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Article ; Online: Refractory Stage M Ganglioneuroblastoma With Bone Metastases and a Favorable, Chronic Course of Disease: Description of a Patient Cohort.

Tas, Michelle L / Molenaar, Jan J / Peek, Annemarie M L / Lequin, Maarten H / Verdijk, Rob M / de Krijger, Ronald R / Tytgat, Godelieve A M / van Noesel, Max M

Journal of pediatric hematology/oncology

2021 Volume 44, Issue 1, Page(s) e5–e13

Abstract: Refractory stage M neuroblastoma (NB) is associated with a poor prognosis and a progressive course ... who were diagnosed with stage M disease based on iodine-123-metaiodobenzylguanidine avid bone metastases ... a small minority of stage M patients. This GNB entity illustrates the clinical heterogeneity ...

Abstract	Refractory stage M neuroblastoma (NB) is associated with a poor prognosis and a progressive course of disease. Here, we describe a unique group of patients with a discrepant clinical course. Seven histologically confirmed ganglioneuroblastoma (GNB) (n=6) and differentiating NB (n=1) patients were identified who were diagnosed with stage M disease based on iodine-123-metaiodobenzylguanidine avid bone metastases. Six patients started on high-risk treatment, without tumor response (stable disease). Treatment was discontinued before the start of consolidation treatment because of refractory response in all patients. Unexpectedly, after cessation of treatment no progression of disease occurred. In 2 patients, the primary tumors expanded (>25%) very slowly during 1.5 and 3 years, and remained stable thereafter. Metabolically, a slow decrease of urinary homovanillic acid and vanillylmandelic acid levels and iodine-123-metaiodobenzylguanidine avidity was observed. All patients are alive with presence of metastatic disease after a median follow-up of 17 years (range: 6.7 to 27 y). Interestingly, at diagnosis, 6 patients were asymptomatic, 6 patients had GNB morphology, and 5 patients had meningeal metastases. These are all features seen in only a small minority of stage M patients. This GNB entity illustrates the clinical heterogeneity of neuroblastic tumors and can be used to further study the developmental origin of different NB subtypes.
MeSH term(s)	Bone Neoplasms/drug therapy ; Bone Neoplasms/secondary ; Bone Neoplasms/urine ; Child, Preschool ; Chronic Disease ; Consolidation Chemotherapy ; Female ; Ganglioneuroblastoma/drug therapy ; Ganglioneuroblastoma/urine ; Humans ; Infant ; Male ; Neoplasm Metastasis ; Neoplasm Staging ; Retrospective Studies
Language	English
Publishing date	2021-04-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1231152-2
ISSN	1536-3678 ; 1077-4114 ; 0192-8562
ISSN (online)	1536-3678
ISSN	1077-4114 ; 0192-8562
DOI	10.1097/MPH.0000000000002067
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Zs.A 1537: Show issues

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Article ; Online: Reply to A. Piccardo et al, E. Hindié et al, M.C. Kreissl et al, M. Doss, J. Buscombe, R. Fisher, M. Sollini et al, M. Lichtenstein, and M. Tulchinsky et al.

Molenaar, Remco J / Sidana, Surbhi / Radivoyevitch, Tomas / Gerds, Aaron T / Carraway, Hetty E / Kalaycio, Matt / Nazha, Aziz / Adelstein, David J / Nasr, Christian / Maciejewski, Jaroslaw P / Majhail, Navneed S / Sekeres, Mikkael A / Mukherjee, Sudipto

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2018 Volume 36, Issue 18, Page(s) 1889–1892

MeSH term(s)	Adenocarcinoma ; Hematologic Neoplasms ; Humans ; Iodine Radioisotopes ; Thyroid Neoplasms
Chemical Substances	Iodine Radioisotopes
Language	English
Publishing date	2018-05-03
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.2018.78.4074
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Zs.A 1847: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Subgrouping with Chain Graphical VAR Models.

Park, Jonathan J / Chow, Sy-Miin / Epskamp, Sacha / Molenaar, Peter C M

Multivariate behavioral research

2024 , Page(s) 1–23

Abstract: Recent years have seen the emergence of an "idio-thetic" class of methods to bridge the gap between nomothetic and idiographic inference. These methods describe nomothetic trends in idiographic processes by pooling intraindividual information across ... ...

Abstract	Recent years have seen the emergence of an "idio-thetic" class of methods to bridge the gap between nomothetic and idiographic inference. These methods describe nomothetic trends in idiographic processes by pooling intraindividual information across individuals to inform group-level inference or vice versa. The current work introduces a novel "idio-thetic" model: the subgrouped chain graphical vector autoregression (scGVAR). The scGVAR is unique in its ability to identify subgroups of individuals who share common dynamic network structures in both lag(1) and contemporaneous effects. Results from Monte Carlo simulations indicate that the scGVAR shows promise over similar approaches when clusters of individuals differ in their contemporaneous dynamics and in showing increased sensitivity in detecting nuanced group differences while keeping Type-I error rates low. In contrast, a competing approach-the Alternating Least Squares VAR (ALS VAR) performs well when groups were separated by larger distances. Further considerations are provided regarding applications of the ALS VAR and scGVAR on real data and the strengths and limitations of both methods.
Language	English
Publishing date	2024-02-13
Publishing country	United States
Document type	Journal Article
ISSN	1532-7906
ISSN (online)	1532-7906
DOI	10.1080/00273171.2023.2289058
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Article ; Online: On Subgrouping Continuous Processes in Discrete Time.

Park, Jonathan J / Fisher, Zachary / Chow, Sy-Miin / Molenaar, Peter C M

Multivariate behavioral research

2023 Volume 58, Issue 1, Page(s) 154–155

Language	English
Publishing date	2023-02-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1532-7906
ISSN (online)	1532-7906
DOI	10.1080/00273171.2022.2160957
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Article ; Online: Research Note: Comparing methods to assess Valgus-Varus deformity in broiler chickens.

van den Brand, H / Molenaar, R / Klaasen, M

Poultry science

2022 Volume 101, Issue 7, Page(s) 101907

Abstract: Valgus-varus deformity (VVD) is one of the leg disorders affecting health and welfare of broiler chickens. In research, several protocols are used to determine the prevalence and/or severity of VVD. This study aimed to investigate effects of five ... ...

Abstract	Valgus-varus deformity (VVD) is one of the leg disorders affecting health and welfare of broiler chickens. In research, several protocols are used to determine the prevalence and/or severity of VVD. This study aimed to investigate effects of five different protocols on the angulation of the tibiotarsal-tarsometatarsal joint. Angulation was determined (1) in living chickens with fixation at the femorotibiotarsal joint; (2) in dead chickens without fixation; (3) in dead chickens with fixation; (4) in dissected legs, including muscles, but without skin; (5) in dissected legs, without muscles, but with intact joints. Fixation of the leg at the femorotibiotarsal joint largely reduced the angulation of the tibiotarsal-tarsometatarsal joint. When fixation was used, no differences in angulation were found when broilers were live, dead or legs were dissected, but when no fixation was used, angulation was considerably higher, due to a large lateral deviation of the leg. It can be concluded that in intact chickens, fixation of the femorotibiotarsal joint is essential to determine VVD angulation in an appropriate way.
MeSH term(s)	Animals ; Chickens/abnormalities ; Joints/abnormalities ; Joints/pathology ; Lower Extremity/anatomy & histology ; Lower Extremity Deformities, Congenital/pathology ; Lower Extremity Deformities, Congenital/veterinary
Language	English
Publishing date	2022-04-06
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.1016/j.psj.2022.101907
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Zs.B 853: Show issues

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Article: Galgangatresie en de operatie volgens Kasai: ervaringen gedurende de periode 1972 t.m. 1981.

Houwen, R H / Molenaar, J C / Sinaasappel, M

Nederlands tijdschrift voor geneeskunde

1983 Volume 127, Issue 35, Page(s) 1565–1568

Title translation	Biliary atresia and Kasai's operation: experiences during the period 1972 through 1981.
MeSH term(s)	Bile Ducts/abnormalities ; Bile Ducts/surgery ; Child ; Child, Preschool ; Female ; Hepatic Duct, Common/surgery ; Humans ; Infant ; Jejunum/surgery ; Male ; Methods ; Prognosis ; Retrospective Studies
Language	Dutch
Publishing date	1983-08-27
Publishing country	Netherlands
Document type	English Abstract ; Journal Article
ZDB-ID	82073-8
ISSN	1876-8784 ; 0028-2162
ISSN (online)	1876-8784
ISSN	0028-2162
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Article ; Online: SETD2: from chromatin modifier to multipronged regulator of the genome and beyond.

Molenaar, Thom M / van Leeuwen, Fred

Cellular and molecular life sciences : CMLS

2022 Volume 79, Issue 6, Page(s) 346

Abstract: Histone modifying enzymes play critical roles in many key cellular processes and are appealing proteins for targeting by small molecules in disease. However, while the functions of histone modifying enzymes are often linked to epigenetic regulation of ... ...

Abstract	Histone modifying enzymes play critical roles in many key cellular processes and are appealing proteins for targeting by small molecules in disease. However, while the functions of histone modifying enzymes are often linked to epigenetic regulation of the genome, an emerging theme is that these enzymes often also act by non-catalytic and/or non-epigenetic mechanisms. SETD2 (Set2 in yeast) is best known for associating with the transcription machinery and methylating histone H3 on lysine 36 (H3K36) during transcription. This well-characterized molecular function of SETD2 plays a role in fine-tuning transcription, maintaining chromatin integrity, and mRNA processing. Here we give an overview of the various molecular functions and mechanisms of regulation of H3K36 methylation by Set2/SETD2. These fundamental insights are important to understand SETD2's role in disease, most notably in cancer in which SETD2 is frequently inactivated. SETD2 also methylates non-histone substrates such as α-tubulin which may promote genome stability and contribute to the tumor-suppressor function of SETD2. Thus, to understand its role in disease, it is important to understand and dissect the multiple roles of SETD2 within the cell. In this review we discuss how histone methylation by Set2/SETD2 has led the way in connecting histone modifications in active regions of the genome to chromatin functions and how SETD2 is leading the way to showing that we also have to look beyond histones to truly understand the physiological role of an 'epigenetic' writer enzyme in normal cells and in disease.
MeSH term(s)	Chromatin/genetics ; Chromatin/metabolism ; Epigenesis, Genetic ; Histones/genetics ; Histones/metabolism ; Methylation ; Protein Processing, Post-Translational/genetics ; Saccharomyces cerevisiae/metabolism
Chemical Substances	Chromatin ; Histones
Language	English
Publishing date	2022-06-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1358415-7
ISSN	1420-9071 ; 1420-682X
ISSN (online)	1420-9071
ISSN	1420-682X
DOI	10.1007/s00018-022-04352-9
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Zs.A 195: Show issues

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Article: SETD2: from chromatin modifier to multipronged regulator of the genome and beyond

Molenaar, Thom M. / van Leeuwen, Fred

Cellular and molecular life sciences. 2022 June, v. 79, no. 6

2022

Abstract	Histone modifying enzymes play critical roles in many key cellular processes and are appealing proteins for targeting by small molecules in disease. However, while the functions of histone modifying enzymes are often linked to epigenetic regulation of the genome, an emerging theme is that these enzymes often also act by non-catalytic and/or non-epigenetic mechanisms. SETD2 (Set2 in yeast) is best known for associating with the transcription machinery and methylating histone H3 on lysine 36 (H3K36) during transcription. This well-characterized molecular function of SETD2 plays a role in fine-tuning transcription, maintaining chromatin integrity, and mRNA processing. Here we give an overview of the various molecular functions and mechanisms of regulation of H3K36 methylation by Set2/SETD2. These fundamental insights are important to understand SETD2’s role in disease, most notably in cancer in which SETD2 is frequently inactivated. SETD2 also methylates non-histone substrates such as α-tubulin which may promote genome stability and contribute to the tumor-suppressor function of SETD2. Thus, to understand its role in disease, it is important to understand and dissect the multiple roles of SETD2 within the cell. In this review we discuss how histone methylation by Set2/SETD2 has led the way in connecting histone modifications in active regions of the genome to chromatin functions and how SETD2 is leading the way to showing that we also have to look beyond histones to truly understand the physiological role of an ‘epigenetic’ writer enzyme in normal cells and in disease.
Keywords	chromatin ; enzymes ; epigenetics ; genome ; histones ; lysine ; methylation ; yeasts
Language	English
Dates of publication	2022-06
Size	p. 346.
Publishing place	Springer International Publishing
Document type	Article
Note	Review
ZDB-ID	1358415-7
ISSN	1420-9071 ; 1420-682X
ISSN (online)	1420-9071
ISSN	1420-682X
DOI	10.1007/s00018-022-04352-9
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Granger Causality Testing with Intensive Longitudinal Data.

Molenaar, Peter C M

Prevention science : the official journal of the Society for Prevention Research

2018 Volume 20, Issue 3, Page(s) 442–451

Abstract: The availability of intensive longitudinal data obtained by means of ambulatory assessment opens up new prospects for prevention research in that it allows the derivation of subject-specific dynamic networks of interacting variables by means of vector ... ...

Abstract	The availability of intensive longitudinal data obtained by means of ambulatory assessment opens up new prospects for prevention research in that it allows the derivation of subject-specific dynamic networks of interacting variables by means of vector autoregressive (VAR) modeling. The dynamic networks thus obtained can be subjected to Granger causality testing in order to identify causal relations among the observed time-dependent variables. VARs have two equivalent representations: standard and structural. Results obtained with Granger causality testing depend upon which representation is chosen, yet no criteria exist on which this important choice can be based. A new equivalent representation is introduced called hybrid VARs with which the best representation can be chosen in a data-driven way. Partial directed coherence, a frequency-domain statistic for Granger causality testing, is shown to perform optimally when based on hybrid VARs. An application to real data is provided.
MeSH term(s)	Causality ; Longitudinal Studies ; Models, Theoretical
Language	English
Publishing date	2018-05-30
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2251270-6
ISSN	1573-6695 ; 1389-4986
ISSN (online)	1573-6695
ISSN	1389-4986
DOI	10.1007/s11121-018-0919-0
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Zs.A 6466: Show issues

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Article ; Online: Examining timing effects in the intergenerational transmission of anxiety and depressive symptoms: A genetically informed study.

Chen, Tong / Liu, Chang / Molenaar, Peter C M / Leve, Leslie D / Ganiban, Jody M / Natsuaki, Misaki N / Shaw, Daniel S / Neiderhiser, Jenae M

Developmental psychology

2024 Volume 60, Issue 4, Page(s) 747–763

Abstract: The present study examined genetic, prenatal, and postnatal environmental pathways in the intergenerational transmission of anxiety and depressive symptoms from parents to early adolescents (when these symptoms start to increase), while considering ... ...

Abstract	The present study examined genetic, prenatal, and postnatal environmental pathways in the intergenerational transmission of anxiety and depressive symptoms from parents to early adolescents (when these symptoms start to increase), while considering timing effects of exposure to parent anxiety and depressive symptoms postnatally. The sample was from the Early Growth and Development Study, including 561 adopted children (57% male, 55% White, 13% Black/African American, 11% Hispanic/Latine, 20% multiracial, 1% other; 407 provided data in early adolescence) and their birth (BP) and adoptive parents (AP). Using a trait-state-occasion model with eight assessments from child ages 9 months to 11 years, we partitioned trait-like AP anxiety and depressive symptoms from time-specific fluctuations of AP anxiety and depressive symptoms. Offspring anxiety and depressive symptoms were assessed at 11 years (while controlling for similar symptoms at 4.5 years). Results suggested that time-specific fluctuations of AP1 (mostly mothers) anxiety/depressive symptoms in infancy (9 months) were indirectly associated with offspring anxiety/depressive symptoms at 11 years via offspring anxiety/depressive symptoms at 4.5 years; time-specific fluctuations of AP1 anxiety/depressive symptoms at child age 11 years were concurrently associated with offspring anxiety/depressive symptoms at 11 years. AP2 (mostly fathers) anxiety/depressive symptoms were not associated with offspring symptoms. Genetic and prenatal influences measured by BP internalizing problems were not associated with offspring symptoms. Results suggested infancy and early adolescence as developmental periods when children are susceptible to influences of parent anxiety and depressive symptoms. Preventive interventions should consider time-specific fluctuations in parent anxiety and depressive symptoms during these developmental periods. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
MeSH term(s)	Female ; Child ; Pregnancy ; Adolescent ; Male ; Humans ; Depression ; Mothers ; Parents ; Anxiety ; Anxiety Disorders
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2066223-3
ISSN	1939-0599 ; 0012-1649
ISSN (online)	1939-0599
ISSN	0012-1649
DOI	10.1037/dev0001694
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