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Article ; Online: Is oxytocin receptor signaling really dispensable for social attachment?

Danoff, Joshua S / Whelan, Emma A / Connelly, Jessica J

Comprehensive psychoneuroendocrinology

2023 Volume 14, Page(s) 100178

Language	English
Publishing date	2023-02-21
Publishing country	England
Document type	Journal Article
ISSN	2666-4976
ISSN (online)	2666-4976
DOI	10.1016/j.cpnec.2023.100178
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Co-creation of health-enabling initiatives in food retail: academic perspectives.

Vargas, Carmen / Brimblecombe, Julie / Allender, Steven / Whelan, Jillian

BMC public health

2023 Volume 23, Issue 1, Page(s) 953

Abstract: Introduction: Co-creation of healthy food retail comprises the systematic collaboration between retailers, academics and other stakeholders to improve the healthiness of food retail environments. Research into the co-creation of healthy food retail is ... ...

Abstract	Introduction: Co-creation of healthy food retail comprises the systematic collaboration between retailers, academics and other stakeholders to improve the healthiness of food retail environments. Research into the co-creation of healthy food retail is in its early stages. Knowledge of the roles and motivations of stakeholders in intervention design, implementation and evaluation can inform successful co-creation initiatives. This study presents academic experiences of stakeholder roles and motivations in the co-creation of healthy food retail environments. Methods: Purposive sampling of academics with research experience in the co-creation of healthy food retail initiatives. Semi-structured interviews conducted between October and December 2021 gathered participants' experiences of multi-stakeholder collaborative research. Thematic analysis identified enablers, barriers, motivations, lessons and considerations for future co-creation of healthy food retail. Results: Nine interviewees provided diverse views and applications of co-creation research in food retail environments. Ten themes were grouped into three overarching areas: (i) identification of stakeholders required for changes to healthier food retail; (ii) motivations and interactions, which included the intrinsic desire to build healthier communities along with recognition of their work; and (iii) barriers and enablers included adequate resourcing, effective and trusting working relationships and open communications. Conclusion: This study provides insights that could help future co-creation in healthy food retail environments. Trusting and respectful relationships and reciprocal acknowledgement between stakeholders are key practices in the co-creation process. These constructs should be considered in developing and testing a model that helps to systematically co-create healthy food retail initiatives that ensure all parties meet their needs while also delivering research outcomes.
MeSH term(s)	Humans ; Food ; Marketing ; Food Supply ; Health Status ; Motivation
Language	English
Publishing date	2023-05-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-023-15771-z
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Article ; Online: Omitting Radiotherapy in Luminal A Breast Cancer. Reply.

Whelan, Timothy J / Parpia, Sameer / Levine, Mark N

The New England journal of medicine

2023 Volume 389, Issue 18, Page(s) 1727–1728

MeSH term(s)	Humans ; Female ; Breast Neoplasms/radiotherapy ; Breast Neoplasms/surgery ; Mastectomy, Segmental ; Radiotherapy, Adjuvant ; Receptor, ErbB-2
Chemical Substances	Receptor, ErbB-2 (EC 2.7.10.1)
Language	English
Publishing date	2023-10-31
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc2310656
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Article ; Online: Commercial vaccine provides cross-protection by reducing colonization of Salmonella enterica serovars Infantis and Hadar in turkeys.

Bearson, Shawn M D / Monson, Melissa S / Bearson, Bradley L / Whelan, Samuel J / Byrd, James A / Burciaga, Selma

Vaccine

2024 Volume 42, Issue 4, Page(s) 727–731

Abstract: ... serovars in turkeys. The live, attenuated S. Typhimurium (serogroup B) vaccine significantly reduced ... and significantly limited systemic dissemination to the spleen. S. Infantis, but not S. Hadar ... disseminated to bone marrow in non-vaccinated turkeys, but vaccination prevented S. Infantis dissemination ...

Abstract	Human foodborne outbreaks with antibiotic-resistant Salmonella enterica associated with contaminated poultry products have recently involved serogroup C serovars Infantis and Hadar. The current study evaluated a commercially available Salmonella vaccine for cross-protection against Infantis and Hadar serovars in turkeys. The live, attenuated S. Typhimurium (serogroup B) vaccine significantly reduced colonization of intestinal tissues (cecum, cecal tonsils, and cloaca) by serovars Infantis (C1) and Hadar (C2) and significantly limited systemic dissemination to the spleen. S. Infantis, but not S. Hadar, disseminated to bone marrow in non-vaccinated turkeys, but vaccination prevented S. Infantis dissemination to the bone marrow. The S. Infantis challenge strain contained the pESI megaplasmid, and virulence mechanism(s) residing on this plasmid may support dissemination and/or colonization of systemic niches such as myeloid tissue. Collectively, the data indicate that vaccinating turkeys with the serogroup B S. Typhimurium vaccine limited intestinal colonization and systemic dissemination by serogroup C serovars Infantis and Hadar.
MeSH term(s)	Animals ; Salmonella enterica ; Salmonella Infections, Animal/prevention & control ; Serogroup ; Turkeys ; Vaccines
Chemical Substances	Vaccines
Language	English
Publishing date	2024-01-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2023.12.054
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Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 458: Show issues

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Article ; Online: Role of paraoxonase 3 in regulating ENaC-mediated Na

Mutchler, Stephanie M / Whelan, Sarah Christine M / Marciszyn, Allison / Chen, Jingxin / Kleyman, Thomas R / Shi, Shujie

The Journal of physiology

2024 Volume 602, Issue 4, Page(s) 737–757

Abstract: Paraoxonase 3 (PON3) is expressed in the aldosterone-sensitive distal nephron, where filtered ... ...

Abstract	Paraoxonase 3 (PON3) is expressed in the aldosterone-sensitive distal nephron, where filtered Na
MeSH term(s)	Mice ; Animals ; Amiloride/pharmacology ; Aryldialkylphosphatase/metabolism ; Epithelial Sodium Channels/metabolism ; Aldosterone/metabolism ; Sodium Chloride/metabolism ; Sodium/metabolism ; Nephrons/metabolism ; Symporters
Chemical Substances	Amiloride (7DZO8EB0Z3) ; Aryldialkylphosphatase (EC 3.1.8.1) ; Epithelial Sodium Channels ; Aldosterone (4964P6T9RB) ; Sodium Chloride (451W47IQ8X) ; Sodium (9NEZ333N27) ; Symporters
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Journal Article
ZDB-ID	3115-x
ISSN	1469-7793 ; 0022-3751
ISSN (online)	1469-7793
ISSN	0022-3751
DOI	10.1113/JP285034
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Article ; Online: Field Epidemiology: Fit for the future.

Hahné, Susan / Hammer, Charlotte / Tostmann, Alma / Whelan, Jane / Williams, Christopher

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

2023 Volume 28, Issue 36

Abstract: In recent years, field epidemiologists have embraced rapidly evolving digital tools, data sources and technologies, and collaborated with an ever-growing field of scientific specialisms. The COVID-19 pandemic put field epidemiology under unprecedented ... ...

Abstract	In recent years, field epidemiologists have embraced rapidly evolving digital tools, data sources and technologies, and collaborated with an ever-growing field of scientific specialisms. The COVID-19 pandemic put field epidemiology under unprecedented demand and scrutiny. As the COVID-19 emergency recedes, it is timely to reflect on the core values of our profession and the unique challenges and opportunities that lie ahead. In November 2022, alumni of the European Programme for Intervention Epidemiology Training (EPIET) and the European Public Health Microbiology (EUPHEM) training programme celebrated 25 years of EPIET, and the present and future of field epidemiology was discussed. The output was recorded and qualitatively analysed. This Perspective reflects the authors' interpretation of the discussion. We should reaffirm our commitment to field epidemiology's core strengths: competence and rigour in epidemiology, surveillance, outbreak investigation and applied research, leading to timely and actionable evidence for public health. Our future success will be defined by an ability to adapt, collaborate, harness innovation, communicate and, ultimately, by our tangible impact on protecting and improving health.
MeSH term(s)	Humans ; COVID-19/epidemiology ; Pandemics/prevention & control ; Disease Outbreaks/prevention & control ; Public Health ; Records
Language	English
Publishing date	2023-09-26
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	1338803-4
ISSN	1560-7917 ; 1025-496X
ISSN (online)	1560-7917
ISSN	1025-496X
DOI	10.2807/1560-7917.ES.2023.28.36.2300347
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Zs.A 5066: Show issues

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Article ; Online: Co-creation, co-design, co-production for public health - a perspective on definition and distinctions.

Vargas, Carmen / Whelan, Jill / Brimblecombe, Julie / Allender, Steven

Public health research & practice

2022 Volume 32, Issue 2

Abstract: Collaboration between community members, researchers, and policy makers drives efforts to solve complex health problems such as obesity, alcohol misuse, and type 2 diabetes. Community participation is essential to ensure the optimal design, ... ...

Abstract	Collaboration between community members, researchers, and policy makers drives efforts to solve complex health problems such as obesity, alcohol misuse, and type 2 diabetes. Community participation is essential to ensure the optimal design, implementation and evaluation of resulting initiatives. The terms 'co-creation', 'co-design' and 'co-production' have been used interchangeably to describe the development of initiatives involving multiple stakeholders. While commonalities exist across these concepts, they have essential distinctions for public health, particularly related to the role of stakeholders and the extent and timing of their engagement. We summarise these similarities and differences drawing from the cross-disciplinary literature, including public administration and governance, service management, design, marketing and public health. Co-creation is an overarching guiding principle encompassing co-design and co-production. A clear definition of these terms clarifies aspects of participatory action research for community-based public health initiatives.
MeSH term(s)	Community Participation ; Diabetes Mellitus, Type 2 ; Health Services Research ; Humans ; Public Health ; Research Personnel
Language	English
Publishing date	2022-06-15
Publishing country	Australia
Document type	Journal Article
ISSN	2204-2091
ISSN (online)	2204-2091
DOI	10.17061/phrp3222211
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Article: Modulating the Blood-Brain Barrier: A Comprehensive Review.

Whelan, Rory / Hargaden, Grainne C / Knox, Andrew J S

Pharmaceutics

2021 Volume 13, Issue 11

Abstract: The highly secure blood-brain barrier (BBB) restricts drug access to the brain, limiting the molecular toolkit for treating central nervous system (CNS) diseases to small, lipophilic drugs. Development of a safe and effective BBB modulator would ... ...

Abstract	The highly secure blood-brain barrier (BBB) restricts drug access to the brain, limiting the molecular toolkit for treating central nervous system (CNS) diseases to small, lipophilic drugs. Development of a safe and effective BBB modulator would revolutionise the treatment of CNS diseases and future drug development in the area. Naturally, the field has garnered a great deal of attention, leading to a vast and diverse range of BBB modulators. In this review, we summarise and compare the various classes of BBB modulators developed over the last five decades-their recent advancements, advantages and disadvantages, while providing some insight into their future as BBB modulators.
Language	English
Publishing date	2021-11-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics13111980
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Article: Optimal adjuvant therapy in older (≥70 years of age) women with low-risk early-stage breast cancer.

Chadha, M / White, J / Swain, S M / Rakovitch, E / Jagsi, R / Whelan, T / Sparano, J A

NPJ breast cancer

2023 Volume 9, Issue 1, Page(s) 99

Abstract: Older women are under-represented in breast cancer (BC) clinical trials, and treatment guidelines are primarily based on BC studies in younger women. Studies uniformly report an increased incidence of local relapse with omission of breast radiation ... ...

Abstract	Older women are under-represented in breast cancer (BC) clinical trials, and treatment guidelines are primarily based on BC studies in younger women. Studies uniformly report an increased incidence of local relapse with omission of breast radiation therapy. Review of the available literature suggests very low rates of distant relapse in women ≥70 years of age. The incremental benefit of endocrine therapy in decreasing rate of distant relapse and improving disease-free survival in older patients with low-risk BC remains unclear. Integration of molecular genomic assays in diagnosis and treatment of estrogen receptor positive BC presents an opportunity for optimizing risk-tailored adjuvant therapies in ways that may permit treatment de-escalation among older women with early-stage BC. The prevailing knowledge gap and lack of risk-specific adjuvant therapy guidelines suggests a compelling need for prospective trials to inform selection of optimal adjuvant therapy, including omission of adjuvant endocrine therapy in older women with low risk BC.
Language	English
Publishing date	2023-12-14
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2374-4677
ISSN	2374-4677
DOI	10.1038/s41523-023-00591-6
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Article ; Online: Adoption, implementation, and sustainability of early childhood feeding, nutrition and active play interventions in real-world settings: a systematic review.

Gelman, Rivka / Whelan, Jillian / Spiteri, Sheree / Duric, Danijela / Oakhill, Winnie / Cassar, Samuel / Love, Penelope

The international journal of behavioral nutrition and physical activity

2023 Volume 20, Issue 1, Page(s) 32

Abstract: Background: Instilling healthy dietary habits and active play in early childhood is an important public health focus. Interventions supporting the establishment of nutrition and active play behaviours in the first years of life have shown positive ... ...

Abstract	Background: Instilling healthy dietary habits and active play in early childhood is an important public health focus. Interventions supporting the establishment of nutrition and active play behaviours in the first years of life have shown positive outcomes and long-term cost-effectiveness, however, most are research trials, with limited evidence regarding real-world application. Implementation science theories, models and frameworks (TMFs) can guide the process of research translation from trial to real-world intervention. The application of TMFs within nutrition and active play intervention studies in early childhood (< 5 years) is currently unknown. This systematic review identified the use of TMFs and barriers/ enablers associated with intervention adoption, implementation, and sustainability in early childhood nutrition and active play interventions implemented under real-world conditions. Methods: Six databases were searched for peer-reviewed publications between 2000-2021. Studies were included if primary outcomes reported improvement in diet, physical activity or sedentary behaviours amongst children aged < 5 years and interventions were delivered under real-world conditions within a community and/or healthcare setting. Two reviewers extracted and evaluated studies, cross checked by a third and verified by all authors. Quality assessment of included studies was completed by two authors using the Mixed Methods Appraisal Tool (MMAT). Results: Eleven studies comprising eleven unique interventions were included. Studies represented low, middle and high-income countries, and were conducted across a range of settings. Five TMFs were identified representing four of Nilsen's implementation model categories, predominantly 'evaluation models'. Ninety-nine barriers/facilitators were extracted across the three intervention phases-Implementation (n = 33 barriers; 33 facilitators), Sustainability (n = 19 barriers; n = 9 facilitators), Adoption (n = 2 barriers; n = 3 facilitators). Identified barriers/facilitators were mapped to the five domains of the Durlak and DuPre framework, with 'funding', 'compatibility' and 'integration of new programming' common across the three intervention phases. Conclusions: Findings demonstrate that there is no systematic application of TMFs in the planning, implementation and/or evaluation of early childhood nutrition and active play interventions in real-world settings, and selective and sporadic application of TMFs occurs across the intervention lifespan. This apparent limited uptake of TMFs is a missed opportunity to enhance real-world implementation success. Trial registration: PROSPERO (CRD42021243841).
MeSH term(s)	Child ; Child, Preschool ; Humans ; Diet ; Nutritional Status ; Implementation Science ; Sedentary Behavior ; Exercise
Language	English
Publishing date	2023-03-20
Publishing country	England
Document type	Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2134691-4
ISSN	1479-5868 ; 1479-5868
ISSN (online)	1479-5868
ISSN	1479-5868
DOI	10.1186/s12966-023-01433-1
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