LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 159

Search options

  1. Article ; Online: Pulmonary arterial compliance: a physiological variable still searching for clinical relevance?

    Kearney, Katherine / Lau, Edmund M

    Heart (British Cardiac Society)

    2023  Volume 109, Issue 14, Page(s) 1052–1053

    MeSH term(s) Humans ; Hypertension, Pulmonary ; Clinical Relevance ; Pulmonary Artery
    Language English
    Publishing date 2023-06-26
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2022-322222
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Planning Ahead: Can Diagnosing Congenital Heart Disease Earlier Improve Outcomes?

    Youssef, David / Kearney, Katherine

    Circulation. Cardiovascular quality and outcomes

    2023  Volume 16, Issue 9, Page(s) e010263

    MeSH term(s) Pregnancy ; Female ; Humans ; Prenatal Diagnosis ; Heart Defects, Congenital/diagnosis ; Heart Defects, Congenital/therapy
    Language English
    Publishing date 2023-08-04
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2483197-9
    ISSN 1941-7705 ; 1941-7713
    ISSN (online) 1941-7705
    ISSN 1941-7713
    DOI 10.1161/CIRCOUTCOMES.123.010263
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Inherited Thrombophilia in Chinese CTEPH Patients: A Rather Common Finding in an Uncommon Condition.

    Kearney, Katherine / Lau, Edmund M

    JACC. Asia

    2022  Volume 2, Issue 3, Page(s) 256–257

    Language English
    Publishing date 2022-05-17
    Publishing country United States
    Document type Editorial
    ISSN 2772-3747
    ISSN (online) 2772-3747
    DOI 10.1016/j.jacasi.2022.03.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Editorial for "Non-Contrast Cardiac MRI Predictors of Heart Failure Hospitalization in Heart Failure With Preserved Ejection Fraction".

    Hungerford, Sara L / Kearney, Katherine / Bart, Nicole K

    Journal of magnetic resonance imaging : JMRI

    2021  Volume 55, Issue 6, Page(s) 1826–1827

    MeSH term(s) Heart Failure/diagnostic imaging ; Hospitalization ; Humans ; Magnetic Resonance Imaging ; Prognosis ; Stroke Volume ; Ventricular Function, Left
    Language English
    Publishing date 2021-09-22
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1146614-5
    ISSN 1522-2586 ; 1053-1807
    ISSN (online) 1522-2586
    ISSN 1053-1807
    DOI 10.1002/jmri.27933
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Plasma Kallikrein as a Forgotten Clotting Factor.

    Kearney, Katherine J / Spronk, Henri M H / Emsley, Jonas / Key, Nigel S / Philippou, Helen

    Seminars in thrombosis and hemostasis

    2023  

    Abstract: For decades, it was considered that plasma kallikrein's (PKa) sole function within the coagulation cascade is the activation of factor (F)XII. Until recently, the two key known activators of FIX within the coagulation cascade were activated FXI(a) and ... ...

    Abstract For decades, it was considered that plasma kallikrein's (PKa) sole function within the coagulation cascade is the activation of factor (F)XII. Until recently, the two key known activators of FIX within the coagulation cascade were activated FXI(a) and the tissue factor-FVII(a) complex. Simultaneously, and using independent experimental approaches, three groups identified a new branch of the coagulation cascade, whereby PKa can directly activate FIX. These key studies identified that (1) FIX or FIXa can bind with high affinity to either prekallikrein (PK) or PKa; (2) in human plasma, PKa can dose dependently trigger thrombin generation and clot formation independent of FXI; (3) in FXI knockout murine models treated with intrinsic pathway agonists, PKa activity results in increased formation of FIXa:AT complexes, indicating direct activation of FIX by PKa
    Language English
    Publishing date 2023-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-0043-57034
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Is There an Association Between Lateralization of Chronic Pain in the Body and Depression?

    Edwards, Karlyn A / Lii, Theresa / Schouten, Troy D / Kearney, Katherine M / Ziadni, Maisa S / Darnall, Beth D / Mackey, Sean C / Gilam, Gadi

    The journal of pain

    2024  

    Abstract: Depression commonly co-occurs with chronic pain and can worsen pain outcomes. Recent theoretical work has hypothesized that pain localized to the left hemibody is a risk factor for worse depression due to overlap in underlying neural substrates. This ... ...

    Abstract Depression commonly co-occurs with chronic pain and can worsen pain outcomes. Recent theoretical work has hypothesized that pain localized to the left hemibody is a risk factor for worse depression due to overlap in underlying neural substrates. This hypothesis has not been tested a priori. Using a large sample of treatment-seeking adults with mixed-etiology chronic pain (N = 1,185), our cross-sectional study tested whether patients with left-sided pain endorse worse depressive symptoms. We also examined differences in other pain-related functioning measures. We tested 4 comparisons based on painful body areas using the CHOIR body map: 1) only left-sided (OL) versus any right-sided pain; 2) only right-sided (OR) versus any left-sided pain; 3) OL versus OR versus bilateral pain; and 4) more left-sided versus more right-sided versus equal-sided pain. Analysis of variance models showed OL pain was not associated with worse depression (F = 5.50, P = .019). Any left-sided pain was associated with worse depression, though the effect was small (F = 8.58, P = .003, Cohens d = .29). Bilateral pain was associated with worse depression (F = 8.05, P < .001, Cohens d = .24-.33). Regardless of pain location, more body areas endorsed was associated with greater depression. Although a more rigorous assessment of pain laterality is needed, our findings do not support the hypothesis that left-lateralized pain is associated with worse depression. PERSPECTIVE: Pain lateralized to the left side of the body has been hypothesized as a risk factor for worse depression in chronic pain, despite never being tested in a large, real-world sample of patients with chronic pain. Findings showed that more widespread pain, not pain laterality, was associated with worse depression.
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2018789-0
    ISSN 1528-8447 ; 1526-5900
    ISSN (online) 1528-8447
    ISSN 1526-5900
    DOI 10.1016/j.jpain.2024.02.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Nicotinamide Adenine Dinucleotide Phosphate Oxidases in Glucose Homeostasis and Diabetes-Related Endothelial Cell Dysfunction.

    Brown, Oliver Ian / Bridge, Katherine Isabella / Kearney, Mark Thomas

    Cells

    2021  Volume 10, Issue 9

    Abstract: Oxidative stress within the vascular endothelium, due to excess generation of reactive oxygen species (ROS), is thought to be fundamental to the initiation and progression of the cardiovascular complications of type 2 diabetes mellitus. The term ROS ... ...

    Abstract Oxidative stress within the vascular endothelium, due to excess generation of reactive oxygen species (ROS), is thought to be fundamental to the initiation and progression of the cardiovascular complications of type 2 diabetes mellitus. The term ROS encompasses a variety of chemical species including superoxide anion (O
    MeSH term(s) Animals ; Biomarkers/blood ; Blood Glucose/metabolism ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/enzymology ; Diabetes Mellitus, Type 2/pathology ; Diabetic Angiopathies/blood ; Diabetic Angiopathies/enzymology ; Diabetic Angiopathies/pathology ; Endothelial Cells/enzymology ; Endothelial Cells/pathology ; Homeostasis ; Humans ; Isoenzymes ; NADPH Oxidases/metabolism ; Oxidative Stress ; Reactive Oxygen Species/metabolism ; Signal Transduction
    Chemical Substances Biomarkers ; Blood Glucose ; Isoenzymes ; Reactive Oxygen Species ; NADPH Oxidases (EC 1.6.3.-)
    Language English
    Publishing date 2021-09-04
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10092315
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Pulmonary Vascular Disease as a Systemic and Multisystem Disease.

    Kearney, Katherine / Kotlyar, Eugene / Lau, Edmund M T

    Clinics in chest medicine

    2021  Volume 42, Issue 1, Page(s) 167–177

    Abstract: Pulmonary arterial hypertension (PAH) is a disease of progressive pulmonary vascular remodeling due to abnormal proliferation of pulmonary vascular endothelial and smooth muscle cells and endothelial dysfunction. PAH is a multisystem disease with ... ...

    Abstract Pulmonary arterial hypertension (PAH) is a disease of progressive pulmonary vascular remodeling due to abnormal proliferation of pulmonary vascular endothelial and smooth muscle cells and endothelial dysfunction. PAH is a multisystem disease with systemic manifestations and complications. This article covers the chronic heart failure syndrome, including the systemic consequences of right ventricle-pulmonary artery uncoupling and neurohormonal activation, skeletal and respiratory muscle effects, systemic endothelial dysfunction and coronary artery disease, systemic inflammation and infection, endocrine and metabolic changes, the liver and gut axis, sleep, neurologic complications, and skin and iron metabolic changes.
    MeSH term(s) Heart Failure/physiopathology ; Heart Ventricles/physiopathology ; Humans ; Hypertension, Pulmonary/complications ; Hypertension, Pulmonary/etiology ; Hypertension, Pulmonary/pathology ; Hypertension, Pulmonary/physiopathology ; Pulmonary Artery/physiopathology
    Language English
    Publishing date 2021-01-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 447455-7
    ISSN 1557-8216 ; 0272-5231
    ISSN (online) 1557-8216
    ISSN 0272-5231
    DOI 10.1016/j.ccm.2020.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Management of Maternal Complex Congenital Heart Disease During Pregnancy.

    Kearney, Katherine / Zentner, Dominica / Cordina, Rachael

    Current heart failure reports

    2021  Volume 18, Issue 6, Page(s) 353–361

    Abstract: Purpose of the review: The purpose of this review is to discuss the risk stratification and management of pregnancy in women with complex congenital heart disease.: Recent findings: Classifying congenital heart defects (CHD) including both anatomy ... ...

    Abstract Purpose of the review: The purpose of this review is to discuss the risk stratification and management of pregnancy in women with complex congenital heart disease.
    Recent findings: Classifying congenital heart defects (CHD) including both anatomy and physiology is important for maternal risk stratification. Although most women with CHD can tolerate the physiological challenge of pregnancy, some may experience serious risks both to their health and that of their foetus. The WHO maternal risk classification model remains the best-validated risk measure. Ideally, women with CHD should have pre-conception assessment with a CHD cardiologist. General principles of management, such as need for expert centre delivery, a multidisciplinary team, epidural and mode of delivery are based on WHO risk in combination with expert assessment of status. CHD is increasingly prevalent in women of child-bearing age. Assessment by an adult CHD cardiologist, ideally pre-conception, is key in assessing and minimising risk to mother and foetus.
    MeSH term(s) Adult ; Female ; Heart Defects, Congenital/epidemiology ; Heart Defects, Congenital/therapy ; Heart Failure ; Humans ; Pregnancy ; Pregnancy Complications, Cardiovascular/epidemiology ; Pregnancy Complications, Cardiovascular/therapy ; Risk Factors
    Language English
    Publishing date 2021-11-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2151202-4
    ISSN 1546-9549 ; 1546-9530
    ISSN (online) 1546-9549
    ISSN 1546-9530
    DOI 10.1007/s11897-021-00534-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Legally involved individuals in state hospitals and community mental health settings: Introduction to the special section.

    Snyder, Jennifer A / Davenport, Katherine M / Kearney, Lisa K / Carr, Erika R

    Psychological services

    2022  Volume 19, Issue 2, Page(s) 201–205

    Abstract: Over the past several years, individuals with serious mental illness (SMI) have become involved with the legal system at an increasing rate. State psychiatric hospitals and community mental health programs have seen a high number of referrals and ... ...

    Abstract Over the past several years, individuals with serious mental illness (SMI) have become involved with the legal system at an increasing rate. State psychiatric hospitals and community mental health programs have seen a high number of referrals and admissions at a time when resources and staffing have been challenges. Individuals with SMI continue to be highly represented among those incarcerated in jails and prisons, often for minor charges. This article serves as an introduction to a special section of Psychological Services on innovations in assessment and treatment of legally involved patients in state hospitals and community mental health settings. Data are presented on the prevalence of legal involvement among individuals with serious mental illness, including the exponential growth in individuals evaluated and found incompetent to stand trial. A brief summary of the articles in the special section is presented, broken down by themes of assessment, treatment, and policy. We hope that the studies described in this issue will lead to further exploration of problems, barriers, and potential solutions for individuals with SMI who become involved with the legal system. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
    MeSH term(s) Hospitals, Psychiatric ; Hospitals, State ; Humans ; Mental Disorders/psychology ; Mental Health ; Prisons
    Language English
    Publishing date 2022-03-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2156662-8
    ISSN 1939-148X ; 1541-1559
    ISSN (online) 1939-148X
    ISSN 1541-1559
    DOI 10.1037/ser0000671
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top