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  1. Article ; Online: Feto-maternal hemorrhage with placental chorioangioma: Two case reports.

    Kinoshita, Yuki / Inoue, Masanori / Sekiguchi, Kazuhito / Maeda, Tomoki / Ihara, Kenji

    Pediatrics international : official journal of the Japan Pediatric Society

    2022  Volume 64, Issue 1, Page(s) e15196

    MeSH term(s) Female ; Hemangioma/complications ; Hemangioma/diagnosis ; Hemorrhage/diagnosis ; Hemorrhage/etiology ; Humans ; Placenta ; Pregnancy
    Language English
    Publishing date 2022-06-15
    Publishing country Australia
    Document type Case Reports ; Journal Article
    ZDB-ID 1470376-2
    ISSN 1442-200X ; 1328-8067
    ISSN (online) 1442-200X
    ISSN 1328-8067
    DOI 10.1111/ped.15196
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  2. Article: Predicting Long-Term Ventricular Arrhythmia Risk in Children with Acute Lymphoblastic Leukemia Using Normal Values of Ventricular Repolarization Markers Established from Japanese Cohort Study.

    Takeguchi, Masahiro / Kusumoto, Satoshi / Sekiguchi, Kazuhito / Suenobu, Souichi / Ihara, Kenji

    Journal of clinical medicine

    2023  Volume 12, Issue 14

    Abstract: Background: Cardiac complications due to anthracycline treatment may become evident several years after chemotherapy and are recognized as a serious cause of morbidity and mortality in cancer patients or childhood cancer survivors.: Objectives: We ... ...

    Abstract Background: Cardiac complications due to anthracycline treatment may become evident several years after chemotherapy and are recognized as a serious cause of morbidity and mortality in cancer patients or childhood cancer survivors.
    Objectives: We analyzed ventricular repolarization parameters in electrocardiography for pediatric acute lymphoblastic leukemia patients during chemotherapy and in long-term follow-up. To establish the reference values of ventricular repolarization parameters in children, we retrospectively summarized the Tpe interval, QT interval, QTc interval, and Tpe/QT ratio in healthy Japanese children.
    Methods: Electrocardiography data recorded from students in 1st and 7th grades were randomly selected from a database maintained by the school-based screening system in the Oita city cohort, Japan. Subsequently, chronological data of the Tpe/QT ratio in 17 pediatric patients with acute lymphoblastic leukemia were analyzed over time.
    Results: The mean ± standard deviation of the Tpe interval in 1st and 7th graders was 70 ± 7 and 78 ± 17 ms, respectively, while the mean ± standard deviation of the Tpe/QT ratio was 0.21 ± 0.02 and 0.22 ± 0.02 ms, respectively. During the intensive phase of treatment, the Tpe/QT ratios of 3 high-risk patients among the 17 patients with acute lymphoblastic leukemia exceeded the upper limit.
    Conclusion: The Tpe/QT ratio has a potential clinical application in predicting the risk of long-term ventricular arrhythmia of cancer patients or childhood cancer survivors from childhood to adulthood.
    Language English
    Publishing date 2023-07-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12144723
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  3. Article ; Online: Myocarditis in 13-Year-Old Monochorionic Diamniotic Twins After COVID-19 Vaccination.

    Nishibayashi, Hayato / Kishimoto, Shintaro / Sekiguchi, Kazuhito / Okada, Satoshi / Ihara, Kenji

    Journal of clinical immunology

    2022  Volume 42, Issue 7, Page(s) 1351–1353

    MeSH term(s) Adolescent ; Humans ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Myocarditis/diagnosis ; Myocarditis/etiology ; Vaccination/adverse effects
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-08-26
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 779361-3
    ISSN 1573-2592 ; 0271-9142
    ISSN (online) 1573-2592
    ISSN 0271-9142
    DOI 10.1007/s10875-022-01360-z
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  4. Article ; Online: Rituximab-induced serum sickness in a girl with nephrotic syndrome.

    Kimura, Yuka / Kiyota, Kyoko / Ikeuchi, Mayo / Sekiguchi, Kazuhito / Ihara, Kenji

    CEN case reports

    2022  Volume 11, Issue 4, Page(s) 506–510

    Abstract: Rituximab (RTX) has been used to treat B cell lineage lymphoma/leukemia or autoimmune or autoinflammatory disorders. RTX therapy has been extensively applied to cases of frequently relapsing nephrotic syndrome (FRNS) and steroid-dependent nephrotic ... ...

    Abstract Rituximab (RTX) has been used to treat B cell lineage lymphoma/leukemia or autoimmune or autoinflammatory disorders. RTX therapy has been extensively applied to cases of frequently relapsing nephrotic syndrome (FRNS) and steroid-dependent nephrotic syndrome. Rituximab-induced serum sickness (RISS) has been recognized as a rare severe type-3 hypersensitivity reaction in patients treated with RTX. We herein report a 10-year-old girl with RISS in FRNS. She was diagnosed with RISS based on characteristic symptoms, such as a fever, rash, arthritis, or proteinuria, during RTX therapy associated with a high level of human anti-chimeric antibody. Even after recovering from acute symptoms by RISS, she suffered from worsening relapses of nephrotic syndrome. The symptoms of RISS are non-specific, resembling viral infections, autoinflammatory diseases and Kawasaki disease, especially in children. While RISS is a rare complication among patients with nephrotic syndrome, it should be carefully considered as a severe complication in patients being treated with RTX.
    MeSH term(s) Child ; Female ; Humans ; Rituximab ; Nephrotic Syndrome/diagnosis ; Serum Sickness/chemically induced ; Immunologic Factors ; Recurrence
    Chemical Substances Rituximab (4F4X42SYQ6) ; Immunologic Factors
    Language English
    Publishing date 2022-05-20
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 2660492-9
    ISSN 2192-4449 ; 2192-4449
    ISSN (online) 2192-4449
    ISSN 2192-4449
    DOI 10.1007/s13730-022-00709-y
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  5. Article: An Algorithm for the Detection of General Movements of Preterm Infants Based on the Instantaneous Heart Rate.

    Maeda, Tomoki / Kobayashi, Osamu / Eto, Eriko / Inoue, Masanori / Sekiguchi, Kazuhito / Ihara, Kenji

    Children (Basel, Switzerland)

    2022  Volume 10, Issue 1

    Abstract: Video recording and editing of general movements (GMs) takes time. We devised an algorithm to automatically extract the period of GMs emergence to assist in the assessment of GMs. The algorithm consisted of δHR: subtracting the moving average heart rate ( ...

    Abstract Video recording and editing of general movements (GMs) takes time. We devised an algorithm to automatically extract the period of GMs emergence to assist in the assessment of GMs. The algorithm consisted of δHR: subtracting the moving average heart rate (HR) for the past 60 s from the average instantaneous HR; and %δHR: the percentage of the instantaneous HR to the moving average HR. Ten-second sections in which δHR was positive for three consecutive sections and contained at least one section with %δHR > 105% were extracted. Extracted periods are called automated extraction sections (AESs). We evaluated the concordance rate between AESs and GMs in three periods (gestational age 24−32, 33−34, and 35−36 weeks). The records of 84 very low birth weight infants were evaluated. Approximately 90% of AESs were accompanied by GMs at any period in both the supine and prone positions. The proportion of full-course (beginning to end) GMs among GMs in the AES was 80−85% in the supine position and 90% in the prone position in all periods. We could extract a sufficient number of assessable GMs with this algorithm, which is expected to be widely used for assisting in the assessment of GMs.
    Language English
    Publishing date 2022-12-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children10010069
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  6. Article ; Online: Clinical characteristics of preterm and term infants with Ureaplasma in gastric fluid.

    Abe, Yoshiichi / Inoue, Masanori / Sekiguchi, Kazuhito / Nakano, Satoko / Tomaru, Yasuhiro / Maeda, Tomoki / Shimizu, Norio / Ihara, Kenji

    Pediatrics and neonatology

    2023  Volume 65, Issue 2, Page(s) 170–176

    Abstract: Background: Ureaplasma spp. is an endemic microorganism that causes placental chorioamnionitis or preterm delivery in pregnant women, and the occurrence of bronchopulmonary dysplasia or intraventricular hemorrhaging in preterm infants after birth, ... ...

    Abstract Background: Ureaplasma spp. is an endemic microorganism that causes placental chorioamnionitis or preterm delivery in pregnant women, and the occurrence of bronchopulmonary dysplasia or intraventricular hemorrhaging in preterm infants after birth, although the pathogenicity of Ureaplasma remains controversial. The association between Ureaplasma exposure and the symptoms or outcomes of infected mothers or their infants born at term remains poorly understood. We investigated the clinical characteristics of preterm and term infants with or without Ureaplasma in their gastric fluid.
    Methods: Gastric fluid samples were collected from 47 newborns in the neonatal intensive-care unit immediately after birth and tested using multiplex polymerase chain reaction (PCR) assays targeting Ureaplasma spp., Ureaplasma parvum, and Ureaplasma urealyticum. The clinical findings and outcomes of the neonates and their mothers were retrospectively evaluated.
    Results: Ureaplasma spp. were detected in 9/47 samples (19%) by multiplex PCR assays. In all cases, the subspecies was U. parvum. The Ureaplasma-positive group had a significantly higher incidence of chorioamnionitis in utero than the Ureaplasma-negative group. Regarding preterm infants, the IgM levels in the Ureaplasma-positive group were significantly higher than in the Ureaplasma-negative group. In contrast, in term infants, the rates of a non-reassuring fetal status, a maternal fever, and maternal leukocyte counts and maternal C-reactive protein levels within five days before delivery in the Ureaplasma-positive group were significantly higher than those in the Ureaplasma-negative group. All three extremely-low-birth-weight infants with Ureaplasma developed bronchopulmonary dysplasia. The length of hospitalization in the Ureaplasma-positive group was almost same as that in the Ureaplasma-negative group for term infants.
    Conclusion: Mothers or their fetuses with exposure to Ureaplasma expressed characteristic clinical features during pregnancy and after birth.
    MeSH term(s) Infant ; Infant, Newborn ; Female ; Humans ; Pregnancy ; Ureaplasma ; Infant, Premature ; Bronchopulmonary Dysplasia/epidemiology ; Bronchopulmonary Dysplasia/etiology ; Chorioamnionitis/epidemiology ; Retrospective Studies ; Placenta
    Language English
    Publishing date 2023-09-12
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2441816-X
    ISSN 2212-1692 ; 1875-9572
    ISSN (online) 2212-1692
    ISSN 1875-9572
    DOI 10.1016/j.pedneo.2023.04.016
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    Zs.B 1083: Show issues Location:
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  7. Article ; Online: Metabolome Characteristics of Liver Autophagy Deficiency under Starvation Conditions in Infancy.

    Sekiguchi, Kazuhito / Miyahara, Hiroaki / Inoue, Masanori / Kiyota, Kyoko / Sakai, Kumiko / Hanada, Toshikatsu / Ihara, Kenji

    Nutrients

    2021  Volume 13, Issue 9

    Abstract: The liver function is essential for metabolism, detoxification, and bile synthesis, even in the neonatal period. Autophagy plays significance roles in THE adult liver, whereas the role of liver autophagy in the early neonatal period largely remains ... ...

    Abstract The liver function is essential for metabolism, detoxification, and bile synthesis, even in the neonatal period. Autophagy plays significance roles in THE adult liver, whereas the role of liver autophagy in the early neonatal period largely remains unclear. To clarify the importance of liver autophagy in the neonatal starvation period, we generated liver-specific autophagy-deficient (
    MeSH term(s) Animals ; Animals, Newborn ; Autophagy ; Autophagy-Related Protein 5/deficiency ; Gas Chromatography-Mass Spectrometry ; Liver/metabolism ; Metabolome ; Mice ; Starvation/blood
    Chemical Substances Autophagy-Related Protein 5
    Language English
    Publishing date 2021-08-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu13093026
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  8. Article ; Online: Caffeine not associated with irritable behaviour in very low-birth-weight infants.

    Maeda, Tomoki / Sekiguchi, Kazuhito / Wasada, Rieko / Ihara, Kenji

    Early human development

    2019  Volume 137, Page(s) 104835

    Abstract: This paper is an examination of irritable behaviour in very low-birth-weight infants in relation to caffeine or aminophylline. We assessed tremulous movement (a sub-score of General Movements Optimality Score) in 18 caffeine-treated subjects and 18 ... ...

    Abstract This paper is an examination of irritable behaviour in very low-birth-weight infants in relation to caffeine or aminophylline. We assessed tremulous movement (a sub-score of General Movements Optimality Score) in 18 caffeine-treated subjects and 18 aminophylline-treated subjects. Caffeine, unlike aminophylline, was not associated with irritable behaviour at standard dose.
    MeSH term(s) Aminophylline/administration & dosage ; Aminophylline/adverse effects ; Aminophylline/therapeutic use ; Apnea/drug therapy ; Bronchodilator Agents/administration & dosage ; Bronchodilator Agents/adverse effects ; Bronchodilator Agents/therapeutic use ; Caffeine/administration & dosage ; Caffeine/adverse effects ; Caffeine/therapeutic use ; Central Nervous System Stimulants/administration & dosage ; Central Nervous System Stimulants/adverse effects ; Central Nervous System Stimulants/therapeutic use ; Female ; Humans ; Infant Behavior ; Infant, Newborn ; Infant, Premature, Diseases/drug therapy ; Infant, Very Low Birth Weight/physiology ; Irritable Mood ; Male ; Movement
    Chemical Substances Bronchodilator Agents ; Central Nervous System Stimulants ; Aminophylline (27Y3KJK423) ; Caffeine (3G6A5W338E)
    Language English
    Publishing date 2019-08-29
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752532-1
    ISSN 1872-6232 ; 0378-3782
    ISSN (online) 1872-6232
    ISSN 0378-3782
    DOI 10.1016/j.earlhumdev.2019.104835
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  9. Article ; Online: The autophagy reaction in the human umbilical cord: a potential marker for estimating fetal nutrition and neonatal growth.

    Sekiguchi, Kazuhito / Miyahara, Hiroaki / Inoue, Masanori / Maeda, Tomoki / Ihara, Kenji

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

    2020  Volume 35, Issue 4, Page(s) 625–629

    Abstract: Objective: To assess the induction of autophagy in the human umbilical cord for physiological adaptation against starvation.: Methods: The expression of autophagy-related proteins (LC3-II, p62) in umbilical cord tissues from 40 neonates was assessed ... ...

    Abstract Objective: To assess the induction of autophagy in the human umbilical cord for physiological adaptation against starvation.
    Methods: The expression of autophagy-related proteins (LC3-II, p62) in umbilical cord tissues from 40 neonates was assessed by Western blotting. The correlation between the expression of autophagy-related proteins and maternal findings (height, weight, body mass index [BMI]), placental weight, neonatal findings (gestational age, height, weight, Apgar score at 1 min and 5 min), and the pH of the umbilical arterial blood were analyzed using Spearman's rank correlation coefficient test (
    Results: The expression of LC3-II was positively correlated with serum total protein (
    Conclusion: The LC3-II or p62 expression in the umbilical cord may suggest the autophagy reaction for the homeostasis of protein or amino acid metabolism in the perinatal period.
    MeSH term(s) Apgar Score ; Autophagy ; Female ; Fetal Blood ; Gestational Age ; Humans ; Infant, Newborn ; Placenta ; Pregnancy ; Umbilical Cord
    Language English
    Publishing date 2020-03-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2077261-0
    ISSN 1476-4954 ; 1057-0802 ; 1476-7058
    ISSN (online) 1476-4954
    ISSN 1057-0802 ; 1476-7058
    DOI 10.1080/14767058.2020.1730320
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    Zs.A 3510: Show issues Location:
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  10. Article ; Online: Non-immune hydrops fetalis neonate born to a mother with yellow nail syndrome.

    Yamamoto, Hiroki / Sekiguchi, Kazuhito / Takahashi, Mizuho / Maeda, Tomoki / Ihara, Kenji

    Pediatrics international : official journal of the Japan Pediatric Society

    2019  Volume 61, Issue 3, Page(s) 313–315

    MeSH term(s) Adult ; Female ; Humans ; Hydrops Fetalis/diagnosis ; Hydrops Fetalis/etiology ; Hydrops Fetalis/therapy ; Infant, Newborn ; Male ; Mothers ; Yellow Nail Syndrome/complications
    Language English
    Publishing date 2019-03-18
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1470376-2
    ISSN 1442-200X ; 1328-8067
    ISSN (online) 1442-200X
    ISSN 1328-8067
    DOI 10.1111/ped.13771
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