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  1. Article: Taking one step further: five equity principles for hospitals to increase their value as anchor institutions.

    Allen, Matilda / Marmot, Michael / Allwood, Dominique

    Future healthcare journal

    2022  Volume 9, Issue 3, Page(s) 216–221

    Abstract: Hospitals have the potential to create value beyond the direct clinical care that they provide through tackling the social determinants of health as an 'anchor institution': shifting the way in which they employ staff; procure goods and services; use ... ...

    Abstract Hospitals have the potential to create value beyond the direct clinical care that they provide through tackling the social determinants of health as an 'anchor institution': shifting the way in which they employ staff; procure goods and services; use their physical and environmental resources and assets; and partner with others. However, the societal value of this work is not automatically or accidentally created, it must be intentionally designed and delivered, particularly if it is to tackle inequities. This article proposes five equity principles for healthcare leaders to consider in their hospitals' anchor institution work. There have already been important shifts from the 'traditional way' of conceiving of a hospital's role in the community, but going 'one step further' could help to maximise the equity impact.
    Language English
    Publishing date 2022-12-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 3016427-8
    ISSN 2514-6653 ; 2514-6645
    ISSN (online) 2514-6653
    ISSN 2514-6645
    DOI 10.7861/fhj.2022-0098
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A view from UK public health registrars on the challenges of COVID-19.

    Allen, Matilda / Braithwaite, Isobel / Collinson, Shelui / Oskrochi, Youssof / Basu, Anamika

    Lancet (London, England)

    2020  Volume 395, Issue 10240, Page(s) 1830

    Keywords covid19
    Language English
    Publishing date 2020-05-27
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(20)31058-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A view from UK public health registrars on the challenges of COVID-19

    Allen, Matilda / Braithwaite, Isobel / Collinson, Shelui / Oskrochi, Youssof / Basu, Anamika

    The Lancet

    2020  Volume 395, Issue 10240, Page(s) 1830

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/s0140-6736(20)31058-8
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Correction: Adverse clinical outcomes in people at clinical high-risk for psychosis related to altered interactions between hippocampal activity and glutamatergic function.

    Allen, Paul / Hird, Emily J / Orlov, Natasza / Modinos, Gemma / Bossong, Matthijs / Antoniades, Mathilde / Sampson, Carly / Azis, Matilda / Howes, Oliver / Stone, James / Perez, Jesus / Broome, Matthew / Grace, Anthony A / McGuire, Philip

    Translational psychiatry

    2021  Volume 11, Issue 1, Page(s) 607

    Language English
    Publishing date 2021-11-30
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2609311-X
    ISSN 2158-3188 ; 2158-3188
    ISSN (online) 2158-3188
    ISSN 2158-3188
    DOI 10.1038/s41398-021-01731-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Concentration-Dependent Inhibition of Mesophilic PETases on Poly(ethylene terephthalate) Can Be Eliminated by Enzyme Engineering.

    Avilan, Luisana / Lichtenstein, Bruce R / König, Gerhard / Zahn, Michael / Allen, Mark D / Oliveira, Liliana / Clark, Matilda / Bemmer, Victoria / Graham, Rosie / Austin, Harry P / Dominick, Graham / Johnson, Christopher W / Beckham, Gregg T / McGeehan, John E / Pickford, Andrew R

    ChemSusChem

    2023  Volume 16, Issue 8, Page(s) e202202277

    Abstract: Enzyme-based depolymerization is a viable approach for recycling of poly(ethylene terephthalate) (PET). PETase from Ideonella sakaiensis (IsPETase) is capable of PET hydrolysis under mild conditions but suffers from concentration-dependent inhibition. In ...

    Abstract Enzyme-based depolymerization is a viable approach for recycling of poly(ethylene terephthalate) (PET). PETase from Ideonella sakaiensis (IsPETase) is capable of PET hydrolysis under mild conditions but suffers from concentration-dependent inhibition. In this study, this inhibition is found to be dependent on incubation time, the solution conditions, and PET surface area. Furthermore, this inhibition is evident in other mesophilic PET-degrading enzymes to varying degrees, independent of the level of PET depolymerization activity. The inhibition has no clear structural basis, but moderately thermostable IsPETase variants exhibit reduced inhibition, and the property is completely absent in the highly thermostable HotPETase, previously engineered by directed evolution, which simulations suggest results from reduced flexibility around the active site. This work highlights a limitation in applying natural mesophilic hydrolases for PET hydrolysis and reveals an unexpected positive outcome of engineering these enzymes for enhanced thermostability.
    MeSH term(s) Polyethylene Terephthalates/chemistry ; Hydrolases ; Phthalic Acids/chemistry ; Ethylenes
    Chemical Substances terephthalic acid (6S7NKZ40BQ) ; Polyethylene Terephthalates ; Hydrolases (EC 3.-) ; Phthalic Acids ; Ethylenes
    Language English
    Publishing date 2023-03-23
    Publishing country Germany
    Document type Journal Article
    ISSN 1864-564X
    ISSN (online) 1864-564X
    DOI 10.1002/cssc.202202277
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Adverse clinical outcomes in people at clinical high-risk for psychosis related to altered interactions between hippocampal activity and glutamatergic function.

    Allen, Paul / Hird, Emily J / Orlov, Natasza / Modinos, Gemma / Bossong, Matthijs / Antoniades, Mathilde / Sampson, Carly / Azis, Matilda / Howes, Oliver / Stone, James / Perez, Jesus / Broome, Matthew / Grace, Anthony A / McGuire, Philip

    Translational psychiatry

    2021  Volume 11, Issue 1, Page(s) 579

    Abstract: Preclinical rodent models suggest that psychosis involves alterations in the activity and glutamatergic function in the hippocampus, driving dopamine activity through projections to the striatum. The extent to which this model applies to the onset of ... ...

    Abstract Preclinical rodent models suggest that psychosis involves alterations in the activity and glutamatergic function in the hippocampus, driving dopamine activity through projections to the striatum. The extent to which this model applies to the onset of psychosis in clinical subjects is unclear. We assessed whether interactions between hippocampal glutamatergic function and activity/striatal connectivity are associated with adverse clinical outcomes in people at clinical high-risk (CHR) for psychosis. We measured functional Magnetic Resonance Imaging of hippocampal activation/connectivity, and
    MeSH term(s) Corpus Striatum ; Hippocampus/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Psychotic Disorders/diagnostic imaging
    Language English
    Publishing date 2021-11-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2609311-X
    ISSN 2158-3188 ; 2158-3188
    ISSN (online) 2158-3188
    ISSN 2158-3188
    DOI 10.1038/s41398-021-01705-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Interactions between hippocampal activity and striatal dopamine in people at clinical high risk for psychosis: relationship to adverse outcomes.

    Modinos, Gemma / Richter, Anja / Egerton, Alice / Bonoldi, Ilaria / Azis, Matilda / Antoniades, Mathilde / Bossong, Matthijs / Crossley, Nicolas / Perez, Jesus / Stone, James M / Veronese, Mattia / Zelaya, Fernando / Grace, Anthony A / Howes, Oliver D / Allen, Paul / McGuire, Philip

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

    2021  Volume 46, Issue 8, Page(s) 1468–1474

    Abstract: Preclinical models propose that increased hippocampal activity drives subcortical dopaminergic dysfunction and leads to psychosis-like symptoms and behaviors. Here, we used multimodal neuroimaging to examine the relationship between hippocampal regional ... ...

    Abstract Preclinical models propose that increased hippocampal activity drives subcortical dopaminergic dysfunction and leads to psychosis-like symptoms and behaviors. Here, we used multimodal neuroimaging to examine the relationship between hippocampal regional cerebral blood flow (rCBF) and striatal dopamine synthesis capacity in people at clinical high risk (CHR) for psychosis and investigated its association with subsequent clinical and functional outcomes. Ninety-five participants (67 CHR and 28 healthy controls) underwent arterial spin labeling MRI and
    MeSH term(s) Corpus Striatum/diagnostic imaging ; Dopamine ; Hippocampus/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Psychotic Disorders/diagnostic imaging
    Chemical Substances Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2021-05-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639471-1
    ISSN 1740-634X ; 0893-133X
    ISSN (online) 1740-634X
    ISSN 0893-133X
    DOI 10.1038/s41386-021-01019-0
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    Zs.A 2379: Show issues Location:
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  9. Article ; Online: The Relationship Between Grey Matter Volume and Clinical and Functional Outcomes in People at Clinical High Risk for Psychosis.

    Tognin, Stefania / Richter, Anja / Kempton, Matthew J / Modinos, Gemma / Antoniades, Mathilde / Azis, Matilda / Allen, Paul / Bossong, Matthijs G / Perez, Jesus / Pantelis, Christos / Nelson, Barnaby / Amminger, Paul / Riecher-Rössler, Anita / Barrantes-Vidal, Neus / Krebs, Marie-Odile / Glenthøj, Birte / Ruhrmann, Stephan / Sachs, Gabriele / Rutten, Bart P F /
    de Haan, Lieuwe / van der Gaag, Mark / Valmaggia, Lucia R / McGuire, Philip

    Schizophrenia bulletin open

    2022  Volume 3, Issue 1, Page(s) sgac040

    Abstract: Objective: To examine the association between baseline alterations in grey matter volume (GMV) and clinical and functional outcomes in people at clinical high risk (CHR) for psychosis.: Methods: 265 CHR individuals and 92 healthy controls were ... ...

    Abstract Objective: To examine the association between baseline alterations in grey matter volume (GMV) and clinical and functional outcomes in people at clinical high risk (CHR) for psychosis.
    Methods: 265 CHR individuals and 92 healthy controls were recruited as part of a prospective multi-center study. After a baseline assessment using magnetic resonance imaging (MRI), participants were followed for at least two years to determine clinical and functional outcomes, including transition to psychosis (according to the Comprehensive Assessment of an At Risk Mental State, CAARMS), level of functioning (according to the Global Assessment of Functioning), and symptomatic remission (according to the CAARMS). GMV was measured in selected cortical and subcortical regions of interest (ROI) based on previous studies (ie orbitofrontal gyrus, cingulate gyrus, gyrus rectus, inferior temporal gyrus, parahippocampal gyrus, striatum, and hippocampus). Using voxel-based morphometry, we analysed the relationship between GMV and clinical and functional outcomes.
    Results: Within the CHR sample, a poor functional outcome (GAF < 65) was associated with relatively lower GMV in the right striatum at baseline (
    Conclusions: In CHR individuals, lower striatal GMV was associated with a poor level of overall functioning at follow-up. This finding was not related to effects of antipsychotic or antidepressant medication. The failure to replicate previous associations between GMV and later psychosis onset, despite studying a relatively large sample, is consistent with the findings of recent large-scale multi-center studies.
    Language English
    Publishing date 2022-06-20
    Publishing country United States
    Document type Journal Article
    ISSN 2632-7899
    ISSN (online) 2632-7899
    DOI 10.1093/schizbullopen/sgac040
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  10. Article ; Online: Humane orientation, work-family conflict, and positive spillover across cultures.

    Beham, Barbara / Ollier-Malaterre, Ariane / Allen, Tammy D / Baierl, Andreas / Alexandrova, Matilda / Artiawati / Beauregard, T Alexandra / Carvalho, Vânia Sofia / Chambel, Maria José / Cho, Eunae / Coden da Silva, Bruna / Dawkins, Sarah / Escribano, Pablo I / Gudeta, Konjit Hailu / Huang, Ting-Pang / Jaga, Ameeta / Kost, Dominique / Kurowska, Anna / Leon, Emmanuelle /
    Lewis, Suzan / Lu, Chang-Qin / Martin, Angela / Morandin, Gabriele / Noboa, Fabrizio / Offer, Shira / Ohu, Eugene / Peters, Pascale / Rajadhyaksha, Ujvala / Russo, Marcello / Sohn, Young Woo / Straub, Caroline / Tammelin, Mia / Triki, Leila / van Engen, Marloes L / Waismel-Manor, Ronit

    The Journal of applied psychology

    2023  Volume 108, Issue 10, Page(s) 1573–1597

    Abstract: Although cross-national work-family research has made great strides in recent decades, knowledge accumulation on the impact of culture on the work-family interface has been hampered by a limited geographical and cultural scope that has excluded countries ...

    Abstract Although cross-national work-family research has made great strides in recent decades, knowledge accumulation on the impact of culture on the work-family interface has been hampered by a limited geographical and cultural scope that has excluded countries where cultural expectations regarding work, family, and support may differ. We advance this literature by investigating work-family relationships in a broad range of cultures, including understudied regions of the world (i.e., Sub-Saharan Africa, Southern Asia). We focus on humane orientation (HO), an overlooked cultural dimension that is however central to the study of social support and higher in those regions. We explore its moderating effect on relationships between work and family social support, work-family conflict, and work-family positive spillover. Building on the congruence and compensation perspectives of fit theory, we test alternative hypotheses on a sample of 10,307 participants from 30 countries/territories. We find HO has mostly a compensatory role in the relationships between workplace support and work-to-family conflict. Specifically, supervisor and coworker supports were most strongly and negatively related to conflict in cultures in which support is most needed (i.e., lower HO cultures). Regarding positive spillover, HO has mostly an amplifying role. Coworker (but not supervisor) support was most strongly and positively related to work-to-family positive spillover in higher HO cultures, where providing social support at work is consistent with the societal practice of providing support to one another. Likewise, instrumental (but not emotional) family support was most strongly and positively related to family-to-work positive spillover in higher HO cultures. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
    MeSH term(s) Humans ; Family Conflict ; Conflict, Psychological ; Family Relations ; Social Support ; Workplace
    Language English
    Publishing date 2023-06-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219157-x
    ISSN 1939-1854 ; 0021-9010
    ISSN (online) 1939-1854
    ISSN 0021-9010
    DOI 10.1037/apl0001093
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