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  1. Article ; Online: Fool's gold? Why blinded trials are not always best.

    Anand, Rohan / Norrie, John / Bradley, Judy M / McAuley, Danny F / Clarke, Mike

    BMJ (Clinical research ed.)

    2020  Volume 368, Page(s) l6228

    MeSH term(s) Clinical Trials as Topic/organization & administration ; Clinical Trials as Topic/standards ; Data Accuracy ; Double-Blind Method ; Humans ; Observer Variation ; Outcome Assessment, Health Care/methods ; Outcome Assessment, Health Care/standards ; Patient Safety ; Randomized Controlled Trials as Topic/methods ; Research Design/standards
    Language English
    Publishing date 2020-01-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.l6228
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  2. Article ; Online: High frequency chest wall oscillation in cystic fibrosis.

    Bradley, Judy M

    Thorax

    2010  Volume 65, Issue 3, Page(s) 189–190

    MeSH term(s) Chest Wall Oscillation/methods ; Cystic Fibrosis/therapy ; Evidence-Based Medicine ; Humans ; Practice Guidelines as Topic
    Language English
    Publishing date 2010-03
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thx.2009.122663
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  3. Article ; Online: Pulmonary hypertension impairs vasomotor function in rat diaphragm arterioles.

    Schulze, Kiana M / Horn, Andrew G / Muller-Delp, Judy M / White, Zachary J / Hall, Stephanie E / Medarev, Steven L / Weber, Ramona E / Poole, David C / Musch, Timothy I / Behnke, Bradley J

    Microvascular research

    2024  , Page(s) 104686

    Abstract: Pulmonary hypertension (PH) is a chronic, progressive condition in which respiratory muscle dysfunction is a primary contributor to exercise intolerance and dyspnea in patients. Contractile function, blood flow distribution, and the hyperemic response ... ...

    Abstract Pulmonary hypertension (PH) is a chronic, progressive condition in which respiratory muscle dysfunction is a primary contributor to exercise intolerance and dyspnea in patients. Contractile function, blood flow distribution, and the hyperemic response are altered in the diaphragm with PH, and we sought to determine whether this may be attributed, in part, to impaired vasoreactivity of the resistance vasculature. We hypothesized that there would be blunted endothelium-dependent vasodilation and impaired myogenic responsiveness in arterioles from the diaphragm of PH rats. Female Sprague-Dawley rats were randomized into healthy control (HC, n = 9) and monocrotaline (MCT, n = 9)-induced PH rats. Endothelium-dependent and -independent vasodilation and myogenic responses were assessed in first-order arterioles (1As) from the medial costal diaphragm in vitro. There was a significant reduction in endothelium-dependent (via acetylcholine; HC, 78 ± 15 % vs. MCT, 47 ± 17 %; P < 0.05) and -independent (via sodium nitroprusside; HC, 89 ± 10 % vs. MCT, 66 ± 10 %; P < 0.05) vasodilation in 1As from MCT rats. MCT-induced PH also diminished myogenic constriction (P < 0.05) but did not alter passive pressure responses. The diaphragmatic weakness, impaired hyperemia, and blood flow redistribution associated with PH may be due, in part, to diaphragm vascular dysfunction and thus compromised oxygen delivery which occurs through both endothelium-dependent and -independent mechanisms.
    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80307-8
    ISSN 1095-9319 ; 0026-2862
    ISSN (online) 1095-9319
    ISSN 0026-2862
    DOI 10.1016/j.mvr.2024.104686
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  4. Article: Airway clearance treatments in bronchiectasis: feasibility of linking survey results to registry data and a survey of patients' and physiotherapists' practices.

    McLeese, Rebecca H / O'Neill, Katherine / O'Neill, Brenda / Chalmers, James D / Boyd, Jeanette / De Soyza, Anthony / McChrystal, Ryan / Crichton, Megan L / Bradley, Judy M

    ERJ open research

    2023  Volume 9, Issue 2

    Abstract: Background and objective: There are limited data on airway clearance treatment (ACT) practices. This study aimed to: 1) assess the feasibility of collecting online surveys on ACTs from patients and physiotherapists and linking the patient survey data to ...

    Abstract Background and objective: There are limited data on airway clearance treatment (ACT) practices. This study aimed to: 1) assess the feasibility of collecting online surveys on ACTs from patients and physiotherapists and linking the patient survey data to outcome data in the Bronch-UK/EMBARC Registry; 2) assess the association between ACT practices and outcome data; and 3) ascertain the factors affecting physiotherapist ACT practices.
    Methods: Survey methodology was used to collect data from patients with bronchiectasis and physiotherapists in Northern Ireland. Associations between patient survey data and linked Bronch-UK/EMBARC Registry patient outcome data were explored.
    Results: It was feasible to conduct an online survey with patients with bronchiectasis and link the data to the Bronch-UK/EMBARC Registry. 13% of patients did not perform ACTs. ACTs were used more often by patients who were symptomatic/had more severe disease compared to those with milder symptoms/disease. Patients used ACTs when they were symptomatic rather than as a preventative management strategy. Physiotherapists generally followed the bronchiectasis guidelines, using the stepwise approach to management.
    Conclusion: Our survey provided information about the feasibility of linking online survey and patient registry data. This study provides up-to-date information on ACT practice throughout the course of the disease trajectory as well as insight into the implementation of bronchiectasis guidelines by physiotherapists. Future work should explore how to optimise ACT data collection to maximise the use of real-world ACT data in bronchiectasis research and inform priority ACT research questions.
    Language English
    Publishing date 2023-03-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00540-2022
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  5. Article ; Online: Response.

    O'Neill, Katherine / Elborn, J Stuart / Tunney, Michael M / Bradley, Judy M

    Chest

    2016  Volume 150, Issue 6, Page(s) 1413–1414

    Language English
    Publishing date 2016
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2016.09.037
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  6. Article ; Online: Airway clearance treatments in bronchiectasis

    Rebecca H. McLeese / Katherine O'Neill / Brenda O'Neill / James D. Chalmers / Jeanette Boyd / Anthony De Soyza / Ryan McChrystal / Megan L. Crichton / Judy M. Bradley

    ERJ Open Research, Vol 9, Iss

    feasibility of linking survey results to registry data and a survey of patients’ and physiotherapists’ practices

    2023  Volume 2

    Abstract: Background and objective There are limited data on airway clearance treatment (ACT) practices. This study aimed to: 1) assess the feasibility of collecting online surveys on ACTs from patients and physiotherapists and linking the patient survey data to ... ...

    Abstract Background and objective There are limited data on airway clearance treatment (ACT) practices. This study aimed to: 1) assess the feasibility of collecting online surveys on ACTs from patients and physiotherapists and linking the patient survey data to outcome data in the Bronch-UK/EMBARC Registry; 2) assess the association between ACT practices and outcome data; and 3) ascertain the factors affecting physiotherapist ACT practices. Methods Survey methodology was used to collect data from patients with bronchiectasis and physiotherapists in Northern Ireland. Associations between patient survey data and linked Bronch-UK/EMBARC Registry patient outcome data were explored. Results It was feasible to conduct an online survey with patients with bronchiectasis and link the data to the Bronch-UK/EMBARC Registry. 13% of patients did not perform ACTs. ACTs were used more often by patients who were symptomatic/had more severe disease compared to those with milder symptoms/disease. Patients used ACTs when they were symptomatic rather than as a preventative management strategy. Physiotherapists generally followed the bronchiectasis guidelines, using the stepwise approach to management. Conclusion Our survey provided information about the feasibility of linking online survey and patient registry data. This study provides up-to-date information on ACT practice throughout the course of the disease trajectory as well as insight into the implementation of bronchiectasis guidelines by physiotherapists. Future work should explore how to optimise ACT data collection to maximise the use of real-world ACT data in bronchiectasis research and inform priority ACT research questions.
    Keywords Medicine ; R
    Subject code 310
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher European Respiratory Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Airway clearance, mucoactive therapies and pulmonary rehabilitation in bronchiectasis.

    O'Neill, Katherine / O'Donnell, Anne E / Bradley, Judy M

    Respirology (Carlton, Vic.)

    2019  Volume 24, Issue 3, Page(s) 227–237

    Abstract: This paper aims to provide physiological rationale for airway clearance, mucoactive therapy and pulmonary rehabilitation (PR) (or exercise interventions) in bronchiectasis. There is increasing emphasis on the role of airway clearance techniques (ACT) in ... ...

    Abstract This paper aims to provide physiological rationale for airway clearance, mucoactive therapy and pulmonary rehabilitation (PR) (or exercise interventions) in bronchiectasis. There is increasing emphasis on the role of airway clearance techniques (ACT) in the management of bronchiectasis. No single ACT has currently shown superior effect over another. Given the large range of different techniques available, consideration of the physiological effects underpinning a technique including expiratory flow, ventilation and oscillation, is essential to effectively personalize ACT. Key clinical trials of mucoactives in bronchiectasis are underway and will provide clarity on the role of these agents in the management of patients with bronchiectasis. Prescription of mucoactive therapies should be done in conjunction with ACT and therefore the mechanism of action of mucoactive drugs and their timing with ACT should be taken into consideration. PR and/or exercise training are recommended in all current bronchiectasis guidelines. There is a clear physiological rationale that muscle weakness and physical inactivity may play a role in disease progression as well as impacting health-related quality of life, frequency of pulmonary exacerbations and ability to mobilize sputum. However, there are residual unanswered questions surrounding the delivery and accessibility to PR. This review summarizes the physiological principles and supporting evidence for airway clearance, mucoactive medication and PR, which are key components in the management of bronchiectasis.
    MeSH term(s) Breathing Exercises ; Bronchiectasis/physiopathology ; Bronchiectasis/rehabilitation ; Bronchiectasis/therapy ; Disease Progression ; Exercise Therapy ; Expectorants/therapeutic use ; Humans ; Mucociliary Clearance ; Quality of Life ; Respiratory Therapy/methods ; Sputum
    Chemical Substances Expectorants
    Language English
    Publishing date 2019-01-16
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.13459
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    Zs.A 4957: Show issues Location:
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  8. Article: The Relationship between Maternal Antibodies to Fetal Brain and Prenatal Stress Exposure in Autism Spectrum Disorder.

    Costa, Amy N / Ferguson, Bradley J / Hawkins, Emily / Coman, Adriana / Schauer, Joseph / Ramirez-Celis, Alex / Hecht, Patrick M / Bruce, Danielle / Tilley, Michael / Talebizadeh, Zohreh / Van de Water, Judy / Beversdorf, David Q

    Metabolites

    2023  Volume 13, Issue 5

    Abstract: Environmental and genetic factors contribute to the etiology of autism spectrum disorder (ASD), but their interaction is less well understood. Mothers that are genetically more stress-susceptible have been found to be at increased risk of having a child ... ...

    Abstract Environmental and genetic factors contribute to the etiology of autism spectrum disorder (ASD), but their interaction is less well understood. Mothers that are genetically more stress-susceptible have been found to be at increased risk of having a child with ASD after exposure to stress during pregnancy. Additionally, the presence of maternal antibodies for the fetal brain is associated with a diagnosis of ASD in children. However, the relationship between prenatal stress exposure and maternal antibodies in the mothers of children diagnosed with ASD has not yet been addressed. This exploratory study examined the association of maternal antibody response with prenatal stress and a diagnosis of ASD in children. Blood samples from 53 mothers with at least one child diagnosed with ASD were examined by ELISA. Maternal antibody presence, perceived stress levels during pregnancy (high or low), and maternal 5-HTTLPR polymorphisms were examined for their interrelationship in ASD. While high incidences of prenatal stress and maternal antibodies were found in the sample, they were not associated with each other (
    Language English
    Publishing date 2023-05-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo13050663
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  9. Article ; Online: Multiple-Breath Washout Outcome Measures in Adults with Bronchiectasis.

    O'Neill, Katherine / Lakshmipathy, Gokul R / Neely, Curtis / Cosgrove, Denise / Ferguson, Kathryn / McLeese, Rebecca / Hill, Adam T / Loebinger, Michael R / Carroll, Mary / Chalmers, James D / Gatheral, Timothy / Johnson, Chris / De Soyza, Anthony / Hurst, John R / Bradbury, Ian / Elborn, Joseph S / Bradley, Judy M

    Annals of the American Thoracic Society

    2022  Volume 19, Issue 9, Page(s) 1489–1497

    Abstract: Rationale: ...

    Abstract Rationale:
    MeSH term(s) Adult ; Bronchiectasis/diagnostic imaging ; Cross-Sectional Studies ; Forced Expiratory Volume ; Humans ; Lung/diagnostic imaging ; Outcome Assessment, Health Care ; Respiratory Function Tests
    Language English
    Publishing date 2022-04-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202006-584OC
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  10. Article ; Online: Clinimetric Properties of Outcome Measures in Bronchiectasis.

    Bradley, Judy M / Ferguson, Kathryn / Bailey, Andrew / O'Neill, Katherine / McLeese, Rebecca H / Hill, Adam T / Loebinger, Michael R / Carroll, Mary / Chalmers, James D / Gatheral, Timothy / Johnson, Christopher / De Soyza, Anthony / Hurst, John R / Downey, Damian G / Elborn, J Stuart

    Annals of the American Thoracic Society

    2022  Volume 20, Issue 5, Page(s) 648–659

    Abstract: Rationale: ...

    Abstract Rationale:
    MeSH term(s) Adult ; Humans ; Female ; Aged ; Male ; Quality of Life ; Cohort Studies ; Reproducibility of Results ; Bronchiectasis ; Outcome Assessment, Health Care
    Language English
    Publishing date 2022-10-14
    Publishing country United States
    Document type Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202206-493OC
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