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Article ; Online: Neuroprotective, Anti-Inflammatory and Antifibrillogenic Offerings by Emodin against Alzheimer's Dementia: A Systematic Review.

Saha, Priyanka / Ahmad, Faraz

ACS omega

2024 Volume 9, Issue 7, Page(s) 7296–7309

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c07178
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Article ; Online: Towards sorptive eradication of pharmaceutical micro-pollutant ciprofloxacin from aquatic environment: A comprehensive review.

Khan, Priyanka / Saha, Rajnarayan / Halder, Gopinath

The Science of the total environment

2024 Volume 919, Page(s) 170723

Abstract: Antibiotics are widely prioritized pharmaceuticals frequently adopted in medication for addressing numerous ailments of humans and animals. However, the non-judicious disposal of ciprofloxacin (CIP) with concentration levels exceeding threshold limit in ... ...

Abstract	Antibiotics are widely prioritized pharmaceuticals frequently adopted in medication for addressing numerous ailments of humans and animals. However, the non-judicious disposal of ciprofloxacin (CIP) with concentration levels exceeding threshold limit in an aqueous environment has been the matter of growing concern nowadays. CIP is found in various waterways with appreciable mobility due to its limited decay in solidified form. Hence, the effective eradication strategy of this non-steroidal anti-inflammatory antibiotic from aqueous media is pivotal for preventing the users and the biosphere from their hazardous impacts. Reportedly several customary techniques like reverse osmosis, precipitation, cross-filtration, nano-filtration, ion exchange, microbial remediation, and adsorption have been employed to eliminate CIP from water. Out of them, adsorption is ascertained to be a potential method because of lesser preliminary investment costs, ease of operation, greater efficiency, less energy usage, reduced chemical and biological slurry production, and ready availability of precursor materials. Towards remediation of ciprofloxacin-laden water, plenty of researchers have used different adsorbents. However, the present-day challenge is opting the promising sorbent and its application towards industrial scale-up which is vital to get reviewed. In this article, adsorbents of diverse origins are reviewed in terms of their performances in CIP removal. The review stresses the impact of various factors on sorptive assimilation of CIP, adsorption kinetics, isotherms, mechanism of ionic interaction, contrivances for CIP detection, cost estimation and reusability assessments of adsorbents also that may endorse the next-generation investigators to decide the efficacious, environmental appealing and cost-competitive adsorbents for effective riddance of CIP from wastewater.
MeSH term(s)	Humans ; Ciprofloxacin/analysis ; Anti-Bacterial Agents ; Wastewater ; Adsorption ; Water ; Pharmaceutical Preparations ; Water Pollutants, Chemical/analysis
Chemical Substances	Ciprofloxacin (5E8K9I0O4U) ; Anti-Bacterial Agents ; Wastewater ; Water (059QF0KO0R) ; Pharmaceutical Preparations ; Water Pollutants, Chemical
Language	English
Publishing date	2024-02-08
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2024.170723
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Article ; Online: The Potential of Epigallocatechin Gallate in Targeting Cancer Stem Cells: A Comprehensive Review.

Chaudhuri, Rupa / Samanta, Anurima / Saha, Priyanka / Ghosh, Sukanya / Sinha, Dona

Current medicinal chemistry

2024

Abstract: The dreadful scenario of cancer prevails due to the presence of cancer stem cells (CSCs), which contribute to tumor growth, metastasis, invasion, resistance to chemo- and radiotherapy, and recurrence. CSCs are a small subpopulation of cells within the ... ...

Abstract	The dreadful scenario of cancer prevails due to the presence of cancer stem cells (CSCs), which contribute to tumor growth, metastasis, invasion, resistance to chemo- and radiotherapy, and recurrence. CSCs are a small subpopulation of cells within the tumor that are characterized by self-renewal capability and have the potential to manifest heterogeneous lineages of cancer cells that constitute the tumor. The major bioactive green tea polyphenol (-)-epigallocatechin gallate (EGCG) has been fruitful in downgrading cancer stemness signaling and CSC biomarkers in cancer progression. EGCG has been evidenced to maneuver extrinsic and intrinsic apoptotic pathways in order to decrease the viability of CSCs. Cancer stemness is intricately related to epithelial-mesenchymal transition (EMT), metastasis and therapy resistance, and EGCG has been evidenced to regress all these CSC-related effects. By inhibiting CSC characteristics EGCG has also been evidenced to sensitize the tumor cells to radiotherapy and chemotherapy. However, the use of EGCG in in vitro and in vivo cancer models raises concern about its bioavailability, stability and efficacy against spheroids raised from parental cells. Therefore, novel nano formulations of EGCG and adjuvant therapy of EGCG with other phytochemicals or drugs or small molecules may have a better prospect in targeting CSCs. However, extensive clinical research is still awaited to elucidate a full proof impact of EGCG in cancer therapy.
Language	English
Publishing date	2024-01-17
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/0109298673281666231227053726
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Article: Investigation of gate-engineered heterostructure tunnel field effect transistor as a label-free biosensor: a compact study.

Ghosh, Rittik / Karmakar, Ananya / Saha, Priyanka

Applied physics. A, Materials science & processing

2023 Volume 129, Issue 2, Page(s) 94

Abstract: In this article, the authors have articulated DC as well as transient response of a dielectric modulated gate-engineered heterostructure tunnel field effect transistor (GE-HTFET)-based biosensor for label-free detection. A low (direct) bandgap material, ... ...

Abstract	In this article, the authors have articulated DC as well as transient response of a dielectric modulated gate-engineered heterostructure tunnel field effect transistor (GE-HTFET)-based biosensor for label-free detection. A low (direct) bandgap material, indium arsenide (InAs) has been selectively used in the source region to achieve improved band-to-band tunneling of carriers in the tunnel FET. The extended gate architecture is incorporated to stabilize the biomolecules in the nano-cavity aiding significant boost in ON current sensitivity. Using SILVACO ATLAS TCAD tool, the sensitivity of the biosensor is evaluated considering two important parameters possessed by bio-targets, i.e. dielectric constant (
Language	English
Publishing date	2023-01-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1398311-8
ISSN	1432-0630 ; 0947-8396
ISSN (online)	1432-0630
ISSN	0947-8396
DOI	10.1007/s00339-023-06393-8
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Article ; Online: Direct Shoot From Root and True-to-Type Micropropagation of Limonium "Misty Blue" in Partially Immersed Culture on an Aluminum Mesh Raft.

Raha, Priyanka / Saha, Gourab / Khatua, Ishita / Bandyopadhyay, Tapas Kumar

Methods in molecular biology (Clifton, N.J.)

2024 Volume 2759, Page(s) 107–130

Abstract: Commercial plant tissue culture now primarily serves the ornamental horticulture industry. The main pillars of the commercial tissue culture business are scalability of production, cost reduction, limited labor involvement, high quality, and genetic ... ...

Abstract	Commercial plant tissue culture now primarily serves the ornamental horticulture industry. The main pillars of the commercial tissue culture business are scalability of production, cost reduction, limited labor involvement, high quality, and genetic homogeneity of propagated plants. Based on these requirements, the current protocol employs a partially immersed liquid culture medium supported by a flexible aluminum mesh raft with a wire stand to facilitate shoot organogenesis from the horizontally placed root explants and hold the plants upright for shoot multiplication and rooting of Limonium Misty Blue. It is a florist crop that is in high demand as both dried and fresh flower fillers in various floral decorations. The majority of cultivated Limonium or statice cultivars are heterozygous in nature and propagate commercially through in vitro propagation to cater to the huge demand for planting materials needed for flower production. This is the first protocol to describe direct shoot organogenesis from the roots in a liquid half-component of Murashige and Skoog's (1962) (MS) basal medium supplemented with 1.6 μM NAA and 1.1 μM BA. The regenerated shoots are multiplied and rooted at the same time on the raft in a MS-based liquid culture medium that included 0.44 μM BA and 1.07 μM NAA. In comparison to agar-gelled medium, plants cultured in liquid medium grow more quickly without any signs of hyperhydricity. In liquid medium, a clump of 4-5 shoots is formed from a single shoot explant within 4 weeks and are rooted simultaneously within 6 weeks. On average, seven explants may fit on each raft, so on average, 25 healthy plants are produced from a single bottle. The regenerated plants are easily hardened in the greenhouse, and using ISSR-based molecular markers, the genetic homogeneity of the randomly selected hardened plants can be determined.
MeSH term(s)	Aluminum ; Plumbaginaceae ; Commerce ; Culture Media ; Dietary Supplements
Chemical Substances	Aluminum (CPD4NFA903) ; Culture Media
Language	English
Publishing date	2024-01-29
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-3654-1_11
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Article ; Online: Occurrence of L1014F and L1014S mutations in insecticide resistant Culex quinquefasciatus from filariasis endemic districts of West Bengal, India.

Rai, Priyanka / Saha, Dhiraj

publication RETRACTED

PLoS neglected tropical diseases

2022 Volume 16, Issue 1, Page(s) e0010000

Abstract: Introduction: Lymphatic filariasis causes long term morbidity and hampers the socio-economic status. Apart from the available treatments and medication, control of vector population Culex quinquefasciatus Say through the use of chemical insecticides is ... ...

Abstract	Introduction: Lymphatic filariasis causes long term morbidity and hampers the socio-economic status. Apart from the available treatments and medication, control of vector population Culex quinquefasciatus Say through the use of chemical insecticides is a widely applied strategy. However, the unrestrained application of these insecticides over many decades has led to resistance development in the vectors. Methods: In order to determine the insecticide susceptibility/resistance status of Cx. quinquefasciatus from two filariasis endemic districts of West Bengal, India, wild mosquito populations were collected and assayed against six different insecticides and presence of L1014F; L1014S kdr mutations in the voltage-gated sodium channel gene was also screened along with the use of synergists to evaluate the role of major detoxifying enzymes in resistance development. Results: The collected mosquito populations showed severe resistance to insecticides and the two synergists used-PBO (piperonyl butoxide) and TPP (triphenyl phosphate), were unable to restore the susceptibility status of the vector thereupon pointing towards a minor role of metabolic enzymes. kdr mutations were present in the studied populations in varying percent with higher L1014F frequency indicating its association with the observed resistance to pyrethroids and DDT. This study reports L1014S mutation in Cx. quinquefasciatus for the first time.
MeSH term(s)	Animals ; Culex/drug effects ; Culex/genetics ; Endemic Diseases ; Female ; Filariasis/transmission ; India/epidemiology ; Insecticide Resistance ; Insecticides/pharmacology ; Mosquito Vectors/drug effects ; Mosquito Vectors/genetics ; Mutation ; Pesticide Synergists/pharmacology
Chemical Substances	Insecticides ; Pesticide Synergists
Language	English
Publishing date	2022-01-13
Publishing country	United States
Document type	Journal Article ; Retracted Publication
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2735
ISSN (online)	1935-2735
ISSN	1935-2735
DOI	10.1371/journal.pntd.0010000
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Article ; Online: Concat_CNN: A Model to Detect COVID-19 from Chest X-ray Images with Deep Learning.

Saha, Priyanka / Neogy, Sarmistha

SN computer science

2022 Volume 3, Issue 4, Page(s) 305

Abstract: COVID-19 is creating havoc on the lives of human beings all around the world. It continues to affect the normal lives of people. As number of cases are high, a cost effective and fast system is required to detect COVID-19 at appropriate time to provide ... ...

Abstract	COVID-19 is creating havoc on the lives of human beings all around the world. It continues to affect the normal lives of people. As number of cases are high, a cost effective and fast system is required to detect COVID-19 at appropriate time to provide the necessary healthcare. Chest X-rays have emerged as an easiest way to detect COVID-19 in no time as RT-PCR takes time to detect the infection. In this paper we propose a concatenation-based CNN model that will detect COVID-19 from chest X-rays. We have developed a multiclass classification problem which can detect and classify a chest X-ray image as either COVID + ve, or viral pneumonia, or normal. We have used chest X-rays collected from different open sources. To maintain class balancing, we took 500 images of COVID, 500 normal images, and 500 pneumonia images. We divided our dataset in training, validation, and test set in 70:10:20 ratio respectively. We used four CNNs as feature extractors from the images and concatenated their feature maps to get better efficiency of the network. After training our model for 5 folds, we have obtained around 96.31% accuracy, 95.8% precision, 92.99% recall, and 98.02% AUC. We have compared our work with state-of-the-art pretrained transfer learning algorithms and other state-of-the-art CNN models referred in different research papers. The proposed model (Concat_CNN) exhibits better accuracy than the state-of-the-art models. We hope our proposed model will help to classify chest X-rays effectively and help medical professionals with their treatment.
Language	English
Publishing date	2022-05-23
Publishing country	Singapore
Document type	Journal Article
ISSN	2661-8907
ISSN (online)	2661-8907
DOI	10.1007/s42979-022-01182-1
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Article: A cross-sectional study exploring the positive aspects of caregiving in opioid dependence and its relation with quality of life, social support, and caregivers' burden.

Saha, Priyanka / Saha, Sayan / Kaloiya, Gauri Shanker / Sarkar, Siddharth

Indian journal of psychiatry

2023 Volume 65, Issue 8, Page(s) 862–868

Abstract: Background and aims: Despite a large body of research linking caregiver burden and social support in substance dependence, positive aspects of caregiving in these disorders have received very minimal attention. This exploratory observational study aimed ...

Abstract	Background and aims: Despite a large body of research linking caregiver burden and social support in substance dependence, positive aspects of caregiving in these disorders have received very minimal attention. This exploratory observational study aimed to assess the positive aspects of caregiving for opioid dependence and evaluate the association of these positive aspects with caregiver quality of life, burden, and social support. Methods: This cross-sectional study included 199 caregivers of patients with opioid dependence recruited through purposive sampling. Participants were assessed using the Scale for Positive Aspects of Caregiving Experience (SPACE), World Health Organization Quality of Life-BREF version, Family Burden Interview Schedule (FBIS), and Social Support Questionnaire. Results: Of the 199 caregivers recruited, a majority of the caregivers were middle-aged women. About two-thirds of the patients were currently using opioids (n = 135, 67.8%), while the remaining were abstinent. Among the SPACE domain scores, the mean was highest for motivation for the caregiving role (2.07), which was followed by self-esteem and social aspect of caring (2.04), caregiving personal gains (1.76), and caregiver satisfaction (1.65). Caregivers of patients currently abstinent experienced greater positive aspects of caregiving (SPACE mean item score 2.57 versus 1.62, Conclusion: Positive aspects of caregiving can be potentially utilized for better caregiver engagement in treatment and improved caregiver outcomes.
Language	English
Publishing date	2023-08-07
Publishing country	India
Document type	Journal Article
ZDB-ID	221523-8
ISSN	0019-5545
ISSN	0019-5545
DOI	10.4103/indianjpsychiatry.indianjpsychiatry_263_23
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Article: Capsaicin Inhibits

Basak, Priyanka / Maitra, Priyanka / Khan, Uzma / Saha, Kalyani / Bhattacharya, Satya Sundar / Dutta, Moumita / Bhattacharya, Sushmita

Frontiers in pharmacology

2022 Volume 13, Page(s) 903438

Abstract: Antibiotic treatment plays an essential role in ... ...

Abstract	Antibiotic treatment plays an essential role in preventing
Language	English
Publishing date	2022-07-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.903438
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Article ; Online: Structural-and-dynamical similarity predicts compensatory brain areas driving the post-lesion functional recovery mechanism.

Chakraborty, Priyanka / Saha, Suman / Deco, Gustavo / Banerjee, Arpan / Roy, Dipanjan

Cerebral cortex communications

2023 Volume 4, Issue 3, Page(s) tgad012

Abstract: The focal lesion alters the excitation-inhibition (E-I) balance and healthy functional connectivity patterns, which may recover over time. One possible mechanism for the brain to counter the insult is global reshaping functional connectivity alterations. ...

Abstract	The focal lesion alters the excitation-inhibition (E-I) balance and healthy functional connectivity patterns, which may recover over time. One possible mechanism for the brain to counter the insult is global reshaping functional connectivity alterations. However, the operational principles by which this can be achieved remain unknown. We propose a novel equivalence principle based on structural and dynamic similarity analysis to predict whether specific compensatory areas initiate lost E-I regulation after lesion. We hypothesize that similar structural areas (SSAs) and dynamically similar areas (DSAs) corresponding to a lesioned site are the crucial dynamical units to restore lost homeostatic balance within the surviving cortical brain regions. SSAs and DSAs are independent measures, one based on structural similarity properties measured by Jaccard Index and the other based on post-lesion recovery time. We unravel the relationship between SSA and DSA by simulating a whole brain mean field model deployed on top of a virtually lesioned structural connectome from human neuroimaging data to characterize global brain dynamics and functional connectivity at the level of individual subjects. Our results suggest that wiring proximity and similarity are the 2 major guiding principles of compensation-related utilization of hemisphere in the post-lesion functional connectivity re-organization process.
Language	English
Publishing date	2023-07-17
Publishing country	United States
Document type	Journal Article
ISSN	2632-7376
ISSN (online)	2632-7376
DOI	10.1093/texcom/tgad012
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