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  1. Article ; Online: Quality or quantity? Questions on the growth of global scientific production.

    Lozada-Martinez, Ivan David / Bolaño-Romero, Maria Paz / Picón-Jaimes, Yelson Alejandro / Moscote-Salazar, Luis Rafael / Narvaez-Rojas, Alexis Rafael

    International journal of surgery (London, England)

    2022  Volume 105, Page(s) 106862

    Language English
    Publishing date 2022-08-27
    Publishing country England
    Document type Letter
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1016/j.ijsu.2022.106862
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6502: Show issues Location:
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  2. Article ; Online: Bayesian analysis of the effect of exosomes in a mouse xenograft model of chronic myeloid leukemia.

    Martínez-Fonseca, Rafael / Vargas-De-León, Cruz / Reyes-Carreto, Ramón / Godínez-Jaimes, Flaviano

    Mathematical biosciences and engineering : MBE

    2023  Volume 20, Issue 11, Page(s) 19504–19526

    Abstract: The aim of this work is to estimate the effect of Imatinib, exosomes, and Imatinib-exosomes mixture in chronic myeloid leukemia (CML). For this purpose, mathematical models based on Gompertzian and logistic growth differential equations were proposed. ... ...

    Abstract The aim of this work is to estimate the effect of Imatinib, exosomes, and Imatinib-exosomes mixture in chronic myeloid leukemia (CML). For this purpose, mathematical models based on Gompertzian and logistic growth differential equations were proposed. The models contained parameters representing the effects of the three components on CML proliferation. Parameters estimation was performed under the Bayesian statistical approach. Experimental data reported in the literature were used, corresponding to four trials of a human leukemia xenograft in BALB/c female rats over a period of forty days. The models were fitted to the following growth dynamics: normal tumor growth, growth with exosomes, growth with Imatinib, and growth with exosomes-Imatinib mixture. For the proposed logistic growth model, it was determined that when using Imatinib treatment the growth rate is 0.93 (95% CrI: 84.33-99.64) slower and reduces the tumor volume to approximately 10% (95% CrI : 8.67-10.81). In the presence of exosome treatment, the growth rate is 0.83 (95% CrI: 1.52-16.59) faster and the tumor volume is expanded by 40% (95% CrI: 25.36-57.28). Finally, in the presence of Imatinib-exosomes mixture treatment, the growth rate is 0.82 (95% CrI: 76.87-88.51) slower and the tumor volume is reduced by 95% (95% CrI: 86.76-99.85). It is concluded that the presence of exosomes partially inactivates the effect of the Imatinib drug on tumor growth in a mouse xenograft model.
    MeSH term(s) Humans ; Female ; Mice ; Rats ; Animals ; Imatinib Mesylate/pharmacology ; Imatinib Mesylate/therapeutic use ; Bayes Theorem ; Heterografts ; Exosomes/pathology ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology ; Disease Models, Animal ; Drug Resistance, Neoplasm ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use
    Chemical Substances Imatinib Mesylate (8A1O1M485B) ; Antineoplastic Agents
    Language English
    Publishing date 2023-11-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2265126-3
    ISSN 1551-0018 ; 1551-0018
    ISSN (online) 1551-0018
    ISSN 1551-0018
    DOI 10.3934/mbe.2023864
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  3. Article ; Online: TO THE EDITOR.

    Rocco, Angelo G / Jaimes, Rafael

    Spine

    2017  Volume 42, Issue 20, Page(s) E1212

    Language English
    Publishing date 2017-07-27
    Publishing country United States
    Document type Letter
    ZDB-ID 752024-4
    ISSN 1528-1159 ; 0362-2436
    ISSN (online) 1528-1159
    ISSN 0362-2436
    DOI 10.1097/BRS.0000000000002366
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1305: Show issues Location:
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  4. Article: Effectiveness of neutral electrolyzed water and copper oxychloride on fungi spores isolated from tropical fruits.

    Vásquez-López, Alfonso / Gómez-Jaimes, Rafael / Villarreal-Barajas, Tania

    Heliyon

    2021  Volume 7, Issue 9, Page(s) e07935

    Abstract: The aim of this study was to assess the antifungal effectiveness of neutral electrolyzed water (NEW) to inhibit the spore germination of post-harvest fungi common in fruits, determine the required available chlorine concentration (ACC) of NEW and to ... ...

    Abstract The aim of this study was to assess the antifungal effectiveness of neutral electrolyzed water (NEW) to inhibit the spore germination of post-harvest fungi common in fruits, determine the required available chlorine concentration (ACC) of NEW and to compare it with copper oxychloride (CO) and sterile distilled water (SDW)
    Language English
    Publishing date 2021-09-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2021.e07935
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  5. Article ; Online: Impact of helminthiasis on gestational anemia in low- and middle-income countries: a systematic review and meta-analysis of more than 19,000 women.

    Alvarado-Gonzalez, Juan Carlos / Alvis-Zakzuk, Nelson Rafael / Castillo-Saavedra, David Ernesto / Lozada-Martinez, Ivan David / Picón-Jaimes, Yelson Alejandro / Narvaez-Rojas, Alexis Rafael / Zakzuk, Josefina

    Le infezioni in medicina

    2023  Volume 31, Issue 1, Page(s) 36–48

    Abstract: Intestinal helminthiasis are a common public health problem in developed and developing countries. It is thought that they can influence pregnancy by causing gestational anemia. The aim of this study was to determine if there is a relationship between ... ...

    Abstract Intestinal helminthiasis are a common public health problem in developed and developing countries. It is thought that they can influence pregnancy by causing gestational anemia. The aim of this study was to determine if there is a relationship between helminth infection and gestational anemia. A structured review of scientific literature was conducted through active search in the electronic databases MEDLINE
    Language English
    Publishing date 2023-03-01
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2041081-5
    ISSN 2532-8689 ; 1124-9390
    ISSN (online) 2532-8689
    ISSN 1124-9390
    DOI 10.53854/liim-3101-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5576: Show issues Location:
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  6. Article ; Online: The end of the bedside clinical round?

    Picón-Jaimes, Yelson / Lozada-Martínez, Ivan / Moscote-Salazar, Luis Rafael / Janjua, Tariq

    The journal of the Royal College of Physicians of Edinburgh

    2021  Volume 51, Issue 2, Page(s) 199–207

    MeSH term(s) Communication ; Humans ; Patient Care Team ; Teaching Rounds
    Language English
    Publishing date 2021-07-20
    Publishing country Scotland
    Document type Letter
    ZDB-ID 2866363-9
    ISSN 2042-8189 ; 0953-0932
    ISSN (online) 2042-8189
    ISSN 0953-0932
    DOI 10.4997/JRCPE.2021.229
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    Zs.A 3088 -Suppl.-: Show issues Location:
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  7. Article ; Online: Cryptogenic stroke: Much and nothing at the same time.

    Picón-Jaimes, Yelson Alejandro / Lozada-Martinez, Ivan David / Janjua, Tariq / Moscote-Salazar, Luis Rafael

    European journal of neurology

    2021  Volume 28, Issue 7, Page(s) e50–e51

    MeSH term(s) Atrial Fibrillation ; Humans ; Ischemic Stroke ; Stroke
    Language English
    Publishing date 2021-05-06
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1280785-0
    ISSN 1468-1331 ; 1351-5101 ; 1471-0552
    ISSN (online) 1468-1331
    ISSN 1351-5101 ; 1471-0552
    DOI 10.1111/ene.14880
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    Zs.A 4738: Show issues Location:
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    Zs.MO 592: Show issues

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  8. Article ; Online: Impact of Time of Day and Season on Outcome in Acute Ischemic Stroke.

    Picón-Jaimes, Yelson Alejandro / Lozada-Martínez, Ivan David / Janjua, Tariq / Moscote-Salazar, Luis Rafael

    Annals of neurology

    2021  Volume 90, Issue 3, Page(s) 518–519

    MeSH term(s) Brain Ischemia/complications ; Humans ; Ischemic Stroke ; Seasons ; Stroke/therapy ; Treatment Outcome
    Language English
    Publishing date 2021-07-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80362-5
    ISSN 1531-8249 ; 0364-5134
    ISSN (online) 1531-8249
    ISSN 0364-5134
    DOI 10.1002/ana.26162
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    Zs.A 1370: Show issues Location:
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    Zs.MO 478: Show issues

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  9. Article: JACC was the TOP cardiology journal with the highest participation of Latin authors in 2021.

    Acevedo-Aguilar, Laura Marcela / Lozada-Martinez, Ivan David / Mass-Hernández, Laura Marcela / Picón-Jaimes, Yelson Alejandro / Moscote-Salazar, Luis Rafael / Narvaez-Rojas, Alexis Rafael

    Annals of medicine and surgery (2012)

    2022  Volume 79, Page(s) 103959

    Language English
    Publishing date 2022-06-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1016/j.amsu.2022.103959
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  10. Article ; Online: Human Cytokine and Coronavirus Nucleocapsid Protein Interactivity Using Large-Scale Virtual Screens

    Tomezsko, Phillip J. / Ford, Colby T. / Meyer, Avery E. / Michaleas, Adam M. / Jaimes, Rafael

    bioRxiv

    Abstract: In the battle against the ever-changing SARS-CoV-2 landscape, understanding the interactions between viral proteins and the human immune system is paramount as it helps to explain potential factors contributing to diverse immunological responses in ... ...

    Abstract In the battle against the ever-changing SARS-CoV-2 landscape, understanding the interactions between viral proteins and the human immune system is paramount as it helps to explain potential factors contributing to diverse immunological responses in infected individuals. In this study, we employed state-of-the-art molecular docking tools to conduct large-scale virtual screens, predicting the binding affinities between 64 human cytokines against 17 coronavirus nucleocapsid proteins. Our comprehensive in silico analyses reveal specific changes in cytokine-nucleocapsid protein interactions, shedding light on potential modulators of the host immune response during infection. These findings offer valuable insights into the molecular mechanisms underlying viral pathogenesis and may guide the future development of targeted interventions. This manuscript serves as insight into the comparison of deep learning based AlphaFold2-Multimer and the semi-physicochemical based HADDOCK for protein-protein docking. We show the two methods are complementary in their predictive capabilities. We also introduce a novel algorithm for rapidly assessing the binding interface of protein-protein docks using graph edit distance: graph-based residue assessment function (G-RAF). The high-performance computational framework presented here will not only aid in accelerating the discovery of effective interventions against emerging viral threats, but extend to other applications of high throughput protein-protein screens.
    Keywords covid19
    Language English
    Publishing date 2023-11-29
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2023.11.28.569056
    Database COVID19

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