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Article ; Online: Optimization of the Zhou Tian Formula extraction technology based on AHP-CRITIC method and analysis of transfer efficiency of key components based on HPLC fingerprinting.

Ma, Yi-Feng / Feng, Yang / Yao, Li-Li / Feng, Pei-Shi / Zhou, Wei-Kang / Fang, Le-Xuan / Tao, Yi / Wang, Ping

2024

Abstract: Introduction: Zhou Tian Formula (ZTF) is an antidepressant traditional Chinese medicine utilized ...

Abstract	Introduction: Zhou Tian Formula (ZTF) is an antidepressant traditional Chinese medicine utilized widely in clinical settings for the treatment of patients with depression. However, shortcomings persist in its extraction technology and quality control. Objective: This study aimed to propose a methodology for ZTF extraction technology based on the analytic hierarchy process (AHP)-criteria importance through intercriteria correlation (CRITIC) method and to establish a quality control framework for the efficient transfer of index components. Method: Firstly, we analyzed the chemical components of ZTF and determined the optimal extraction technology. Secondly, we calculated the transfer efficiency of the index components during the conversion of water decoction to extract powder and subsequently to granules. Thirdly, we established HPLC fingerprints for 15 batches of ZTF water decoction, extract powder, and granules. We employed SIMCA software to analyze the chemicals responsible for variations in quality among different batches of ZTF granules. Results: We determined the optimal extraction process. The average transfer efficiency of ferulic acid, puerarin, mirificin, isoferulic acid, and calycosin during the conversion of water decoction to extract powder and subsequently to granules exceeded 41%. The HPLC fingerprints of ZTF exhibited a similarity exceeding 0.890. Variable importance in projection values indicated that calycosin, ferulic acid, and puerarin were the primary contributors to quality variations. Conclusions: The AHP-CRITIC method, coupled with an orthogonal array design, could be used for exploring extraction technology. In addition, the rules governing the transfer of index components from water decoction to extract powder, and subsequently to granules, could be applied for the evaluation and quality assessment of ZTF.
Language	English
Publishing date	2024-02-17
Publishing country	England
Document type	Journal Article
ZDB-ID	1073576-8
ISSN	1099-1565 ; 0958-0344
ISSN (online)	1099-1565
ISSN	0958-0344
DOI	10.1002/pca.3334
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Article ; Online: The Tian-Men-Dong decoction suppresses the tumour-infiltrating G-MDSCs via IL-1β-mediated signalling in lung cancer.

Su, Lin / Zhang, Fei / Liu, Ming-Xi / Li, Hong / Li, Qiang / Zhu, Yang-Zhuangzhuang / Hou, Yi-Fei / Chen, Xiao / Wang, Xiao-Yu / Qian, Chun-Mei / Yao, Chao / Wang, Li-Xin / Jiao, Xiao-Ning / Zhu, Xian-Dan / Xu, Zi-Hang / Zou, Chun-Pu

Journal of ethnopharmacology

2023 Volume 313, Page(s) 116491

Abstract: Ethnopharmacological relevance: The traditional Chinese medicine (TCM) Tian-Men-Dong decoction (TD ...

Abstract	Ethnopharmacological relevance: The traditional Chinese medicine (TCM) Tian-Men-Dong decoction (TD) has been able to effectively treat lung cancer in China for thousands of years. TD improves the quality of life in lung cancer patients by promoting nourishment of yin and reducing dryness, clearing the lung and removing toxins. Pharmacological studies show that TD contains active antitumour ingredients, but its underlying mechanism remains unknown. Aim of the study: This study aims at exploring potential mechanisms of TD in the treatment of lung cancer by regulating granulocytic-myeloid-derived suppressor cells (G-MDSCs). Materials and methods: An orthotopic lung cancer mouse model was generated by intrapulmonary injection with LLC-luciferase cells in immunocompetent C57BL/6 mice or immunodeficient nude mice. TD/saline was orally administered once to the model mice daily for 4 weeks. Live imaging was conducted to monitor tumour growth. Immune profiles were detected by flow cytometry. H&E and ELISA were applied to test the cytotoxicity of the TD treatment. RT-qPCR and western blotting were performed to detect apoptosis-related proteins in G-MDSCs. A neutralizing antibody (anti-Ly6G) was utilized to exhaust the G-MDSCs via intraperitoneal injection. G-MDSCs were adoptively transferred from wild-type tumour-bearing mice. Immunofluorescence, TUNEL and Annexin V/PI staining were conducted to analyse apoptosis-related markers. A coculture assay of purified MDSCs and T cells labelled with CFSE was performed to test the immunosuppressive activity of MDSCs. The presence of TD/IL-1β/TD + IL-1β in purified G-MDSCs cocultured with the LLC system was used for ex vivo experiments to detect IL-1β-mediated apoptosis of G-MDSCs. Results: TD prolonged the survival of immune competent C57BL/6 mice in an orthotopic lung cancer model, but did not have the same effect in immunodeficient nude mice, indicating that its antitumour properties of TD are exerted by regulating immunity. TD induced G-MDSC apoptosis via the IL-1β-mediated NF-κB signalling cascade leading to effectively weaken the immunosuppressive activity of G-MDSCs and promote CD8 Conclusion: This study reveals for the first time that TD, a classic TCM prescription, is able to regulate G-MDSC activity and trigger its apoptosis via the IL-1β-mediated NF-κB signalling pathway, reshaping the tumour microenvironment and demonstrating antitumour effects. These findings provide a scientific foundation the clinical treatment of lung cancer with TD.
MeSH term(s)	Mice ; Animals ; Myeloid-Derived Suppressor Cells ; Mice, Nude ; NF-kappa B/metabolism ; Quality of Life ; Mice, Inbred C57BL ; Lung Neoplasms/metabolism ; Immunosuppressive Agents/pharmacology ; Tumor Microenvironment
Chemical Substances	NF-kappa B ; Immunosuppressive Agents
Language	English
Publishing date	2023-04-16
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116491
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Article ; Online: The Tian-Men-Dong decoction suppresses the tumour-infiltrating G-MDSCs via IL-1β-mediated signalling in lung cancer

Su, Lin / Zhang, Fei / Liu, Ming-xi / Li, Hong / Li, Qiang / Zhu, Yang-zhuangzhuang / Hou, Yi-fei / Chen, Xiao / Wang, Xiao-yu / Qian, Chun-mei / Yao, Chao / Wang, Li-xin / Jiao, Xiao-ning / Zhu, Xian-dan / Xu, Zi-hang / Zou, Chun-pu

Journal of Ethnopharmacology. 2023 Apr. 16, p.116491-

2023 , Page(s) 116491–

Abstract: The traditional Chinese medicine (TCM) Tian-Men-Dong decoction (TD) has been able to effectively ...

Abstract	The traditional Chinese medicine (TCM) Tian-Men-Dong decoction (TD) has been able to effectively treat lung cancer in China for thousands of years. TD improves the quality of life in lung cancer patients by promoting nourishment of yin and reducing dryness, clearing the lung and removing toxins. Pharmacological studies show that TD contains active antitumour ingredients, but its underlying mechanism remains unknown. This study aims at exploring potential mechanisms of TD in the treatment of lung cancer by regulating granulocytic-myeloid-derived suppressor cells (G-MDSCs). An orthotopic lung cancer mouse model was generated by intrapulmonary injection with LLC-luciferase cells in immunocompetent C57BL/6 mice or immunodeficient nude mice. TD/saline was orally administered once to the model mice daily for 4 weeks. Live imaging was conducted to monitor tumour growth. Immune profiles were detected by flow cytometry. H&E and ELISA were applied to test the cytotoxicity of the TD treatment. RT–qPCR and western blotting were performed to detect apoptosis-related proteins in G-MDSCs. A neutralizing antibody (anti-Ly6G) was utilized to exhaust the G-MDSCs via intraperitoneal injection. G-MDSCs were adoptively transferred from wild-type tumour-bearing mice. Immunofluorescence, TUNEL and Annexin V/PI staining were conducted to analyse apoptosis-related markers. A coculture assay of purified MDSCs and T cells labelled with CFSE was performed to test the immunosuppressive activity of MDSCs. The presence of TD/IL-1β/TD + IL-1β in purified G-MDSCs cocultured with the LLC system was used for ex vivo experiments to detect IL-1β-mediated apoptosis of G-MDSCs. TD prolonged the survival of immune competent C57BL/6 mice in an orthotopic lung cancer model, but did not have the same effect in immunodeficient nude mice, indicating that its antitumour properties of TD are exerted by regulating immunity. TD induced G-MDSC apoptosis via the IL-1β-mediated NF-κB signalling cascade leading to effectively weaken the immunosuppressive activity of G-MDSCs and promote CD8⁺ T-cell infiltration, which was supported by both the depletion and adoptive transfer of G-MDSCs assays. In addition, TD also showed minimal cytotoxicity both in vivo and in vitro. This study reveals for the first time that TD, a classic TCM prescription, is able to regulate G-MDSC activity and trigger its apoptosis via the IL-1β-mediated NF-κB signalling pathway, reshaping the tumour microenvironment and demonstrating antitumour effects. These findings provide a scientific foundation the clinical treatment of lung cancer with TD.
Keywords	Oriental traditional medicine ; T-lymphocytes ; antibodies ; apoptosis ; coculture ; cytotoxicity ; flow cytometry ; fluorescent antibody technique ; immunosuppression ; intraperitoneal injection ; lung neoplasms ; lungs ; mice ; models ; quality of life ; China ; Traditional Chinese medicine ; Tian-Men-Dong decoction ; G-MDSCs ; CD8+ T cells ; IL-1β
Language	English
Dates of publication	2023-0416
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116491
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Assessment of the anti-rheumatoid arthritis activity of Gastrodia elata (tian-ma) and Radix aconitic lateralis preparata (fu-zi) via network pharmacology and untargeted metabolomics analyses.

Yang, Jie / Zhang, Yu / Li, Wei-Hong / Guo, Bu-Fa / Peng, Qi-Lun / Yao, Wei-Yi / Gong, Di-Hong / Ding, Wei-Jun

International journal of rheumatic diseases

2021 Volume 24, Issue 3, Page(s) 380–390

Abstract: Aim: Gastrodia elata and Radix aconiti lateralis preparrata are respectively named as Tian-Ma and ... with our network pharmacological predictions.: Conclusions: The anti-RA properties of Tian-Ma and Fu-Zi are ...

Abstract	Aim: Gastrodia elata and Radix aconiti lateralis preparrata are respectively named as Tian-Ma and Fu-Zi (TF) in Chinese. We explored the active components against rheumatoid arthritis (RA) from an extensively used couplet of Chinese herbs, Gastrodia elata and Radix aconiti lateralis preparata (TF) via untargeted metabolomics and network pharmacological approaches. Methods: Water extracts of TF were mixed at ratios 1:1, 3:2 and 2:3 (w/w). Ultra-performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) was then utilized as metabolomics screening. Human Metabolome (http://www.hmdb.ca/) and Lipidmaps (http://www.lipidmaps.org/) databases were used to annotate detected compounds. Further identification of vital genes and important pathways associated with the anti-RA properties of the TF preparations was done via network pharmacology, and verified by real-time quantitative polymerase chain reaction (RT-qPCR). Results: Four key compounds involved in unsaturated fatty acid biosynthesis and isoflavonoid biosynthesis were identified through metabolomics analyses. Three key components of TF associated with anti-RA activity were linoleic acid, daidzein, and daidzin. Results of RT-qPCR revealed that all 3 tested TF couplets (1:1, 3:2, and 2:3) markedly suppressed the transcription of PTGS2. These results were consistent with our network pharmacological predictions. Conclusions: The anti-RA properties of Tian-Ma and Fu-Zi are associated with the inhibition of arachidonic acid metabolism pathway.
MeSH term(s)	Aconitum ; Animals ; Arachidonic Acid/antagonists & inhibitors ; Arachidonic Acid/metabolism ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/genetics ; Arthritis, Rheumatoid/metabolism ; Chromatography, Liquid ; Cyclooxygenase 1/biosynthesis ; Cyclooxygenase 1/genetics ; Cyclooxygenase 2/biosynthesis ; Cyclooxygenase 2/genetics ; DNA/genetics ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Gastrodia ; Gene Expression Regulation/drug effects ; Humans ; Male ; Membrane Proteins/biosynthesis ; Membrane Proteins/genetics ; Metabolomics/methods ; Plant Extracts/pharmacology ; Rats ; Rats, Sprague-Dawley ; Tandem Mass Spectrometry
Chemical Substances	Drugs, Chinese Herbal ; Membrane Proteins ; Plant Extracts ; Arachidonic Acid (27YG812J1I) ; DNA (9007-49-2) ; Cyclooxygenase 1 (EC 1.14.99.1) ; Cyclooxygenase 2 (EC 1.14.99.1) ; Ptgs1 protein, rat (EC 1.14.99.1) ; Ptgs2 protein, rat (EC 1.14.99.1)
Language	English
Publishing date	2021-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2426924-4
ISSN	1756-185X ; 1756-1841
ISSN (online)	1756-185X
ISSN	1756-1841
DOI	10.1111/1756-185X.14063
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Book: Tian tang cha yu

Ai, Changwei / Ma, Laijun / Yao, Jin

2010

Author's details	zhu bian Ai Changwei; Ma Laijun; Yao Jin
Language	Chinese
Size	getr. Zählung, Ill.
Edition	Di 1 ban
Publisher	Zhejiang University Presss
Publishing place	Hangzhou
Document type	Book
ISBN	9787308076838 ; 7308076830
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Response to Feng Tian et al.: mTOR mediates the cross-talk of macrophage polarization and autophagy in atherosclerosis.

Guo, Yuan-Yuan / Yao, Min / Wu, Shan

International journal of cardiology

2015 Volume 184, Page(s) 262

MeSH term(s)	Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Humans ; Macrophages/pathology ; TOR Serine-Threonine Kinases/metabolism
Chemical Substances	TOR Serine-Threonine Kinases (EC 2.7.1.1)
Language	English
Publishing date	2015-02-24
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2015.02.057
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Article: Terrace sequence along the Yushanguxi River in the southern piedmont of Tian Shan and its relationship to climate and tectonics in northwestern China

Wu, Chuanyong / Zheng, Wenjun / Zhang, Zhuqi / Jia, Qichao / Yu, Jingxing / Zhang, Huiping / Han, Guihong / Yao, Yuan

Geomorphology. 2018 July 15, v. 313

2018

Abstract: ... climatic changes. This work focuses on the Yushanguxi River in the southern piedmont of Tian Shan, which is ...

Abstract	Controversies persist regarding the formation of terraces under the control of tectonic factors or climatic changes. This work focuses on the Yushanguxi River in the southern piedmont of Tian Shan, which is an intense tectonic uplift area where the terraces are very developed and the river has deeply downcut. Nine main terraces are distinguished (labelled T1 to Th, from youngest to oldest) based on the interpretation of a high-resolution remote sensing image, field investigations and detailed surveying with differential GPS. The results of the determination of 10Be exposure and 14C show abandoned ages of ~2.1 ka for T1, ~4.1 ka for T2, ~4.2 ka for T3, ~8.2 ka for T4, ~18.1 ka for T5, ~18.8 ka for T6, ~102.1 ka for T7, ~100.6 ka for T81, ~113.9 ka for T82, ~144.6 ka for Th1, ~210.7 ka for Th2, and ~284.3 ka for Th3. Since ~18 ka, the incision rate began to increase from ~0.6 mm a−1 to ~12 mm a−1, which is obviously higher than the fault slip rate of ~0.7 mm a−1. We suggest that the rapid downcutting along the Yushanguxi River during the Holocene has mainly been caused by frequent climate fluctuations.
Keywords	carbon ; climate ; climate change ; global positioning systems ; piedmont ; remote sensing ; rivers ; surveys ; tectonics ; terraces ; China
Language	English
Dates of publication	2018-0715
Size	p. 48-57.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	58028-4
ISSN	0169-555X
ISSN	0169-555X
DOI	10.1016/j.geomorph.2018.04.009
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Article ; Online: Comprehensive and Holistic Analysis of HT-29 Colorectal Cancer Cells and Tumor-Bearing Nude Mouse Model: Interactions Among Fractions Derived From the Chinese Medicine Formula Tian Xian Liquid in Effects on Human Colorectal Carcinoma.

Leigh, Annballaw Bridget / Cheung, Ho Pan / Lin, Li-Zhu / Ng, Tzi Bun / Lao, Lixing / Zhang, Yanbo / Zhang, Zhang-Jin / Tong, Yao / Sze, Stephen Cho Wing

Integrative cancer therapies

2017 Volume 16, Issue 3, Page(s) 339–350

Abstract: The Chinese medicine formula Tian Xian Liquid (TXL) has been used clinically for cancer therapy ...

Abstract	The Chinese medicine formula Tian Xian Liquid (TXL) has been used clinically for cancer therapy in China for more than 25 years. However, the comprehensive and holistic effects of its bioactive fractions for various antitumor therapeutic effects have not been unraveled. This is the first study to scientifically elucidate the holistic effect of Chinese medicine formula for treating colon cancer, hence allowing a better understanding of the essence of Chinese medicine formula, through the comparison of the actions of TXL and its functional constituent fractions, including ethyl acetate (EA), butanol (BU), and aqueous (WA) fractions. Tissue-specific proliferative/antiproliferative effects of these fractions on human colorectal carcinoma HT-29 cells and splenocytes were studied by using the MTT assay. Their modulations on the expression of markers of antiproliferation, antimetastasis, reversion of multidrug resistance in treated HT-29 cells were examined with real-time polymerase chain reaction and Western blot analysis, and their modulations in a xenografted nude mouse model were examined by Western blot analysis. Results revealed that EA fraction slightly inhibited the proliferation of HT-29 cells, but tissue-specifically exerted the most potent antiproliferative effect on splenocytes. On the contrary, only TXL and BU fraction tissue-specifically contributed to the proliferation of splenocytes, but inhibited the proliferation of HT-29 cells. WA fraction exerted the most potent antiproliferative effect on HT-29 cells and also the strongest inhibitory action on tumor size in the nude mouse model in our previous study. In the HT-29 model, TXL and WA fraction exerted the most pronounced effect on upregulation of p21 mRNA and protein; TXL, and EA and WA fractions exerted the effect on downregulation of G1 phase cell cycle protein, cyclin D1 mRNA and protein; EA and BU fractions exerted the most prominent anti-invasive effect on anti-invasion via downregulation of MMP-1 mRNA; TXL potently reversed most multidrug resistance via downregulation of MDR-1 protein. In conclusion, the comprehensive and holistic effects of TXL were demonstrated with ( a) mutual accentuation and mutual enhancement, ( b) mutual counteraction and mutual suppression, and ( c) mutual antagonism among the 3 constituent fractions. Moreover, the design of the present study may lead to further development of more tissue-specific effective drugs with minimal side effects for clinical use in combating carcinoma.
Language	English
Publishing date	2017-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2182320-0
ISSN	1552-695X ; 1534-7354
ISSN (online)	1552-695X
ISSN	1534-7354
DOI	10.1177/1534735416651969
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Article: Comparison of glaciological and geodetic mass balance at Urumqi Glacier No. 1, Tian Shan, Central Asia

Wang, Puyu / Hongbing Yao / Huilin Li / Wenbin Wang / Zhongqin Li

Global and Planetary Change. 2014 Mar., v. 114

2014

Abstract: Glaciological and geodetic measurements are two methods to determine glacier mass balances. The mass balance of Urumqi Glacier No. 1 has been measured since 1959 by the glaciological method using ablation stakes and snow pits, except during the period ... ...

Abstract	Glaciological and geodetic measurements are two methods to determine glacier mass balances. The mass balance of Urumqi Glacier No. 1 has been measured since 1959 by the glaciological method using ablation stakes and snow pits, except during the period 1967â1979 when the observations were interrupted. Moreover, topographic surveys have been carried out at various time intervals since the beginning of the glacier observations. Therefore, glacier volume changes are calculated by comparing topographic maps of different periods during nearly 50 years. Between 1962 and 2009, Urumqi Glacier No. 1 lost an ice volume of 29.51Ã106m3, which corresponds to a cumulative ice thickness loss of 8.9m and a mean annual loss of 0.2m. The results are compared with glaciological mass balances over the same time intervals. The differences are 2.3%, 2.8%, 4.6%, 4.7% and 5.9% for the period 1981â1986, 1986â1994, 1994â2001, 2001â2006 and 2006â2009, respectively. For the mass balance measured with the glaciological method, the systematic errors accumulate linearly with time, whereas the errors are random for the geodetic mass balance. The geodetic balance is within the estimated error of the glaciological balance. In conclusion, the geodetic and glaciological mass balances are of high quality, and therefore, there is no need to calibrate the mass balance series of Urumqi Glacier No. 1.
Keywords	geodesy ; glaciers ; ice ; snow ; surveys ; topographic maps ; topography ; Central Asia
Language	English
Dates of publication	2014-03
Size	p. 14-22.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2016967-X
ISSN	0921-8181
ISSN	0921-8181
DOI	10.1016/j.gloplacha.2014.01.001
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Article ; Online: Tian Xian Liquid (TXL) induces apoptosis in HT-29 colon cancer cell in vitro and inhibits tumor growth in vivo.

Liu, Qing / Tong, Yao / Sze, Stephen Cho Wing / Liu, Wing Keung / Lam, Lam / Chu, Ellie Shihng Meir / Yow, Christine Miu Ngan

Chinese medicine

2010 Volume 5, Page(s) 25

Abstract: Background: Tian Xian Liquid (TXL) is a Chinese medicine decoction and has been used ...

Abstract	Background: Tian Xian Liquid (TXL) is a Chinese medicine decoction and has been used as an anticancer dietary supplement. The present study aims to investigate the effects of TXL on the apoptosis of HT-29 cells and tumor growth in vivo. Method: HT-29 colon cancer cells were treated with gradient dilution of TXL. The mitochondrial membrane potential was measured by JC-1 assay. The release of cytochrome c from mitochondrial and apoptosis-related proteins Bax, Bcl-2, cleaved caspase-3, 9 were examined by Western blot analysis. HT-29 cells were implanted in nude mice to examine the effects of TXL on tumor growth. Result: TXL inhibited HT-29 xenografted model and showed a strong and dose-dependent inhibitory effect on the proliferation of HT-29 cells. Mitochondrial membrane potential was reduced by TXL at the concentration of 0.5% above. For Western blot analysis, an increase in Bax expression and a decrease in Bcl-2 expression were observed in TXL-treated cells. TXL treatment increased the protein level of cleaved casepase-3 and caspase-9, and the release of cytochrome c in cytoplasm was up-regulated as well. Conclusion: TXL significantly inhibits cell proliferation in the HT-29 cells and HT-29 xenografted model via the mitochondrial cell death pathway.
Language	English
Publishing date	2010-07-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2260322-0
ISSN	1749-8546 ; 1749-8546
ISSN (online)	1749-8546
ISSN	1749-8546
DOI	10.1186/1749-8546-5-25
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