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  1. Article ; Online: A versatile mouse model of COVID-19.

    Borrmann, Helene / Rigby, Rachel E

    Nature reviews. Immunology

    2020  Volume 20, Issue 8, Page(s) 460

    Keywords covid19
    Language English
    Publishing date 2020-06-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-020-0369-3
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  3. Article ; Online: A versatile mouse model of COVID-19

    Borrmann, Helene / Rigby, Rachel E.

    Nature Reviews Immunology

    2020  Volume 20, Issue 8, Page(s) 460–460

    Keywords Immunology ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-020-0369-3
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  4. Article ; Online: The Circadian Clock and Viral Infections.

    Borrmann, Helene / McKeating, Jane A / Zhuang, Xiaodong

    Journal of biological rhythms

    2020  Volume 36, Issue 1, Page(s) 9–22

    Abstract: The circadian clock controls several aspects of mammalian physiology and orchestrates the daily oscillations of biological processes and behavior. Our circadian rhythms are driven by an endogenous central clock in the brain that synchronizes with clocks ... ...

    Abstract The circadian clock controls several aspects of mammalian physiology and orchestrates the daily oscillations of biological processes and behavior. Our circadian rhythms are driven by an endogenous central clock in the brain that synchronizes with clocks in peripheral tissues, thereby regulating our immune system and the severity of infections. These rhythms affect the pharmacokinetics and efficacy of therapeutic agents and vaccines. The core circadian regulatory circuits and clock-regulated host pathways provide fertile ground to identify novel antiviral therapies. An increased understanding of the role circadian systems play in regulating virus infection and the host response to the virus will inform our clinical management of these diseases. This review provides an overview of the experimental and clinical evidence reporting on the interplay between the circadian clock and viral infections, highlighting the importance of virus-clock research.
    MeSH term(s) Animals ; CLOCK Proteins/genetics ; CLOCK Proteins/metabolism ; Circadian Clocks/physiology ; Circadian Rhythm/physiology ; Gene Expression ; Host-Pathogen Interactions/genetics ; Humans ; Virus Diseases/genetics ; Virus Diseases/metabolism ; Virus Diseases/virology ; Virus Replication/genetics ; Viruses/genetics ; Viruses/pathogenicity
    Chemical Substances CLOCK Proteins (EC 2.3.1.48)
    Keywords covid19
    Language English
    Publishing date 2020-11-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 896387-3
    ISSN 1552-4531 ; 0748-7304
    ISSN (online) 1552-4531
    ISSN 0748-7304
    DOI 10.1177/0748730420967768
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  5. Article ; Online: Inhibition of salt inducible kinases reduces rhythmic HIV-1 replication and reactivation from latency.

    Borrmann, Helene / Ismed, Dini / Kliszczak, Anna E / Borrow, Persephone / Vasudevan, Sridhar / Jagannath, Aarti / Zhuang, Xiaodong / McKeating, Jane A

    The Journal of general virology

    2023  Volume 104, Issue 8

    Abstract: Human immunodeficiency virus type 1 (HIV-1) causes a major burden on global health, and eradication of latent virus infection is one of the biggest challenges in the field. The circadian clock is an endogenous timing system that oscillates with a ~24 h ... ...

    Abstract Human immunodeficiency virus type 1 (HIV-1) causes a major burden on global health, and eradication of latent virus infection is one of the biggest challenges in the field. The circadian clock is an endogenous timing system that oscillates with a ~24 h period regulating multiple physiological processes and cellular functions, and we recently reported that the cell intrinsic clock regulates rhythmic HIV-1 replication. Salt inducible kinases (SIK) contribute to circadian regulatory networks, however, there is limited evidence for SIKs regulating HIV-1 infection. Here, we show that pharmacological inhibition of SIKs perturbed the cellular clock and reduced rhythmic HIV-1 replication in circadian synchronised cells. Further, SIK inhibitors or genetic silencing of
    MeSH term(s) Humans ; HIV-1/genetics ; HIV Infections ; Virus Latency/genetics ; Virus Replication
    Language English
    Publishing date 2023-08-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 219316-4
    ISSN 1465-2099 ; 0022-1317
    ISSN (online) 1465-2099
    ISSN 0022-1317
    DOI 10.1099/jgv.0.001877
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  6. Article ; Online: Time-of-Day Variation in SARS-CoV-2 RNA Levels during the Second Wave of COVID-19.

    Zhuang, Xiaodong / Wang, Wei / Borrmann, Helene / Balfe, Peter / Matthews, Philippa C / Eyre, David W / Klerman, Elizabeth B / McKeating, Jane A

    Viruses

    2022  Volume 14, Issue 8

    Abstract: Circadian rhythms influence and coordinate an organism's response to its environment and to invading pathogens. We studied the diurnal variation in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in nasal/throat swabs collected in late ... ...

    Abstract Circadian rhythms influence and coordinate an organism's response to its environment and to invading pathogens. We studied the diurnal variation in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in nasal/throat swabs collected in late 2020 to spring 2021 in a population immunologically naïve to SARS-CoV-2 and prior to widespread vaccination. SARS-CoV-2 diagnostic PCR data from 1698 participants showed a significantly higher viral load in samples obtained in the afternoon, in males, and in hospitalised patients when linear mixed modelling was applied. This study illustrates the importance of recording sample collection times when measuring viral replication parameters in clinical and research studies.
    MeSH term(s) COVID-19/diagnosis ; COVID-19 Testing ; Humans ; Male ; RNA, Viral/analysis ; RNA, Viral/genetics ; SARS-CoV-2/genetics ; Specimen Handling
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2022-08-05
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14081728
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  7. Article ; Online: Molecular components of the circadian clock regulate HIV-1 replication.

    Borrmann, Helene / Ulkar, Görkem / Kliszczak, Anna E / Ismed, Dini / Schilling, Mirjam / Magri, Andrea / Harris, James M / Balfe, Peter / Vasudevan, Sridhar / Borrow, Persephone / Zhuang, Xiaodong / McKeating, Jane A

    iScience

    2023  Volume 26, Issue 7, Page(s) 107007

    Abstract: Human immunodeficiency virus 1 (HIV-1) causes major health burdens worldwide and still lacks curative therapies and vaccines. Circadian rhythms are endogenous daily oscillations that coordinate an organism's response to its environment and invading ... ...

    Abstract Human immunodeficiency virus 1 (HIV-1) causes major health burdens worldwide and still lacks curative therapies and vaccines. Circadian rhythms are endogenous daily oscillations that coordinate an organism's response to its environment and invading pathogens. Peripheral viral loads of HIV-1 infected patients show diurnal variation; however, the underlying mechanisms remain unknown. Here, we demonstrate a role for the cell-intrinsic clock to regulate rhythmic HIV-1 replication in circadian-synchronized systems. Silencing the circadian activator
    Language English
    Publishing date 2023-05-29
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.107007
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  8. Article: The Circadian Clock and Viral Infections

    Borrmann, Helene / McKeating, Jane A / Zhuang, Xiaodong

    J Biol Rhythms

    Abstract: The circadian clock controls several aspects of mammalian physiology and orchestrates the daily oscillations of biological processes and behavior. Our circadian rhythms are driven by an endogenous central clock in the brain that synchronizes with clocks ... ...

    Abstract The circadian clock controls several aspects of mammalian physiology and orchestrates the daily oscillations of biological processes and behavior. Our circadian rhythms are driven by an endogenous central clock in the brain that synchronizes with clocks in peripheral tissues, thereby regulating our immune system and the severity of infections. These rhythms affect the pharmacokinetics and efficacy of therapeutic agents and vaccines. The core circadian regulatory circuits and clock-regulated host pathways provide fertile ground to identify novel antiviral therapies. An increased understanding of the role circadian systems play in regulating virus infection and the host response to the virus will inform our clinical management of these diseases. This review provides an overview of the experimental and clinical evidence reporting on the interplay between the circadian clock and viral infections, highlighting the importance of virus-clock research.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #916335
    Database COVID19

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  9. Article ; Online: Clocks, Viruses, and Immunity: Lessons for the COVID-19 Pandemic.

    Sengupta, Shaon / Ince, Louise / Sartor, Francesca / Borrmann, Helene / Zhuang, Xiaodong / Naik, Amruta / Curtis, Annie / McKeating, Jane A

    Journal of biological rhythms

    2021  Volume 36, Issue 1, Page(s) 23–34

    Abstract: Circadian rhythms are evolutionarily conserved anticipatory systems that allow the host to prepare and respond to threats in its environment. This article summarizes a European Biological Rhythms Society (EBRS) workshop held in July 2020 to review ... ...

    Abstract Circadian rhythms are evolutionarily conserved anticipatory systems that allow the host to prepare and respond to threats in its environment. This article summarizes a European Biological Rhythms Society (EBRS) workshop held in July 2020 to review current knowledge of the interplay between the circadian clock and viral infections to inform therapeutic strategies against SARS-CoV-2 and COVID-19. A large body of work supports the role of the circadian clock in regulating various aspects of viral replication, host responses, and associated pathogenesis. We review the evidence describing the multifaceted role of the circadian clock, spanning host susceptibility, antiviral mechanisms, and host resilience. Finally, we define the most pressing research questions and how our knowledge of chronobiology can inform key translational research priorities.
    MeSH term(s) Animals ; COVID-19/epidemiology ; COVID-19/immunology ; COVID-19/virology ; Circadian Clocks/physiology ; Circadian Rhythm/physiology ; Host-Pathogen Interactions/immunology ; Humans ; Immune System/immunology ; Immune System/metabolism ; Immune System/virology ; Pandemics ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; SARS-CoV-2/physiology ; Virus Replication/genetics ; Virus Replication/immunology
    Language English
    Publishing date 2021-01-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 896387-3
    ISSN 1552-4531 ; 0748-7304
    ISSN (online) 1552-4531
    ISSN 0748-7304
    DOI 10.1177/0748730420987669
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  10. Article ; Online: Hypoxia inducible factors inhibit respiratory syncytial virus infection by modulation of nucleolin expression

    Xiaodong Zhuang / Giulia Gallo / Parul Sharma / Jiyeon Ha / Andrea Magri / Helene Borrmann / James M. Harris / Senko Tsukuda / Eleanor Bentley / Adam Kirby / Simon de Neck / Hongbing Yang / Peter Balfe / Peter A.C. Wing / David Matthews / Adrian L. Harris / Anja Kipar / James P. Stewart / Dalan Bailey /
    Jane A. McKeating

    iScience, Vol 27, Iss 1, Pp 108763- (2024)

    2024  

    Abstract: Summary: Respiratory syncytial virus (RSV) is a global healthcare problem, causing respiratory illness in young children and elderly individuals. Our knowledge of the host pathways that define susceptibility to infection and disease severity are limited. ...

    Abstract Summary: Respiratory syncytial virus (RSV) is a global healthcare problem, causing respiratory illness in young children and elderly individuals. Our knowledge of the host pathways that define susceptibility to infection and disease severity are limited. Hypoxia inducible factors (HIFs) define metabolic responses to low oxygen and regulate inflammatory responses in the lower respiratory tract. We demonstrate a role for HIFs to suppress RSV entry and RNA replication. We show that hypoxia and HIF prolyl-hydroxylase inhibitors reduce the expression of the RSV entry receptor nucleolin and inhibit viral cell-cell fusion. We identify a HIF regulated microRNA, miR-494, that regulates nucleolin expression. In RSV-infected mice, treatment with the clinically approved HIF prolyl-hydroxylase inhibitor, Daprodustat, reduced the level of infectious virus and infiltrating monocytes and neutrophils in the lung. This study highlights a role for HIF-signalling to limit multiple aspects of RSV infection and associated inflammation and informs future therapeutic approaches for this respiratory pathogen.
    Keywords Molecular biology ; Omics ; Transcriptomics ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
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