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  1. Article ; Online: New approach to the use of propolis against dermatomycosis.

    Galinari, Camila B / Conrado, Pollyanna C V / Sakita, Karina M / Arita, Glaucia S / Melo, Raquel C / Capoci, Isis Regina / Dos Santos, Rafaela S / Bruschi, Marcos L / Kioshima, Erika S / Svidzinski, Terezinha I E / Bonfim-Mendonça, Patrícia de S

    Natural product research

    2021  Volume 36, Issue 16, Page(s) 4215–4220

    Abstract: In recent years, propolis extract (PE) has demonstrated antimicrobial and anti-inflammatory properties. The aim of this study was to evaluate the antifungal activity of a bioadhesive thermoresponsive system containing 16% propolis (BTSP 16%) ... ...

    Abstract In recent years, propolis extract (PE) has demonstrated antimicrobial and anti-inflammatory properties. The aim of this study was to evaluate the antifungal activity of a bioadhesive thermoresponsive system containing 16% propolis (BTSP 16%) against
    MeSH term(s) Antifungal Agents/pharmacology ; Biofilms ; Dermatomycoses/drug therapy ; Dermatomycoses/microbiology ; Microbial Sensitivity Tests ; Microsporum ; Propolis/pharmacology ; Trichophyton
    Chemical Substances Antifungal Agents ; Propolis (9009-62-5)
    Language English
    Publishing date 2021-09-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2021.1973457
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A systematic review of photodynamic therapy as an antiviral treatment: Potential guidance for dealing with SARS-CoV-2.

    Conrado, Pollyanna C V / Sakita, Karina M / Arita, Glaucia S / Galinari, Camila B / Gonçalves, Renato S / Lopes, Luciana D G / Lonardoni, Maria V C / Teixeira, Jorge J V / Bonfim-Mendonça, Patrícia S / Kioshima, Erika S

    Photodiagnosis and photodynamic therapy

    2021  Volume 34, Page(s) 102221

    Abstract: Background: SARS-CoV-2, which causes the coronavirus disease (COVID-19), presents high rates of morbidity and mortality around the world. The search to eliminate SARS-CoV-2 is ongoing and urgent. This systematic review seeks to assess whether ... ...

    Abstract Background: SARS-CoV-2, which causes the coronavirus disease (COVID-19), presents high rates of morbidity and mortality around the world. The search to eliminate SARS-CoV-2 is ongoing and urgent. This systematic review seeks to assess whether photodynamic therapy (PDT) could be effective in SARS-CoV-2 inactivation.
    Methods: The focus question was: Can photodynamic therapy be used as potential guidance for dealing with SARS-CoV-2?". A literature search, according to PRISMA statements, was conducted in the electronic databases PubMed, EMBASE, SCOPUS, Web of Science, LILACS, and Google Scholar. Studies published from January 2004 to June 2020 were analyzed. In vitro and in vivo studies were included that evaluated the effect of PDT mediated by several photosensitizers on RNA and DNA enveloped and non-enveloped viruses.
    Results: From 27 selected manuscripts, 26 publications used in vitro studies, 24 were exclusively in vitro, and two had in vitro/in vivo parts. Only one analyzed publication was exclusively in vivo. Meta-analysis studies were unfeasible due to heterogeneity of the data. The risk of bias was analyzed in all studies.
    Conclusion: The in vitro and in vivo studies selected in this systematic review indicated that PDT is capable of photoinactivating enveloped and non-enveloped DNA and RNA viruses, suggesting that PDT can potentially photoinactivate SARS-CoV-2.
    MeSH term(s) Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19 ; Humans ; Photochemotherapy/methods ; Photosensitizing Agents/therapeutic use ; SARS-CoV-2
    Chemical Substances Antiviral Agents ; Photosensitizing Agents
    Language English
    Publishing date 2021-02-15
    Publishing country Netherlands
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 2149918-4
    ISSN 1873-1597 ; 1572-1000
    ISSN (online) 1873-1597
    ISSN 1572-1000
    DOI 10.1016/j.pdpdt.2021.102221
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: New approach to the use of propolis against dermatomycosis

    Galinari, Camila B. / Conrado, Pollyanna C. V. / Sakita, Karina M. / Arita, Glaucia S. / Melo, Raquel C. / Capoci, Isis Regina / dos Santos, Rafaela S. / Bruschi, Marcos L. / Kioshima, Erika S. / Svidzinski, Terezinha I. E. / Bonfim-Mendonça, Patrícia de S.

    Natural Product Research. 2022 July 29, v. 36, no. 16 p.4215-4220

    2022  

    Abstract: In recent years, propolis extract (PE) has demonstrated antimicrobial and anti-inflammatory properties. The aim of this study was to evaluate the antifungal activity of a bioadhesive thermoresponsive system containing 16% propolis (BTSP 16%) against ... ...

    Abstract In recent years, propolis extract (PE) has demonstrated antimicrobial and anti-inflammatory properties. The aim of this study was to evaluate the antifungal activity of a bioadhesive thermoresponsive system containing 16% propolis (BTSP 16%) against Microsporum canis, Nannizzia gypsea, Trichophyton mentagrophytes and T. rubrum. We also evaluated PE alone against the same strains. The results showed that both PE and BTSP 16% significantly reduced the fungal viability of all evaluated strains. In addition, they interacted with the biofilm of these species in different stages of biofilm formation. We observed that the bioadhesive and thermoresponsive properties of BTSP 16% prolonged propolis presence at infection sites, leading to positive results against planktonic fungal cells and mature biofilms. These characteristics make this formulation a valuable alternative treatment for dermatomycosis.
    Keywords Microsporum canis ; Nannizzia ; Trichophyton mentagrophytes ; antifungal properties ; bioadhesives ; biofilm ; dermatomycoses ; fungi ; plankton ; propolis ; research ; viability ; dermatophytes ; biofilms ; therapy ; antifungal
    Language English
    Dates of publication 2022-0729
    Size p. 4215-4220.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2021.1973457
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Hypericin-P123-photodynamic therapy in an ex vivo model as an alternative treatment approach for onychomycosis caused by Fusarium spp.

    Conrado, Pollyanna C V / Sakita, Karina M / Arita, Glaucia S / Gonçalves, Renato S / Cesar, Gabriel B / Caetano, Wilker / Hioka, Noboru / Voidaleski, Morgana F / Vicente, Vania A / Svidzinski, Terezinha I E / Bonfim-Mendonça, Patrícia S / Kioshima, Erika S

    Photodiagnosis and photodynamic therapy

    2021  Volume 35, Page(s) 102414

    Abstract: BackgroundFusarium has been considered an opportunistic pathogen, causing several infections in humans, including onychomycosis. In addition, a high resistance to conventional antifungals has been linked to this genus. Photodynamic Therapy (PDT), known ... ...

    Abstract BackgroundFusarium has been considered an opportunistic pathogen, causing several infections in humans, including onychomycosis. In addition, a high resistance to conventional antifungals has been linked to this genus. Photodynamic Therapy (PDT), known as a non-invasive therapy, can be an alternative treatment for fungal infections, based on the excitation of a photosensitizing compound (PS) by a specific length of light, causing damage to the target. The aim of this study was to evaluate the effects of a formulation of Hypericin (Hyp) encapsulated in Pluronic™ (P123), via photodynamic therapy (PDT), on planktonic cells and biofilms in Fusarium spp. using in vitro and ex vivo assays. Materials & Methods epidemiology studies about Fusarium spp. in onychomycosis was perfomed, carried out molecular identification, compared the antifungal activity of the conventional antifungals with PDT with encapsulated Hypericin (Hyp-P123), carried out detection of reactive oxygen species, and measured the antibiofilm effect of the Hyp-P123-PDT in vitro and in an ex vivo model of onychomycosis. Results Hyp-P123-PDT exhibited a fungicidal effect in vitro with reductions ≥ 3 log
    MeSH term(s) Anthracenes ; Fusarium ; Humans ; Onychomycosis/drug therapy ; Perylene/analogs & derivatives ; Perylene/pharmacology ; Photochemotherapy/methods ; Photosensitizing Agents/pharmacology
    Chemical Substances Anthracenes ; Photosensitizing Agents ; Perylene (5QD5427UN7) ; hypericin (7V2F1075HD)
    Language English
    Publishing date 2021-06-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2149918-4
    ISSN 1873-1597 ; 1572-1000
    ISSN (online) 1873-1597
    ISSN 1572-1000
    DOI 10.1016/j.pdpdt.2021.102414
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Serial systemic candidiasis alters Candida albicans macromorphology associated with enhancement of virulence attributes

    Arita, Glaucia Sayuri / Vincenzi Conrado, Pollyanna Cristina / Sakita, Karina Mayumi / Vilugron Rodrigues-Vendramini, Franciele Abigail / Faria, Daniella Renata / Kioshima, Erika Seki / de Souza Bonfim-Mendonça, Patrícia / Estivalet Svidzinski, Terezinha Inez

    Microbial pathogenesis. 2022 Mar., v. 164

    2022  

    Abstract: ... In our previous study using a murine model of serial systemic candidiasis, virulence of the recovered C. albicans ...

    Abstract Candida albicans is one of the major pathogens found in superficial and invasive infections. This fungus expresses several virulence factors and fitness attributes that are essential to the pathogenesis. In our previous study using a murine model of serial systemic candidiasis, virulence of the recovered C. albicans was enhanced and several virulence factors were also modified after five successive passages through mice (P1–P5). In this study, we aimed to correlate the different fungal morphologies, as well as the filamentation, invasion, and stress resistance abilities, of the cells recovered after passing through this model of infection with our previous findings regarding virulence. We obtained two colony morphology types from the recovered cells, differing in their peripheral filamentation. The morphotype 1, which presented zero to five filaments in the colony edge, was higher in P2, while morphotype 2, which presented more than five filaments in the colony edge, was predominant from P3 to P5. In general, morphotype 1 showed similar levels regarding filamentation in serum, invasion of agar and cells, and resistance to osmotic, oxidative, and thermal stress in all passages analyzed. The morphotype 2, however, exhibited an enhancement in these abilities over the passages. We observed an accordance with the increased virulence over the passages obtained in our previous study and the increased adaptability profile of morphotype 2. Therefore, we suggest that the behavior observed previously in the pathogenesis and virulence could be attributed, at least in part, to the greater presence and ability of morphotype 2.
    Keywords Candida albicans ; agar ; animal models ; blood serum ; candidiasis ; fungi ; morphs ; pathogenesis ; stress tolerance ; thermal stress ; virulence
    Language English
    Dates of publication 2022-03
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 632772-2
    ISSN 1096-1208 ; 0882-4010
    ISSN (online) 1096-1208
    ISSN 0882-4010
    DOI 10.1016/j.micpath.2022.105413
    Database NAL-Catalogue (AGRICOLA)

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