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Article ; Online: FoxP3 associates with enhancer-promoter loops to regulate T

Ramirez, Ricardo N / Chowdhary, Kaitavjeet / Leon, Juliette / Mathis, Diane / Benoist, Christophe

Science immunology

2022 Volume 7, Issue 67, Page(s) eabj9836

Abstract: Gene expression programs are specified by higher-order chromatin structure and enhancer-promoter loops (EPLs). T regulatory cell ( ... ...

Abstract	Gene expression programs are specified by higher-order chromatin structure and enhancer-promoter loops (EPLs). T regulatory cell (T
MeSH term(s)	Animals ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/immunology ; Gene Expression Regulation/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Promoter Regions, Genetic/genetics ; T-Lymphocytes, Regulatory/immunology
Chemical Substances	Forkhead Transcription Factors ; Foxp3 protein, mouse
Language	English
Publishing date	2022-01-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2470-9468
ISSN (online)	2470-9468
DOI	10.1126/sciimmunol.abj9836
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Article ; Online: A perspective into the relationships between amphibian (

Hossainey, Muhammad Riadul Haque / Hauser, Kelsey A / Garvey, Christina N / Kalia, Namarta / Garvey, Juliette M / Grayfer, Leon

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

2023 Volume 378, Issue 1882, Page(s) 20220124

Abstract: Macrophage ( ... ...

Abstract	Macrophage (M
MeSH term(s)	Animals ; Xenopus laevis ; Myeloid Cells ; Anura ; Macrophages ; Leukocytes ; Mammals
Chemical Substances	1,4-bis(3-carboxy-4-hydroxyphenylethenyl)-benzene
Language	English
Publishing date	2023-06-12
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	208382-6
ISSN	1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
ISSN (online)	1471-2970
ISSN	0080-4622 ; 0264-3839 ; 0962-8436
DOI	10.1098/rstb.2022.0124
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Article ; Online: Letter: is the AHHS score really useful in clinically severe alcoholic hepatitis?

Buchard, Benjamin / Sévigné, Luc / Darcha, Claude / Muti, Leon / Joubert, Juliette / Abergel, Armand

Alimentary pharmacology & therapeutics

2021 Volume 53, Issue 10, Page(s) 1160–1161

MeSH term(s)	Hepatitis, Alcoholic/diagnosis ; Histological Techniques ; Humans ; Liver Cirrhosis ; Prognosis
Language	English
Publishing date	2021-04-21
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	639012-2
ISSN	1365-2036 ; 0269-2813 ; 0953-0673
ISSN (online)	1365-2036
ISSN	0269-2813 ; 0953-0673
DOI	10.1111/apt.16307
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Article ; Online: Mutations from patients with IPEX ported to mice reveal different patterns of FoxP3 and Treg dysfunction.

Leon, Juliette / Chowdhary, Kaitavjeet / Zhang, Wenxiang / Ramirez, Ricardo N / André, Isabelle / Hur, Sun / Mathis, Diane / Benoist, Christophe

Cell reports

2023 Volume 42, Issue 8, Page(s) 113018

Abstract: Mutations of the transcription factor FoxP3 in patients with "IPEX" (immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome) disrupt regulatory T cells (Treg), causing an array of multiorgan autoimmunity. To understand the functional ... ...

Abstract	Mutations of the transcription factor FoxP3 in patients with "IPEX" (immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome) disrupt regulatory T cells (Treg), causing an array of multiorgan autoimmunity. To understand the functional impact of mutations across FoxP3 domains, without genetic and environmental confounders, six human FOXP3 missense mutations are engineered into mice. Two classes of mutations emerge from combined immunologic and genomic analyses. A mutation in the DNA-binding domain shows the same lymphoproliferation and multiorgan infiltration as complete FoxP3 knockouts but delayed by months. Tregs expressing this mutant FoxP3 are destabilized by normal Tregs in heterozygous females compared with hemizygous males. Mutations in other domains affect chromatin opening differently, involving different cofactors and provoking more specific autoimmune pathology (dermatitis, colitis, diabetes), unmasked by immunological challenges or incrossing NOD autoimmune-susceptibility alleles. This work establishes that IPEX disease heterogeneity results from the actual mutations, combined with genetic and environmental perturbations, explaining then the intra-familial variation in IPEX.
MeSH term(s)	Animals ; Female ; Humans ; Male ; Mice ; Alleles ; Forkhead Transcription Factors/genetics ; Mice, Inbred NOD ; Mutation/genetics ; T-Lymphocytes, Regulatory
Chemical Substances	Forkhead Transcription Factors ; FOXP3 protein, human
Language	English
Publishing date	2023-08-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2023.113018
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Article: Establishment of an Inactivation Method for Ebola Virus and SARS-CoV-2 Suitable for Downstream Sequencing of Low Cell Numbers.

Olejnik, Judith / Leon, Juliette / Michelson, Daniel / Chowdhary, Kaitavjeet / Galvan-Pena, Silvia / Benoist, Christophe / Mühlberger, Elke / Hume, Adam J

Pathogens (Basel, Switzerland)

2023 Volume 12, Issue 2

Abstract: Technologies that facilitate the bulk sequencing of small numbers of cells as well as single-cell RNA sequencing (scRNA-seq) have aided greatly in the study of viruses as these analyses can be used to differentiate responses from infected versus ... ...

Abstract	Technologies that facilitate the bulk sequencing of small numbers of cells as well as single-cell RNA sequencing (scRNA-seq) have aided greatly in the study of viruses as these analyses can be used to differentiate responses from infected versus bystander cells in complex systems, including in organoid or animal studies. While protocols for these analyses are typically developed with biosafety level 2 (BSL-2) considerations in mind, such analyses are equally useful for the study of viruses that require higher biosafety containment levels. Many of these workstreams, however, are not directly compatible with the more stringent biosafety regulations of BSL-3 and BSL-4 laboratories ensuring virus inactivation and must therefore be modified. Here we show that TCL buffer (Qiagen), which was developed for bulk sequencing of small numbers of cells and also facilitates scRNA-seq, inactivates both Ebola virus (EBOV) and SARS-CoV-2, BSL-4 and BSL-3 viruses, respectively. We show that additional heat treatment, necessary for the more stringent biosafety concerns for BSL-4-derived samples, was additionally sufficient to inactivate EBOV-containing samples. Critically, this heat treatment had minimal effects on extracted RNA quality and downstream sequencing results.
Language	English
Publishing date	2023-02-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens12020342
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Article ; Online: Complement-driven hemolytic uremic syndrome.

Leon, Juliette / LeStang, Marie-Bénédicte / Sberro-Soussan, Rebecca / Servais, Aude / Anglicheau, Dany / Frémeaux-Bacchi, Véronique / Zuber, Julien

American journal of hematology

2023 Volume 98 Suppl 4, Page(s) S44–S56

Abstract: Overactivation of the complement alternative pathway drives the pathogenesis of primary atypical hemolytic uremic syndrome (aHUS). Genetically-determined or acquired dysregulation of the complement is frequently identified in patients with aHUS, ... ...

Abstract	Overactivation of the complement alternative pathway drives the pathogenesis of primary atypical hemolytic uremic syndrome (aHUS). Genetically-determined or acquired dysregulation of the complement is frequently identified in patients with aHUS, pregnancy-related hemolytic uremic syndrome (HUS), and severe hypertension-associated HUS. In contrast, it is still unclear whether self-limited complement activation, which frequently occurs in other forms of HUS, provides key mechanistic clues or results from endothelial damage. Development of novel biomarkers is underway to firmly establish complement-driven pathogenesis. C5 blockade therapy has revolutionized the management of aHUS patients, resulting in a halving of the subpopulation under chronic dialysis over the course of a few years. On the other hand, the efficacy of C5 blockade in secondary forms of HUS, as assessed by small and uncontrolled case series, is less compelling and should be investigated through properly designed prospective clinical trials. The increased risk of meningococcal infection, related to C5 inhibition, must be rigorously addressed with suitable prophylaxis. Treatment duration should be determined based on an individualized benefit/risk assessment.
MeSH term(s)	Humans ; Prospective Studies ; Atypical Hemolytic Uremic Syndrome/therapy ; Complement Activation ; Risk Factors ; Biomarkers
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-01-22
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	196767-8
ISSN	1096-8652 ; 0361-8609
ISSN (online)	1096-8652
ISSN	0361-8609
DOI	10.1002/ajh.26854
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Article ; Online: Zootoxins and Domestic Animals: A European View.

Nagy, Andras-Laszlo / Ardelean, Sabrina / Chapuis, Ronan J J / Bouillon, Juliette / Pivariu, Dalma / De Felice, Beatrice / Bertazzo, Mirko / Fossati, Paola / Spicer, Leon J / Dreanca, Alexandra Iulia / Caloni, Francesca

Toxins

2024 Volume 16, Issue 1

Abstract: Zootoxins are produced by venomous and poisonous species and are an important cause of poisoning in companion animals and livestock in Europe. Little information about the incidence of zootoxin poisoning is available in Europe, with only a few case ... ...

Abstract	Zootoxins are produced by venomous and poisonous species and are an important cause of poisoning in companion animals and livestock in Europe. Little information about the incidence of zootoxin poisoning is available in Europe, with only a few case reports and review papers being published. This review presents the most important zootoxins produced by European venomous and poisonous animal species responsible for poisoning episodes in companion animals and livestock. The main zootoxin-producing animal species, components of the toxins/venoms and their clinical effects are presented. The most common zootoxicoses involve terrestrial zootoxins excreted by the common toad, the fire salamander, the pine processionary caterpillar, and vipers. The lack of a centralized reporting/poison control system in Europe makes the evaluation of the epidemiology of zootoxin-induced poisonings extremely difficult. Even if there are many anecdotal reports in the veterinary community about the exposure of domestic animals to terrestrial and marine zootoxins, the number of published papers regarding these toxicoses is low. Climate change and its consequences regarding species distribution and human-mediated transportation are responsible for the emerging nature of some intoxications in which zootoxins are involved. Although new venomous or poisonous animal species have emerged in regions where they were previously unreported, zootoxins produced by native species remain the main concern in Europe. The diversity of poisonous and venomous animal species and the emerging nature of certain poisonings warrant the continuous update to such knowledge by veterinary professionals and animal owners. This review offers an overview about zootoxin-related poisonings in domestic animals in Europe and also provides important information from a health perspective.
MeSH term(s)	Animals ; Humans ; Animals, Domestic ; Climate Change ; Europe/epidemiology ; Livestock
Language	English
Publishing date	2024-01-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518395-3
ISSN	2072-6651 ; 2072-6651
ISSN (online)	2072-6651
ISSN	2072-6651
DOI	10.3390/toxins16010048
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Article ; Online: De novo posttransplant membranous nephropathy following BNT162b2 mRNA COVID-19 vaccine in a kidney transplant recipient.

Chavarot, Nathalie / Padden, Michael / Amrouche, Lucile / Malard, Stéphanie / Scemla, Anne / Sberro-Soussan, Rebecca / Léon, Juliette / Legendre, Christophe / Duong, Jean Paul / Zuber, Julien / Anglicheau, Dany / Rabant, Marion / Isnard, Pierre

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

2022 Volume 22, Issue 12, Page(s) 3188–3189

MeSH term(s)	Humans ; BNT162 Vaccine ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Glomerulonephritis, Membranous/etiology ; Kidney Transplantation/adverse effects ; RNA, Messenger
Chemical Substances	BNT162 Vaccine ; COVID-19 Vaccines ; RNA, Messenger
Language	English
Publishing date	2022-08-24
Publishing country	United States
Document type	Letter
ZDB-ID	2060594-8
ISSN	1600-6143 ; 1600-6135
ISSN (online)	1600-6143
ISSN	1600-6135
DOI	10.1111/ajt.17166
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Article ; Online: Does Kono-S Anastomosis Reduce Recurrence in Crohn's Disease Compared with Conventional Ileocolonic Anastomosis? A Nationwide Propensity Score-matched Study from GETAID Chirurgie Group [KoCoRICCO Study].

Alibert, Line / Betton, Louis / Falcoz, Antoine / Manceau, Gilles / Benoist, Stéphane / Zerbib, Philippe / Podevin, Juliette / Maggiori, Léon / Brouquet, Antoine / Tyrode, Gaëlle / Vuitton, Lucine / Vernerey, Dewi / Lefevre, Jérémie H / Lakkis, Zaher

Journal of Crohn's & colitis

2023 Volume 18, Issue 4, Page(s) 525–532

Abstract: Background and aims: Postoperative recurrence is a major concern in Crohn's disease. The Kono-S anastomosis has been described to reduce the rate of recurrence. However, the level of evidence for its effectiveness remains low. The KoCoRICCO study aimed ... ...

Abstract	Background and aims: Postoperative recurrence is a major concern in Crohn's disease. The Kono-S anastomosis has been described to reduce the rate of recurrence. However, the level of evidence for its effectiveness remains low. The KoCoRICCO study aimed to compare outcomes between Kono-S anastomosis and conventional anastomosis in two nationwide, prospective cohorts. Methods: Adult patients with Crohn's disease, who underwent ileocolonic resection with Kono-S anastomosis, were prospectively included in seven referral centres between 2020 and 2022. Patients with conventional side-to-side anastomosis were enrolled from a previously published cohort. A propensity score analysis was performed to compare recurrence at first endoscopy in a matched 1:2 ratio population. Results: A total of 433 patients with ileocolonic anastomosis were enrolled, of whom 155 had a Kono-S anastomosis. Before matching, both groups were unbalanced for preoperative, intraoperative, and postoperative characteristics. After matching patients with available endoscopic follow-up, endoscopic recurrence ≥i2 was found in 47.5% of the Kono-S group and 44.3% of the conventional side-to-side group [p = 0.6745]. Conclusions: The KoCoRICCO study suggests that Kono-S anastomosis does not reduce the risk of endoscopic recurrence in Crohn's disease compared with conventional side-to-side anastomosis. Further research with a longer follow-up is necessary to determine whether there is a potential benefit on surgical recurrence.
MeSH term(s)	Humans ; Crohn Disease/surgery ; Anastomosis, Surgical/methods ; Male ; Female ; Propensity Score ; Adult ; Ileum/surgery ; Recurrence ; Colon/surgery ; Colon/pathology ; Prospective Studies ; Middle Aged
Language	English
Publishing date	2023-10-18
Publishing country	England
Document type	Journal Article ; Comparative Study ; Multicenter Study
ZDB-ID	2390120-2
ISSN	1876-4479 ; 1873-9946
ISSN (online)	1876-4479
ISSN	1873-9946
DOI	10.1093/ecco-jcc/jjad176
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Article ; Online: Design and Biochemical Characterization of Peptidic Inhibitors of the Myb/p300 Interaction.

Jones, Matthew / Grosche, Philipp / Floersheimer, Andreas / André, Jérome / Gattlen, Raphael / Oser, Dieter / Tinchant, Juliette / Wille, Roman / Chie-Leon, Barbara / Gerspacher, Marc / Ertl, Peter / Ostermann, Nils / Altmann, Eva / Manchado, Eusebio / Vorherr, Thomas / Chène, Patrick

Biochemistry

2023 Volume 62, Issue 7, Page(s) 1321–1329

Abstract: The Myb transcription factor is involved in the proliferation of hematopoietic cells, and deregulation of its expression can lead to cancers such as leukemia. Myb interacts with various proteins, including the histone acetyltransferases p300 and CBP. Myb ...

Abstract	The Myb transcription factor is involved in the proliferation of hematopoietic cells, and deregulation of its expression can lead to cancers such as leukemia. Myb interacts with various proteins, including the histone acetyltransferases p300 and CBP. Myb binds to a small domain of p300, the KIX domain (p300
MeSH term(s)	Peptides/pharmacology ; Protein Binding ; Proto-Oncogene Proteins c-myb/antagonists & inhibitors ; Proto-Oncogene Proteins c-myb/chemistry ; E1A-Associated p300 Protein/antagonists & inhibitors ; E1A-Associated p300 Protein/chemistry
Chemical Substances	Peptides ; Proto-Oncogene Proteins c-myb ; E1A-Associated p300 Protein (EC 2.3.1.48)
Language	English
Publishing date	2023-03-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1108-3
ISSN	1520-4995 ; 0006-2960
ISSN (online)	1520-4995
ISSN	0006-2960
DOI	10.1021/acs.biochem.2c00690
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