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  1. Article: Hepatoprotective and cardioprotective effect of

    Thakur, Shalini / Kumar, Rakesh / Asrani, R K / Thakur, Meenakshi / Patel, Shailesh Kumar / Patil, Rajendra Damu / Obaidullah, Ahmad J / Emran, Talha Bin

    Heliyon

    2024  Volume 10, Issue 4, Page(s) e25709

    Abstract: Artemisia ... ...

    Abstract Artemisia nilagirica
    Language English
    Publishing date 2024-02-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e25709
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Budesonide: A promising candidate therapeutic for early COVID-19.

    Patel, Shailesh Kumar / Kumar, Rakesh / Rana, Jigyasa / Agrawal, Aditya / Singh, Alok / Kumar, Adesh

    Annals of medicine and surgery (2012)

    2021  Volume 68, Page(s) 102605

    Language English
    Publishing date 2021-08-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1016/j.amsu.2021.102605
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Synthesis, in vitro cytotoxic activity and molecular docking study of androstene and estrone derivatives.

    Mistry, Shailesh / Thakkar, Mittal / Singh, Akhilesh Kumar / Patel, Dhaval

    Steroids

    2023  Volume 197, Page(s) 109259

    Abstract: The development and discovery of steroidal drugs to cure cervical cancer is of the most important. The Claisen condensation of androstene and estrone with aromatic aldehydes was catalyzed by potassium tert. butoxide in tert. butanol to give the ... ...

    Abstract The development and discovery of steroidal drugs to cure cervical cancer is of the most important. The Claisen condensation of androstene and estrone with aromatic aldehydes was catalyzed by potassium tert. butoxide in tert. butanol to give the corresponding 2-arylidene and 16-arylidene estrone. Subsequently, the 16-arylidene estrone reacted with acid chloride in presence of quaternary amine in halogenated solvent resulting in the steroidal arylidene derivatives. Synthesis, Characterization and in vitro cytotoxic activity of arylidenes are rationalized. Fifteen compounds are synthesized and six of them were evaluated for cytotoxic activity against cervical cancer cell line. HT-3 cell line examination revealed a considerable growth inhibition. Compounds 4a, 4b, 6b, 8c, and 8d, which are estrone-based arylidenes, are the most potent of the series, with IC
    MeSH term(s) Female ; Humans ; Structure-Activity Relationship ; Molecular Docking Simulation ; Estrone/chemistry ; Cell Line, Tumor ; Uterine Cervical Neoplasms ; Antineoplastic Agents/chemistry ; Androstenes/pharmacology ; Molecular Structure ; Cell Proliferation ; Drug Screening Assays, Antitumor ; Dose-Response Relationship, Drug
    Chemical Substances Estrone (2DI9HA706A) ; Antineoplastic Agents ; Androstenes
    Language English
    Publishing date 2023-06-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80312-1
    ISSN 1878-5867 ; 0039-128X
    ISSN (online) 1878-5867
    ISSN 0039-128X
    DOI 10.1016/j.steroids.2023.109259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Pathomolecular epidemiology, antimicrobial resistance, and virulence genes of Streptococcus dysgalactiae subsp. equisimilis isolates from slaughtered pigs in India.

    Patel, Sagar M / Sahoo, Monalisa / Thakor, Jigarji Chaturji / Murali, Dinesh / Kumar, Pradeep / Singh, Rajendra / Singh, Karam Pal / Saikumar, G / Jana, Chandrakanta / Patel, Shailesh Kumar / Mote, Akash B / Karthikeyan, Ravichandran / Vandre, Rajesh Kumar / Biswal, Jitendra Kumar / Sahoo, Nihar Ranjan

    Journal of applied microbiology

    2024  Volume 135, Issue 1

    Abstract: Aims: We aimed to investigate the prevalence, pathology, and characterization of Streptococcus dysgalactiae subsp. equisimilis (SDSE) in slaughtered pigs of India.: Methods and results: We collected 1254 morbid tissues (lungs-627 and spleen-627) and ... ...

    Abstract Aims: We aimed to investigate the prevalence, pathology, and characterization of Streptococcus dysgalactiae subsp. equisimilis (SDSE) in slaughtered pigs of India.
    Methods and results: We collected 1254 morbid tissues (lungs-627 and spleen-627) and 627 heart-blood from 627 slaughtered pigs. The bacterial isolation, antibiogram, virulence gene profiling, and mouse pathogenicity testing were performed for the detection and characterization of SDSE. A total of 177 isolates (heart-blood-160 and tissues-17) were recovered from 627 slaughtered pigs with higher isolation rate in heart-blood (25.51%). The prevalence of SDSE was 11% in morbid tissues by polymerase chain reaction. Majority of isolates showed higher detection of streptolysin O, followed by streptokinase and extracellular phospholipase A virulence genes with higher degree of resistance to azithromycin, clindamycin, erythromycin, and penicillin antibiotics. Mouse pathogenicity testing confirmed virulence based on histopathological lesions and re-isolation of SDSE.
    Conclusions: Our findings highlight the high prevalence of SDSE in slaughtered pigs. The presence of virulence genes and mouse pathogenicity testing confirm their pathogenic potential.
    MeSH term(s) Animals ; Swine ; Mice ; Virulence/genetics ; Anti-Bacterial Agents/pharmacology ; Streptococcal Infections/epidemiology ; Streptococcal Infections/veterinary ; Streptococcal Infections/microbiology ; Drug Resistance, Bacterial/genetics ; Streptococcus
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1358023-1
    ISSN 1365-2672 ; 1364-5072
    ISSN (online) 1365-2672
    ISSN 1364-5072
    DOI 10.1093/jambio/lxae002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article: Resurgence of cholera in the COVID-19 era: a global health concern.

    Niranjan, Ankush K / Patel, Shailesh K / Channabasappa, Nikhil K / Rana, Jigyasa / Agrawal, Aditya / Kumar, Rakesh / Pandey, Megha K / Tiwari, Sita P / Singh, Devendra R

    Annals of medicine and surgery (2012)

    2023  Volume 85, Issue 4, Page(s) 1321–1322

    Language English
    Publishing date 2023-04-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1097/MS9.0000000000000415
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The posterity of Zebrafish in paradigm of in vivo molecular toxicological profiling.

    Verma, Suresh K / Nandi, Aditya / Sinha, Adrija / Patel, Paritosh / Mohanty, Swabhiman / Jha, Ealisha / Jena, Snehasmita / Kumari, Puja / Ghosh, Aishee / Jerman, Ivan / Chouhan, Raghuraj Singh / Dutt, Ateet / Samal, Shailesh Kumar / Mishra, Yogendra Kumar / Varma, Rajender S / Panda, Pritam Kumar / Kaushik, Nagendra Kumar / Singh, Deobrat / Suar, Mrutyunjay

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2024  Volume 171, Page(s) 116160

    Abstract: The aggrandised advancement in utility of advanced day-to-day materials and nanomaterials has raised serious concern on their biocompatibility with human and other biotic members. In last few decades, understanding of toxicity of these materials has been ...

    Abstract The aggrandised advancement in utility of advanced day-to-day materials and nanomaterials has raised serious concern on their biocompatibility with human and other biotic members. In last few decades, understanding of toxicity of these materials has been given the centre stage of research using many in vitro and in vivo models. Zebrafish (Danio rerio), a freshwater fish and a member of the minnow family has garnered much attention due to its distinct features, which make it an important and frequently used animal model in various fields of embryology and toxicological studies. Given that fertilization and development of zebrafish eggs take place externally, they serve as an excellent model organism for studying early developmental stages. Moreover, zebrafish possess a comparable genetic composition to humans and share almost 70% of their genes with mammals. This particular model organism has become increasingly popular, especially for developmental research. Moreover, it serves as a link between in vitro studies and in vivo analysis in mammals. It is an appealing choice for vertebrate research, when employing high-throughput methods, due to their small size, swift development, and relatively affordable laboratory setup. This small vertebrate has enhanced comprehension of pathobiology and drug toxicity. This review emphasizes on the recent developments in toxicity screening and assays, and the new insights gained about the toxicity of drugs through these assays. Specifically, the cardio, neural, and, hepatic toxicology studies inferred by applications of nanoparticles have been highlighted.
    MeSH term(s) Animals ; Humans ; Zebrafish ; Models, Animal ; Liver ; Nanostructures ; Mammals
    Language English
    Publishing date 2024-01-17
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2024.116160
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    In stock of ZB MED Cologne/Königswinter

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  7. Article: A Multi-Model Based Stability Analysis Employing Multi-Environmental Trials (METs) Data for Discerning Heat Tolerance in Chickpea (

    Danakumara, Thippeswamy / Kumar, Tapan / Kumar, Neeraj / Patil, Basavanagouda Siddanagouda / Bharadwaj, Chellapilla / Patel, Umashankar / Joshi, Nilesh / Bindra, Shayla / Tripathi, Shailesh / Varshney, Rajeev Kumar / Chaturvedi, Sushil Kumar

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 21

    Abstract: Identifying a congenially targeted production environment and understanding the effects of genotype by environmental interactions on the adaption of chickpea genotypes is essential for achieving an optimal yield stability. Different models like additive ... ...

    Abstract Identifying a congenially targeted production environment and understanding the effects of genotype by environmental interactions on the adaption of chickpea genotypes is essential for achieving an optimal yield stability. Different models like additive main effect and multiplicative interactions (AMMI 1, AMM2), weighted average absolute scores of BLUPs (WAASB), and genotype plus genotype-environment (GGE) interactions were used to understand their suitability in the precise estimation of variance and their interaction. Our experiment used genotypes that represent the West Asia-North Africa (WANA) region. This trial involved two different sowing dates, two distinct seasons, and three different locations, resulting in a total of 12 environments. Genotype IG 5871(G1) showed a lower heat susceptibility index (HSI) across environments under study. The first four interactions principal component axis (IPCA) explain 93.2% of variations with significant genotype-environment interactions. Considering the AMMI stability value (ASV), the genotypes IG5862(G7), IG5861(G6), ILC239(G40), IG6002(G26), and ILC1932(G39), showing ASV scores of 1.66, 1.80, 2.20, 2.60, and 2.84, respectively, were ranked as the most stable and are comparable to the weighted average absolute scores of BLUPs (WAASB) ranking of genotypes. The which-won-where pattern of genotype plus genotype-environment (GGE) interactions suggested that the target environment consists of one mega environment. IG5866(G10), IG5865(G9), IG5884(G14), and IG5862(G7) displayed higher stability, as they were nearer to the origin. The genotypes that exhibited a superior performance in the tested environments can serve as ideal parental lines for heat-stress tolerance breeding programs. The weighted average absolute scores of BLUPs (WAASB) serve as an ideal tool to discern the variations and identify the stable genotype among all methods.
    Language English
    Publishing date 2023-10-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12213691
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  8. Article: Vitamin D in therapy and management: armor against COVID-19 - correspondence.

    Channabasappa, Nikhil K / Patel, Shailesh K / Singh, Devendra R / Niranjan, Ankush K / Rana, Jigyasa / Agrawal, Aditya / Govil, Kumar / Pandey, Megha K / Tiwari, Sita P

    Annals of medicine and surgery (2012)

    2023  Volume 85, Issue 4, Page(s) 1319–1320

    Language English
    Publishing date 2023-03-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1097/MS9.0000000000000390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Pathological and molecular investigation of porcine kobuvirus (PKV) from Indian pigs

    Patel, Shailesh Kumar / Pathak, Mamta / Singh, Alok / Saikumar, G.

    Indian journal of animal research. 2022 June, v. 56, no. 6

    2022  

    Abstract: The porcine kobuvirus (PKV) is a single-stranded, positive-sense, RNA virus of the family Picornaviridae which composed of small, non-enveloped viruses. The PKV is suspected to cause large outbreaks of diarrhoea and dehydration along with vomition in ... ...

    Abstract The porcine kobuvirus (PKV) is a single-stranded, positive-sense, RNA virus of the family Picornaviridae which composed of small, non-enveloped viruses. The PKV is suspected to cause large outbreaks of diarrhoea and dehydration along with vomition in suckling piglets with a high morbidity rate. Despite of its economical importance very few studies are available on the pathology of PKV. The present study was conducted with the aim to investigate PKV in naturally infected Indian pigs. A total of 41 intestinal content and tissue samples from dead pigs were collected from post-mortem facility of, ICAR-IVRI during April, 2019 to July 2020. All the carcasses were subjected to detailed necropsy examination and appropriate tissue samples were collected for histopathological examination and molecular investigation. The amplification of 3D region of PKV was carried out via RT-PCR using the specific primers. The Genetic characterization of Indian isolate of the PKV was done on the basis of viral 3D gene of PKV. A total of six out of 41 necropsied piglets were found positive for the PKV. The diarrhoea and dehydration were observed as the main clinical signs. The thickening and clouding of brain meninges, congestion of brain, pneumonia along with catarrhal and haemorrhagic enteritis was observed as common gross lesions. Microscopic lesions observed in brain were mild to moderate perivascular cuffing, congestion of meningeal and cerebral vessels, focal gliosis and neuronophagia. Mild to severe interstitial pneumonia and emphysema was noticed in lungs. Intestinal mucosa revealed severe inflammatory changes along with sloughing of villi. The genetic characterization revealed maximum identity of 91–93% with Indian isolate of PKV MH394282 and Chinese strain of PKV FJ459905. This study reported the first pathological investigation of PKV from Indian pigs and described the molecular findings in detail. Further explorative surveillance along with epidemiological studies are highly warranted to find out the real impact of the PKV on Indian pigs.
    Keywords Aichivirus C ; animal research ; brain ; diarrhea ; genes ; hemorrhagic enteritis ; histopathology ; intestinal mucosa ; meninges ; monitoring ; morbidity ; necropsy ; pneumonia ; pulmonary emphysema
    Language English
    Dates of publication 2022-06
    Size p. 748-753.
    Publishing place Agricultural Research Communication Centre
    Document type Article
    ISSN 0976-0555
    DOI 10.18805/IJAR.B-4488
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Monkeypox: A global threat to domestic and wild animals - Correspondence.

    Nikhil, K C / Rana, Jigyasa / Patel, Shailesh Kumar / Agrawal, Aditya / Govil, Kumar / Singh, Alok / Pandey, Megha Katare / Desai, Dhruv Nitinkumar / Tiwari, Sita Prasad

    International journal of surgery (London, England)

    2022  Volume 107, Page(s) 106974

    MeSH term(s) Animals ; Mpox (monkeypox) ; Animals, Wild
    Language English
    Publishing date 2022-10-31
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1016/j.ijsu.2022.106974
    Database MEDical Literature Analysis and Retrieval System OnLINE

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