulties of this population is not a common practice. Additional studies on interventions aimed at optimizing SODFs are needed to support the safety and efficacy of oral therapy in this patient group.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Deglutition ; Deglutition Disorders/epidemiology ; Female ; Humans ; Middle Aged ; Nervous System Diseases/complications
Language	English
Publishing date	2021-10-15
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	632764-3
ISSN	1432-0460 ; 0179-051X
ISSN (online)	1432-0460
ISSN	0179-051X
DOI	10.1007/s00455-021-10352-x
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Zs.A 2130: Show issues

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Article ; Online: Safety of Antiretroviral Therapy in the Treatment of HIV/AIDS in Children: Systematic Review and Meta-analysis.

Szpak, Renata / Lombardi, Natália F / Dias, Frederico A / Borba, Helena H L / Pontarolo, Roberto / Wiens, Astrid

AIDS reviews

2021 Volume 23, Issue 4, Page(s) 196–203

Abstract: The safety of using different antiretroviral therapies (ART) in pediatric HIV/AIDS patients is not well-established. Therefore, this study aimed to assess the safety of ART in children. A systematic review of randomized clinical trials (RCTs) was ... ...

Abstract	The safety of using different antiretroviral therapies (ART) in pediatric HIV/AIDS patients is not well-established. Therefore, this study aimed to assess the safety of ART in children. A systematic review of randomized clinical trials (RCTs) was conducted to assess the safety of ART used by pediatric patients living with HIV/AIDS. The electronic search was conducted in PubMed and Scopus, in addition to a manual search. Studies were included if they assessed the safety of ART compared to placebo or another ART. Direct and indirect meta-analyses were conducted regarding safety outcomes. The systematic review included 21 RCTs. The studies included more than 5500 participants, and age ranged from 3 months to 18 years. The drugs evaluated were nucleoside reverse transcriptase inhibitors (NRTI); non-NRTI; and protease inhibitors. The predominant route of infection was vertical. Direct meta-analyses were performed for the outcomes sleep disorders, hepatobiliary disorders, respiratory disorders, hypertransaminasemia, neutropenia, hospitalization, and death. For these outcomes, no statistically significant differences were found. Indirect meta-analyses were performed for the outcomes anemia, gastrointestinal disorders, liver disorders, severe adverse events (AE), AE that led to changes in treatment, fever, and skin manifestations. However, no statistically significant differences were found for these outcomes. In this study, non-significant differences were detected in the safety of different ART used in pediatric individuals. The choice of appropriate therapy should be based on its efficacy and the individual characteristics of each patient.
MeSH term(s)	Acquired Immunodeficiency Syndrome/drug therapy ; Anti-HIV Agents/therapeutic use ; Child ; Drug Therapy, Combination ; HIV Infections/drug therapy ; Humans ; Infant ; Reverse Transcriptase Inhibitors
Chemical Substances	Anti-HIV Agents ; Reverse Transcriptase Inhibitors
Language	English
Publishing date	2021-12-29
Publishing country	Spain
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	2086783-9
ISSN	1698-6997 ; 1139-6121
ISSN (online)	1698-6997
ISSN	1139-6121
DOI	10.24875/AIDSRev.200001071
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Zs.A 5711: Show issues

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Article ; Online: Risk factors for postpartum maternal mortality and hospital readmission in low- and middle-income countries: a systematic review.

Symonds, Nicola E / Vidler, Marianne / Wiens, Matthew O / Omar, Shazmeen / English, L Lacey / Ukah, U Vivian / Ansermino, J Mark / Ngonzi, Joseph / Bebell, Lisa M / Hwang, Bella / Christoffersen-Deb, Astrid / Kissoon, Niranjan / Payne, Beth A

BMC pregnancy and childbirth

2023 Volume 23, Issue 1, Page(s) 303

Abstract: Background: In low- and middle-income countries, approximately two thirds of maternal deaths occur in the postpartum period. Yet, care for women beyond 24 h after discharge is limited. The objective of this systematic review is to summarize current ... ...

Abstract	Background: In low- and middle-income countries, approximately two thirds of maternal deaths occur in the postpartum period. Yet, care for women beyond 24 h after discharge is limited. The objective of this systematic review is to summarize current evidence on socio-demographic and clinical risk factors for (1) postpartum mortality and (2) postpartum hospital readmission. Methods: A combination of keywords and subject headings (i.e. MeSH terms) for postpartum maternal mortality or readmission were searched. Articles published up to January 9, 2021 were identified in MEDLINE, EMBASE, and CINAHL databases, without language restrictions. Studies reporting socio-demographic or clinical risk factors for postpartum mortality or readmission within six weeks of delivery among women who delivered a livebirth in a low- or middle-income country were included. Data were extracted independently by two reviewers based on study characteristics, population, and outcomes. Included studies were assessed for quality and risk of bias using the Downs and Black checklist for ratings of randomized and non-randomized studies. Results: Of 8783 abstracts screened, seven studies were included (total N = 387,786). Risk factors for postpartum mortality included Caesarean mode of delivery, nulliparity, low or very low birthweight, and shock upon admission. Risk factors for postpartum readmission included Caesarean mode of delivery, HIV positive serostatus, and abnormal body temperature. Conclusions: Few studies reported individual socio-demographic or clinical risk factors for mortality or readmission after delivery in low- and middle-income countries; only Caesarean delivery was consistently reported. Further research is needed to identify factors that put women at greatest risk of post-discharge complications and mortality. Understanding post-discharge risk would facilitate targeted postpartum care and reduce adverse outcomes in women after delivery. Trial registration: PROSPERO registration number: CRD42018103955.
MeSH term(s)	Pregnancy ; Female ; Humans ; Patient Readmission ; Aftercare ; Developing Countries ; Maternal Mortality ; Patient Discharge ; Postpartum Period ; Risk Factors
Language	English
Publishing date	2023-04-29
Publishing country	England
Document type	Systematic Review ; Journal Article
ZDB-ID	2059869-5
ISSN	1471-2393 ; 1471-2393
ISSN (online)	1471-2393
ISSN	1471-2393
DOI	10.1186/s12884-023-05459-y
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Article ; Online: Analysis of completeness for spontaneous reporting of disease-modifying therapies in multiple sclerosis.

Araujo, Ariane G S / Lucchetta, Rosa C / Tonin, Fernanda S / Pontarolo, Roberto / Borba, Helena H L / Wiens, Astrid

Expert opinion on drug safety

2021 Volume 20, Issue 6, Page(s) 735–740

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	Adverse Drug Reaction Reporting Systems/standards ; Adverse Drug Reaction Reporting Systems/statistics & numerical data ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Humans ; Immunologic Factors/administration & dosage ; Immunologic Factors/adverse effects ; Multiple Sclerosis/drug therapy ; Pharmacovigilance ; Product Surveillance, Postmarketing/standards ; Product Surveillance, Postmarketing/statistics & numerical data ; United States ; United States Food and Drug Administration
Chemical Substances	Immunologic Factors
Language	English
Publishing date	2021-03-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2088728-0
ISSN	1744-764X ; 1474-0338
ISSN (online)	1744-764X
ISSN	1474-0338
DOI	10.1080/14740338.2021.1897566
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Zs.A 6096: Show issues

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Article ; Online: Evaluation of the application of the Diabetes Quality of Life Questionnaire in patients with diabetes mellitus.

Pereira, Edilene Vieira / Tonin, Fernanda Stumpf / Carneiro, Jaqueline / Pontarolo, Roberto / Wiens, Astrid

Archives of endocrinology and metabolism

2020 Volume 64, Issue 1, Page(s) 59–65

Abstract: Objective Diabetes mellitus (DM) is a chronic disease with great impact on patients' quality of life (QoL). This variable can be measured using reliable, standardized, and validated instruments. The purpose of this study was to evaluate the application ... ...

Abstract	Objective Diabetes mellitus (DM) is a chronic disease with great impact on patients' quality of life (QoL). This variable can be measured using reliable, standardized, and validated instruments. The purpose of this study was to evaluate the application and reporting of the Diabetes Quality of Life Measure (DQOL) or the Diabetes Quality of Life for Youths Measure (DQOLY), an adapted version for young patients with DM. Materials and methods A systematic review of interventional and observational studies using the DQOL or DQOLY was performed. Searches were conducted in the electronic databases Medline, Scopus, Web of Science, Lilacs, and SciELO. Results After conducting the searches, 111 studies met the inclusion criteria and were included in the qualitative analysis. Of these, 32 studies were classified as interventional and 79 as observational, with 27,481 patients. The DQOL was applied in 82 studies, the DQOLY in another 27, and two studies used both instruments. DM was classified as type 1 DM in 69 studies and type 2 DM in 35 studies. Six studies included both patients. Improvement in patients' QoL after an intervention was observed in 13 interventional studies. Most of the studies (90%) provide a detailed description of the instrument and 52% the previous validation. The interpretation of the scores obtained varies among the studies, probably due to the differences inherent in cultural validations, translations, and adaptations. Conclusion The application of the instruments in clinical practice must be rigorously standardized and requires an accurate understanding of psychometric and statistical concepts. Arch Endocrinol Metab. 2020;64(1):59-65.
MeSH term(s)	Adolescent ; Diabetes Mellitus, Type 1/psychology ; Diabetes Mellitus, Type 2/psychology ; Female ; Humans ; Male ; Psychometrics ; Quality of Life/psychology ; Surveys and Questionnaires
Language	English
Publishing date	2020-03-13
Publishing country	Brazil
Document type	Journal Article ; Systematic Review
ISSN	2359-4292
ISSN (online)	2359-4292
DOI	10.20945/2359-3997000000196
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Article ; Online: Outcome measures for disease-modifying therapies in relapsing multiple sclerosis randomized clinical trials: a scoping review protocol.

Lucchetta, Rosa C / Oliveira, Magda L / Bonetti, Aline F / Fernandez-Llimos, Fernando / Wiens, Astrid

JBI evidence synthesis

2020 Volume 18, Issue 8, Page(s) 1781–1787

Abstract: Objective: The objective of the review is to explore randomized controlled trials on disease-modifying therapies for relapsing multiple sclerosis to identify and quantify the different outcome measures, instruments and definitions of efficacy, safety ... ...

Abstract	Objective: The objective of the review is to explore randomized controlled trials on disease-modifying therapies for relapsing multiple sclerosis to identify and quantify the different outcome measures, instruments and definitions of efficacy, safety outcomes, health-related quality of life instruments and population subgroups. Introduction: A wide range of therapies are available for relapsing multiple sclerosis, as well as a wide range of outcome measures and definitions, which can be explained by the absence of a core outcome set for this disease. Establishing a core outcome set is fundamental for guiding future studies as they improve the consistency and relevance of new findings and enable the results of trials to be compared and combined. These features are especially important for relapsing multiple sclerosis due to the limited number of head-to-head studies on this disease. Although many systematic reviews and meta-analyses have focused on the efficacy and safety of disease-modifying therapies in relapsing multiple sclerosis, none have had the specific objective of mapping outcome measures. Inclusion criteria: This review will consider randomized controlled trials that explore populational subgroups, efficacy, safety outcomes, health-related quality of life instruments and their definitions in the context of disease-modifying therapies for adults with relapsing multiple sclerosis. Methods: Electronic searches will be performed in PubMed, Scopus, the Cochrane Library, ClinicalTrials.gov, and JBI Evidence Synthesis with no time limit. Two researchers will independently select registries (screening and eligibility steps) and extract data on study characteristics, outcome measures, definitions and population subgroups. Data will be presented in graphical or tabular form, accompanied by a narrative summary.
MeSH term(s)	Humans ; Multiple Sclerosis ; Multiple Sclerosis, Relapsing-Remitting/drug therapy ; Outcome Assessment, Health Care ; Quality of Life ; Recurrence ; Review Literature as Topic
Language	English
Publishing date	2020-09-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2689-8381
ISSN (online)	2689-8381
DOI	10.11124/JBISRIR-D-19-00178
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Article ; Online: Diagnosis and prediction of COVID-19 severity: can biochemical tests and machine learning be used as prognostic indicators?

Cobre, Alexandre de Fátima / Stremel, Dile Pontarolo / Noleto, Guilhermina Rodrigues / Fachi, Mariana Millan / Surek, Monica / Wiens, Astrid / Tonin, Fernanda Stumpf / Pontarolo, Roberto

Computers in biology and medicine

2021 Volume 134, Page(s) 104531

Abstract: Objective: This study aimed to implement and evaluate machine learning based-models to predict COVID-19' diagnosis and disease severity.: Methods: COVID-19 test samples (positive or negative results) from patients who attended a single hospital were ... ...

Abstract	Objective: This study aimed to implement and evaluate machine learning based-models to predict COVID-19' diagnosis and disease severity. Methods: COVID-19 test samples (positive or negative results) from patients who attended a single hospital were evaluated. Patients diagnosed with COVID-19 were categorised according to the severity of the disease. Data were submitted to exploratory analysis (principal component analysis, PCA) to detect outlier samples, recognise patterns, and identify important variables. Based on patients' laboratory tests results, machine learning models were implemented to predict disease positivity and severity. Artificial neural networks (ANN), decision trees (DT), partial least squares discriminant analysis (PLS-DA), and K nearest neighbour algorithm (KNN) models were used. The four models were validated based on the accuracy (area under the ROC curve). Results: The first subset of data had 5,643 patient samples (5,086 negatives and 557 positives for COVID-19). The second subset included 557 COVID-19 positive patients. The ANN, DT, PLS-DA, and KNN models allowed the classification of negative and positive samples with >84% accuracy. It was also possible to classify patients with severe and non-severe disease with an accuracy >86%. The following were associated with the prediction of COVID-19 diagnosis and severity: hyperferritinaemia, hypocalcaemia, pulmonary hypoxia, hypoxemia, metabolic and respiratory acidosis, low urinary pH, and high levels of lactate dehydrogenase. Conclusion: Our analysis shows that all the models could assist in the diagnosis and prediction of COVID-19 severity.
Language	English
Publishing date	2021-05-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	127557-4
ISSN	1879-0534 ; 0010-4825
ISSN (online)	1879-0534
ISSN	0010-4825
DOI	10.1016/j.compbiomed.2021.104531
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Zs.A 653: Show issues

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Article ; Online: Cost effectiveness of dressing in the prevention of catheter-related infection in critically ill patients.

Pedrolo, Edivane / Danski, Mitzy Tannia Reichembach / Wiens, Astrid / Boostel, Radamés

Journal of infection in developing countries

2018 Volume 12, Issue 10, Page(s) 871–877

Abstract: Introduction: Catheter-related infection is a complication of high morbimortality. The aim was to perform a cost-effectiveness analysis of gauze and medical tape, transparent semi-permeable and chlorhexidine-impregnated dressings for short-term central ... ...

Abstract	Introduction: Catheter-related infection is a complication of high morbimortality. The aim was to perform a cost-effectiveness analysis of gauze and medical tape, transparent semi-permeable and chlorhexidine-impregnated dressings for short-term central venous catheter, within the Brazilian Public Healthcare System (Sistema Único de Saúde - SUS) scenario. Methodology: a decision tree was elaborated in order to evaluate the cost-effectiveness of dressings in the prevention of catheter-related infection in critically ill patients. The outcome was the probability of catheter-related infections prevention. Moreover, only direct medical expenses were considered. Sensitivity analyses were performed to evaluate the model uncertainties. Results: Chlorhexidine-impregnated dressing presented higher cost-effectiveness when the base case was analyzed (cost of US$ 655 per case prevented, 99% of effectiveness), in comparison to gauze and medical tape dressing (US$ 696, effectiveness of 96%). Dressing changes performed before the recommended period, treatment performed exclusively in inpatient units and high effectiveness of gauze and medical tape dressing were variables that interfered with the results. The probability of death has also demonstrated to have a major impact on cost-effectiveness. Conclusion: In the context of a Brazilian public hospital, the chlorhexidine-impregnated dressing presented higher cost-effectiveness when compared to the gauze and medical tape dressing or the transparent semi-permeable dressing.
MeSH term(s)	Adult ; Aged ; Anti-Infective Agents, Local/administration & dosage ; Anti-Infective Agents, Local/economics ; Anti-Infective Agents, Local/therapeutic use ; Bandages/economics ; Brazil ; Catheter-Related Infections/economics ; Catheter-Related Infections/prevention & control ; Chlorhexidine/administration & dosage ; Chlorhexidine/economics ; Chlorhexidine/therapeutic use ; Cost-Benefit Analysis ; Critical Illness ; Cross Infection/economics ; Cross Infection/prevention & control ; Decision Trees ; Female ; Hospital Costs/statistics & numerical data ; Humans ; Male ; Middle Aged ; Retrospective Studies
Chemical Substances	Anti-Infective Agents, Local ; Chlorhexidine (R4KO0DY52L)
Language	English
Publishing date	2018-10-31
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2394024-4
ISSN	1972-2680 ; 2036-6590
ISSN (online)	1972-2680
ISSN	2036-6590
DOI	10.3855/jidc.10269
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